Abstract Objectives Stable and appropriate condyle positioning is necessary for maintaining temporomandibular joint function. It is unclear if this position remains stable in patients after free fibular flap (FFF) condylar reconstruction. We investigated whether condylar position deviated after reconstruction, and whether this affected functional recovery. Materials and methods...
Thu May 21, 2020 03:00
Abstract Objective The non-carious cervical lesion (NCCL) is commonly produced by improper toothbrushing techniques, occlusion trauma, anatomic mal-positioned teeth, and acid erosion, thus sharing the same etiology of gingival recession (GR). The association of a graft to the coronally advanced flap had demonstrated the best long-term outcome for root coverage (RC). However, substitutes for the autogenous graft must be studied. This split-mouth...
Thu May 21, 2020 03:00
ABSTRACT Dietary fat consumption during accelerated stages of mammary gland development such as peripubertal maturation or pregnancy is known to increase the risk for breast cancer. However, the underlying molecular mechanisms are not fully understood. Here we examined the gene expression profile of mouse mammary epithelial cells (MMECs) on exposure to a high‐fat diet (HFD) or control diet (CD). Trp53 ‐/‐ female mice were fed with the experimental diets for 5 weeks during the peripubertal period...
Thu May 21, 2020 19:00
Abstract Emerging evidence has shown that dynamic crosstalk among cells in the tumor microenvironment modulates the progression and chemotherapeutic responses of cancer. Extracellular vesicles comprise a crucial form of intracellular communication by horizontal transfer of bioactive molecules, including long non‐coding RNAs (lncRNAs), to neighboring cells. Three main types of extracellular vesicles are exosomes, microvesicles and apoptotic bodies, exhibiting a wide range of size and different biogenesis....
Thu May 21, 2020 18:49
Abstract Cancer is one of the primary causes of human mortality worldwide despite persistent efforts and developments. No independent life on earth can live without iron whereas some species can without oxygen. Iron provides us with a double‐edged sword. Excess iron is a risk for carcinogenesis whilst its deficiency causes anemia leading to oxygen shortage. Every cell is eventually destined to death, which has been classified either into apoptosis or necrosis by morphology. According with the scientific...
Thu May 21, 2020 18:38
Abstract Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer compared with luminal or epidermal growth factor receptor 2 subtypes, thus effective therapeutic options for TNBC are yet to be developed. Nowadays, oncogenic long noncoding RNAs (lncRNAs) are applied to cancer management as a new class of therapeutic targets. We previously showed that thymopoietin antisense transcript 1 (TMPO‐AS1 ) is a proliferation‐associated lncRNA that contributes to hormone‐dependent breast...
Thu May 21, 2020 18:37
Objectives/Hypothesis To confirm the standard of care pertaining to postoperative mobilization practices following initial tracheostomy, to establish face validity of novel early mobilization tools, and to conduct a safety and feasibility pilot study. Study Design Multi‐institutional survey and prospective cohort study. Methods Experts at our tertiary‐care children's hospital developed an Early Pediatric Mobility Pathway for tracheostomy patients utilizing a novel risk‐assessment tool....
Thu May 21, 2020 13:07
Efficient Postoperative Disposition Selection in Pediatric Otolaryngology Patients: A Novel Approach
Objective Pediatric patients undergoing surgery on the aerodigestive tract require a wide range of postoperative airway support that may be difficult predict in the preoperative period. Inaccurate prediction of postoperative resource needs leads to care inefficiencies in the form of unanticipated intensive care unit (ICU) admissions, ICU bed request cancellations, and overutilization of ICU resources. At our hospital, inefficient utilization of pediatric intensive care unit (PICU) resources was...
Thu May 21, 2020 13:07
Objectives The objective was to explore the effect of the proneuronal transcription factor neurogenic differentiation 1 (Neurod1, ND1) on Schwann cells (SC) and schwannoma cell proliferation. Methods Using a variety of transgenic mouse lines, we investigated how expression of Neurod1 effects medulloblastoma (MB) growth, schwannoma tumor progression, vestibular function, and SC cell proliferation. Primary human vestibular schwannoma (VS) cell cultures were transduced with adenoviral vectors...
Thu May 21, 2020 13:07
Objectives/Hypothesis To investigate the profile of patients with laryngopharyngeal reflux (LPR) at hypopharyngeal–esophageal multichannel intraluminal impedance‐pH (HEMII‐pH) monitoring and the relationship between hypopharyngeal‐proximal reflux episodes (HREs) and saliva pepsin concentration. Study Design Prospective non‐controlled. Methods Patients were recruited from three European hospitals from January 2018 to October 2019. Patients benefited from HEMII‐pH monitoring and saliva...
