ER alpha selective chromone, isoxazolylchromones, induces ROS-mediated cell death without autophagy.
Related Articles ER alpha selective chromone, isoxazolylchromones, induces ROS-mediated cell death without autophagy. Chem Biol Drug Des. 2019 07;94(1):1352-1367 Authors: Kaushik S, Sanawar R, Lekshmi A, Chandrasekhar L, Nair M, Bhatnagar S, Santhoshkumar TR Abstract Chromones are recognized as privileged structures and useful templates for the design of novel compounds with promising pharmacological activity. Several reports implicate chromone...
Tue Aug 25, 2020 13:17
Related Articles Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors. Nat Med. 2020 05;26(5):688-692 Authors: Schalper KA, Carleton M, Zhou M, Chen T, Feng Y, Huang SP, Walsh AM, Baxi V, Pandya D, Baradet T, Locke D, Wu Q, Reilly TP, Phillips P, Nagineni V, Gianino N, Gu J, Zhao H, Perez-Gracia JL, Sanmamed MF, Melero I Abstract Serum interleukin-8 (IL-8)...
Tue Aug 25, 2020 13:17
Related Articles Biomarker-Guided Risk Assessment for Acute Kidney Injury: Time for Clinical Implementation? Ann Lab Med. 2021 01;41(1):1-15 Authors: Albert C, Haase M, Albert A, Zapf A, Braun-Dullaeus RC, Haase-Fielitz A Abstract Acute kidney injury (AKI) is a common and serious complication in hospitalized patients, which continues to pose a clinical challenge for treating physicians. The most recent Kidney Disease Improving Global Outcomes...
Tue Aug 25, 2020 13:17
Related Articles Minichromosome maintenance protein 5 is an important pathogenic factor of oral squamous cell carcinoma. Oncol Lett. 2020 Oct;20(4):109 Authors: Hao M, Wang H, Zhang C, Li C, Wang X Abstract Oral squamous cell carcinoma is one of the most common causes of malignancy-associated death. Early diagnosis of oral squamous cell carcinoma (OSCC) is important in patient treatment and prognostic evaluation. Due to the lack of significant...
Tue Aug 25, 2020 13:17
Related Articles Anti-cancer effects of Porphyra haitanensis polysaccharides on human colon cancer cells via cell cycle arrest and apoptosis without causing adverse effects in vitro. 3 Biotech. 2020 Sep;10(9):386 Authors: Yao WZ, Veeraperumal S, Qiu HM, Chen XQ, Cheong KL Abstract In this study, the anticancer effects of Porphyra haitanensis polysaccharides (PHPs) on human colon cancer cells and non-cancerous cells were evaluated. PHP was...
Tue Aug 25, 2020 13:17
Related Articles Design, Synthesis, and Biological Evaluation of Novel 7H-[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazine Inhibitors as Antitumor Agents. ACS Omega. 2020 Aug 18;5(32):20170-20186 Authors: Ismail MI, Mohamady S, Samir N, Abouzid KAM Abstract A series of novel anticancer hydrazinotriazolothiadiazine-based derivatives were designed based on the structure-activity relationship of the previously reported anticancer triazolothiadiazines....
Tue Aug 25, 2020 13:17
Related Articles Inactive Tlk associating with Tak1 increases p38 MAPK activity to prolong the G2 phase. Sci Rep. 2019 02 13;9(1):1885 Authors: Liaw GJ, Chiang CS Abstract To guard genome integrity, response mechanisms coordinately execute the G2/M checkpoint in responding to stress. p38 MAPK is activated to prolong the G2 phase for completion of damage repair. Tlk activity is required for DNA repair, chromosome segregation and G2 recovery....
