Related Articles Outcomes of frontolateral vertical partial laryngectomy in T1b glottic carcinomas. Acta Otolaryngol. 2020 Sep 17;:1-7 Authors: Jadeed R, Westhofen M Abstract BACKGROUND: The treatment of T1b glottic carcinomas with invasion of the anterior commissure (AC) is still a challenge in larynx oncology. The diversity in treatment protocols is due to the difficulty in achieving safety margins of resection, especially in the AC. ...
Fri Sep 18, 2020 16:15
Related Articles Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats: implications on COVID 19 infections. Laryngoscope. 2020 Sep 17;: Authors: Sato T, Ueha R, Goto T, Yamauchi A, Kondo K, Yamasoba T Abstract OBJECTIVE: Patients with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibit not only respiratory symptoms but also symptoms of chemo-sensitive...
Fri Sep 18, 2020 16:15
Vocal fold granulomas in six brachycephalic dogs: clinical, macroscopical and histological features.
Related Articles Vocal fold granulomas in six brachycephalic dogs: clinical, macroscopical and histological features. J Small Anim Pract. 2020 07;61(7):458-461 Authors: Sarran D, Caron A, Billet JP Abstract Vocal cord granulomas are rarely observed in brachycephalic breeds but often reported in humans as contact granulomas. Six French bulldogs were included in this retrospective descriptive study. Endoscopic laryngeal examinations were performed...
Sun Sep 20, 2020 07:57
Related Articles Detection of Mycoplasma hyopneumoniae in nasal and laryngeal swab specimens in endemically infected pig herds. Vet Rec. 2020 01 04;186(1):27 Authors: Moiso N, Pieters M, Degano F, Vissio C, Camacho P, Estanguet A, Parada J, Tamiozzo PJ Abstract BACKGROUND: Apparently, laryngeal swabs (LS) are more sensitive than nasal swabs (NS) and allow earlier detection of Mycoplasma hyopneumoniae by PCR. However, antecedents about the compared...
Sun Sep 20, 2020 07:57
Related Articles Dupilumab therapy for patients with refractory eosinophilic otitis media associated with bronchial asthma. Auris Nasus Larynx. 2020 Sep 14;: Authors: Iino Y, Sekine Y, Yoshida S, Kikuchi S Abstract OBJECTIVES: Eosinophilic otitis media (EOM) is an intractable otitis media mostly associated with bronchial asthma. Dupilumab, an anti-interleukin (IL)-4 receptor (R)α, is effective and has been approved for use in patients with moderate...
Sun Sep 20, 2020 07:57
Related Articles Phase 1B Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck. Clin Cancer Res. 2020 Sep 17;: Authors: Shin DM, Nannapaneni S, Patel MR, Shi Q, Liu Y, Chen Z, Chen A, El-Deiry MW, Beitler JJ, Steuer CE, Roser SM, Klein AM, Owonikoko TK, Ramalingam SS, Khuri FR, Chen ZG, Saba NF Abstract PURPOSE: Based on synergistic effects between green...
Sun Sep 20, 2020 07:57
Related Articles Supraglottic Carcinoma in Intravenous Opioid Drug Abusers: A Distinct Disease with Improved Survival. Laryngoscope. 2020 Sep 18;: Authors: Yaniv D, Reuven Y, Lahav Y, Cohen O, Hamzany Y, Moore A, Rapana OG, Argaman N, Halperin D, Popovtzer A, Bachar G, Shoffel-Havakuk H Abstract OBJECTIVES/HYPOTHESIS: Recent evidence indicates an increased prevalence of intravenous opioid drug abusers (IVDAs) among supraglottic squamous cell...
Sun Sep 20, 2020 07:57
Related Articles Relapse-free survival after adjuvant radioactive iodine therapy in patients with differentiated thyroid carcinoma with a microscopically positive tumor margin. Ann Nucl Med. 2020 Sep 17;: Authors: Watanabe K, Igarashi T, Uchiyama M, Ojiri H Abstract OBJECTIVE: In patients with differentiated thyroid carcinoma (DTC) with a microscopically positive tumor margin, the optimal first dose of I-131 during adjuvant radioactive...
Fri Sep 18, 2020 15:48
Related Articles IN-SITU GAMMA-RAY SPECTROMETRY FOR RADIOACTIVITY ANALYSIS OF SOIL USING NaI(Tl) AND LaBr3(Ce) DETECTORS. Radiat Prot Dosimetry. 2019 Dec 31;187(3):300-309 Authors: Lee JH, Byun JI Abstract In this study, the full energy peak count rates to radioactivity conversion factors of 3″Ø × 3″ NaI(Tl) and 2″Ø × 2″ LaBr3(Ce) detectors for radioactivity analysis in the soil were determined on site using a semi-empirical method with point-like...