Thu May 21, 2020 13:07
New Findings What is the central question of this study ? Can Granger causality analysis of RR intervals, systolic blood pressure, and respiration evidence different physiological mechanisms induced during thermoneutral water immersion, 6° head‐down tilt, and supine position tests, that are not accessible using traditional heart rate variability and baroreflex methods ? What is the main finding and its importance ? The Granger analysis demonstrated a significant difference in...
Thu May 21, 2020 14:56
New Findings What is the central question of this study? What is the immediate impact of moderate preterm birth on the structure and function of major conduit arteries using a pre‐clinical sheep model? What is the main finding and its importance? Postnatal changes in conduit arteries including a significant decrease in collagen within the thoracic aortic wall (predominately males), narrowed carotid arteries, reduced aortic systolic blood flow and upregulation in the mRNA expression...
Thu May 21, 2020 14:56
New Findings What is the central question of this study? We set out to test the hypothesis that hemoglobin mass and red blood cell volume would become increased in elite cyclists training in a hot environment compared to control group training in normal temperature. What is the main finding and its importance? We demonstrate that five weeks of heat training increases hemoglobin mass in elite cyclists. At the same time we reveal small to intermediate effect sizes for exercise parameters favoring...
Thu May 21, 2020 14:55
New Findings What is the central question of this study? Can the change in haemoglobin's affinity for oxygen in the human cerebral circulation be modelled in vivo? What is the main finding and its importance? We provide a novel method for modelling the oxyhaemoglobin dissociation curve at the cerebral capillary level in humans, so that the cerebral capillary and mitochondrial oxygen tensions can reliably be estimated. This may be useful in future human‐experimental studies on...
Thu May 21, 2020 14:54
New Findings Instantaneous selective increases in aortic pressure causes an immediate increase in right ventricular end‐systolic pressure independent of the pericardium. Whereas selective increases in pulmonary artery pressure decreases left ventricular diastolic compliance due to a subsequent increasing right ventricular end‐diastolic volume as a function of an intact pericardium limiting bi‐ventricular volume. Finally, changes in contraction synchrony of either ventricle do not appear to be...
Thu May 21, 2020 14:34
Two anthropologists reflect on their experiences and ask what it will take to make our discipline and our Annual Meeting more accessible. Why should you care about accessibility? And what does it mean to make our discipline and our Annual Meeting more accessible? Beyond the technical and logistical modifications, accessibility entails the recognition that disabled scholars and their research are central to anthropological epistemology. We, as disabled identified scholars, are not just another group...
Thu May 21, 2020 22:56
Guided orthognathic surgery involves increasing the predictability of osteotomy using bone-supported custom-made guides and miniplates specific to the simulation.1,2
Thu May 21, 2020 03:00
Thu May 21, 2020 03:00
Radiation treatment (RT) is an effective option for men with localized prostate cancer (PCa).[1] However, local recurrences (LR) remain common in patients treated with external beam radiotherapy (EBRT) alone.[2] Dose-escalated RT to the whole gland (WG) has demonstrated increased locoregional and biochemical control in localized PCa.[3-5] A meta-analysis concluded that each 1-Gray (Gy) increased in dose delivered reduces 1.8% the risk of biochemical failure.[6] Nevertheless, concerns have been raised...
Thu May 21, 2020 03:00
Lung cancer is the leading cause of cancer death worldwide. Small cell lung cancer (SCLC) accounts for approximately 15% of all lung cancers. About one third of patients will present with limited TNM stage I-III at the time of diagnosis (1). Standard of care for those patients is concurrent thoracic chemo-radiotherapy and prophylactic cranial irradiation (PCI)(2, 3).
Thu May 21, 2020 03:00
Early-stage Hodgkin lymphoma (HL) is a largely curable disease with 10-year overall survival rates of over 90% [1–3] with most patients achieving long-term complete remission. However, HL survivors are at risk of developing therapy-related complications years after treatment responsible for increased morbidity and mortality [4]. Therefore, significant efforts have been made to balance the cure with the toxic effects by using less toxic chemotherapy regimens and decreasing radiation dose and field...
Thu May 21, 2020 03:00
Since the Italian “Patient Zero” was identified, an enormous effort was made by the entire Radiotherapy (RT) centers, included the “Fondazione IRCCS-Istituto Nazionale dei Tumori di Milano” (INT) [1], to pursue the Care Mission during the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-COVID 19 pandemic [2,3].
