Abstract In accordance with Article 6 of Regulation (EC ) No 396/2005, the applicant Du Pont (UK ) submitted a request to the competent national authority in the United Kingdom to set an import tolerance for the active substance oxathiapiprolin in various crops in support of authorised uses in the United States. The data submitted in support of the request were found to be sufficient to derive maximum residue level (MRL ) proposals for citrus fruits, blackberries, raspberries, Chinese cabbage, basil...
Tue Jun 16, 2020 11:58
Abstract According to Article 12 of Regulation (EC ) No 396/2005, EFSA has reviewed the maximum residue levels (MRL s) currently established at European level for the pesticide active substance flubendiamide. To assess the occurrence of flubendiamide residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EU ) No 188/2011, the MRL s established by the Codex Alimentarius Commission as well as the...
Tue Jun 16, 2020 11:55
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP ) was asked to deliver a scientific opinion on the safety and efficacy of OptiPhos PLUS ®, intended to be used as a feed additive for laying hens, turkeys for breeding, chickens for breeding, minor poultry species for egg production purposes and breeding. The active substance is 6‐phytase produced by a genetically modified strain of Komagataella phaffii . The EFSA...
Mon Jun 15, 2020 22:00
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP ) was asked to deliver a scientific opinion on the safety and efficacy of 3‐phytase FLF 1000 and FSF 10000 as a feed additive for turkeys for fattening or reared for breeding, pigs for fattening and minor porcine species for growing. This additive contains 3‐phytase produced by a genetically modified strain of Komagataella phaffii and it is authorised in the EU...
Mon Jun 15, 2020 12:17
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP ) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of Pediococcus pentosaceus DSM 16244 as a technological additive for all animal species. The applicant has provided evidence that the additive currently in the market complies with the existing conditions of authorisation. There was no new evidence that...
Mon Jun 15, 2020 12:10
Abstract Introduction New techniques for adjuvant radiation therapy after breast conservation include prone positioning, hypofractionation and intensity‐modulated radiation therapy (IMRT). Long‐term evaluations of this combination are lacking, and we report our own experience. Methods Patients with invasive breast cancer followed for a minimum 36 months post‐IMRT were eligible. Dose used was 40 Gray in 15 fractions over 3 weeks to the whole breast via forward‐planned prone, whole breast...
Tue Jun 16, 2020 14:30
Abstract Background Dual‐energy CT is able to distinguish between materials based on differences in X‐ray absorption at different X‐ray beam energies. The strong k‐edge photoelectric effect of materials with a high atomic number makes this modality ideal for identifying iodine‐containing compounds. We aim to evaluate dual‐energy CT for the detection of Gastrografin (GG) (diatrizoate, Bayer PLC, Reading, UK) enteric contrast medium and validate the conditions for the measurement in ex vivo samples....
Mon Jun 15, 2020 19:05
Recent guidelines advise against prophylactic antibiotics in patients with necrotizing pancreatitis, advocating instead a step-up drainage and necrosectomy strategy with antibiotics as dictated by microbiologi...
Mon Jun 15, 2020 03:00
Abstract Background Central sensitization (CS) is a form of neuroplasticity characterized by changes in the neural sensitivity, responsiveness and/or output that are not contingent on peripheral input nor activity dependent. CS is characterized by activation of unmyelinated C‐fibers resulting in a cascade of events at molecular and cellular levels which eventuate into generation of synaptic currents at rest. CS therefore, contributes to heightened generalized pain sensitivity, further complicates...
Mon Jun 15, 2020 16:20
Abstract Background Primary Sjogren’s syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper‐2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of IL‐6, 5 and 4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with...
Mon Jun 15, 2020 12:17
Asthma is a chronic inflammatory condition characterized by T-helper (Th)2 polarization. In children, the prevalence of obesity is associated with an increased incidence of asthma. Notably, obesity is linked with Th1-mediated inflammation and has been identified as a major risk factor of asthma.
Tue Jun 16, 2020 03:00
Condition: Adenoid Cystic Carcinoma of the Head and NeckInterventions: Drug: All-trans Retinoic Acid; Drug: VEGFR inhibitor; Drug: ChemotherapySponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityRecruiting
Tue Jun 16, 2020 15:06
Condition: OtomycosisInterventions: Drug: miconazole 2% oil; Drug: vehicle oilSponsors: Hill Dermaceuticals, Inc.; Abond CRO Inc.Not yet recruiting
Tue Jun 16, 2020 15:06
Condition: DeliriumIntervention: Diagnostic Test: hypertensionSponsor: Zhang LeiRecruiting
Tue Jun 16, 2020 15:06
Conditions: HPV Positive Cancer; Vulvar, Vaginal, Penile, Rectal Cancer; Anal Cancer; Oropharyngeal Cancer; Cervical CancerInterventions: Biological: PRGN-2009; Biological: M7824Sponsor: National Cancer Institute (NCI)Not yet recruiting
Tue Jun 16, 2020 15:06
Condition: Breast CancerIntervention: Drug: Definity Suspension for InjectionSponsor: Sunnybrook Health Sciences CentreRecruiting
Tue Jun 16, 2020 15:06
Condition: Head and Neck CancerIntervention: Drug: Definity Suspension for InjectionSponsor: Sunnybrook Health Sciences CentreRecruiting
Tue Jun 16, 2020 15:06
Condition: HealthyIntervention: Other: axial loadSponsor: Balgrist University HospitalRecruiting
Tue Jun 16, 2020 15:06
Publication date: Available online 15 June 2020Source: Pathology - Research and PracticeAuthor(s): Mathias Schmidt, Christina Gräf, Dominik Gross
Tue Jun 16, 2020 15:01
Publication date: Available online 15 June 2020Source: Pathology - Research and PracticeAuthor(s): Hafsah A. Arain, Mark Li-cheng Wu
Tue Jun 16, 2020 15:01
Objective Microlaryngeal surgery typically requires oxygenation and ventilation via either an endotracheal tube (ETT), jet ventilation (JV), or intermittent apnea with an ETT. Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) delivered by high flow nasal cannula has been reported as an alternative technique. This method of apneic oxygenation and ventilation allows for stable, unobstructed visualization of immobile laryngeal structures. We aim to describe the technique and characterize...
