Abstract Background Fear of pain and movement is an important factor in the development of hypervigilance and avoidance behaviours. Objective We examined the effectiveness of exercise training on improving fear-avoidance beliefs. Methods A systematic review (data...
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Related Articles New perspectives in bronchial asthma: Pathological, immunological alterations, biological targets and pharmacotherapy. Immunopharmacol Immunotoxicol. 2020 Sep 16;:1-72 Authors: Mandlik DS, Mandlik SK Abstract Asthma is the most common, long-lasting inflammatory airway disease that affects more than 10% of the world population. It is characterized by bronchial narrowing, airway hyperresponsiveness, vasodilatation, airway edema...
Related Articles Immunological effects of AFM1 in experimental subchronic dosing in mice prevented by lactic acid bacteria. Immunopharmacol Immunotoxicol. 2020 Sep 16;:1-27 Authors: Ben Salah-Abbès J, Belgacem H, Ezdini K, Mannai M, Oueslati R, Abbès S Abstract Aim: Recently, higher contamination by aflatoxin M1 (AFM1) has been detected in many countries. Unfortunately, many tons of contaminated milk and milk byproducts removed from the food...
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Abstract The auditory pathway consists of multiple recurrent loops of afferent and efferent connections that extend from the cochlea up to the prefrontal cortex. The early‐filter theory proposes that these loops allow top‐down filtering of early and middle latency auditory responses. Furthermore, the adaptive filtering model suggests that the filtering of irrelevant auditory stimuli should start lower in the pathway during more demanding tasks. If so, the 40‐Hz auditory steady‐state responses (ASSRs)...
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The combination of different approaches has successfully delimited new species within many Neotropical species complexes traditionally classified as a single nominal organism. Recent studies have shown that the Amazonian endemic genus Amazophrynella, currently composed of 12 small-sized species, could harbor several additional species. Based on morphology and molecular data, we describe a new species of Amazophrynella from east of the Guiana Shield, in Pará state, Brazil. The new species is characterized...
The differences in small noncoding RNAs (sncRNAs), including miRNAs, piRNAs, and tRNA-derived fragments (tsRNAs), between X and Y sperm of mammals remain unclear. Here, we employed high-throughput sequencing to systematically compare the sncRNA profiles of X and Y sperm from bulls (n = 3), which may have a wider implication for the whole mammalian class. For the comparison of miRNA profiles, we found that the abundance of bta-miR-652 and bta-miR-378 were significantly higher in X sperm, while nine...
Current projections suggest that climate warming will be accompanied by more frequent and severe drought events. Peatlands store ca. one third of the world’s soil organic carbon. Warming and drought may cause peatlands to become carbon sources through stimulation of microbial activity increasing ecosystem respiration, with positive feedback effect on global warming. Micro-eukaryotes play a key role in the carbon cycle through food web interactions and therefore, alterations in their community structure...
Although dragonflies are excellent environmental indicators for monitoring terrestrial water ecosystems, automatic monitoring techniques using digital tools are limited. We designed a novel camera trapping system with an original dragonfly detector based on the hypothesis that perching dragonflies can be automatically detected using inexpensive and energy-saving photosensors built in a perch-like structure. A trial version of the camera trap was developed and evaluated in a case study targeting red...
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Publication date: Available online 18 September 2020Source: Allergology InternationalAuthor(s): Hirokazu Kimura, Hironi Makita, Natsuko Taniguchi, Nozomu Takei, Munehiro Matsumoto, Hiroki Kimura, Houman Goudarzi, Kaoruko Shimizu, Masaru Suzuki, Masaharu Nishimura, Satoshi Konno, The Hi-CARAT investigators
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Related Articles Higher Energy and Zinc Intakes from Complementary Feeding Are Associated with Decreased Risk of Undernutrition in Children from South America, Africa, and Asia. J Nutr. 2020 Sep 16;: Authors: Maciel BLL, Costa PN, Filho JQ, Ribeiro SA, Rodrigues FAP, Soares AM, Júnior FS, Ambikapathi R, McQuade ETR, Kosek M, Ahmed T, Bessong P, Kang G, Shresthra S, Mduma E, Bayo E, Guerrant RL, Caulfield LE, Lima AAM Abstract BACKGROUND: Few...
Related Articles Fried-Food Consumption Does Not Increase the Risk of Stroke in the Spanish Cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. J Nutr. 2020 Sep 16;: Authors: Rey-García J, Guallar-Castillón P, Donat-Vargas C, Moreno-Iribas C, Barricarte A, Rodriguez-Barranco M, Colorado-Yohar S, Huerta JM, Chirlaque MD, Lasheras C, Amiano P, Imaz L, Agudo A, Sánchez MJ Abstract BACKGROUND: The nutritional...
Related Articles Placental Telomere Length: Linking Maternal Nutrition to Transgenerational Healthy Aging? J Nutr. 2020 Sep 16;: Authors: Cheng WH PMID: 32939537 [PubMed - as supplied by publisher]
Related Articles Reducing Child Stunting: Moving Forward on Evaluating Effectiveness of Programs. J Nutr. 2020 Sep 16;: Authors: Dewey KG PMID: 32939541 [PubMed - as supplied by publisher]
Related Articles Associations between Plasma Choline Metabolites and Genetic Polymorphisms in One-Carbon Metabolism in Postmenopausal Women: The Women's Health Initiative Observational Study. J Nutr. 2020 Sep 16;: Authors: Ilozumba MN, Cheng TD, Neuhouser ML, Miller JW, Beresford SAA, Duggan DJ, Toriola AT, Song X, Zheng Y, Bailey LB, Shadyab AH, Liu S, Malysheva O, Caudill MA, Ulrich CM Abstract BACKGROUND: Choline plays an integral role in...
Related Articles A Novel Combination of Fruits and Vegetables Prevents Diet-Induced Hepatic Steatosis and Metabolic Dysfunction in Mice. J Nutr. 2020 Sep 16;: Authors: Guo W, Wu D, Dao MC, Li L, Lewis ED, Ortega EF, Eom H, Thomas M, Nikolova-Karakashian M, Meydani M, Meydani SN Abstract BACKGROUND: Epidemiological studies suggest that higher fruits and vegetables (F&V) consumption correlates with reduced risk of hepatic steatosis, yet evidence...
Related Articles High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study. J Nutr. 2020 Sep 16;: Authors: Papandreou C, Hernández-Alonso P, Bulló M, Ruiz-Canela M, Li J, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Cofán M, Fitó M, Razquin C, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Liang L, Martínez-González...
Related Articles High-Dose Neonatal Vitamin A Supplementation to Bangladeshi Infants Increases the Percentage of CCR9-Positive Treg Cells in Infants with Lower Birthweight in Early Infancy, and Decreases Plasma sCD14 Concentration and the Prevalence of Vitamin A Deficiency at Two Years of Age. J Nutr. 2020 Sep 16;: Authors: Ahmad SM, Huda MN, Raqib R, Qadri F, Alam MJ, Afsar MNA, Peerson JM, Tanumihardjo SA, Stephensen CB Abstract BACKGROUND:...
Related Articles Dietary Patterns, Ceramide Ratios, and Risk of All-Cause and Cause-Specific Mortality: The Framingham Offspring Study. J Nutr. 2020 Sep 16;: Authors: Walker ME, Xanthakis V, Peterson LR, Duncan MS, Lee J, Ma J, Bigornia S, Moore LL, Quatromoni PA, Vasan RS, Jacques PF Abstract BACKGROUND: Prior evidence suggests that diet modifies the association of blood ceramides with the risk of incident cardiovascular disease (CVD). It remains...
Glycine, a Dispensable Amino Acid, Is Conditionally Indispensable in Late Stages of Human Pregnancy.
Related Articles Glycine, a Dispensable Amino Acid, Is Conditionally Indispensable in Late Stages of Human Pregnancy. J Nutr. 2020 Sep 16;: Authors: Rasmussen BF, Ennis MA, Dyer RA, Lim K, Elango R Abstract BACKGROUND: Recently, we showed that there are higher protein, lysine, and phenylalanine requirements in late stages of pregnancy compared with early stages. Animal studies have suggested an increased dietary need for specific dispensable...