Wed Aug 26, 2020 13:22
Related Articles DRUGPATH - a novel bioinformatic approach identifies DNA-damage pathway as a regulator of size maintenance in human ESCs and iPSCs. Sci Rep. 2019 02 13;9(1):1897 Authors: Kovacic B, Rosner M, Schlangen K, Kramer N, Hengstschläger M Abstract Genetic and biochemical screening approaches often fail to identify functionally relevant pathway networks because many signaling proteins contribute to multiple gene ontology pathways....
Wed Aug 26, 2020 13:22
Related Articles The Dichloromethane Fraction of Vernonia cinerea Impart Pro-Apoptotic, Genotoxic, Cell Cycle Arrest, and Drug Efflux Inhibitory Effects in Human Adenocarcinoma Cells. Recent Pat Anticancer Drug Discov. 2020 Aug 24;: Authors: Beeran AA, Udupa N, Maliyakkal N Abstract <P>Background: Vernonia cinerea (VC) is an important medicinal plant used in the indigenous system of therapy. In ethnomedicine, VC has demonstrated anticancer...
Wed Aug 26, 2020 13:22
Related Articles Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Mol Psychiatry. 2020 Aug 24;: Authors: Figueiredo T, Mendes APD, Moreira DP, Goulart E, Oliveira D, Kobayashi GS, Stern S, Kok F, Marchetto MC, Santos R, Gage FH, Zatz M Abstract A homozygous mutation in the inositol monophosphatase 1 (IMPA1) gene was recently identified in nine individuals with severe...
Wed Aug 26, 2020 13:22
Related Articles The introduction of immunosuppressor (TDO inhibitor) significantly improved the efficacy of irinotecan in treating hepatocellular carcinoma. Cancer Immunol Immunother. 2020 Aug 25;: Authors: Liu Q, Hua S, Wang X, Chen F, Gou S Abstract As TDO inhibitors can improve the efficacy of tumor chemotherapeutics, two TDO-targeted conjugates consisting of irinotecan (Ir) and a TDO inhibitor unit were designed and prepared to reverse...
Wed Aug 26, 2020 13:22
Related Articles Cytotoxic Screening and Transcriptomics Reveal Insights into the Molecular Mechanisms of Trihexyl Phosphate-triggered Hepatotoxicity. Environ Sci Technol. 2020 Aug 25;: Authors: Li Z, Tang X, Zhu L, Qi X, Cao G, Lu G Abstract Mounting evidence shows that organophosphate flame retardants (OPFRs), especially aryl- and halogenated-OPFRs, exert various adverse health effects on living organisms. This study evaluated the hepatotoxic...
Wed Aug 26, 2020 13:22
Related Articles A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells. Eur J Pharmacol. 2020 Aug 22;:173497 Authors: Jin F, Wang R, Zhu Y, Chen J, Cao W, Wang Y, Wu Y, Song X, Huang Y, Dong J, Ren Z Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide....
Wed Aug 26, 2020 15:22
Related Articles The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Rep. 2019 07 16;28(3):698-711.e5 Authors: Li L, Ruan X, Wen C, Chen P, Liu W, Zhu L, Xiang P, Zhang X, Wei Q, Hou L, Yin B, Yuan J, Qiang B, Shu P, Peng X Abstract Histone methylation is essential for regulating gene expression during organogenesis to maintain stem cells and execute a proper differentiation program...
Fri Aug 28, 2020 13:27
Related Articles Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1. Cell Chem Biol. 2019 11 21;26(11):1573-1585.e10 Authors: Bakail M, Gaubert A, Andreani J, Moal G, Pinna G, Boyarchuk E, Gaillard MC, Courbeyrette R, Mann C, Thuret JY, Guichard B, Murciano B, Richet N, Poitou A, Frederic C, Le Du MH, Agez M, Roelants C, Gurard-Levin ZA, Almouzni G, Cherradi N, Guerois R, Ochsenbein F Abstract Anti-silencing...
Fri Aug 28, 2020 13:27
microRNA-17 functions as an oncogene by downregulating Smad3 expression in hepatocellular carcinoma.