Thu May 21, 2020 03:00
Abstract Bemcentinib is a newly developed AXL inhibitor that is currently under investigation in phase II trails for the treatment of acute myeloblastic leukemia (AML). Clinical and radiographic findings in this case were very similar to cases of MRONJ in patients receiving Sunitinib or other anti-angiogenetic substances, assuming that Bemcentinib may cause similar oral side effects. We present a male 81-year-old patient with a manifestation of alveolar bone necrosis at the central...
Thu May 21, 2020 03:00
Abstract Interpersonal distance, an essential component of social interaction, is modulated by the emotion conveyed by others and associated physiological response. However, in modern societies with overcrowded and hyperstimulating environments, we can only surreptitiously glimpse the faces of others in order to quickly make behavioral adjustments. How this impacts social interactions is not yet well understood. In the present study, we investigated this issue by testing whether facial expressions...
Thu May 21, 2020 16:04
Tinnitus, the perception of sound without an external source, is a phenomenon that interests people from many backgrounds and disciplines. In the United States, it is estimated that 30 million adults experience tinnitus on a daily basis, and for upward of 5% of them, the experience is severely disruptive and negatively impacts quality of life. Therefore, there are many individuals with tinnitus who may benefit from this issue by learning what is currently known about tinnitus cause and treatments.
Thu May 21, 2020 03:00
Vocal performance students at the collegiate level are faced with rigorous training protocols for which they are required to maintain optimal vocal quality and function. The purpose of this study was to compare the vocal habits and hygiene practices of incoming undergraduate Bachelor of Music (BM), Master of Music (MM), Doctor of Musical Arts (DMA), and Artist Diploma (AD) vocal performance students at a tier I music conservatory. To date, no study has compared the reported vocal habits of undergraduate...
Thu May 21, 2020 03:00
Thu May 21, 2020 15:20
ABSTRACT The ongoing COVID 19 epidemic has brought to the fore many concerns related to use of immunosuppressive agents (ISAs) in dermatology. While it is unclear whether the patients on ISAs for skin conditions are more prone to develop COVID 19, and what impact the ISA may have on the clinical outcome if a patient does get infected, rationalizations based on the specific immune effects of each drug, and existing literature on incidence of various infections with each, are possible. In this review,...
Thu May 21, 2020 15:13
Abstract Background Fractional lasers have become widespread in dermatology owing to their efficacy and safety. Objective Comparative analysis of histological features after laser rejuvenation using a 1064‐nm fractionated handpiece picosecond laser with different energy fluence levels (1.1 J/cm2 or 2.1 J/cm2). Patients and methods An open‐label, study of 28 women aged 36‐60 years with signs of age‐related photodamage and skin changes of the face and neck was conducted using a fractional...
Thu May 21, 2020 15:40
Abstract Background Percutaneous tracheostomy (PT) in patients with coronavirus disease (COVID‐19) included several critical steps associated with increased risk of aerosol generation. We reported a modified PT technique aiming to minimize the risk of aerosol generation and to increase the staff safety in COVID‐19 patients. Methods PT was performed with a modified technique including the use of a smaller endotracheal tube (ETT) cuffed at the carina during the procedure. Results The...
Thu May 21, 2020 17:27
Abstract Background To summarize outcomes of reirradiation with intensity‐modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). Methods Primary endpoints were 2‐year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. Results A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation...
Thu May 21, 2020 17:24
Thu May 21, 2020 17:23
Abstract Objective To investigate olfactory dysfunction (OD) in patients with mild coronavirus disease 2019 (COVID‐19) through patient‐reported outcome questionnaires and objective psychophysical testing. Methods COVID‐19 patients with self‐reported sudden‐onset OD were recruited. Epidemiological and clinical data were collected. Nasal complaints were evaluated with the sinonasal outcome‐22. Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination...
Thu May 21, 2020 17:13
Abstract As COVID‐19 continues to challenge the practice of head and neck oncology, clinicians are forced to make new decisions in the setting of the pandemic that impact the safety of their patients, their institutions, and themselves. The difficulty inherent in these decisions is compounded by potentially serious ramifications to the welfare of patients and health‐care staff, amid a scarcity of data on which to base informed choices. This paper explores the risks of COVID‐19 incurred while striving...
Thu May 21, 2020 17:09
Abstract Background Cigarette smoking is a major risk factor for head and neck squamous cell carcinoma. Still, the effect of cigarette smoke on the molecular level is unclear. The aim of the present study was to investigate the early effects of cigarette smoke on carcinogenesis of head and neck squamous cell carcinoma. Methods Human oral keratinocytes were exposed for 1 week to standardized cigarette smoke extract, and subsequently RT‐quantitative PCR array was performed. Protein expression...
Thu May 21, 2020 16:51
Abstract Background Objective data on chemosensitive disorders during COVID‐19 are lacking in the Literature. