Related Articles Middle Cranial Fossa Approach to Vestibular Schwannoma Resection in the Older Patient Population. Otol Neurotol. 2020 Sep 16;: Authors: Kohlberg GD, Lipschitz N, Raghavan AM, Breen JT, Pensak ML, Zuccarello M, Samy RN Abstract OBJECTIVE: Compare outcomes of middle cranial fossa approach (MCF) to vestibular schwannoma (VS) resection in patients 60 years of age and older to patients under 60. STUDY DESIGN: Retrospective...
Sun Sep 20, 2020 06:28
Where Do We Look? Assessing Gaze Patterns in Cosmetic Facelift Surgery with Eye Tracking Technology.
Related Articles Where Do We Look? Assessing Gaze Patterns in Cosmetic Facelift Surgery with Eye Tracking Technology. Plast Reconstr Surg. 2020 Sep 09;: Authors: Liao D, Ishii M, Ishii LE PMID: 32947522 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 06:28
Related Articles Liquid lncRNA Biopsy for the Evaluation of Locally Advanced and Metastatic Squamous Cell Carcinomas of the Head and Neck. J Pers Med. 2020 Sep 16;10(3): Authors: Łasińska I, Kolenda T, Guglas K, Kopczyńska M, Sobocińska J, Teresiak A, Strzelecki NO, Lamperska K, Mackiewicz A, Mackiewicz J Abstract Background: Long non-coding RNA (lncRNA) are RNA molecules that are more than 200 nucleotides long and have the ability to modify...
Sun Sep 20, 2020 13:21
Related Articles Impact of Number of Segmented Tissues on SAR Prediction Accuracy in Deep Pelvic Hyperthermia Treatment Planning. Cancers (Basel). 2020 Sep 16;12(9): Authors: VilasBoas-Ribeiro I, van Rhoon GC, Drizdal T, Franckena M, Paulides MM Abstract In hyperthermia, the general opinion is that pre-treatment optimization of treatment settings requires a patient-specific model. For deep pelvic hyperthermia treatment planning (HTP), tissue...
Sun Sep 20, 2020 13:21
Related Articles Correction to: Increased risk of tinnitus following a trigeminal neuralgia diagnosis: a one-year follow-up study. J Headache Pain. 2020 Sep 18;21(1):113 Authors: Cheng YF, Xirasagar S, Yang TH, Wu CS, Kao YW, Shia BC, Lin HC Abstract An amendment to this paper has been published and can be accessed via the original article. PMID: 32948125 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 13:21
Related Articles Multiple paragangliomas: a case report. BMC Med Genomics. 2020 Sep 18;13(Suppl 8):125 Authors: Pavlov VS, Kalinin DV, Lukyanova EN, Golovyuk AL, Fedorova MS, Pudova EA, Savvateeva MV, Lipatova AV, Guvatova ZG, Kaprin AD, Kiseleva MV, Demidova TB, Simanovsky SA, Melnikova NV, Dmitriev AA, Krasnov GS, Snezhkina AV, Kudryavtseva AV Abstract BACKGROUND: Carotid and vagal paragangliomas (CPGLs and VPGLs) are rare neoplasms that...
Sun Sep 20, 2020 13:21
Related Articles Mutation profiling in eight cases of vagal paragangliomas. BMC Med Genomics. 2020 Sep 18;13(Suppl 8):115 Authors: Kudryavtseva AV, Kalinin DV, Pavlov VS, Savvateeva MV, Fedorova MS, Pudova EA, Kobelyatskaya AA, Golovyuk AL, Guvatova ZG, Razmakhaev GS, Demidova TB, Simanovsky SA, Slavnova EN, Poloznikov AА, Polyakov AP, Melnikova NV, Dmitriev AA, Krasnov GS, Snezhkina AV Abstract BACKGROUND: Vagal paragangliomas (VPGLs)...
Sun Sep 20, 2020 13:21
Related Articles Validity of a rapid diagnostic programme for head and neck cancer. Acta Otorrinolaringol Esp. 2020 Sep 15;: Authors: Rosell Ferrer R, Aguilà Artal A, Escamilla Carpintero Y, Cardesin Revilla A, Campos Motamayor M, Díaz Argüello JJ, Martínez Arias A, Martínez Vila C Abstract INTRODUCTION AND OBJECTIVES: Given the epidemiological knowledge of squamous cell carcinomas of the head and neck, the prognosis in survival according...
Sun Sep 20, 2020 13:21
Related Articles Development of a Prognostic Signature Based on Autophagy-related Genes for Head and Neck Squamous Cell Carcinoma. Arch Med Res. 2020 Sep 15;: Authors: Jin Y, Qin X Abstract BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor with relative low survival rate. Increasingly evidences have emphasized the importance of autophagy in cancer initiation, progression, and the responses to cancer treatment....
Sun Sep 20, 2020 13:21
Related Articles Lymph node extracapsular extension as a marker of aggressive phenotype: Classification, prognosis and associated molecular biomarkers. Eur J Surg Oncol. 2020 Sep 10;: Authors: Bhattacharya P, Mukherjee R Abstract Lymph node extracapsular extension, also termed extranodal extension or extracapsular spread (ECS) from lymph nodes, is a key characteristic of aggressive phenotype in cancer, carrying a major impact on prognosis....
Sun Sep 20, 2020 13:21
Related Articles Brachytherapy in India: Learning from the past and looking into the future. Brachytherapy. 2020 Sep 15;: Authors: Kumar A, Chopra S, Mahantshetty U, Reddy VA Abstract India has a longstanding tradition in the practice of brachytherapy and has actively contributed to the scientific literature by conducting prospective studies, clinical audits, developing innovative techniques, and performing randomized studies. Indian investigators...
