Abstract Ernst Mayr argued that the emergence of biology as a special science in the early nineteenth century was possible due to the demise of the mathematical model of science and its insistence on demonstrative knowledge. More recently, John Zammito has claimed that the rise of biology as a special science was due to a distinctive experimental, anti-metaphysical, anti-mathematical, and anti-rationalist strand of thought coming from outside of Germany. In this paper we argue...
Tue Jun 16, 2020 03:00
Oikopleura dioica is a tunicate model organism in various fields of biology. We describe sampling methods, species identification, culturing setup, and culturing protocols for the animals and algal feed. We highlight key factors that helped strengthen the culture system and discuss the possible problems and resolutions.
Tue Jun 16, 2020 22:53
Correction of chromatic shifts in three-dimensional (3D) multicolor fluorescence microscopy images is crucial for quantitative data analyses. This protocol is developed to measure and correct chromatic shifts in biological samples through acquisition of suitable reference images and processing with the open-source software, Chromagnon.
Tue Jun 16, 2020 21:54
This work describes protocols for the preparation of magnetic nanoparticles, its coating with SiO2, followed by its amine functionalization with (3-aminopropyl)triethoxysilane (APTES) and its conjugation with deferoxamine using a succinyl moiety as a linker. A deep structural characterization description and a capture bacteria assay using Y. enterocolitica for all the intermediate nanoparticles and the final conjugate are also described in detail.
Tue Jun 16, 2020 21:54
This protocol describes the procedure for sectioning and culturing human cardiac slices for preclinical drug testing and details the use of optical mapping for recording transmembrane voltage and intracellular calcium signals simultaneously from these slices.
Tue Jun 16, 2020 20:55
Here, we present practical recommendations for performing thoracic high-resolution computed tomography for diagnosing and assessing systemic sclerosis-related interstitial lung disease.
Tue Jun 16, 2020 20:55
We present a methodology to establish the pollination requirements of apricot (Prunus armeniaca L.) cultivars combining the determination of self-(in)compatibility by fluorescence microscopy with the identification of the S-genotype by PCR analysis.
Tue Jun 16, 2020 19:56
Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a hepatic disorder occurring predominantly in childhood and is difficult to diagnose. PFIC3, being a rare autosomal recessive disease, is caused by genetic mutations in both alleles of ABCB4, resulting in the disruption of the bile secretory pathway. The identification of pathogenic effects resulting from different mutations in ABCB4 is the key to revealing the internal cause of disease. These mutations cause truncation, instability,...
Tue Jun 16, 2020 13:35
Publication date: July–August 2020Source: Journal of Surgical Education, Volume 77, Issue 4Author(s):
Tue Jun 16, 2020 22:23
Publication date: July–August 2020Source: Journal of Surgical Education, Volume 77, Issue 4Author(s):
Tue Jun 16, 2020 22:23
Publication date: Available online 15 June 2020Source: Journal of Surgical EducationAuthor(s): Brendan P. Lovasik, Hannah Rutledge, Emily Lawson, Shishir K. Maithel, Keith A. Delman
Tue Jun 16, 2020 22:23
Publication date: Available online 15 June 2020Source: Journal of Surgical EducationAuthor(s): Elizabeth R Berger, Lindsey Kreutzer, Amy Halverson, Anthony D. Yang, Stephen Reinhart, Kevin J. O’ Leary, Mark V. Williams, Karl Y. Bilimoria, Julie K. Johnson, ISQIC Advisory Committee
Tue Jun 16, 2020 22:23
I teach an anthropology course within the Wisconsin Department of Corrections. The course is online in that video lectures, movies, assignments, and discussions are carried out via a computer. The learning process is estranged but also incredibly intimate. I never see my students face-to-face. Students admit to you their deepest fears such as failure to succeed on the outside. They reveal their most profound sins including homicide. They read everything I assign. Their writing is detailed. And,...
Tue Jun 16, 2020 21:30
Tue Jun 16, 2020 06:42
Future Oncology, Ahead of Print.
Tue Jun 16, 2020 05:54
Future Oncology, Ahead of Print.