Sun Sep 20, 2020 08:13
Related Articles Testicular Changes Associated with SARS-CoV-2. Arch Pathol Lab Med. 2020 Sep 18;: Authors: Flaifel A, Guzzetta M, Occidental M, Najari BB, Melamed J, Thomas KM, Deng FM PMID: 32947611 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 08:46
Related Articles Nothing unusual: bilateral recurrent laryngeal nerves have followed the rule. Surg Radiol Anat. 2020 Sep 18;: Authors: Prabhu S, Mehra S PMID: 32945905 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 08:46
Related Articles [Medical examination: Preparation for ENT specialization : Part 50]. HNO. 2020 Sep 17;: Authors: Eichhorn T PMID: 32940770 [PubMed - as supplied by publisher]
Fri Sep 18, 2020 16:31
Related Articles [Slowly progressive soft tumor of the anthelix]. HNO. 2020 Sep 17;: Authors: Breitrück NY, Ortmann M, Klussmann JP, Meyer MF PMID: 32944819 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 08:50
Related Articles [Unusual cause of dysphagia in the emergency department]. HNO. 2020 Sep 17;: Authors: Plößl S, Gufler H, Plontke SK PMID: 32944820 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 08:50
Related Articles [Sore throat as indication for tonsillectomy before and after implementation of the German guideline for tonsillitis : Longitudinal study covering 115.839 procedures]. HNO. 2020 Sep 18;: Authors: Windfuhr JP, Schmuker C, Günster C Abstract BACKGROUND: Tonsillectomy is a reasonable indication in the management of sore throat not responding to antibiotic treatment. This longitudinal patient-level study was conducted to estimate...
Sun Sep 20, 2020 08:50
Related Articles Screening for obstructive sleep apnea with novel hybrid acoustic smartphone app technology. J Thorac Dis. 2020 Aug;12(8):4476-4495 Authors: Tiron R, Lyon G, Kilroy H, Osman A, Kelly N, O'Mahony N, Lopes C, Coffey S, McMahon S, Wren M, Conway K, Fox N, Costello J, Shouldice R, Lederer K, Fietze I, Penzel T Abstract Background: Obstructive sleep apnea (OSA) has a high prevalence, with an estimated 425 million adults with apnea...
Sun Sep 20, 2020 09:13
Chronic rhinosinusitis due to cyano-acrylic glue after endoscopic transsphenoidal pituitary surgery.
Related Articles Chronic rhinosinusitis due to cyano-acrylic glue after endoscopic transsphenoidal pituitary surgery. BMC Surg. 2020 Sep 16;20(1):205 Authors: Bani-Ata M, Alzoubi F, Abuzayed B, Alhowary AAA, Aleshawi AJ Abstract BACKGROUND: To reduce the risk of cerebrospinal fluid leak, clinicians utilize a filling material placed in the sella followed by floor reconstruction with various materials, including glue sealing. Cyano-acrylic glue...
Fri Sep 18, 2020 16:44
Related Articles Face-to-face four hand technique in vestibular schwannoma surgery: results from 256 Danish patients with larger tumors. Acta Neurochir (Wien). 2020 01;162(1):61-69 Authors: Springborg JB, Lang JM, Fugleholm K, Poulsgaard L Abstract BACKGROUND: The objective of this study was to investigate the clinical outcome after microsurgical treatment of vestibular schwannomas using face-to-face four hand technique in 256 Danish patients...
Sun Sep 20, 2020 09:18
Related Articles Middle Cranial Fossa Approach to Vestibular Schwannoma Resection in the Older Patient Population. Otol Neurotol. 2020 Sep 16;: Authors: Kohlberg GD, Lipschitz N, Raghavan AM, Breen JT, Pensak ML, Zuccarello M, Samy RN Abstract OBJECTIVE: Compare outcomes of middle cranial fossa approach (MCF) to vestibular schwannoma (VS) resection in patients 60 years of age and older to patients under 60. STUDY DESIGN: Retrospective...
Sun Sep 20, 2020 09:18
Related Articles Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy. Brain Res. 2019 07 15;1715:203-212 Authors: Zhu J, Dou S, Jiang Y, Chen J, Wang C, Cheng B Abstract The dopaminergic neurodegeneration in the substantia nigrapars compacta (SNpc) and striatum of the midbrain is the important pathological feature of Parkinson's disease...
Sun Sep 20, 2020 09:32
Related Articles [New drug approval: Olaparib - pancreatic cancer with BRCA germline mutation]. Bull Cancer. 2020 Sep 14;: Authors: Hilmi M, Neuzillet C PMID: 32943226 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 09:38
Related Articles Hemodynamic Changes with 1:1000 Epinephrine on Wrung-Out Pledgets Before and During Sinus Surgery. Ann Otol Rhinol Laryngol. 2020 Sep 18;:3489420959107 Authors: Peleman JR, Tarwade P, Han X, Penning DH, Craig JR Abstract BACKGROUND: Intranasal topical 1:1000 epinephrine has been used safely and effectively for hemostasis during endoscopic sinus surgery (ESS). Prior studies assessing hemodynamic changes after intranasal...
Sun Sep 20, 2020 09:38
Related Articles Utility of invasive electroencephalography in children 3 years old and younger with refractory epilepsy. J Neurosurg Pediatr. 2020 Sep 18;:1-6 Authors: Uribe-Cardenas R, Boyke AE, Schwarz JT, Morgenstern PF, Greenfield JP, Schwartz TH, Rutka JT, Drake J, Hoffman CE Abstract OBJECTIVE: Early surgical intervention for pediatric refractory epilepsy is increasingly advocated as surgery has become safer and data have demonstrated...
Sun Sep 20, 2020 09:46
Related Articles Use of fast-sequence spine MRI in pediatric patients. J Neurosurg Pediatr. 2020 Sep 18;:1-6 Authors: Gewirtz JI, Skidmore A, Smyth MD, Limbrick DD, Goyal M, Shimony JS, McKinstry RC, Groves ML, Strahle JM Abstract OBJECTIVE: The immediate and long-term risk of anesthesia in the pediatric population is controversial. Traditional spine MRI protocols require the patient to remain still during the examination, and in young children...