Sun Sep 20, 2020 13:21
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Sun Sep 20, 2020 13:21
Related Articles Assessment of side effects after serial intralesional steroid injections for idiopathic subglottic stenosis. Eur Arch Otorhinolaryngol. 2020 Sep 18;: Authors: Celebi OO, Song SA, Santeerapharp A, Choksawad K, Franco RA Abstract PURPOSE: To assess the incidence and severity of 12 systemic side effects of serial intralesional steroid injections (SILSI) in patients with idiopathic subglottic stenosis (iSGS). METHODS:...
Sun Sep 20, 2020 13:21
Related Articles Benign paroxysmal positional vertigo, dizziness, and health-related quality of life among older adults in a population-based setting. Eur Arch Otorhinolaryngol. 2020 Sep 19;: Authors: Lindell E, Kollén L, Johansson M, Karlsson T, Rydén L, Falk Erhag H, Wetterberg H, Zettergren A, Skoog I, Finizia C Abstract PURPOSE: Dizziness may affect quality of life in a negative way and contribute to falls. The aim of this study was...
Sun Sep 20, 2020 13:21
Related Articles Price Transparency for COVID-19 Testing Among Top US Hospitals. J Gen Intern Med. 2020 Sep 18;: Authors: Xiao R, Rathi VK PMID: 32948951 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 13:21
Related Articles A real-world comparison of cisplatin vs cetuximab used concurrently with radiation in the treatment of locally advanced oropharyngeal carcinoma. Head Neck. 2020 Sep 19;: Authors: Fung AS, Afzal AR, Banerjee R, Debenham B, Hao D Abstract BACKGROUND: This population-based retrospective study compares the efficacy of cisplatin (cis-RT) vs cetuximab (cetux-RT) with concurrent radiation as definitive treatment in patients with...
Sun Sep 20, 2020 13:21
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Sun Sep 20, 2020 13:21
Related Articles The diagnostic performance of CT and MRI for detecting extranodal extension in patients with head and neck squamous cell carcinoma: a systematic review and diagnostic meta-analysis. Eur Radiol. 2020 Sep 19;: Authors: Park SI, Guenette JP, Suh CH, Hanna GJ, Chung SR, Baek JH, Lee JH, Choi YJ Abstract OBJECTIVE: To review the diagnostic performance of CT and MRI for detecting extranodal extension (ENE) in head and neck squamous...
Sun Sep 20, 2020 13:21
Related Articles Patient-reported outcome measures in patients undergoing radiotherapy for head and neck cancer. Support Care Cancer. 2020 Sep 19;: Authors: Hamilton SN, Tran E, Ho C, Berthelet E, Wu J, DeVries K, LaPointe V, Bowman A, Lagman M, Olson R Abstract OBJECTIVES: Head and neck (H&N) cancer patients experience significant acute side effects from treatment. This study evaluates prospectively collected patient-reported outcomes...
Sun Sep 20, 2020 13:21
Related Articles Identification of novel fusion transcripts in meningioma. J Neurooncol. 2020 Sep 19;: Authors: Khan AB, Gadot R, Shetty A, Bayley JC, Hadley CC, Cardenas MF, Jalali A, Harmanci AS, Harmanci AO, Wheeler DA, Klisch TJ, Patel AJ Abstract INTRODUCTION: Meningiomas are the most common primary intracranial tumor. Recent next generation sequencing analyses have elaborated the molecular drivers of this disease. We aimed to identify...
Sun Sep 20, 2020 13:21
Related Articles Long-term outcome in patients with Fanconi anemia who received hematopoietic stem cell transplantation: a retrospective nationwide analysis. Int J Hematol. 2020 Sep 19;: Authors: Yabe M, Morio T, Tabuchi K, Tomizawa D, Hasegawa D, Ishida H, Yoshida N, Koike T, Takahashi Y, Koh K, Okamoto Y, Sano H, Kato K, Kanda Y, Goto H, Takita J, Miyamura T, Noguchi M, Kato K, Hashii Y, Astuta Y, Yabe H Abstract We retrospectively analyzed...
Sun Sep 20, 2020 13:21
Related Articles Hey Siri: How Effective are Common Voice Recognition Systems at Recognizing Dysphonic Voices? Laryngoscope. 2020 Sep 19;: Authors: Rohlfing ML, Buckley DP, Piraquive J, Stepp CE, Tracy LF Abstract OBJECTIVES/HYPOTHESIS: Interaction with voice recognition systems, such as Siri™ and Alexa™, is an increasingly important part of everyday life. Patients with voice disorders may have difficulty with this technology, leading to...
Sun Sep 20, 2020 13:21
Related Articles Effect of Endoscope Sinus Surgery on Pulmonary Function in Cystic Fibrosis Patients: A Meta-Analysis. Laryngoscope. 2020 Sep 19;: Authors: Yin M, Gao X, Di L, Yang P, Liu J, Li X, Yan X, Wang W, Cui H Abstract OBJECTIVE: The objective of this study was to quantify the effect of endoscopic sinus surgery on pulmonary function in patients with cystic fibrosis and chronic rhinosinusitis. METHODS: The PubMed, MEDLINE,...
Sun Sep 20, 2020 13:21
Related Articles Acceptance of patients towards task-autonomous robotic cochlear implantation: an exploratory study. Int J Med Robot. 2020 Sep 19;:e2172 Authors: Jank BJ, Haas M, Riss D, Baumgartner WD Abstract BACKGROUND: Recently, task-autonomous image-guided robotic cochlear implantation has been successful completed in patients. However, no data exists on patients' perspective of this new technology. The aim of this study was to evaluate...