Mon Jun 15, 2020 11:24
Future Oncology, Ahead of Print.
Mon Jun 15, 2020 11:18
Future Oncology, Ahead of Print.
Mon Jun 15, 2020 11:08
Future Oncology, Ahead of Print.
Mon Jun 15, 2020 11:00
The aims of the study were to compare the effects of Invisalign® with and without Dental Monitoring® (DM) GoLive® on the following parameters: treatment duration, number of appointments, number of refinements,...
Mon Jun 15, 2020 03:00
Background. Although Botulinum Toxin Type A (BTXA) has been applied to scar prevention and treatment, the mechanisms still require further exploration. Objective. To investigate the effects of BTXA on microvessels in the hypertrophic scar models on rabbit ears. Methods. Eight big-eared New Zealand rabbits (males or females) were selected to establish scar models. One ear of each rabbit (4 models in each ear) was selected randomly to be injected with BTXA immediately after modeling and included in...
Tue Jun 16, 2020 17:35
Objective. Familial adenomatous polyposis (FAP) is one major type of inherited duodenal cancer. The estimate of duodenal cancer risk in patients with FAP is critical for selecting the optimal treatment strategy. Methods. Microarray datasets related with FAP were retrieved from the Gene Expression Omnibus (GEO) database. Differentially expressed genes were identified by FAP vs. normal samples and FAP and duodenal cancer vs. normal samples. Furthermore, functional enrichment analyses of these differentially...
Tue Jun 16, 2020 17:35
Background. Sympathetic sprouting in the dorsal root ganglion (DRG) following nerve injuries had been proved to induce adult neuropathic pain. However, it is unclear whether the abnormal sprouting occurs in infant nerve injury. Methods. L5 spinal nerve ligation (SNL) or sham surgery was performed on adult rats and 10-day-old pups, and mechanical thresholds and heat hyperalgesia were analyzed on 3, 7, 14, 28, and 56 postoperative days. Tyrosine hydroxylase-labeled sympathetic fibers were observed...
Tue Jun 16, 2020 15:05
Acute kidney injury (AKI) is a common complication of sepsis and has also been observed in some patients suffering from the new coronavirus pneumonia COVID-19, which is currently a major global concern. Thymoquinone (TQ) is one of the most active ingredients in Nigella sativa seeds. It has a variety of beneficial properties including anti-inflammatory and antioxidative activities. Here, we investigated the possible protective effects of TQ against kidney damage in septic BALB/c mice. Eight-week-old...
Tue Jun 16, 2020 15:05
Background. Concurrent chemoradiotherapy (CCRT) is the main treatment for esophageal cancer, but the response to treatment varies from individual to individual. MR imaging methods, such as diffusion-weighted (DW) MRI and the use of dynamic contrast-enhanced (DCE) MRI, have the potential to provide additional biomarkers that could evaluate the effect of CCRT in patients with esophageal carcinoma. Materials and Methods. Fifty-six patients with esophageal carcinoma, verified by histopathology, underwent...
Tue Jun 16, 2020 10:50
In silico T-cell epitope prediction plays an important role in immunization experimental design and vaccine preparation. Currently, most epitope prediction research focuses on peptide processing and presentation, e.g., proteasomal cleavage, transporter associated with antigen processing (TAP), and major histocompatibility complex (MHC) combination. To date, however, the mechanism for the immunogenicity of epitopes remains unclear. It is generally agreed upon that T-cell immunogenicity may be influenced...
Tue Jun 16, 2020 10:50
Endophytic and rhizosphere fungi are understood to be aiding the host plant to overcome a range of biotic and abiotic stresses (nutrition depletion, droughts, etc.) hence, they remain to be reservoirs of plethora of natural products with immense use. Consequently, this investigation of endophytic and rhizosphere fungi isolated from Mikania cordata (a perennial vine that is well established in Sri Lanka) for their antimicrobial properties was performed with the aim of future derivation of potential...