Tue Jun 16, 2020 12:40
Key points Paternal obesity negatively influences the metabolic outcomes in adult rat offspring. Maternal voluntary physical activity has previously been reported to improve glucose metabolism in adult rat offspring sired by healthy fathers. Here, we investigated whether a structured program of maternal exercise training before and during gestation can attenuate the negative impacts that paternal obesity has on insulin sensitivity and secretion in female adult offspring. Exercise before and...
Mon Jun 15, 2020 15:31
Key points The maintenance of optimal mitochondrial content and function is critical for muscle health. Mitochondrial dynamics play key roles in mitochondrial quality control, however, the exact role that mitochondrial fission plays in skeletal muscle health remains unclear. Here we report knocking down Drp1 (a protein regulating mitochondrial fission) for 4 months in adult mouse skeletal muscle resulted in severe muscle atrophy (40% to 50%). Drp1 knockdown also led to a reduction in ADP‐stimulated...
Mon Jun 15, 2020 15:31
Mon Jun 15, 2020 15:29
Key points Enhancing cortical excitability can be achieved by either reducing intracortical inhibition or by enhancing intracortical excitation. Here we compare the consequences of reducing the intracortical inhibition and of enhancing intracortical excitation on the processing of communication sounds in the primary auditory cortex. Local application of Gabazine and of AMPA enlarged the spectrotemporal receptives fields and increased the responses to communication to the same extent. The Mutual...
Mon Jun 15, 2020 15:28
Key points The vagus nerve is the largest cranial nerve and innervates many structures in the neck, thorax and abdomen While single‐unit recordings from the vagus nerve have been performed in experimental animals for seven decades, no recordings have ever been made from the human vagus nerve The vagus nerve is routinely stimulated clinically, yet we know little of its physiology in humans We describe the methodology and provide preliminary results of the first intraneural single‐unit recordings...
Mon Jun 15, 2020 15:27
Key points Increased plasma nitrite concentrations may have beneficial effects on skeletal muscle function. The physiological basis explaining these observations has not been clearly defined and it may involve positive effects on muscle contraction force, microvascular O2 delivery and skeletal muscle oxidative metabolism. In the isolated canine gastrocnemius model, we evaluated the effects of acute nitrite infusion on muscle force and skeletal muscle oxidative metabolism. Under hypoxic conditions,...
Sun Jun 14, 2020 17:52
Publication date: Available online 15 June 2020Source: Journal of Neuroscience MethodsAuthor(s): Shachar Hochman, Shahaf Leshem, Avishai Henik, Eyal Kalanthroff
Tue Jun 16, 2020 14:43
Objective We analyzed the longitudinal profile of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in early Parkinson's disease (PD) compared with healthy controls (HC) and tested baseline CSF biomarkers for prediction of clinical decline in PD. Methods Amyloid‐β (Aβ42), total tau (t‐tau) and tau phosphorylated at the threonine 181 position (p‐tau) were measured using the high‐precision Roche Elecsys® electrochemiluminescence immunoassay in all available CSF samples from longitudinally...
Tue Jun 16, 2020 12:44
Mon Jun 15, 2020 20:28
Vision therapy in the form of ocular motor training is increasingly used to treat visual complaints, particularly in the setting of persistent symptoms after mild traumatic brain injury (mTBI). In this review we discuss the rationale behind this intervention and the evidence for its efficacy. While the efficacy of exercises for primary convergence insufficiency is plausible and supported by data, there is not yet strong evidence of benefit for the post‐traumatic variant. It is not established that...
Mon Jun 15, 2020 20:24
Objective Cathodal direct current stimulation (cDCS) induces long‐term depression (LTD)‐like reduction of cortical excitability (DCS‐LTD), which has been tested in the treatment of epilepsy with modest effects. In part, this may be due to variable cortical neuron orientation relative to the electric field. We tested, in vivo and in vitro , whether DCS‐LTD occurs throughout the cortical thickness, and if not, then whether drug‐DCS pairing can enhance the uniformity of the cortical response and the...
Mon Jun 15, 2020 20:20
Mon Jun 15, 2020 20:18
Objective Insula epilepsy is rare and can be evaluated effectively by Stereotactic intracerebral EEG (SEEG). Many previous studies of insulo‐opercular seizures have been unable to separate insular and opercular onset. With adequate sampling of the insula, this study shows this is possible. Methods We analysed intra‐insular dynamics and extra‐insular propagation in twelve patients with “pure” insula epilepsy (n = 9) or insular and only deepest opercular involvement (n = 3) at seizure onset....
Mon Jun 15, 2020 19:17
Publication date: Available online 16 June 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Niels Jacobsen, Christian P. Nolsøe, Lars Konge, Ole Graumann, Christoph F. Dietrich, Paul S. Sidhu, Fabio Piscaglia, Odd H. Gilja, Christian B. Laursen
Tue Jun 16, 2020 14:38
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.