Related Articles Partial Replacement of Animal Proteins with Plant Proteins for 12 Weeks Accelerates Bone Turnover Among Healthy Adults: A Randomized Clinical Trial. J Nutr. 2020 Sep 16;: Authors: Itkonen ST, Päivärinta E, Pellinen T, Viitakangas H, Risteli J, Erkkola M, Lamberg-Allardt C, Pajari AM Abstract BACKGROUND: Plant-based diets may reduce the risk of chronic diseases, but can also lead to low calcium and vitamin D intakes, posing a...
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Related Articles Yeast Rgd3 is a phospho-regulated F-BAR-containing RhoGAP involved in the regulation of Rho3 distribution and cell morphology. Mol Biol Cell. 2020 Sep 17;:mbcE20050288 Authors: Gingras RM, Lwin KM, Miller AM, Bretscher A Abstract Polarized growth requires the integration of polarity pathways with the delivery of exocytic vesicles for cell expansion and counterbalancing endocytic uptake. In budding yeast, the myosin-V Myo2 is...
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Publication date: Available online 17 September 2020Source: Revista de Logopedia, Foniatría y AudiologíaAuthor(s): Silvia Nieva, Barbara Conboy, Eva Aguilar-Mediavilla, Lidia Rodríguez
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Related Articles Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab. Future Oncol. 2020 Sep 17;: Authors: Bharmal M, Nolte S, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ, Pusceddu S, Hanna GJ, Hassel JC, Kiecker F, Ellers-Lenz B, Bajars M, Güzel G, Nghiem P, Hunger M, Schlichting M, Henry-Szatkowski M, D'Angelo SP Abstract Aim: To evaluate changes in health-related quality of...
Related Articles PIVOT-10: Phase II study of bempegaldesleukin plus nivolumab in cisplatin-ineligible advanced urothelial cancer. Future Oncol. 2020 Sep 17;: Authors: Huddart RA, Siefker-Radtke AO, Balar AV, Bilen MA, Powles T, Bamias A, Castellano D, Khalil MF, Van Der Heijden MS, Koshkin VS, Pook DW, Özgüroğlu M, Santiago L, Zhong B, Chien D, Lin W, Tagliaferri MA, Loriot Y Abstract The choice of first-line therapy for patients with metastatic...
Related Articles Interaction of HULC polymorphisms with Helicobacter pylori infection plays a strong role for the prediction of gastric cancer risk. Future Oncol. 2020 Sep;16(26):1997-2006 Authors: Wang BG, Ding HX, Lv Z, Xu Q, Yuan Y Abstract Aim: Gene-environment interactions have better efficacy in predicting cancer susceptibility than a single gene. Materials & methods: Eight tag single nucleotide polymorphisms encompassing the whole...
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Related Articles Editorial. World J Surg. 2020 Sep 16;: Authors: Sosa JA PMID: 32939594 [PubMed - as supplied by publisher]
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Related Articles Laryngeal polyp associated with reflux disease: a case report. J Med Case Rep. 2020 Jan 04;14(1):2 Authors: Hassan WA Abstract BACKGROUND: Among the most common benign laryngeal lesions are vocal nodules and polyps. Their etiology is related to vocal abuse. Gastroesophageal reflux disease is a common condition presenting with a broad spectrum of symptoms, among which are extraesophageal manifestations such as laryngeal polyps....
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Nine pharmaceutical company leaders took the unprecedented step on September 8, 2020, of stating that they would refuse to apply for approval of a Covid-19 vaccine until adequate trial data are available. This announcement reflected an unusual role reversal at a time of unexpected regulatory…
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Nature Communications, Published online: 18 September 2020; doi:10.1038/s41467-020-18384-xDesigning efficient nanowire chip-based electrical and optical devices remains a challenge. Here, the authors present an axial p-n junction GaAs nanowire X-ray detector that enables achieving a spatial resolution of 200 nm; probing the internal electrical field and observing hot electron effects at the nanoscale.
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Related Articles Quantitative assessment of artefacts and identification of gaps in prosthetic crowns: a comparative in vitro study between periapical radiography and CBCT images. Dentomaxillofac Radiol. 2020 Sep 17;:20200134 Authors: Mauad LQ, Doriguêtto PVT, Almeida D, Fardim KAC, Machado AH, Devito KL Abstract OBJECTIVES: To evaluate, in an in vitro study, the quantity of artefacts generated by two different restorative materials, and...
Related Articles Comparison of radiographical characteristics and diagnostic accuracy of intraosseous jaw lesions on panoramic radiographs and CBCT. Dentomaxillofac Radiol. 2020 Sep 17;:20200165 Authors: Mao WY, Lei J, Lim LZ, Gao Y, Tyndall DA, Fu K Abstract OBJECTIVE: To investigate the differences in imaging characteristics and the diagnostic accuracy of 225 intraosseous jaw lesions on panoramic radiographs (PAN) versus cone beam computed...
Related Articles Development of a model of soft tissue simulation using ballistic gelatin for CBCT acquisitions related to dentomaxillofacial radiology research. Dentomaxillofac Radiol. 2020 Sep 17;:20200191 Authors: Nascimento EHL, Fontenele RC, Lopes PA, Santaella GM, Vasconcelos KF, de Freitas DQ, Oenning AC, Groppo FC Abstract OBJECTIVES: To present the ballistic gelatin as a new material capable of simulating the soft tissues in cone-beam...
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Publication date: Available online 17 September 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Elin Sandberg, Margareta Möller, Stefan Särnblad, Peter Appelros, Anna Duberg
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Related Articles Response letter to the editor. Expert Rev Anticancer Ther. 2020 Sep 17;: Authors: Barr RD, Ladas EJ PMID: 32938239 [PubMed - as supplied by publisher]
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Abstract Background The cause of chronic nausea can be difficult to diagnose. Idiopathic rapid gastric emptying (iRGE) can cause nausea, but limited literature exists on clinical and pathophysiological features. In contrast, dumping syndrome or post‐surgical rapid gastric emptying (psRGE) is well‐known and may present with early phase vasomotor symptoms, diarrhea, and late phase reactive hypoglycemia. Our aim is to compare clinical and gastric motility characteristics in patients with iRGE and...
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Related Articles Why is Pimozide Uniquely Useful for the Treatment of Delusional Patients in Dermatology? J Dermatolog Treat. 2020 Sep 17;:1-4 Authors: Brownstone N, Koo J PMID: 32940111 [PubMed - as supplied by publisher]
Related Articles An assessment of current practices in hidradenitis suppurativa: the rise of biologic therapy. J Dermatolog Treat. 2020 Sep 17;:1-15 Authors: Muddasani S, Flood KS, Fleischer AB Abstract Introduction: Treatments for hidradenitis suppurativa (HS) have changed in the last decade. In this context, we sought to study if management practices have shifted accordingly.Methods: We analyzed the National Ambulatory Medical Care Survey...
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Zusammenfassung Hintergrund Die Tonsillektomie (TE) zielt darauf ab, die Gaumenmandeln als Ursache von rezidivierenden akuten Tonsillitiden zu entfernen, wenn diese konservativen Maßnahmen nicht zugänglich sind. Konsentierte Leitlinienempfehlungen hierzu wurden in Deutschland im Jahr 2015 publiziert. Die vorliegende Studie zielte darauf ab, dem Effekt dieser Leitlinie auf die Indikationsstellung der TE unter Nutzung von individuellen Patientendaten...
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Related Articles Potential association between recurrent facial nerve palsy and migraines. J Laryngol Otol. 2020 Sep 17;:1-4 Authors: Kontorinis G, Tyagi A Abstract OBJECTIVE: This study aimed to investigate the possible association between recurrent facial nerve palsy and migraines. METHOD: This study was a prospective case series with a two-year follow-up at an academic, tertiary referral centre and included patients with at least...
Related Articles Single-use lidocaine hydrochloride 5 per cent w/v and phenylephrine hydrochloride 0.5 per cent w/v topical spray; can it now be employed as a multi-use atomiser? J Laryngol Otol. 2020 Sep 17;:1-4 Authors: Jog M, Zudovaite I, O'Dwyer M, Saeed K, Singh T Abstract OBJECTIVE: This study investigated the risk of contamination of lidocaine hydrochloride 5 per cent w/v and phenylephrine hydrochloride 0.5 per cent w/v topical solution...