Tue Jun 16, 2020 10:50
Background. Bedside biliary drainage by endoscopic retrograde cholangiopancreatography (ERCP) without fluoroscopy for critically ill patients in the intensive care unit (ICU) remains challenging for endoscopists. The present study was to evaluate the efficacy and safety of radiation-free ERCP for these patients. Methods. Consecutive ICU patients with severe pancreaticobiliary disorders who underwent bedside radiation-free ERCP were retrospectively analyzed. Results. Radiation-free ERCP was performed...
Tue Jun 16, 2020 10:50
Among various risk factors for the initiation and progression of cancer, alternative polyadenylation (APA) is a remarkable endogenous contributor that directly triggers the malignant phenotype of cancer cells. APA affects biological processes at a transcriptional level in various ways. As such, APA can be involved in tumorigenesis through gene expression, protein subcellular localization, or transcription splicing pattern. The APA sites and status of different cancer types may have diverse modification...
Tue Jun 16, 2020 09:20
Introduction. To assess the efficacy of the autologous platelet concentrates (APCs) combined with autologous bone or bone substitute for the maxillary sinus floor lifting by a meta-analysis. Materials and Methods. Electronic databases (PUBMED, Web of Science, EMBASE through OVID, and Cochrane Library) were searched until Dec 31, 2019, and only randomized controlled trials (RCTs) in English were identified. Outcome variables included histologic evaluation, the implant stability quotient values, and...
Tue Jun 16, 2020 07:05
Publication date: Available online 16 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): John Patrik Matthias Burkhard, Sabine Koba, Fabian Schlittler, Tateyuki Iizuka, Benoît Schaller
Tue Jun 16, 2020 20:27
Publication date: Available online 15 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Jia Xu, Zin Mar Aung, Sousan Cheong, Taeho Won, Ruhong Zhang, Feng Xu, Jiajun Fan, Dong Han
Tue Jun 16, 2020 20:27
Fusarium is a filamentous fungus that is ubiquitous in nature and can cause severe opportunistic infections in immunocompromised hosts. The association between Fusarium and hyper-IgE syndrome is exceedingly rare and has only been documented in a single report previously. A 44-year-old male, working as marijuana grower, with prior diagnosis of hyper-IgE syndrome and recurrent infections presented with enlarging right knee ulcer that did not respond to antimicrobial treatment. The patient was diagnosed...
Tue Jun 16, 2020 11:05
Introduction. We report a case of diastasis rectus abdominis (DRA), in which the improvement of the appearance was obtained by performing extra skin resection. Case Report. A 30-year-old woman presented persistent abdominal bulging after her second delivery. She was diagnosed as DRA by computed tomography. We underwent a surgery that tacking the anterior layer of the rectus sheath and resecting excess skin. Results. There has been no clinical evidence of recurrence, and the patient satisfies her...
Tue Jun 16, 2020 12:20
Abstract Since 2016, certified prostate cancer centres have been able to participate in the Prostate Cancer Outcomes (PCO) study. The aim of this study is to compare outcomes across centres after local treatment for prostate cancer. The study originated from a support group initiative and is jointly carried out by the German Cancer Society (Deutsche Krebsgesellschaft), the certification institute OnkoZert, patient support groups and the participating centres. So far, centres have...
Tue Jun 16, 2020 03:00
Nature Communications, Published online: 16 June 2020; doi:10.1038/s41467-020-16251-3The shortage of viable donated livers limits patient access to liver transplantation. Here the authors report the use of normothermic machine perfusion to help identify viable organs from livers discarded based on current clinical criteria, which are then transplanted to recipients in a single-arm clinical trial.
Tue Jun 16, 2020 03:00
Nature Communications, Published online: 16 June 2020; doi:10.1038/s41467-020-16663-1Anomalously specular radar reflections (ASRR) from Titan’s tropical region were interpreted earlier as evidence for liquid surfaces, but the Cassini spacecraft did not observe lakes/seas at the anomalously specular locations. Here, the authors show that ASRR originate from one terrain unit, likely paleolakes/paleoseas.
Tue Jun 16, 2020 03:00
Tue Jun 16, 2020 03:00
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