Sun Sep 20, 2020 09:46
Related Articles Postoperative fever workup in pediatric neurosurgery patients. J Neurosurg Pediatr. 2020 Sep 18;:1-5 Authors: Raviv N, Field N, Adamo MA Abstract OBJECTIVE: Fevers are common in the postoperative period, and adult data indicate that workup for an isolated fever is not warranted in the first 4 postoperative days (PODs). Pediatric literature on the subject similarly questions the value of further investigation during the first...
Sun Sep 20, 2020 09:46
Related Articles Effectiveness of Neuromuscular Electrical Stimulation on Post-Stroke Dysphagia: A Systematic Review of Randomized Controlled Trials. Clin Interv Aging. 2020;15:1521-1531 Authors: Alamer A, Melese H, Nigussie F Abstract The purpose of this review was to summarize the latest best scientific evidence on the efficacy of neuromuscular electrical stimulation on swallowing function in dysphagic stroke patients. A comprehensive systematic...
Sun Sep 20, 2020 09:59
Related Articles Analysis of clinical outcomes in elderly patients with impaired swallowing function. PLoS One. 2020;15(9):e0239440 Authors: Sunata K, Terai H, Seki H, Mitsuhashi M, Kagoshima Y, Nakayama S, Wakabayashi K, Muraoka K, Suzuki Y, Suzuki Y Abstract Japan is the world's leading aging society, and increasing medical expenses for elderly people is an urgent issue. Since aspiration pneumonia in elderly people with impaired swallowing...
Sun Sep 20, 2020 09:59
Related Articles Travel-associated COVID-19: a challenge for surveillance? Euro Surveill. 2020 Sep;25(37): Authors: Beauté J, Spiteri G PMID: 32945253 [PubMed - in process]
Sun Sep 20, 2020 10:15
Related Articles Poor self-reported adherence to COVID-19-related quarantine/isolation requests, Norway, April to July 2020. Euro Surveill. 2020 Sep;25(37): Authors: Steens A, Freiesleben de Blasio B, Veneti L, Gimma A, Edmunds WJ, Van Zandvoort K, Jarvis CI, Forland F, Robberstad B Abstract To limit SARS-CoV-2 spread, quarantine and isolation are obligatory in several situations in Norway. We found low self-reported adherence to requested measures...
Sun Sep 20, 2020 10:15
Related Articles Letter to the editor: COVID-19 cases among school-aged children and school-based measures in Hong Kong, July 2020. Euro Surveill. 2020 Sep;25(37): Authors: Fong MW, Cowling BJ, Leung GM, Wu P PMID: 32945255 [PubMed - in process]
Sun Sep 20, 2020 10:15
Related Articles Resurgence of an international hepatitis A outbreak linked to imported frozen strawberries, Germany, 2018 to 2020. Euro Surveill. 2020 Sep;25(37): Authors: Ruscher C, Faber M, Werber D, Stark K, Bitzegeio J, Michaelis K, Sagebiel D, Wenzel JJ, Enkelmann J Abstract Following outbreaks linked to frozen strawberries in Sweden and Austria in 2018, 65 cases linked to the same hepatitis A virus strain were detected in Germany between...
Sun Sep 20, 2020 10:15
Abstract The finding that intuitions about the reference of proper names vary cross-culturally (Machery et al. Cognition 92: 1–12. 2004) was one of the early milestones in experimental philosophy. Many follow-up studies investigated the scope and magnitude of such cross-cultural effects, but our paper provides the first systematic meta-analysis of studies replicating (Machery et al. Cognition 92: 1–12. 2004). In the light of our results, we assess the existence and significance...
Sun Sep 20, 2020 03:00
Novel activity is reported for the diiron N‐oxygenase PvfB from the Pseudomonas virulence factor pathway. Instead of modifying anilines like other N‐oxygenases, PvfB oxygenates the α‐amine of valine tethered to a carrier protein, first to a hydroxylamine then a nitroso, as characterized by protein NMR spectroscopy. The activity of PvfB is key to the biosynthesis of two different types of N−O bond‐containing natural products. Abstract The Pseudomonas virulence factor (pvf) operon is essential...
Fri Sep 18, 2020 12:05
The biological application of an air‐, water‐, and culture‐medium‐stable germylene is demonstrated. The compound DPMGeOH (DPM=dipyrromethene ligand) shows strong antiproliferative effects on human cancer cell lines but is only minimally toxic to normal epithelial cells. Abstract The biological applications of germylenes remain unrealised owing to their unstable nature. We report the isolation of air‐, water‐, and culture‐medium‐stable germylene DPMGeOH (3; DPM=dipyrromethene ligand) and...
Fri Sep 18, 2020 12:05
A NIR photo‐switched miRNA amplifier is proposed for precise photodynamic therapy of early‐stage cancers. The designed photozipper avoids off‐target damage during in vivo delivery and can be controllably cleaved to trigger miRNA‐responsive cascade activation of photosensitizers under UV and blue emissions of UCNPs, which amplifies ROS generation for highly efficient cancer treatment. Abstract Stimuli‐responsive photodynamic therapy (PDT) is a hot topic in precise medicine, but the low abundance...