Sun Sep 20, 2020 13:21
Related Articles Individualized Use of Facelift, Retroauricular Hairline, and V-Shaped Incisions for Parotidectomy. J Oral Maxillofac Surg. 2020 Aug 26;: Authors: Ahn D, Lee GJ, Sohn JH Abstract PURPOSE: Despite the increased need for better cosmetic outcomes following parotidectomy, there is no study on the individualized use of esthetic approaches for parotidectomy. We aimed to evaluate the feasibility of individualzsed esthetic approaches...
Sun Sep 20, 2020 14:20
Related Articles Non-coding RNA in thyroid cancer - Functions and mechanisms. Cancer Lett. 2020 Sep 16;: Authors: Cao J, Zhang M, Zhang L, Lou J, Zhou F, Fang M Abstract Thyroid cancer is the most common endocrine malignant tumor, and its incidence has increased significantly in the past few years. A growing number of noncoding RNAs (ncRNAs) have shown abnormal expression patterns in human thyroid cancer in recent studies. Depending on...
Sun Sep 20, 2020 14:20
Related Articles Identification and functional analysis of a novel missense mutation of PAX3 associated with Waardenburg syndrome type I. Eur Arch Otorhinolaryngol. 2020 Sep 17;: Authors: Niu Z, Mei L, Tang F, Li J, Wang X, Sun J, He C, Cheng H, Liu Y, Cai X, Song J, Feng Y, Jiang L Abstract PURPOSE: Waardenburg syndrome type 1 (WS1) is a rare genetic disorder characterized by dystopia canthorum, abnormal iris pigmentation, and congenital hearing...
Fri Sep 18, 2020 16:40
Related Articles Perception of male otolaryngologists on gender discrimination: a comparative study. Eur Arch Otorhinolaryngol. 2020 Sep 17;: Authors: Haberal Can İ, İncesulu A, Eyigör H, Şenol Y, Kara CO Abstract PURPOSE: To gather information on perception of male otolaryngologists (MORLs) about gender discrimination towards female otolaryngologists (FORLs). METHODS: MORLs were invited to participate to an online survey. Minimum participation...
Sun Sep 20, 2020 09:21
Related Articles Is ossicular chain fixation predictable for tympanosclerosis on preoperative temporal bone computed tomography? Eur Arch Otorhinolaryngol. 2020 Sep 18;: Authors: Yildiz S, Balık AÖ, Zer Toros S Abstract PURPOSE: To report the predictability of ossicular chain (OC) fixation on preoperative temporal bone computed tomography (TBCT) in chronic otitis media (COM) with tympanosclerosis (TS). METHODS: Fifty-six patients who...
Sun Sep 20, 2020 09:21
Related Articles Association of serum vitamin D with Chronic RhinoSinusitis in adults residing at high altitudes. Eur Arch Otorhinolaryngol. 2020 Sep 18;: Authors: Thakur P, Potluri P Abstract PURPOSE: To evaluate the association of serum vitamin D levels with chronic rhinosinusitis (CRS) in population residing at high altitudes and to assess its correlation with severity of CRS. METHODS: A prospective case-control study comparing vitamin...
Sun Sep 20, 2020 09:21
Related Articles Contribution of noise reduction pre-processing and microphone directionality strategies in the speech recognition in noise in adult cochlear implant users. Eur Arch Otorhinolaryngol. 2020 Sep 18;: Authors: Goffi-Gomez MVS, Muniz L, Wiemes G, Onuki LC, Calonga L, Osterne FJ, Kós MI, Caldas FF, Cardoso C, Cagnacci B Abstract PURPOSE: Refinement currently offered in new sound processors may improve noise listening capability reducing...
Sun Sep 20, 2020 13:21
Related Articles Audiological benefit and subjective satisfaction with the ADHEAR hearing system in children with unilateral conductive hearing loss. Eur Arch Otorhinolaryngol. 2020 Sep 19;: Authors: Hirth D, Weiss R, Stöver T, Kramer S Abstract OBJECTIVE: The ADHEAR system (MED-EL, Innsbruck, Austria) is a new adhesive bone conduction hearing aid. This study evaluates the audiological benefit and subjective satisfaction as well as the manageability...
Sun Sep 20, 2020 13:21
Related Articles Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases. Pharmaceutics. 2020 Sep 14;12(9): Authors: Ortega MÁ, Guzmán Merino A, Fraile-Martínez O, Recio-Ruiz J, Pekarek L, G Guijarro L, García-Honduvilla N, Álvarez-Mon M, Buján J, García-Gallego S Abstract Infectious diseases are one of the main global public health risks, predominantly caused by viruses, bacteria, fungi, and parasites....
Fri Sep 18, 2020 13:24
Related Articles Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab. Future Oncol. 2020 Sep 17;: Authors: Bharmal M, Nolte S, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ, Pusceddu S, Hanna GJ, Hassel JC, Kiecker F, Ellers-Lenz B, Bajars M, Güzel G, Nghiem P, Hunger M, Schlichting M, Henry-Szatkowski M, D'Angelo SP Abstract Aim: To evaluate changes in health-related quality of...
Fri Sep 18, 2020 13:24
Related Articles PIVOT-10: Phase II study of bempegaldesleukin plus nivolumab in cisplatin-ineligible advanced urothelial cancer. Future Oncol. 2020 Sep 17;: Authors: Huddart RA, Siefker-Radtke AO, Balar AV, Bilen MA, Powles T, Bamias A, Castellano D, Khalil MF, Van Der Heijden MS, Koshkin VS, Pook DW, Özgüroğlu M, Santiago L, Zhong B, Chien D, Lin W, Tagliaferri MA, Loriot Y Abstract The choice of first-line therapy for patients with metastatic...
Fri Sep 18, 2020 13:24
Related Articles Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations. Crit Care. 2020 Sep 16;24(1):559 Authors: Flaczyk A, Rosovsky RP, Reed CT, Bankhead-Kendall BK, Bittner EA, Chang MG Abstract Critically ill patients with COVID-19 are at increased risk for thrombotic complications which has led to an intense...
Fri Sep 18, 2020 13:24
Related Articles Leukemia escape in immune desert: intraocular relapse of pediatric pro-B-ALL during systemic control by CD19-CAR T cells. J Immunother Cancer. 2020 Sep;8(2): Authors: Willier S, Raedler J, Blaeschke F, Stenger D, Pazos Escudero M, Jurgeleit F, Grünewald TGP, Binder V, Schmid I, Albert MH, Wolf A, Feuchtinger T Abstract BACKGROUND: Relapsed/refractory B-precursor acute lymphoblastic leukemia (BCP-ALL) remains a major therapeutic...
Fri Sep 18, 2020 13:24
Related Articles Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy. Nat Commun. 2020 09 16;11(1):4660 Authors: Bastola S, Pavlyukov MS, Yamashita D, Ghosh S, Cho H, Kagaya N, Zhang Z, Minata M, Lee Y, Sadahiro H, Yamaguchi S, Komarova S, Yang E, Markert J, Nabors LB, Bhat K, Lee J, Chen Q, Crossman DK, Shin-Ya K, Nam DH, Nakano I Abstract Intratumor spatial heterogeneity facilitates therapeutic...
Fri Sep 18, 2020 13:24
Related Articles LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5. Oncogene. 2020 Sep 16;: Authors: Yuan J, Song Y, Pan W, Li Y, Xu Y, Xie M, Shen Y, Zhang N, Liu J, Hua H, Wang B, An C, Yang M Abstract Lymph node metastasis is the major adverse feature for recurrence and death of thyroid cancer patients. To identify lncRNAs involved in thyroid cancer metastasis,...
Fri Sep 18, 2020 13:24
Related Articles METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway. Cancer Gene Ther. 2020 Sep 16;: Authors: Bi X, Lv X, Liu D, Guo H, Yao G, Wang L, Liang X, Yang Y Abstract Methyltransferase-like 3 (METTL3) functions as an RNA methyltransferase that controls the modification of N(6)-methyladenosine (m6A) to influence the biosynthesis, decay, and translation of mRNAs. This study...
Fri Sep 18, 2020 13:24
Related Articles Targeting co-stimulatory molecules in autoimmune disease. Nat Rev Drug Discov. 2020 Sep 16;: Authors: Edner NM, Carlesso G, Rush JS, Walker LSK Abstract Therapeutic targeting of immune checkpoints has garnered significant attention in the area of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T lymphocyte antigen 4 (CTLA4) and PD1, both of which are members of the CD28 family. In autoimmunity,...
Fri Sep 18, 2020 13:24
Related Articles 18F-fluorodeoxyglucose positron emission tomography/ computed tomography in the diagnosis of suspected paraneoplastic syndromes: A retrospective analysis. World J Nucl Med. 2020 Apr-Jun;19(2):124-130 Authors: Bresler R, Schroeder HW, Chow DZ, Lim R Abstract Paraneoplastic syndromes are a rare clinical presentation of tumor thought to affect 0.01% of patients with cancer. Paraneoplastic syndromes present a diagnostic challenge...
Fri Sep 18, 2020 13:24
Related Articles Preparation, escalation, de-escalation, and normal activities. J Card Surg. 2020 Sep 16;: Authors: Sadeghipour P, Mohebbi B, Mousavizadeh M, Hosseini S, Maleki M Abstract Iran is one of the earliest countries involved with coronavirus disease 2019 (COVID-19) pandemic. In the present short report, we have presented our experiences as a cardiovascular tertiary center during the COVID-19 outbreak. At the beginning, we have pursued...
Fri Sep 18, 2020 13:24
Related Articles VI-RADS for Bladder Cancer: Current Applications and Future Developments. J Magn Reson Imaging. 2020 Sep 17;: Authors: Panebianco V, Pecoraro M, Del Giudice F, Takeuchi M, Muglia VF, Messina E, Cipollari S, Giannarini G, Catalano C, Narumi Y Abstract Bladder cancer (BCa) is among the ten most frequent cancers globally. It is the tumor with the highest lifetime treatment-associated costs, and among the tumors with the heaviest...
Fri Sep 18, 2020 13:24
Related Articles Administrative data identify sickle cell disease: A critical review of approaches in U.S. health services research. Pediatr Blood Cancer. 2020 Sep 17;:e28703 Authors: Grosse SD, Green NS, Reeves SL Abstract To identify people living with sickle cell disease (SCD) and study their healthcare utilization, researchers can either use clinical records linked to administrative data or use billing diagnosis codes in stand-alone administrative...
Fri Sep 18, 2020 13:24
Related Articles NCI support for pediatric radiation therapy: Past, present, and future. Pediatr Blood Cancer. 2020 Sep 17;:e28689 Authors: Buchsbaum JC, Vikram B PMID: 32939959 [PubMed - as supplied by publisher]
Fri Sep 18, 2020 13:24
Related Articles A Study of the Immune Infiltrate and Patient Outcomes in Esophageal Cancer. Carcinogenesis. 2020 Sep 17;: Authors: Conroy MJ, Kennedy SA, Doyle SL, Hayes B, Kavanagh M, P van der Stok E, O'Sullivan K, Cathcart MC, Reynolds JV, Lysaght J Abstract Cancer patient outcomes and selection for novel therapies are heavily influenced by the immune contexture of the tumor microenvironment. Esophageal cancer is associated with poor outcomes....
