We employed Functional Lumen Imaging Probe (EndoFLIP)tests toshowincreases in pyloric diameter and variability of diameter after gastricperoralendoscopicmyotomy(G‐POEM ingastroparesis patients (left graphs). Variability of pyloric activity was noted before and after G‐POEM which was partly due to propagated antropyloriccontractions (3‐D plot on right) detected by EndoFLIP. Abstract Background Functional Lumen Imaging Probe (EndoFLIP) tests typically measure static pyloric parameters, but the...
Mon Jun 15, 2020 18:25
New Findings Pre‐inspiratory activity manifesting in hypoglossal neural efferent discharge may be potentiated by mechanical interruption of vagal continuity and challenge with administration of a hypoxic and/or hypercapnic gas mixture and attenuated by static and/or dynamic pulmonary stretch. Differential excitability of, or premotoneuronal volleys exhibiting distinct spatiotemporal patterns of discharge arriving at, motoneurons residing within the hypoglossal motor nucleus may emergently generate...
Mon Jun 15, 2020 15:32
New Findings What is the central question of this study? REM sleep deprivation is associated with increased oxidative stress, but its effects on the blood vessel are poorly documented. We investigated whether REM sleep deprivation induces oxidative stress and causes lipid peroxidation in the aorta. What is the main finding and its important? We demonstrate that REM sleep deprivation induces oxidative stress and mediates lipid peroxidation in the aorta. This can cause endothelial...
Mon Jun 15, 2020 15:30
Background and Objectives Mycological diagnosis of onychomycosis is based on direct microscopy using external fluorophores to visualize fungal tissue in nail samples and agar culture. Ultraviolet fluorescence excitation imaging (u‐FEI) has shown potential in monitoring biological processes by exploiting variations in autofluorescence. This study aimed at assessing the potential of a handheld u‐FEI system as a practical screening tool for fungal nail infections. Study Design/Materials and Methods...
Mon Jun 15, 2020 12:52
Tue Jun 16, 2020 12:27
The Prickly Dogfish is an understudied species of shark. We provide an illustrated account the tooth morphology and microstructure of this species and discuss them in the context of the Prickly Dogfish’s dietary specialization Abstract This study describes and illustrates the jaws, teeth, and tooth microstructure of the Prickly Dogfish Oxynotus bruniensis . Detailed accounts of the dental morphology of O. bruniensis are rare and have not addressed the tissue arrangement or microstructure of the...
Mon Jun 15, 2020 17:42
Abstract Semantic reversal anomalies (SRAs) – sentences where an implausibility is created by reversing participant roles – have attracted much attention in the literature on the electrophysiology of language. In spite of being syntactically well‐formed but semantically implausible, these sentences unexpectedly elicited a monophasic P600 effect in English and Dutch rather than an N400 effect. Subsequent research revealed variability in the presence/absence of an N400 effect to SRAs depending on...
Mon Jun 15, 2020 22:57
Abstract Mind‐wandering is a ubiquitous mental phenomenon that is defined as self‐generated thought irrelevant to the ongoing task. Mind‐wandering tends to occur when people are in a low‐vigilance state or when they are performing a very easy task. In the current study, we investigated whether mind‐wandering is completely dependent on vigilance and current task demands, or whether it is an independent phenomenon. To this end, we trained support vector machine (SVM) classifiers on EEG data in conditions...
Mon Jun 15, 2020 14:15
Abstract Malignant rhabdoid tumour (MRT) is a childhood neoplasm of high malignancy characterised by biallelic mutation and/or loss of the epigenetic master regulator SMARCB1, accompanied by no or few other oncogenic drivers. In spite of their generally low mutational burden, an intratumoural T cell response has been reported in a subset of MRTs, indicating that immune checkpoint inhibition may be considered a viable therapy option for some patients. We here assess the evolution over time and space...
Tue Jun 16, 2020 11:48
Abstract The platysma skin flap was used for laryngeal reconstruction after vertical partial laryngectomy to improve the postoperative voice quality of patients with T2 and T3 glottic laryngeal carcinoma. Sixty‐nine patients with unilateral T2 and T3 glottic laryngeal carcinoma were included. Forty‐six patients received vertical partial laryngectomy, and a platysma skin flap was used for laryngeal reconstruction. The other 23 patients underwent transoral laser microsurgery. Subjective and objective...