Related Articles Differences between primary care physicians and specialised neurotologists in the diagnosis of dizziness and vertigo in Japan. J Laryngol Otol. 2020 Sep 17;:1-5 Authors: Ito T, Matsuyama S, Shiozaki T, Nishikawa D, Akioka H, Yamanaka T, Kitahara T Abstract OBJECTIVE: Vertigo and dizziness are frequent symptoms in patients at out-patient services. An accurate diagnosis for vertigo or dizziness is essential for symptom relief;...
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Related Articles Potential Predictors of Poor Prognosis among Critical COVID-19 Pneumonia Patients Requiring Tracheal Intubation. Tohoku J Exp Med. 2020;252(2):103-107 Authors: Kishaba T, Maeda A, Nabeya D, Nagano H Abstract Coronavirus disease 2019 (COVID-19) is a global public health concern that can be classified as mild, moderate, severe, or critical, based on disease severity. Since the identification of critical patients is crucial for...
Related Articles Selection of and Retention in Surgical Specialty during Early Career in Japan. Tohoku J Exp Med. 2020;252(2):95-102 Authors: Tomizawa Y, Miyazaki S, Matsumoto T, Uetsuka Y Abstract The number of surgeons is decreasing in Japan. We investigated the trend and factors influencing surgeons' selection of and retention in surgical specialty. In 2016, we obtained data of biennial surveys conducted by the government, and analyzed the...
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Publication date: Available online 18 September 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): B.M. Naji, S.S. Abdelsameaa, A.Y. Alqutaibi, W.M. Said Ahmed
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Related Articles Treatment of Frontal Sinus Osteomyelitis in the Age of Endoscopy. Am J Rhinol Allergy. 2020 Sep 16;:1945892420959587 Authors: Thompson HM, Tilak AM, Miller PL, Grayson JW, Cho DY, Woodworth BA Abstract OBJECTIVE: Frontal sinus osteomyelitis is a severe complication which can result from chronic rhinosinusitis, trauma, or as a complication of reconstruction or obliteration of the frontal sinus. The objective of the current...
Related Articles Infection After Endoscopic Dacryocystorhinostomy: Incidence and Implications. Am J Rhinol Allergy. 2020 Sep 16;:1945892420958905 Authors: Jafari A, Lehmann AE, Shen SA, Banks CG, Scangas GA, Metson R Abstract BACKGROUND: Endoscopic dacryocystorhinostomy (EN-DCR) is an increasingly common procedure performed by otolaryngologists. While EN-DCR has a high rate of success at relieving blockage of the lacrimal system, little...
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Related Articles Extramedullary Plasmacytoma: Long-Term Clinical Outcomes in a Single-Center in China and Literature Review. Ear Nose Throat J. 2020 Sep 17;:145561320950587 Authors: Zhu X, Wang L, Zhu Y, Diao W, Li W, Gao Z, Chen X Abstract The aim is to analyze the clinical outcomes of patients with extramedullary plasmacytoma (EMP) and review the characteristics of this disease. We retrospectively reviewed the clinical data of a cohort...
Related Articles Intralabyrinthine Schwannoma of the Intravestibular Subtype: A Difficult Diagnosis. Ear Nose Throat J. 2020 Sep 17;:145561320957761 Authors: Mesolella M, di Lorenzo G, Petti A, Allosso S, di Lullo AM, Cavaliere M PMID: 32941084 [PubMed - as supplied by publisher]
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Publication date: Available online 17 September 2020Source: BrachytherapyAuthor(s): Shane Mesko, Bhavana V. Chapman, Chad Tang, Rajat J. Kudchadker, Teresa L. Bruno, Jeremiah Sanders, Prajnan Das, Chelsea C. Pinnix, Nikhil G. Thaker, Steven J. Frank
Publication date: Available online 17 September 2020Source: BrachytherapyAuthor(s): Jason C. Sanders, Timothy N. Showalter, Zoubir Ouhib, Bruce R. Thomadsen, Dayee Jacob, Manuj Agarwal, Gil'ad N. Cohen, Matt Giles, Geethpriya Palaniswammy, Abhishek A. Solanki, Neil K. Taunk, Members of the ABS Quality and Safety Committee
Publication date: Available online 17 September 2020Source: BrachytherapyAuthor(s): Ankur Mourya, Lalit Mohan Aggarwal, Sunil Choudhary
Publication date: Available online 17 September 2020Source: BrachytherapyAuthor(s): A. Keller, J.L. Rodríguez-López, A.K. Patel, J.A. Vargo, H. Kim, C.J. Houser, P. Sukumvanich, J.L. Berger, M.M. Boisen, R.P. Edwards, S.E. Taylor, M.B. Courtney-Brooks, B.C. Orr, A.B. Olawaiye, S. Beriwal
HDR brachytherapy well chamber calibration and stability evaluated over twenty years of clinical use
Publication date: Available online 17 September 2020Source: BrachytherapyAuthor(s): Stephanie Keehan, Ryan L. Smith, Duncan Butler
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Abstract While much is known about the initial communication of a definitive pediatric cancer diagnosis by the child’s pediatric oncologist, little is known about the discussions leading up to this formal conversation, which are often had with nononcologists. We sought to describe these initial conversations regarding the possibility of a child’s oncologic diagnosis, from the perspective of both the patient/family as well as the provider. Semistructured interviews were performed...
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Abstract Background Patients who had gone through orthodontic treatment experienced pain and discomfort which could be the highest-ranking reason for treatment disturbance or early termination. Thus, this review aimed to assess the efficacy of analgesics on the relief of pain in orthodontic treatment. Methods A computerized literature...
Abstract Background Molar incisor hypomineralization (MIH) is a growing health problem, and its treatment is a challenge. The purpose of the present study was to evaluate and compare the perceptions, knowledge, and clinical experiences of MIH in general dental practitioners (GDPs) and paediatric dentists (PDs) in Spain. Methods All dentists...
Abstract Background Tooth impaction is a common problem in orthodontic practice and in some cases accompanied by pain and pathological changes of surrounding teeth. Understanding the cellular and molecular mechanisms underlying tooth impaction allows finding the most effective orthodontic treatment for patients with impacted teeth (IT). RANK (receptor activator of NF-κB) / RANKL (RANK ligand) / OPG (osteoprotegerin) signaling...
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Abstract Background and aim Solid tumors, including pediatric malignancies, depend on angiogenesis for tumor growth, invasion, and metastases. We aimed to evaluate the prognostic impact of circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) on treatment response and survival of pediatric patients with solid tumors. Methods ...
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Related Articles Radioactive gold nanocluster (198-AuNCs) showed inhibitory effects on cancer cells lines. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):1214-1221 Authors: Xuan S, de Barros AODS, Nunes RC, Ricci-Junior E, da Silva AX, Sahid M, Alencar LMR, Dos Santos CC, Morandi V, Alexis F, Iram SH, Santos-Oliveira R Abstract Cancer is a global epidemic disease responsible for over ten millions death worldwide. The early diagnosis and...
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Publication date: Available online 17 September 2020Source: Archives of Oral BiologyAuthor(s): Hongzhi Quan, Sixuan Liu, Zhongyan Shan, Ziyi Liu, Tianjun Chen, Yanjia Hu, Zhigang Yao, Liangjuan Fang
Publication date: Available online 18 September 2020Source: Archives of Oral BiologyAuthor(s): Kinjal D. Patel, Yesha V. Barasiya, Jayendra B. Patel, Prabhudas S. Patel
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Publication date: Available online 17 September 2020Source: Journal of Neuroscience MethodsAuthor(s): Xin Zhang, Chun-qiao Chen, Ming-kang Zhang, Chang-yu Ma, Yin Zhang, Hui Wang, Qing-qian Guo, Tao Hu, Zhao-bang Liu, Yan Chang, Ke-jia Hu, Xiao-dong Yang
Publication date: Available online 17 September 2020Source: Journal of Neuroscience MethodsAuthor(s): Weilong Zhao, Zishen Xu, Wen Li, Wei Wu
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Related Articles Clinical and immune responses to anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (EGFR BATs) in pancreatic cancer patients. Oncoimmunology. 2020 Jun 10;9(1):1773201 Authors: Lum LG, Thakur A, Choi M, Deol A, Kondadasula V, Schalk D, Fields K, Dufrense M, Philip P, Dyson G, Aon HD, Shields AF Abstract Purpose This was a phase I/II adoptive T cell trial in 7 locally advanced and metastatic pancreatic cancer...