Related Articles microRNA-17 functions as an oncogene by downregulating Smad3 expression in hepatocellular carcinoma. Cell Death Dis. 2019 09 26;10(10):723 Authors: Lu Z, Li X, Xu Y, Chen M, Chen W, Chen T, Tang Q, He Z Abstract The sekelsky mothers against dpp3 (Smad3) functions as a transcriptional modulator activated by transforming growth factor-β (TGF-β). Accumulated evidences indicated that Smad3 played the important roles in carcinogenesis...
Fri Aug 28, 2020 13:27
Related Articles 2'-Hydroxyflavanone inhibits the progression of pancreatic cancer cells and sensitizes the chemosensitivity of EGFR inhibitors via repressing STAT3 signaling. Cancer Lett. 2020 02 28;471:135-146 Authors: Yue Y, Qian W, Li J, Wu S, Zhang M, Wu Z, Ma Q, Wang Z Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and chemotherapy is still an important treatment. It is urgent to develop new...
Fri Aug 28, 2020 13:27
Related Articles Exploration of the effects of the CYCLOPS gene RBM17 in hepatocellular carcinoma. PLoS One. 2020;15(6):e0234062 Authors: Li C, Ge S, Zhou J, Peng J, Chen J, Dong S, Feng X, Su N, Zhang L, Zhong Y, Deng L, Tang X Abstract BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most lethal and malignant tumours worldwide. New therapeutic targets for HCC are urgently needed. CYCLOPS (copy number alterations yielding cancer liabilities...
Fri Aug 28, 2020 13:27
Related Articles [Effect of circular RNA hsa_circ_0008898 on oral squamous cell carcinoma and its mechanism]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2020 Aug 09;55(8):578-585 Authors: Zhou HX, Wang LY, Chen S, Wang DD, Fang Z Abstract Objective: To investigate the effect and molecular mechanism of hsa_circ_0008898 on the cell proliferation, migration, invasion and tumor formation of oral squamous cell carcinoma (OSCC). Methods: Quantitative...
Fri Aug 28, 2020 13:27
Related Articles Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway. Sci Rep. 2020 Aug 25;10(1):14156 Authors: Zou ZV, Gul N, Lindberg M, Bokhari AA, Eklund EM, Garellick V, Patel AAH, Dzanan JJ, Titmuss BO, Le Gal K, Johansson I, Tivesten Å, Forssell-Aronsson E, Bergö MO, Staffas A, Larsson E, Sayin VI, Lindahl P Abstract Recent data suggest that the transcription factor Zfp148 represses activation of...
Fri Aug 28, 2020 13:27
Related Articles Alerting the immune system to DNA damage: micronuclei as mediators. Essays Biochem. 2020 Aug 26;: Authors: MacDonald KM, Benguerfi S, Harding SM Abstract Healthy cells experience thousands of DNA lesions per day during normal cellular metabolism, and ionizing radiation and chemotherapeutic drugs rely on DNA damage to kill cancer cells. In response to such lesions, the DNA damage response (DDR) activates cell-cycle checkpoints,...
Fri Aug 28, 2020 13:27
Related Articles Decorin in the Tumor Microenvironment. Adv Exp Med Biol. 2020;1272:17-38 Authors: Baghy K, Reszegi A, Tátrai P, Kovalszky I Abstract The tumor microenvironment plays a determining role in cancer development through a plethora of interactions between the extracellular matrix and tumor cells. Decorin is a prototype member of the SLRP family found in a variety of tissues and is expressed in the stroma of various forms of cancer....
Fri Aug 28, 2020 13:27
Related Articles Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage. Cell Rep. 2020 Aug 25;32(8):108077 Authors: Park SR, Namkoong S, Friesen L, Cho CS, Zhang ZZ, Chen YC, Yoon E, Kim CH, Kwak H, Kang HM, Lee JH Abstract DNA damage often induces heterogeneous cell-fate responses, such as cell-cycle arrest and apoptosis. Through single-cell RNA sequencing (scRNA-seq), we characterize the...
