Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity:



Nature Communications, Published online: 23 September 2020; doi:10.1038/s41467-020-18396-7

Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug structural signatures to determine an integrated predictive signature of cardiotoxicity.