Related Articles PD-1 checkpoint blockade in advanced melanoma patients: NK cells, monocytic subsets and host PD-L1 expression as predictive biomarker candidates. Oncoimmunology. 2020 Aug 28;9(1):1786888 Authors: Pico de Coaña Y, Wolodarski M, van der Haar Àvila I, Nakajima T, Rentouli S, Lundqvist A, Masucci G, Hansson J, Kiessling R Abstract Blockade of the PD-1 receptor has revolutionized the treatment of metastatic melanoma, with significant...
Related Articles An integrated classifier improves prognostic accuracy in non-metastatic gastric cancer. Oncoimmunology. 2020 Aug 30;9(1):1792038 Authors: Xing X, Jia S, Leng Y, Wang Q, Li Z, Dong B, Guo T, Cheng X, Du H, Hu Y, Feng Q, Lian S, Luan F, Ma X, Li Z, Ni M, Li Z, Ji J Abstract The American Joint Committee on Cancer (AJCC) staging system is insufficiently prognostic for gastric cancer (GC) patients and complementary factors are...
Related Articles Primary and metastatic breast tumors cross-talk to influence immunotherapy responses. Oncoimmunology. 2020 Aug 30;9(1):1802979 Authors: Oliver AJ, Keam SP, von Scheidt B, Zanker DJ, Harrison AJ, Tantalo DG, Darcy PK, Kershaw MH, Slaney CY Abstract The presence of a tumor can alter host immunity systematically. The immune-tumor interaction in one site may impact the local immune microenvironment in distal tissues through...
Related Articles Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis. Oncoimmunology. 2020 Aug 28;9(1):1807291 Authors: Li B, Zhang B, Wang X, Zeng Z, Huang Z, Zhang L, Wei F, Ren X, Yang L Abstract Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is considered a novel anti-tumor target comparable to programmed cell death 1 ligand 1(PD-L1). However, little is known...
Related Articles Immune responses during COVID-19 infection. Oncoimmunology. 2020 Aug 25;9(1):1807836 Authors: Melenotte C, Silvin A, Goubet AG, Lahmar I, Dubuisson A, Zumla A, Raoult D, Merad M, Gachot B, Hénon C, Solary E, Fontenay M, André F, Maeurer M, Ippolito G, Piacentini M, Wang FS, Ginhoux F, Marabelle A, Kroemer G, Derosa L, Zitvogel L Abstract Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome...
Related Articles Human innate immune cell crosstalk induces melanoma cell senescence. Oncoimmunology. 2020 Aug 30;9(1):1808424 Authors: Funck F, Pahl J, Kyjacova L, Freund L, Oehrl S, Gräbe G, Pezer S, Hassel JC, Sleeman J, Cerwenka A, Schäkel K Abstract Mononuclear phagocytes and NK cells constitute the first line of innate immune defense. How these cells interact and join forces against cancer is incompletely understood. Here, we observed...
Related Articles Firing up the cold tumors by targeting Vps34. Oncoimmunology. 2020 Aug 31;9(1):1809936 Authors: Janji B, Hasmim M, Parpal S, Berchem G, Noman MZ Abstract Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration. In our recent report published in Science...
Related Articles β-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer. Oncoimmunology. 2020 Aug 31;9(1):1809947 Authors: Wang C, Yan J, Yin P, Gui L, Ji L, Ma B, Gao WQ Abstract In colorectal cancer, Wnt/β-catenin signaling is often aberrantly activated and associated with a T-cell-excluded phenotype which is a major obstacle for many immunotherapies. However, the effects of Wnt/β-catenin inhibition...