Mon Jun 15, 2020 15:38
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05213
Mon Jun 15, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03118
Mon Jun 15, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04583
Mon Jun 15, 2020 07:00
Abstract Impulse control disorders (ICDs) in Parkinson's disease (PD) are defined as a failure to resist an “urge” to behave in a way that may be debilitating for oneself or others. The suggested immobilization test (SIT) has been developed to assess the “urge” to move and support the diagnosis of restless legs syndrome (RLS) in the general population and in PD. A clinical association between RLS and ICDs has been shown in PD and in the general population. We hypothesized that there could be a semiological...
Mon Jun 15, 2020 13:59
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01927
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00150
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01610
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00809
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00338
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01294
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01399
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00839
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01884
Mon Jun 15, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01261
Sun Jun 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00952
Fri Jun 12, 2020 07:00
Abstract Alpha‐gal syndrome (AGS) describes a wide spectrum of hypersensitivity reactions mediated by specific IgE to the α‐gal epitope (galactose‐α‐1,3‐ galactose) ubiquitously expressed on glycoproteins/glycolipids of most mammals. This fascinating new entity has completely changed the paradigms of allergy as allergic response is directed against an oligosaccharide and the reactions can be both immediate and delayed. They appear to be stimulated only by tick bites which induce production of α‐gal...
Mon Jun 15, 2020 15:35
Abstract Background Sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐8 is expressed on mast cells and eosinophils, but information about Siglec‐8 expression and function in the lung is limited. A humanized antibody, antolimab (AK002), targeting Siglec‐8 is undergoing development for treatment of diseases associated with mast cell and eosinophil‐driven inflammation. Objective To characterize Siglec‐8 expression in the airway in asthma and determine if antibodies that target Siglec‐8...
Mon Jun 15, 2020 15:32
Abstract Background Lettuce‐associated respiratory allergy has never been reported before. The aim of this study was to clarify the clinical condition of lettuce‐associated respiratory allergy and to identify the lettuce antigen which induces allergic symptoms. Methods We distributed questionnaires to 1,168 lettuce farmers and performed medical examinations in those who exhibited respiratory symptoms related to occupational exposure to lettuce. We analyzed specific IgE‐binding proteins...
Mon Jun 15, 2020 15:30
Abstract Many studies have reported a positive association between lower socioeconomic status (SES) and higher head and neck cancer (HNC) risk. Fewer studies have examined the impact of SES on the association between alcohol or cigarette use and HNC risk. The current case‐control study (1,104 HNC cases and 1,363 controls) investigated the influence of education, a SES indicator, on the association between HNC and the use of alcohol, cigarettes, or betel quids in Taiwan, a country with universal...
Mon Jun 15, 2020 18:29
Abstract PD‐L1 expressed on the cancer cells can cause immune escape of NSCLC. Elucidation of the regulatory mechanisms of the PD‐L1 expression is a prerequisite for establishment of new tumor immunotherapy strategies. Deubiquitinase UCHL1 is a regulator of cellular signaling transduction and expressed aberrantly in NSCLC. But it is not known whether UCHL1 regulates the expression of PD‐L1 in NSCLC cells. In the present study, we found that UCHL1 promotes the expression of PD‐L1 in NSCLC cell lines....
Mon Jun 15, 2020 18:29
Abstract Accumulating evidence on the association of VEGF‐C with lymphangiogenesis and lymph node metastasis implicates lymphatic vessels as a potential target in anti‐cancer therapy. To evaluate whether blocking VEGF‐C and VEGFR‐3 signaling can inhibit multi‐organ metastases, a mouse metastatic mammary cancer model was subjected to gene therapy using a soluble VEGFR‐3 expression vector (psVEGFR‐3). We showed that psVEGFR‐3 significantly diminished cell growth with and without added VEGF‐C in vitro...
Mon Jun 15, 2020 18:28
Abstract This study was undertaken to clarify the risk factors, including the mutation status of CTNNB1 , for the local recurrence after surgery of the rare disease, desmoid‐type fibromatosis. It was designed as a multi‐institutional joint research project with seven major centers in Japan participating. The committee members of seven major medical centers specializing in bone and soft tissue tumors formed this study group to develop clinical care guidelines. Of 196 cases with specimens and medical...
Mon Jun 15, 2020 18:24
Background This study assessed mental health (MH) outcomes across age groups in a nationally representative US sample of adult cancer survivors. Methods The 2015 to 2017 National Survey on Drug Use and Health was used to identify respondents aged 18 to 64 years. The authors compared MH outcomes between respondents with a cancer history and respondents without a cancer history in adjusted analyses controlling for demographics and socioeconomic status. Outcomes included past‐year major depressive...