Fri Sep 18, 2020 15:05
Related Articles Circulating Tumor DNA Markers for Early Progression on Fulvestrant With or Without Palbociclib in ER+ Advanced Breast Cancer. J Natl Cancer Inst. 2020 Jun 17;: Authors: O'Leary B, Cutts RJ, Huang X, Hrebien S, Liu Y, André F, Loibl S, Loi S, Garcia-Murillas I, Cristofanilli M, Bartlett CH, Turner NC Abstract BACKGROUND: There are no established molecular biomarkers for patients with breast cancer receiving combination endocrine...
Fri Sep 18, 2020 15:05
Related Articles Perception of Oncology Evaluated by Medical Students (P.O.E.M.S)-a Single Institutional Study. J Cancer Educ. 2020 Sep 17;: Authors: Roy P, Basu A, Samaddar D, Chowdhury H Abstract Rising incidence of cancer coupled with lack of structured oncology teaching in the undergraduate (UG) medical curriculum could be detrimental by generating unmet needs in the proper care of cancer patients in the future. To determine the orientation...
Fri Sep 18, 2020 15:05
Related Articles The Impact of Ovarian Cancer on Individuals and their Caregivers: A Qualitative Analysis. Psychooncology. 2020 Sep 17;: Authors: Hui Tan J, Sharpe L, Russell H Abstract OBJECTIVE: Ovarian cancer remains an understudied cancer with poor prognosis, few effective treatments and little understanding of the how individuals and their families face the challenges and uncertainty following diagnosis. This study synthesized the subjective...
Fri Sep 18, 2020 15:05
Related Articles Interaction of HULC polymorphisms with Helicobacter pylori infection plays a strong role for the prediction of gastric cancer risk. Future Oncol. 2020 Sep;16(26):1997-2006 Authors: Wang BG, Ding HX, Lv Z, Xu Q, Yuan Y Abstract Aim: Gene-environment interactions have better efficacy in predicting cancer susceptibility than a single gene. Materials & methods: Eight tag single nucleotide polymorphisms encompassing the whole...
Fri Sep 18, 2020 15:05
Related Articles Clinical applications of artificial intelligence in urologic oncology. Curr Opin Urol. 2020 Sep 15;: Authors: Hosein S, Reitblat CR, Cone EB, Trinh QD Abstract PURPOSE OF REVIEW: This review aims to shed light on recent applications of artificial intelligence in urologic oncology. RECENT FINDINGS: Artificial intelligence algorithms harness the wealth of patient data to assist in diagnosing, staging, treating, and monitoring...
Fri Sep 18, 2020 15:05
Related Articles A Phase I Dose Escalation Study of Neoadjuvant SBRT plus Elective Nodal Radiation with Concurrent Capecitabine for Resectable Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2020 Sep 14;: Authors: Witt JS, Kuczmarska-Haas A, Lubner M, Reeder SB, Cho SY, Minter R, Weber S, Ronnekleiv-Kelly S, Abbott D, LoConte N, Mulkerin DL, Lubner SJ, Uboha NV, Deming D, Ritter MA, Mohindra P, Bassetti MF Abstract BACKGROUND: and Purpose:...
Fri Sep 18, 2020 15:05
Related Articles The future of cell-free DNA testing to guide therapeutic decisions in B-cell lymphomas. Curr Opin Hematol. 2019 07;26(4):281-287 Authors: Condoluci A, Rossi D Abstract PURPOSE OF REVIEW: Tissue biopsy is the current gold standard technique for diagnosis and molecular profiling of lymphomas, but it carries several disadvantages in terms of procedural risks (infectious and haemorrhagic complications, anaesthesiologic risks) and...
Sun Sep 20, 2020 07:05
Related Articles Bromodomain and Extra-Terminal domain inhibitors for lymphoid malignancies. Curr Opin Hematol. 2019 07;26(4):273-280 Authors: Bertoni F, Stathis A Abstract PURPOSE OF REVIEW: Pharmacological inhibition of Bromodomain and Extra-Terminal (BET) domain proteins is a very exciting epigenetic therapeutic modality. Due to the central role of BET proteins in transcription regulation, their inhibition heavily affects lymphoma cells...
Sun Sep 20, 2020 07:05
Related Articles HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line. Cancers (Basel). 2020 Sep 15;12(9): Authors: Lee HJ, Shin S, Kang J, Han KC, Kim YH, Bae JW, Park KH Abstract Lapatinib, a Human Epidermal growth factor Receptor 2 (HER2)-targeting therapy in HER2-overexpressing breast cancer, has been widely used clinically,...
Sun Sep 20, 2020 07:05
Related Articles Exercise interventions in metastatic cancer disease: a literature review and a brief discussion on current and future perspectives. BMJ Support Palliat Care. 2020 Sep 17;: Authors: Wilk M, Kepski J, Kepska J, Casselli S, Szmit S Abstract Exercise is a well-established factor which improves outcomes of oncological patients during curative treatment as well as in cancer survivors. However, the role of physical activity in metastatic...
Sun Sep 20, 2020 07:05
Related Articles Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer. Oncogenesis. 2020 Sep 17;9(9):82 Authors: Wang Z, Yang C, Li L, Jin X, Zhang Z, Zheng H, Pan J, Shi L, Jiang Z, Su K, Li B, Shao X, Qiu F, Yan J, Huang J Abstract Triple-negative breast cancer (TNBC) is highly aggressive, difficult to treat and commonly develops visceral metastasis, including lung metastasis....
Sun Sep 20, 2020 07:05
Related Articles Establishment and characterization of a new gastric cancer cell line, XGC-1. Cancer Cell Int. 2020;20:437 Authors: Peng J, Xu H, Cai J Abstract Background: To establish a primary human gastric cancer cell line. Methods: Fresh gastric cancer tissue samples were separated into a cell suspension, and DMEM/F12 medium containing 10% foetal bovine serum was used for primary culture and subculture. The morphology of the cells...
Sun Sep 20, 2020 07:05
Related Articles Increased small extracellular vesicle secretion after chemotherapy via upregulation of cholesterol metabolism in acute myeloid leukaemia. J Extracell Vesicles. 2020 Aug 07;9(1):1800979 Authors: Hong CS, Jeong E, Boyiadzis M, Whiteside TL Abstract Most patients with acute myeloid leukaemia (AML) experience disease recurrence after chemotherapy largely due to the development of drug resistance. Small extracellular vesicles (sEVs)...
Sun Sep 20, 2020 07:05
Related Articles Video-assisted thoracoscopy for lung cancer: who is the future of thoracic surgery? J Thorac Dis. 2020 Aug;12(8):4427-4433 Authors: Jiang Y, Su Z, Liang H, Liu J, Liang W, He J Abstract As the computer processing technique and display technology evolved dramatically, the surgical approach to early-stage non-small cell lung cancer (NSCLC) has made a rapid progress within the past few years. Currently, the gold standard for NSCLC...
Sun Sep 20, 2020 07:05
Related Articles Combining immunotherapy and radiotherapy in lung cancer: a promising future? J Thorac Dis. 2020 Aug;12(8):4498-4503 Authors: Zhou J, Huang Q, Huang Z, Li J PMID: 32944363 [PubMed]
Sun Sep 20, 2020 07:05
Related Articles CAR-T cell therapy for lung cancer: a promising but challenging future. J Thorac Dis. 2020 Aug;12(8):4516-4521 Authors: Zhong S, Cui Y, Liu Q, Chen S PMID: 32944366 [PubMed]
Sun Sep 20, 2020 07:05
Related Articles Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma. Cancer Biol Med. 2020 Aug 15;17(3):555-568 Authors: Shen S, Chen L, Liu J, Yang L, Zhang M, Wang L, Zhang R, Uemura Y, Wu Q, Yu X, Liu T Abstract In the interaction between a tumor and the immune system, immune checkpoints play an important role, and in tumor immune escape, co-inhibitory immune checkpoints are important. Immune checkpoint...
Sun Sep 20, 2020 07:05
Related Articles Incidence and preoperative predictors for major complications following radical nephroureterectomy. Transl Androl Urol. 2020 Aug;9(4):1786-1793 Authors: Kocher NJ, Canes D, Bensalah K, Roupret M, Lallas C, Margulis V, Shariat S, Colin P, Matin S, Tracy C, Xylinas E, Wagner A, Roumiguie M, Kassouf W, Klatte T, Raman JD Abstract Background: Radical nephroureterectomy (RNU) is the referent standard for managing bulky, invasive,...
Sun Sep 20, 2020 07:05
Related Articles Controversies in management of the bladder cuff at nephroureterectomy. Transl Androl Urol. 2020 Aug;9(4):1868-1880 Authors: Braun AE, Srivastava A, Maffucci F, Kutikov A Abstract Upper tract urothelial carcinoma (UTUC) accounts for roughly 5% of urothelial carcinomas. Historically, the gold standard for high-risk or bulky low-risk UTUC was an open radical nephroureterectomy with formal bladder cuff excision (BCE). The development...
Sun Sep 20, 2020 07:05
Related Articles Downregulated Mucin 1 alleviates paclitaxel resistance in non‑small cell lung cancer cells. Mol Med Rep. 2020 Jul 20;: Authors: Xu H, Gao H, Li H, Li D, Yuan W, Zhang L, Cheng P, Su X, Li Z, Wang G, Zhang T Abstract Multidrug resistance of non‑small cell lung cancer (NSCLC) is a common clinical problem, which is one of the main reasons leading to the failure of chemotherapy. Therefore, how to overcome or prevent drug resistance...
Sun Sep 20, 2020 07:05
Related Articles Daily dosimetric variation between image-guided volumetric modulated arc radiotherapy and MR-guided daily adaptive radiotherapy for prostate cancer stereotactic body radiotherapy. Acta Oncol. 2020 Sep 18;:1-7 Authors: Nicosia L, Sicignano G, Rigo M, Figlia V, Cuccia F, De Simone A, Giaj-Levra N, Mazzola R, Naccarato S, Ricchetti F, Vitale C, Ruggieri R, Alongi F Abstract AIM: To evaluate differences between MR-guided daily-adaptive...
Sun Sep 20, 2020 07:05
Related Articles Communication Skills: Use of the Interprofessional Communication Curriculum to Address Physical Aspects of Care. Clin J Oncol Nurs. 2020 Oct 01;24(5):547-553 Authors: Ferrell B, Buller H, Paice JA Abstract BACKGROUND: The literature has emphasized the importance of effective communication regarding psychosocial needs; however, other aspects of patient care, including attention to physical needs, are equally important. ...
Sun Sep 20, 2020 07:05
Related Articles Applications of artificial intelligence (AI) in diagnostic radiology: a technography study. Eur Radiol. 2020 Sep 18;: Authors: Rezazade Mehrizi MH, van Ooijen P, Homan M Abstract OBJECTIVES: Why is there a major gap between the promises of AI and its applications in the domain of diagnostic radiology? To answer this question, we systematically review and critically analyze the AI applications in the radiology domain. ...
Sun Sep 20, 2020 07:05
Related Articles The "Day Zero Talk": the Initial Communication of a Pediatric Oncology Diagnosis by Primary Care Physicians and Other Primary Care Providers. J Cancer Educ. 2020 Sep 18;: Authors: Wharton B, Beeler DM, Cooper S Abstract While much is known about the initial communication of a definitive pediatric cancer diagnosis by the child's pediatric oncologist, little is known about the discussions leading up to this formal conversation,...