Related Articles Identification and validation of an excellent prognosis subtype of muscle-invasive bladder cancer patients with intratumoral CXCR5+ CD8+ T cell abundance. Oncoimmunology. 2020 Aug 28;9(1):1810489 Authors: Huang Q, Zhou Q, Zhang H, Liu Z, Zeng H, Chen Y, Qu Y, Xiong Y, Wang J, Chang Y, Xia Y, Wang Y, Liu L, Zhu Y, Xu L, Dai B, Guo J, Wang Z, Bai Q, Zhang W Abstract Bladder cancer is the ninth most frequent-diagnosed disease...
Related Articles The consensus Immunoscore in phase 3 clinical trials; potential impact on patient management decisions. Oncoimmunology. 2020 Aug 28;9(1):1812221 Authors: Pagès F, Taieb J, Laurent-Puig P, Galon J Abstract The consensus Immunoscore has a prognostic value that has been confirmed in two randomized phase 3 clinical trials, and it provides a reliable estimate of the recurrence risk in colon cancer. The latest edition of the...
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Abstract Objectives To identify the immunohistochemical pattern of non‐tumoral epithelium adjacent to lip cancer (ANTE) to unveil molecular alterations and potential biomarkers in lip cancer patients. Materials and Methods A systematic search at MEDLINE, EMBASE, and Proceedings Web of Science, OpenGrey, and WorldCat. Population: lip cancer patients; Intervention: immunostaining with biomarkers in surgical specimens; Comparisons: ANTE vs LC; Outcomes: Primary: to identify the immunohistochemical...
Abstract Objectives Periodontitis is an inflammatory bone loss disease initiated by oral bacterial inflammation. Herein, we determined whether inhibition of sphingosine‐1‐phosphate receptor 2 (S1PR2, a G protein‐coupled receptor) by its specific antagonist, JTE013, could alleviate ligature‐induced periodontitis in mice. Materials and Methods C57BL/6 mice were placed with silk ligatures at the left maxillary second molar to induce experimental periodontitis. Mice were treated with JTE013...
Abstract Objectives Primary focused question for this systematic review (SR) was: “Which is the evidence about surfaces decontamination and protection masks for SARS‐Cov‐2 in dental practice?”. Secondary question was: “Which is the evidence about surfaces decontamination and protection masks against airborne pathogens and directly transmitted viral pathogens causing respiratory infections?” Materials and Methods PRISMA guidelines were used. Studies on surfaces decontamination and protective...
Abstract Objective The aim of this investigation was to study the effects of Runt‐related transcription factor 2 (Runx2) on the junctional epithelium and alveolar bone. Methods The attachment level of the junctional epithelium and the resorption of alveolar bone were analyzed by histology and scanning electron microscopy. The expression of Amelotin was determined by immunohistochemistry, western blot, and real‐time PCR. The ultrastructure of the dentogingival interface was observed by transmission...
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By comparing genetic variants differing in the two fly populations, researchers found that polygenic traits led to the quickness of adaptation; many genes, each with very small effects, worked together to determine the rate of development. The research illustrates that crop pests and insect disease vectors with similar biology may rapidly respond to changing climates by a similar genetic mechanism.
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Objective: The aim of this study was to evaluate the feasibility and safety of transcanal underwater endoscopic bone resection (TUEBR) of the external auditory canal (EAC) for the management of cholesteatoma involving the antrum and mastoid. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Pediatric and adult patients with primary cholesteatoma extending to the antrum and mastoid who underwent transcanal endoscopic ear surgery (TEES)...
Objective: To compare the treatment outcomes and complications of single cycle versus multiple cycles of the canalith repositioning procedure (CRP). Study Design: Randomized controlled trial. Setting: Academic tertiary referral center; Chiang Mai University, Thailand. Patients: One hundred and forty-three adults who had unilateral posterior canal benign paroxysmal positional vertigo (BPPV). Intervention: Therapeutic. Patients received either a single cycle...
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Abstract Purpose This study presents the surgical and postoperative results achieved with a rigid proctoscope using the transanal endoscopic technique to excise rectal adenomas. The results are compared to the results obtained with other currently employed transanal techniques. Methods We investigated the medical records of patients who underwent transanal endoscopic operations from April 2000 to June 2018 at two tertiary referral centers for colorectal cancer. Results This study included 99...
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