Fri Sep 18, 2020 12:05
Natural‐product‐like polycyclic pyrrolo[2,3‐c]quinoline derivatives have been easily constructed in one‐step process from easily available starting materials. This reaction involves two ring enlargements and four heterocyclic ring formations via cascade rearrangement process. DFT studies reveal the crucial hydrogen‐bonding interaction in the detailed mechanistic investigation. Abstract An efficient cascade reaction of tryptamine‐derived isocyanides with C,N‐cyclic azomethine imines is described....
Fri Sep 18, 2020 12:05
By combining synthetic biology and protein engineering, anisotropic protein organofibers with extraordinary mechanical properties for cellular mechanobiology applications are assembled. This approach can be used to fabricate novel protein‐based fiber devices that are suitable for various translations such as mechano‐patch engraftments as well as organ‐regeneration matrix scaffolds in the near future. Abstract Hydrogels enable a variety of applications due to their dynamic networks, structural...
Fri Sep 18, 2020 12:08
An artificial neural network calculates whether two molecules are likely to form a co‐crystal. The approach shows excellent performance on the proposed co‐crystal training and validation sets, and has an estimated accuracy of 80 % for molecules for which previous co‐crystallization data is unavailable. The figure illustrates the prediction of the newly discovered drug–drug co‐crystal containing ketoprofen and carbamazepine. Abstract A significant amount of attention has been given to the...
Fri Sep 18, 2020 12:09
The allosteric transcription factor TetR acts as a sensor and actuator in this quantum dot enabled fluorescent bead assay for the small molecule anhydrotetracycline. This rapid, antibody‐free biosensor produces a visible change in fluorescent color, which can be detected by eye or with an inexpensive digital camera, based on dose‐dependent analyte‐responsive protein‐DNA binding. The adaptable sensor uses easily accessible biomolecular components. Abstract Recently, allosteric transcription...
Fri Sep 18, 2020 14:13
Two‐dimensional (2D) boron nanosheet that exhibits high theoretical capacitance, around four times that of graphene, has become significant supercapacitor electrode. However, its bulk structure with low interlaminar conduction and porosity restricts the charge transfer, ion diffusion and energy density. Herein, we develop a new 2D hetero‐nanosheet made of anisotropic boron‐carbon nanosheets (ABCNs) by B‐C chemical bonds via gas‐phase exfoliation and condensation bottom‐up strategy. The ABCNs are...
Fri Sep 18, 2020 14:13
As a favourite descriptor, the size effect of Cu‐based catalysts has been regularly utilized for activity and selectivity regulation toward CO 2 /CO electroreduction reactions (CO 2 /CORR). However, little progress has been made in regulating the size of Cu nanoclusters at the atomic level. Here, the size‐gradient Cu catalysts from single atoms (SAs) to subnanometric clusters (SCs, 0.5−1 nm) to nanoclusters (NCs, 1−1.5 nm) on graphdiyne matrix are readily prepared via a creative acetylenic‐bond‐directed...
Fri Sep 18, 2020 15:38
Temperature is often not considered as a precision stimulus for artificial chemical systems in contrast to the host‐guest interactions related to many natural processes. Similarly, mimicking multi‐state volatile memory operations using a single molecular system with temperature as a precision stimulus is highly laborious. Here we demonstrate how a mixture of iron(II) chloride and bipyridine can be used as a reversible color‐to‐colorless thermochromic switch and counter operators. The generality...
Fri Sep 18, 2020 15:38
Total synthesis allowed the question to be answered which of eight possible stereoisomeric compounds represents the cytotoxic marine macrolides of the formosalide family. The underlying blueprint was inherently modular to ensure that each conceivable isomer could be reached. This flexibility derived from the use of strictly catalyst‐controlled transformations to set the stereocenters, except for the anomeric position that is under thermodynamic control; as an extra safety measure, all chiral centers...
Fri Sep 18, 2020 17:05
Non‐metal‐based single‐atom catalysts (SACs) feature low cost, simple synthesis methods and effective regulation for substrates, while there are few studies on this aspect. Herein, we developed a simplified pressurized gas‐assisted process, and first reported a non‐metal single‐atom phosphorus with atomic‐level dispersion on unique single‐crystal Mo 2 C hexagonal nanosheet arrays with (001) plane exposure supported by carbon sheet (SAP‐Mo 2 C‐CS). The SAP‐Mo 2 C‐CS is structurally stable and...
Fri Sep 18, 2020 18:05
Supramolecular cages/vesicles in biology display sophisticated structures and functions by utilizing few types of protein subunits quasi‐equivalently serving on distinct geometrical locations. However, the synthetic supramolecular cages still lack comparable complexity to reach the high levels of functionality found in natural systems. Here we report the self‐assembly of giant pentagonal supramolecular prisms (molecular weight > 50 kDa) with tetratopic pyridinyl subunits serving different geometrical...
Fri Sep 18, 2020 20:17
The development of enantioconvergent cross‐coupling of racemic alkyl halides directly with heteroarene C( sp 2 )–H bonds has been impeded by the commonly necessary use of base at elevated temperature that leads to racemization. We herein report a copper(I)/cinchona‐alkaloid‐derived N , N , P ‐ligand catalytic system that enables oxidative addition with racemic alkyl bromides under mild conditions. Thus, the coupling with azole C( sp 2 )–H bonds has been achieved in high enantioselectivity,...
