Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development

Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development:



Nature Communications, Published online: 23 September 2020; doi:10.1038/s41467-020-18528-z

Inflammasome activation may contribute to type 2 diabetes, but whether targeting inflammasome is beneficial is unclear. Here the authors show that repurposing nucleoside reverse transcriptase inhibitors for inhibiting inflammasome activation is associated with reduced diabetes development in people and improves insulin sensitivity in experimental settings.