Fri Aug 28, 2020 13:27
Related Articles Transport, metabolism and remedial potential of functional food extracts (FFEs) in Caco-2 cells monolayer: A review. Food Res Int. 2020 Oct;136:109240 Authors: Iftikhar M, Iftikhar A, Zhang H, Gong L, Wang J Abstract Caco-2, a human intestinal carcinoma cell line, has been used to test the absorption and transport mechanism of functional foods and drugs across the intestinal epithelium in order to study their antioxidant,...
Fri Aug 28, 2020 13:27
Related Articles Antiproliferative activity of green, black tea and olive leaves polyphenols subjected to biosorption and in vitro gastrointestinal digestion in Caco-2 cells. Food Res Int. 2020 Oct;136:109317 Authors: Jilani H, Cilla A, Barberá R, Hamdi M Abstract Olive (Olea europaea L.) leaves and tea (Camellia sinensis) are rich sources of bioactive compounds, especially polyphenols. Our previous studies have evidenced the potential...
Fri Aug 28, 2020 13:27
Related Articles Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated using Patient HIV-1 Isolates and Computational Modeling. J Virol. 2020 Aug 26;: Authors: Salamango DJ, McCann JL, Demir Ö, Becker JT, Wang J, Lingappa JR, Temiz NA, Brown WL, Amaro RE, Harris RS Abstract HIV-1 Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A-E)....
Fri Aug 28, 2020 13:27
Related Articles ASF1B promotes cervical cancer progression through stabilization of CDK9. Cell Death Dis. 2020 Aug 26;11(8):705 Authors: Liu X, Song J, Zhang Y, Wang H, Sun H, Feng X, Hou M, Chen G, Tang Q, Ji M Abstract Cervical cancer (CC) is one of the most deadly cancers in women, its current treatments still result in poor outcomes and developing the novel targets and therapeutic strategies are urgently needed. Recent studies have...
Fri Aug 28, 2020 13:27
Related Articles Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity. Drug Des Devel Ther. 2020;14:3111-3130 Authors: Mourad AAE, Mourad MAE, Jones PG Abstract Introduction: In order to develop novel anticancer HDAC/tubulin dual inhibitors, a novel series of α-phthalimido-substituted chalcones-based hybrids was synthesized...
Fri Aug 28, 2020 13:27
Related Articles Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer. Drug Des Devel Ther. 2020;14:3301-3313 Authors: Sun Y, Li G, Zhou Q, Shao D, Lv J, Zhou J Abstract Objective: To investigate the effect of erianin on tumor growth and immune response in human colorectal cancer cells (CRC). Methods: The effect of erianin on tumor growth was determined by CCK8 and colony formation assay. Western...
Fri Aug 28, 2020 13:27
Related Articles Tanshinone Inhibits NSCLC by Downregulating AURKA Through Let-7a-5p. Front Genet. 2020;11:838 Authors: Liu X, Zou H, Zhao Y, Chen H, Liu T, Wu Z, Yang C, Li Q, Li Y Abstract Lung cancer is the most deadly malignancy in the last decade, accounting for about 1.6 million deaths every year globally. Tanshinone is the constituent of Salvia miltiorrhiza; it has been found that they influence tumorigenesis. However, the role of...
Fri Aug 28, 2020 13:27
Related Articles Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts. Front Genet. 2020;11:867 Authors: Chen W, Wang X, Wei G, Huang Y, Shi Y, Li D, Qiu S, Zhou B, Cao J, Chen M, Qin P, Jin W, Ni T Abstract Replicative senescence is a hallmark of aging, which also contributes to individual aging. Mouse embryonic fibroblasts (MEFs) provide a convenient...