Sat Sep 19, 2020 12:35
A pair of MRI scans showing the imaging pattern of Bornavirus‐1 encephalitis. The left hand image shows a normal MRI scan on the left, and a drawing on the right of the most affected areas of the brain, which are in warmer colors (yellow to red indicating progressively greater involvement). The right hand image shows a FLAIR image of the brain of a patient 35 days after onset of symptoms, with the lighter areas illustrating greater degree of damage in this case. Note that the insular cortex and striatum...
Fri Sep 18, 2020 11:14
This study aimed to characterise both neuronal autoantibodies and levels of IFNα, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). CSF and plasma from 35 SLE patients (15 with NPSLE) showed no antibodies against natively‐expressed NMDA receptors, or the surface of live hippocampal neurons. By comparison to controls (n=104), SLE patient antibodies bound a peptide representing the extracellular domain of NMDARs (p<0.0001), however, binding was retained against...
Sat Sep 19, 2020 21:44
Abstract Background The clinical impact of Medicaid expansion in otolaryngology is uncertain. Herein, we evaluate the impact of Medicaid expansion on treatment patterns (primary radiotherapy vs surgery) in the early glottic cancer population. Methods Data regarding adults with Tis‐T2N0M0 glottic cancer that were treated with either surgery or radiotherapy between January 2010 and December 2016 were obtained from the Surveillance, Epidemiology, and End Results (SEER) cancer database. Changes...
Fri Sep 18, 2020 12:39
Abstract Background To assess hybrid positron emission tomography (PET) imaging in the initial staging and outcome prediction of sinonasal malignancies. Methods Retrospective study on patients with sinonasal malignancies undergoing hybrid PET imaging for initial staging. Results Complete remission (CR) was achieved in 45 of 65 patients (69.2%). Overall sensitivity for detection of primaries using 18F‐fluoro‐deoxy‐d‐glucose PET (FDG‐PET) was 95.4%, for lymph node metastases 100% and...
Fri Sep 18, 2020 15:42
Abstract Background This population‐based retrospective study compares the efficacy of cisplatin (cis‐RT) vs cetuximab (cetux‐RT) with concurrent radiation as definitive treatment in patients with oropharyngeal carcinoma (OPC). Methods Patients with OPC treated in Alberta with cis‐RT or cetux‐RT between 2006 and 2016 were evaluated. Median disease‐free survival (DFS) and overall survival (OS) were assessed using the Kaplan‐Meier method. Multivariable analysis (MVA) was completed with a...
Sat Sep 19, 2020 11:36
Objectives/Hypothesis Assumed advantages of a minimally invasive endoscopic transmeatal approach in ear surgery are less postoperative pain, faster healing, and preservation of functional anatomy. We evaluated pain after ear surgery and compared endoscopic transmeatal, microscopic endaural, and retroauricular approaches. Study Design Prospective cohort study. Methods A prospective evaluation of pain during 3 weeks after ear surgery was performed. Three groups were defined: endoscopic...
Fri Sep 18, 2020 14:20
Objectives To evaluate the incidence of histopathologic diagnostic discrepancy for patients referred to our institution, identify pathologies susceptible to diagnostic error, and assess the impact on survival of histopathologic diagnostic discrepancies. Methods Three hundred ninety‐seven patients with sinonasal cancers were identified, and discordance between the outside pathologic report and MD Anderson Cancer Center pathologic report was assessed. Overall survival and disease‐specific survival...
Fri Sep 18, 2020 19:42
Supraglottic Carcinoma in Intravenous Opioid Drug Abusers: A Distinct Disease with Improved Survival
Objectives/Hypothesis Recent evidence indicates an increased prevalence of intravenous opioid drug abusers (IVDAs) among supraglottic squamous cell carcinoma (SG‐SCC) patients. This study investigates whether the clinical course of SG‐SCC in IVDA differs from SG‐SCC in non‐IVDA. Study Design A retrospective case–control study conducted in a in two tertiary referral centers. Methods This case–control study compares IVDA with non‐IVDA patients diagnosed and treated for SG‐SCC in between...
Fri Sep 18, 2020 19:45
Effect of Endoscope Sinus Surgery on Pulmonary Function in Cystic Fibrosis Patients: A Meta‐Analysis
Objective The objective of this study was to quantify the effect of endoscopic sinus surgery on pulmonary function in patients with cystic fibrosis and chronic rhinosinusitis. Methods The PubMed, MEDLINE, Cochrane Library, and Embase databases were searched for studies published in English, without any language and time restrictions from their inception to March 1, 2020. Studies examining pulmonary function outcomes in patients with cystic fibrosis and chronic rhinosinusitis following endoscopic...
Sat Sep 19, 2020 16:02
Objectives/Hypothesis Interaction with voice recognition systems, such as Siri™ and Alexa™, is an increasingly important part of everyday life. Patients with voice disorders may have difficulty with this technology, leading to frustration and reduction in quality of life. This study evaluates the ability of common voice recognition systems to transcribe dysphonic voices. Study Design Retrospective evaluation of "Rainbow Passage" voice samples from patients with and without voice disorders....
Sat Sep 19, 2020 16:04
Key points The functional roles of the capsaicin receptor, TRPV1, outside of sensory nerves are unclear. We mapped TRPV1 in the mouse circulation, revealing extensive expression in the smooth muscle of resistance arterioles supplying skeletal muscle, heart and adipose. Activation of TRPV1 in vascular myocytes constricted arteries, reduced coronary flow in isolated hearts, and increased systemic blood pressure. These functional effects were retained after sensory nerve ablation, indicating specific...