Sun Sep 20, 2020 07:05
Related Articles Ameliorative effect of ferruginol on isoprenaline hydrochloride-induced myocardial infarction in rats. Environ Toxicol. 2020 Sep 18;: Authors: Zhang X, Li X, Wang C, Li H, Wang L, Chen Y, Feng J, Ali Alharbi S, Deng Y Abstract Cardiovascular-related diseases continue to be a leading cause of death globally. Among ischemic-induced cardiac diseases, myocardial infarction (MI) is reported to be of an alarming value. Despite numerous...
Sun Sep 20, 2020 07:05
Related Articles New advances in the clinical management of RAS and BRAF mutant colorectal cancer patients. Expert Rev Gastroenterol Hepatol. 2020 Sep 18;: Authors: Ruffinelli JC, Santos Vivas C, Sanz-Pamplona R, Moreno V Abstract INTRODUCTION: In colorectal carcinogenesis, genetic alterations in RAS and BRAF oncogenes play an important role for cancer initiation and/or progression and represent a key focus in the search for targeted therapies....
Sun Sep 20, 2020 07:05
Related Articles Unraveling Hematopoiesis through the Lens of Genomics. Cell. 2020 Sep 17;182(6):1384-1400 Authors: Liggett LA, Sankaran VG Abstract Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis. In the past decade, the genomics revolution has ushered in powerful new methods for investigating the hematopoietic system that have provided transformative insights into its biology. As part of the advances...
Sun Sep 20, 2020 07:05
Related Articles Detection of chemotherapy-resistant patient-derived acute lymphoblastic leukemia clones in murine xenografts using cellular barcodes. Exp Hematol. 2020 Sep 15;: Authors: Jacobs S, Ausema A, Zwart E, Weersing E, de Haan G, Bystrykh LV, Belderbos ME Abstract Clonal heterogeneity fuels leukemia evolution, therapeutic resistance and relapse. Upfront detection of therapy-resistant leukemia clones at diagnosis may allow adaptation...
Sun Sep 20, 2020 07:05
Related Articles Considerations for environmentally sustainable head and neck surgical oncology practice. Am J Otolaryngol. 2020 Sep 12;41(6):102719 Authors: Sanabria A, Kowalski LP, Nixon IJ, Shaha A, De Bree R, Mäkitie AA, Rinaldo A, Ferlito A Abstract OBJECTIVE: To evaluate the potential role of head and neck oncologic surgeons in environmental protection, sustainability of health-care systems and avoidance of procedures contributing to climate...
Sun Sep 20, 2020 07:05
Related Articles Prognostic and Predictive Factors in Metastatic Renal Cell Carcinoma: Current Perspective and a Look Into the Future. Cancer J. 2020 Sep/Oct;26(5):365-375 Authors: Gan CL, Dudani S, Heng DYC Abstract Metastatic renal cell carcinoma (mRCC) comprises a highly heterogeneous group of diseases with varied clinical outcomes. As a result, models to estimate prognosis were developed in an attempt to aid patient counseling, treatment...
Sun Sep 20, 2020 07:05
Related Articles The Role of Targeted Therapy in the Management of High-Risk Resected Kidney Cancer: What Have We Learned and How Will It Inform Future Adjuvant Trials. Cancer J. 2020 Sep/Oct;26(5):376-381 Authors: Brown LC, Zhang T, George DJ Abstract The primary treatment for localized renal cell carcinoma (RCC) is surgical resection with curative intent. Despite this, many patients, especially those with high-risk features, will develop recurrent...
Sun Sep 20, 2020 07:05
Related Articles The Immunotherapy Revolution in Kidney Cancer Treatment: Scientific Rationale and First-Generation Results. Cancer J. 2020 Sep/Oct;26(5):419-431 Authors: Hasanov E, Gao J, Tannir NM Abstract The recent discovery of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, including the treatment for renal cell carcinoma (RCC). Following the eras of cytokines and molecularly targeted therapies including vascular...
Sun Sep 20, 2020 07:05
Related Articles Advanced Non-Clear Cell Kidney Cancer: In Search of Rational Treatment Approaches. Cancer J. 2020 Sep/Oct;26(5):441-447 Authors: Ornstein MC, Hutson TE Abstract Non-clear cell renal cell carcinoma (nccRCC) accounts for approximately 25% of RCC diagnoses. Although broadly labeled as "nccRCC," they comprised a host of histologies that include papillary, chromophobe, unclassified, and others. Moreover, these histological variants...
Sun Sep 20, 2020 07:05
Related Articles Treatment and Mortality of Hemophagocytic Lymphohistiocytosis in Adult Critically Ill Patients: A Systematic Review With Pooled Analysis. Crit Care Med. 2020 Sep 18;: Authors: Knaak C, Schuster FS, Nyvlt P, Spies C, Feinkohl I, Beutel G, Schenk T, La Rosée P, Janka G, Brunkhorst FM, Keh D, Lachmann G Abstract OBJECTIVES: Hemophagocytic lymphohistiocytosis is a cytokine release syndrome caused by uncontrolled immune activation...
Sun Sep 20, 2020 07:05
Related Articles Parents' ratings of post-discharge healthcare for their children born very preterm and their suggestions for improvement: a European cohort study. Pediatr Res. 2020 Sep 18;: Authors: Seppänen AV, Sauvegrain P, Draper ES, Toome L, Rafei RE, Petrou S, Barros H, Zimmermann LJI, Cuttini M, Zeitlin J, SHIPS Research Group Abstract BACKGROUND: Follow-up of very preterm infants is essential for reducing risks of health and developmental...
Sun Sep 20, 2020 07:05
Related Articles Bioinformatics Data Mining Repurposes the JAK2 (Janus Kinase 2) Inhibitor Fedratinib for Treating Pancreatic Ductal Adenocarcinoma by Reversing the KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-Driven Gene Signature. J Pers Med. 2020 Sep 16;10(3): Authors: Liu LW, Hsieh YY, Yang PM Abstract Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive and lethal cancer types due to the late diagnosis, high...