Fri Aug 28, 2020 13:27
Related Articles 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-κB Signalling Pathways in Lung Cancer A549 Cells. Evid Based Complement Alternat Med. 2020;2020:7375862 Authors: Shen GN, Wang C, Luo YH, Wang JR, Wang R, Xu WT, Zhang Y, Zhang Y, Zhang DJ, Jin CH Abstract Two novel compounds, 2-(2-hydroxyethylthio)-5,8-dimethoxy-1,4-naphthoquinone (HEDMNQ) and 2-(6-hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone...
Fri Aug 28, 2020 13:27
Related Articles Preclinical evaluation of the anti-tumor activity of pralatrexate in high-risk neuroblastoma cells. Oncotarget. 2020 Aug 11;11(32):3069-3077 Authors: Clark RA, Lee S, Qiao J, Chung DH Abstract INTRODUCTION: Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase exhibiting high affinity for reduced folate carrier-1 with antineoplastic and immunosuppressive activities, similar to methotrexate. Despite advances...
Fri Aug 28, 2020 13:27
Related Articles Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity. Front Oncol. 2020;10:1289 Authors: Huang X, Zhang X, Xu J, Wang X, Zhang G, Tang T, Shen X, Liang T, Bai X Abstract The efficacy of cancer immunotherapy depends on the fine interplay between tumoral immune checkpoints and host immune system. However, the up-to-date clinical performance of checkpoint blockers in cancer therapy revealed that higher-level...
Fri Aug 28, 2020 13:27
Related Articles p28 Bacterial Peptide, as an Anticancer Agent. Front Oncol. 2020;10:1303 Authors: Yaghoubi A, Khazaei M, Avan A, Hasanian SM, Cho WC, Soleimanpour S Abstract Cancer remains a major cause of morbidity and mortality irrespective of the type of conventional chemotherapy. Therefore, there is an urgent need for new and effective anticancer therapeutic agents. Bacterial proteins and their derivative peptides appear as a promising...
Fri Aug 28, 2020 13:27
Related Articles 2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression. Front Oncol. 2020;10:1319 Authors: Chen CY, Fang JY, Chen CC, Chuang WY, Leu YL, Ueng SH, Wei LS, Cheng SF, Hsueh C, Wang TH Abstract Magnolia officinalis is widely used in Southeast Asian countries for the treatment of fever, headache, diarrhea, and stroke. Magnolol is a phenolic...
Fri Aug 28, 2020 13:27
Related Articles Nimotuzumab Combined With Irradiation Enhances the Inhibition to the HPV16 E6-Promoted Growth of Cervical Squamous Cell Carcinoma. Front Oncol. 2020;10:1327 Authors: Xu Z, Shu H, Zhang F, Luo W, Li Y, Chu J, Zhao Q, Lv Y Abstract Human papillomavirus (HPV) 16 E6 has been proved to increase the radiosensitivity and lead to the EGFR overexpression in cervical cancer cells. In this study, to investigate the inhibition of nimotuzumab-mediated...
Fri Aug 28, 2020 13:27
Related Articles A Role for Malignant Brain Tumor Domain-Containing Protein 1 in Human Endometrial Stromal Cell Decidualization. Front Cell Dev Biol. 2020;8:745 Authors: Chadchan SB, Maurya VK, Krekeler GL, Jungheim ES, Kommagani R Abstract Up to 30% of women experience early miscarriage due to impaired decidualization. For implantation to occur, the uterine endometrial stromal fibroblast-like cells must differentiate into decidual cells,...
Fri Aug 28, 2020 13:27
Related Articles Pharmacological Properties of Pt(II) and Pt(IV) Complexes with 2,2'-Dipyridylamine; the Comparative In Vitro Thereof. Cell Biochem Biophys. 2020 Aug 27;: Authors: Aghmasheh S, Ostad SN, Abedi A Abstract Pt-based drugs such as cisplatin are frontline drugs used for the treatment of different solid malignancies. However, they represent major problems, such as severe side effects and drug resistance. To find out the structure-activity...
Fri Aug 28, 2020 13:27
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