Thu Sep 17, 2020 20:21
Abstract Skin structure and function results from a dynamic interplay between dermal and epidermal cell types. Optimizing skin health through an effective and long‐lasting skin care regime therefore requires a global approach, encompassing various mechanisms to stimulate this interplay beyond the action scope of a classical topical solution. This study evaluates the impact of a novel home‐use device combining a topical serum, light‐emitting diodes and massage on the clinical signs of extrinsic skin...
Sat Sep 19, 2020 15:50
Abstract Objective The aim of this study was to investigate the safety and performance of Princess® VOLUME Lidocaine in nasolabial fold correction. Materials and Methods In this prospective, open label, multicenter, postmarket study subjects received injections of Princess® VOLUME Lidocaine into both NLF at Baseline (Day 0) and if considered necessary by the investigator, at Week 2 (touch‐up treatment). This study was conducted in Austria at the Department of Dermatology and Venereology,...
Fri Sep 18, 2020 18:33
Abstract Some studies have demonstated that neurotransmitters are involved in the pathogenesis of numerous skin conditions, including psoriasis, addressing the close correlation between the skin and the central nervous system. There are reports showing psoriasis improvement after peripheral nervous system injury. In addition, botulinum toxin has been reported as a treatment for several diseases, including psoriasis. This is a proof‐of‐concept study of botulinum toxin and psoriasis, involving 8...
Sat Sep 19, 2020 13:29
Reflectance confocal microscopy for striae distansae treatment monitoring after CO2 fractional laser
Abstract The aim of this study is to describe the efficacy and safety of CO2 fractional laser to treat striae distensae (SD), before (T0) and 1 month after the last laser session (T1), in patients following different protocols based on the number of laser sessions, ≤4 and > 4. Efficacy was estimated with global assessment improvement scale (GAIS) performed by both physicians and patients, reflectance confocal microscopy (RCM), dermatology life quality index (DLQI). Safety was evaluated through...
Sat Sep 19, 2020 13:30
ABSTRACT Background During the outbreak of COVID‐19 many pernio‐like lesions have been increasingly reported. The aim of the study is to describe our management of these skin manifestations and to evaluate a possible correlation to SARS‐CoV‐2 infection. Methods All patients underwent clinical and laboratory tests to detect a possible underlying connective disease and also to specific SARS‐CoV‐2 investigations such as oropharyngeal swab and IgG‐IgM serology. Results Nine patients aged...
Sat Sep 19, 2020 16:34
Abstract Background Gracilaria algae is red macro algae which has demonstrated considerable anti‐inflammatory effects. Our objective was to compare the efficacy of Gracilaria algae topical cream 3% versus Clobetasol cream 0.05% in treatment of plaque‐type psoriasis. Material and methods 30 adult patients with baseline modified PASI score ≤12 were randomized to receive either Clobetasol or Gracilaria algae cream on right or left‐sided symmetric plaques once daily for 8 weeks and follow‐up...
Sat Sep 19, 2020 20:59
Abstract Objective: To investigate the application of the vermillion myocutaneous flap in restoration after lip cancer resection. Method: From July 2012 to December 2019, six patients with lip cancer admitted in our department were included in this study. Total defect of the whole layer of the lip, accounted for 1/3‐1/2 of the total length of the lip after tumor resection, were repaired by vermillion myocutaneous flap. For the case defect presenting >1/2 of the total length of the lip, a local...
Sat Sep 19, 2020 21:14
Abstract Pitt–Hopkins syndrome (PTHS, MIM #610954) is a rare neurodevelopmental disease characterized by the association of intellectual disability, characteristic facial gestalt and episodes of abnormal and irregular breathing. PTHS is due to heterozygous loss‐of‐function variants in the TCF4 gene (transcription factor 4, MIM #602272) encoding for a basic helix–loop–helix transcription factor. TCF4 is highly expressed during early development of the nervous system, and it is involved in cellular...
Fri Sep 18, 2020 11:58
Abstract We report a patient with phenotypic semblance to the congenital microgastria‐limb reduction association (MLRD). Our patient presented with microgastria, bilateral upper limb anomalies, asplenia, solitary kidney, and mild micrognathia. In addition to the anomalies seen in our patient, MLRD has been associated with respiratory, cardiovascular, and central nervous system anomalies. MLRD is thought to arise from a developmental field defect during embryonic weeks five and six; however, no genetic...
Fri Sep 18, 2020 14:15
Abstract The aim of this study was to evaluate the oral, dental, and craniofacial features of individuals affected by the chronic forms of acid sphingomyelinase deficiency (ASMD). This study comprised a sample of adult and pediatric patients (n = 8) with chronic ASMD. The individuals underwent oral examinations to evaluate the occurrence of caries, as well as full‐mouth periodontal examinations, to assess the occurrence and severity of periodontal diseases. Panoramic and profile radiographs were...
Fri Sep 18, 2020 15:38
Abstract Differences in sex development (DSD) are a group of rare conditions involving genes, hormones and reproductive organs, including genitals. Although these disorders are common, information about the molecular causes remain limited. Many genes have been identified in association with DSD but in many cases the causative gene could not be identified. The Lhx9 gene has been studied in mice and birds, and biallelic mutations in this gene have been found to cause 46,XY DSD and limb abnormalities....
Sat Sep 19, 2020 11:10
Abstract Blepharophimosis‐ptosis‐intellectual disability syndrome (BPID) is an extremely rare recognizable blepharophimosis intellectual disability syndrome (BID). It is caused by biallelic variants in the UBE3B gene with only 24 patients described worldwide. Herein, we report on the clinical, brain imaging and molecular findings of additional nine patients from six unrelated Egyptian families. Patients presented with the characteristic features of the syndrome including blepharophimosis, ptosis,...
Sat Sep 19, 2020 11:11
Abstract Disorders of sex development (DSD) are congenital conditions with atypical development of chromosomal, gonadal, or anatomical sex. The estimated incidence ranges from 1 in 4,500–5,500 for strictly defined “ambiguous genitalia” to 1 in 300 or higher when a broader definition is implemented. In this study, we aim to define DSD phenotypes encountered in a large heterogeneous cohort of molecularly characterized Mendelian disorders in a single center. Data were retrieved for patients with documented...
Sat Sep 19, 2020 11:24
Abstract BackgroundCystoscopy plays an important role in the diagnosis of bladder tumors. As a typical representative of the deep learning algorithm, the convolutional neural network has shown great advantages in the field of image recognition and segmentation.Methods1002 photographs of normal bladder tissue and 734 photos of bladder tumors under cystoscopy were taken from 175 patients. Caffe deep learning framework and EasyDL platform were used to structure and train the model. The trained model...
Fri Sep 18, 2020 13:33
Abstract—During minimally invasive (either robotic or traditional laparoscopic) surgery, vascular injuries may occur because of inadvertent surgical tool movements or actions. These vascular injuries can lead to arterial or venous bleeding with varying degrees of severity that may be life‐threatening. In this paper, we present a novel local‐entropy‐based image processing algorithm that has the potential to detect spurts of blood and locate their source in real‐time. Given that a bloody spot is characterized...
Fri Sep 18, 2020 18:19
Abstract BackgroundThe robotic‐assisted unicompartmental knee arthroplasty (UKA) is proposed to improve the accuracy of component positioning.MethodsWe conducted a literature search in Medline, Embase, Web of Science, and the Cochrane Library until April 2020.ResultsOur meta‐analysis included 10 articles, involving 1231 knees. Our meta‐analysis demonstrated that the robotic group had significantly better results in outliers of limb alignment (P< 0.001) and outliers of tibial alignment (P<0.001)....
Fri Sep 18, 2020 22:11
Abstract BackgroundRobot‐assisted pedicle screw insertion has gained popularity in the spinal surgery field. Due to high cost, these spinal robots are not extensively applied in clinical surgeries. Developing an effective robot system with low cost and high clinical acceptability is one of the future trends.MethodsWe developed a novel fluoroscopy‐based robot system for pedicle screw insertion. 4 live pigs were conducted with percutaneous pedicle screw insertion. Robot‐assisted surgery was performed...
Sat Sep 19, 2020 16:39
Abstract BackgroundRecently, task‐autonomous image‐guided robotic cochlear implantation has been successful completed in patients. However, no data exists on patients' perspective of this new technology. The aim of this study was to evaluate the acceptance of patients towards task‐autonomous robotic cochlear implantation (TARCI).MethodsWe prospectively surveyed 63 subjects (51 patients and 12 parents of infants) scheduled for manual cochlear implantation. We collected sociodemographic and clinicopathological...
Sat Sep 19, 2020 18:58
Related Articles Semioccluded Vocal Tract Exercises Improve Self-Perceived Voice Quality in Healthy Actors. J Voice. 2020 Sep 14;: Authors: Di Natale V, Cantarella G, Manfredi C, Ciabatta A, Bacherini C, DeJonckere PH Abstract PURPOSE: Semi-occluded vocal tract exercises (SOVTE) have shown to lead to more effective and efficient vocal production for individuals with voice disorders and for singers. The aim of the present study is to investigate...
Sun Sep 20, 2020 12:09
Related Articles A case of follicular thyroid carcinoma associated with phosphatase and tensin homologue hamartoma tumour syndrome. J Paediatr Child Health. 2019 May;55(5):601-603 Authors: Esen I, Okdemir D PMID: 30575166 [PubMed - indexed for MEDLINE]
Sun Sep 20, 2020 07:00
Related Articles Dendrimer-Based Platform for Effective Capture of Tumor Cells after TGFβ1-Induced Epithelial-Mesenchymal Transition. Anal Chem. 2019 07 02;91(13):8374-8382 Authors: Myung JH, Cha A, Tam KA, Poellmann M, Borgeat A, Sharifi R, Molokie RE, Votta-Velis G, Hong S Abstract Detection of circulating tumor cells (CTCs) relying on their expression of epithelial cell markers, such as epithelial cell adhesion molecule (EpCAM), has been...
Sun Sep 20, 2020 07:00
Related Articles Efficacy and safety of apatinib in advanced sarcoma: an open-label, nonrandomized, single-center study of 45 patients. Anticancer Drugs. 2019 08;30(7):e0778 Authors: Weitao Y, Fangxing W, Qiqing C, Jiaqiang W Abstract Sarcoma is a rare tumor with more than 50 histologic subtypes. Patients with advanced sarcoma have a poor prognosis. The aim of this study was to evaluate the efficacy and safety of apatinib, an oral vascular...
Sun Sep 20, 2020 07:00
Related Articles Apatinib, combined with chemotherapy or alone is effective in treating angiosarcoma: a case report. Anticancer Drugs. 2019 08;30(7):e0738 Authors: Liu M, Liu Y, Guo H, Fu D, Lv L, Chen C, Li Y, Zhang W, Yao M, Zhao L Abstract Angiosarcomas are rare but aggressive tumors with poor prognosis. The treatment of angiosarcomas with vascular endothelial growth factor receptor inhibitors is still in the stage of clinical exploration....