Mon Jun 15, 2020 15:00
Abstract Background The superficial circumflex iliac artery perforator (SCIP) flap cannot be used for coverage of large defects. We introduce a novel flap design to overcome the SCIP flap's size limitation. Methods Data of patients who underwent coverage of defects exceeding 113 cm2 (12 × 12 cm) using combined flaps composed of an SCIP flap and either a superficial inferior epigastric artery (SIEA) flap or a deep inferior epigastric artery perforator (DIEP) flap from September 2015 to September...
Mon Jun 15, 2020 18:14
Abstract Introduction In 2016, March of Dimes (MOD) launched its Prematurity Collaborative to engage a broad cross section of national experts to address persistent and widening racial disparities in preterm birth by achieving equity and demonstrated improvements in preterm birth. African-American and Native American women continue to have disproportionate rates of preterm birth and maternal death. As part of the Collaborative, MOD...
Tue Jun 16, 2020 03:00
Abstract Background Cystic thyroid lesions represent one of the most common causes of unsatisfactory fine‐needle aspiration sampling. Thus, it is important to access the maximum number of follicular cells from cystic fluid in order to reduce unsatisfactory rates. We compared the traditional method of smearing with an alternative one. Methods For each thyroid nodule, two smears were collected. Each smear was prepared using a distinct approach: either using the traditional technique or the...
Mon Jun 15, 2020 17:40
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveWe explored a method for the quantitative sonographic analysis of myometrial texture using computer-aided image analysis software to assess outcomes following treatment with gonadotrophin-releasing hormone (GnRH) agonist for adenomyosis in women with infertility.MethodData for patients with ultrasound images of the myometrium obtained at Taipei Medical University Hospital from 1 September 2018 to 5 April 5 2019 were...
Mon Jun 15, 2020 10:23
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Regenerative medicine represents a major challenge for the scientific community. The choice of the biological sources used, such as stem cells and grafts, is crucial. Stem cell therapy is mainly related to the use of mesenchymal stem cells; however, clinical trials are still needed to investigate their safety. The micrografting technique was conceived by Cicero Parker Meek in 1958. It is based on the principle that by increasing...
Mon Jun 15, 2020 10:20
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Extracorporeal shockwave lithotripsy (ESWL) is a common and effective treatment method for most renal and upper ureteral calculi. Aortic rupture after ESWL is an extremely rare complication. Seven cases of aortic rupture have been reported to date, and only one case involved the rupture of a calcified abdominal aorta. We herein describe a Chinese patient who was hospitalized for rupture of the abdominal aorta 5 days after ESWL...
Mon Jun 15, 2020 04:25
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveRadical nephroureterectomy remains the gold standard for the surgical treatment of upper urinary tract urothelial carcinoma (UTUC). Based on previous research, we prospectively compared the advantages of transperitoneal laparoscopic radical nephroureterectomy (TLNU) with a three-port technique in a single position versus retroperitoneal laparoscopic radical nephroureterectomy (RLNU).MethodsWe evaluated 48 patients...
Mon Jun 15, 2020 04:24
Blood vessel invasion (BVI) is a prognostic indicator in various cancers. Elastic stain, which highlights blood vessel walls, is commonly used to detect BVI. In the breast, however, its diagnostic usefulness is limited because it also highlights some intraductal carcinoma components, which often mimic BVI. In this study, we aimed to improve BVI detection in breast cancer and developed a double staining: Victoria blue for elastin and immunohistochemistry for collagen IV. Collagen IV fibers were retained...
Mon Jun 15, 2020 19:22
BRCA1‐associated protein 1 (BAP1) or methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) or 9p21 fluorescence in situ hybridization (FISH) are useful for the diagnosis of malignant pleural mesothelioma (MPM). However, the effect of these assays on the diagnostic yield of effusion cytology in MPM cases with suspicious cytomorphology or the diagnostic challenges in BAP1 or MTAP IHC have not been fully elucidated. Two cohorts of cytologic preparations obtained from pleural effusions...
Mon Jun 15, 2020 19:21
Genetic analysis on formalin‐fixed paraffin‐embedded (FFPE) tissue specimens has become a mainstream method, from conventional direct sequencing to comprehensive analysis using next‐generation sequencing (NGS). In this study, we evaluated the quality of DNA and RNA extracted from FFPE sections, derived from surgical specimens of different tumor types. Electrophoresis was performed using a 4200 TapeStation to evaluate DNA and RNA fragmentation. DNA Ct values were higher and significantly increased...
Mon Jun 15, 2020 19:21
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.