Sun Sep 20, 2020 13:25
Related Articles Expression profile of SYNE3 and bioinformatic analysis of its prognostic value and functions in tumors. J Transl Med. 2020 Sep 18;18(1):355 Authors: Liao L, Zhang L, Yang M, Wang X, Huang W, Wu X, Pan H, Yuan L, Huang W, Wu Y, Guan J Abstract BACKGROUND: Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker of the cytoskeleton and nucleoskeleton (LINC) complex, namely...
Sun Sep 20, 2020 13:25
Related Articles Assessment of the quality of recommendations from 161 clinical practice guidelines using the Appraisal of Guidelines for Research and Evaluation-Recommendations Excellence (AGREE-REX) instrument shows there is room for improvement. Implement Sci. 2020 Sep 18;15(1):79 Authors: Florez ID, Brouwers MC, Kerkvliet K, Spithoff K, Alonso-Coello P, Burgers J, Cluzeau F, Férvers B, Graham I, Grimshaw J, Hanna S, Kastner M, Kho M, Qaseem A, Straus S ...
Sun Sep 20, 2020 13:25
Related Articles Comprehensive Cervical Cancer Prevention in Tanzania (CONCEPT) study: Cohort profile. BMJ Open. 2020 Sep 18;10(9):e038531 Authors: Mchome B, Swai P, Wu C, Katanga J, Kahesa C, Manongi R, Mwaiselage JD, Kjaer S, Rasch V, Linde DS Abstract PURPOSE: Cervical cancer is a major cause of death among women in Eastern Africa, and the distribution of human papillomavirus (HPV) according to HIV status is inadequately characterised in...
Sun Sep 20, 2020 13:25
Related Articles Response to neoadjuvant treatment among rectal cancer patients in a population-based cohort. Int J Colorectal Dis. 2020 Sep 19;: Authors: Alwers E, Jansen L, Kather J, Amitay E, Bläker H, Kloor M, Tagscherer KE, Roth W, Herpel E, Chang-Claude J, Brenner H, Hoffmeister M Abstract BACKGROUND: In rectal cancer, prediction of tumor response and pathological complete response (pCR) to neoadjuvant treatment could contribute to refine...
Sun Sep 20, 2020 13:25
Related Articles Abdominal and pelvic 18F-FDG PET/MR: a review of current and emerging oncologic applications. Abdom Radiol (NY). 2020 Sep 19;: Authors: Ward RD, Amorim B, Li W, King J, Umutlu L, Groshar D, Harisinghani M, Catalano O Abstract Positron emission tomography (PET) using fluorodeoxyglucose (18F-FDG) combined with magnetic resonance imaging (MR) is an emerging hybrid modality that has shown utility in evaluating abdominal and pelvic...
Sun Sep 20, 2020 13:25
Related Articles Immune evasion in renal cell carcinoma: biology, clinical translation, future directions. Kidney Int. 2020 Sep 16;: Authors: Wang X, Lopez R, Luchtel RA, Hafizi S, Gartrell B, Shenoy N Abstract Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in...
Sun Sep 20, 2020 14:59
Related Articles Development of a Stakeholder Driven Serious Illness Communication Program for Advance Care Planning in Children, Adolescents, and Young Adults with Serious Illness. J Pediatr. 2020 Sep 16;: Authors: DeCourcey DD, Partin L, Revette A, Bernacki R, Wolfe J Abstract OBJECTIVES: To develop a generalizable advance care planning ACP intervention for children and children, adolescents, and young adults with serious illness using a multi-stage...
Sun Sep 20, 2020 14:59
Related Articles Malignant peripheral nerve sheath tumors - Outcomes and prognostic factors based on the reference center experience. Surg Oncol. 2020 Sep 12;35:276-284 Authors: Sobczuk P, Teterycz P, Czarnecka AM, Świtaj T, Koseła-Paterczyk H, Kozak K, Falkowski S, Goryń T, Zdzienicki M, Morysiński T, Rutkowski P Abstract INTRODUCTION: Malignant peripheral nerve sheath tumor (MPNST) accounts for about 5% of soft tissue sarcomas. It can occur...
Sun Sep 20, 2020 14:59
Related Articles A Comment on: "Safety and efficacy of Lactobacillus for preventing necrotizing enterocolitis in preterm infants" (International Journal of Surgery 2020; 76:79-87). Int J Surg. 2020 Sep 15;: Authors: Ansari F, Pourrostami K, Pourjafar H PMID: 32947059 [PubMed - as supplied by publisher]
Sun Sep 20, 2020 06:29
Related Articles Changing the Innate Consensus About Mesh Fixation in Trans-abdominal Preperitoneal Laparoscopic Inguinal Hernioplasty in Adults: Short and Long Term Outcome.Randomized Controlled Clinical Trial. Int J Surg. 2020 Sep 15;: Authors: Habeeb TAAM, Mahmoud Mokhtar M, Sieda B, Osman G, Ibrahim A, Metwalli AM, Riad M, Khalil OMH, Mansour MI, Elshahidy TM, Abdelhamid MI, Mohamed MB Abstract INTRODUCTION: Inguinal hernioplasty is...
Sun Sep 20, 2020 06:29
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Sun Sep 20, 2020 06:29
Related Articles Impact of choledochotomy techniques during laparoscopic CBD exploration on short- and long-term clinical outcomes: time to change concepts A retrospective cohort study. Int J Surg. 2020 Sep 16;: Authors: Ahmed EA, Redwan AA Abstract BACKGROUND: complications after laparoscopic common bile duct exploration (LCBDE) regarding choledochotomy techniques have not been adequately studied in the literature. Therefore, this study...
Sun Sep 20, 2020 14:27
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