Sun Sep 20, 2020 07:00
Related Articles Prognostic factors and nomogram for survival prediction in patients with primary pulmonary lymphoma: a SEER population-based study. Leuk Lymphoma. 2019 12;60(14):3406-3416 Authors: Low SK, Zayan AH, Istanbuly O, Nguyen Tran MD, Ebied A, Mohamed Tawfik G, Huy NT Abstract Primary pulmonary lymphomas (PPLs) are rare lymphoproliferative malignancies arising from the lungs. The prognostic factors and optimal management of PPL have...
Sun Sep 20, 2020 07:00
Related Articles Comparative study of laparoscopic versus open radical gastrectomy in advanced gastric neuroendocrine carcinoma: Analysis from a high-volume institution. Asian J Surg. 2020 Mar;43(3):488-496 Authors: Zhao YJ, Zhuang LP, Liu YY, Chen RC, Zhang J, Zhu HX, Wang YC, You H, Zhang MW, He XY Abstract BACKGROUND: Gastric neuroendocrine carcinomas (G-NECs) are rare. This study aimed to explore the feasibility and clinical efficacy of...
Sun Sep 20, 2020 07:00
Related Articles Detection and verification of 2.3 million cancer mutations in NCI60 cancer cell lines with a cloud search engine. J Proteomics. 2019 10 30;209:103488 Authors: Prakash A, Majumder S, Ahmad S, Varkey M, Anish TA, Jenkins C, Rigby M, Orsburn B Abstract Today we have unprecedented access to human genomic and proteomic data that appear to be rapidly approaching our current understanding of comprehensive coverage. Combining genomic...
Sun Sep 20, 2020 07:00
Related Articles Gastrointestinal bleeding due to duodenal mucormycosis in an immunocompetent host mimicking malignancy. Rev Esp Enferm Dig. 2019 12;111(12):961-962 Authors: Li C, Zhu H, Tan Y, Liu D Abstract Mucormycosis is a rare and fatal infection, largely confined to immunocompromised hosts. Duodenal involvement is extremely rare. We report a case of a 67-year-old female presented with hematemesis eventually diagnosed with duodenal mucormycosis,...
Sun Sep 20, 2020 07:00
Related Articles Primary colon mantle lymphoma: a misleading macroscopic appearance! Rev Esp Enferm Dig. 2019 Dec;111(12):965-967 Authors: Arieira C, Dias de Castro F, Boal Carvalho P, Cotter J Abstract Mantle cell lymphoma (MCL) of the colon is a rare entity, usually presenting as lymphomatous polyposis. We report the case of a 43-year-old male with an unusual colonic MCL in the form of a single exophytic and ulcerous lesion with necrotic...
Sun Sep 20, 2020 07:00
Related Articles An Unusual Location of Hydatid Cyst, Cause of Severe Pollakiuria. Arch Iran Med. 2019 08 01;22(8):472-475 Authors: Khanmohammadi M, Karimi J, Ardabili F, Shabanluoi H, Ganji S Abstract Hydatidosis is an important zoonotic parasite disease in several herbivorous mammals. Human cystic echinococcosis (CE) caused by infection with larval stage of Echinococcus granulosus has been frequently reported from different organs. Here,...
Sun Sep 20, 2020 07:00
Related Articles Pure Androgen-Secreting Adrenocortical Carcinoma Presenting with Hypoglycemia. Arch Iran Med. 2019 09 01;22(9):527-530 Authors: Karimi F, Dehghanian A, Fallahi M, Dalfardi B Abstract Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Most patients present with steroid hormone excess or abdominal mass effect. Pure androgen-secreting ACCs are rare, while hypoglycemia is an unusual presentation of this malignancy....
Sun Sep 20, 2020 07:00
Related Articles C4 cervical spine osteoblastoma associated with secondary aneurysmal bone cyst in an adolescent patient: 2-year follow-up. Spinal Cord Ser Cases. 2019;5:89 Authors: Gahlot N, Jalan D, Elhence P Abstract Introduction: Osteoblastoma and aneurysmal bone cyst (ABC) are rare bone tumors with individual prevalence of <1%. Their combined occurrence is a rare subclass of tumors in the spinal column with only a few cases reported...
Sun Sep 20, 2020 07:00
Related Articles Erdheim-Chester disease mimicking lumbar nerve schwannoma: case report and literature review. Spinal Cord Ser Cases. 2019;5:90 Authors: Huang Z, Li S, Hong J, Peng Y, Liang A, Huang D, Ye W Abstract Introduction: Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis. The clinical spectrum of ECD is diverse, varying from asymptomatic focal lesion to life-threatening multisystem infiltration. Neurological...
Sun Sep 20, 2020 07:00
Related Articles Immunobiology of Merkel cell carcinoma. Curr Opin Oncol. 2020 03;32(2):114-121 Authors: Samimi M, Kervarrec T, Touze A Abstract PURPOSE OF REVIEW: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, which is associated in 80% of cases with the Merkel cell polyomavirus (MCPyV). Advanced stages respond to immune checkpoint inhibitors in 50% of cases. Major issues remain unanswered regarding its oncogenesis and optimal...
Sun Sep 20, 2020 07:00
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