Macrophage secretion of miR-106b-5p causes renin-dependent hypertension

Macrophage secretion of miR-106b-5p causes renin-dependent hypertension:



Nature Communications, Published online: 23 September 2020; doi:10.1038/s41467-020-18538-x

Myeloid cells are involved in hypertension, but their exact role in renin-induced hypertension remains unclear. Here the authors show that impaired vitamin D signaling in myeloid cells causes hypertension via macrophage-specific miR-106b-5p secretion, which activates renin production in the kidney.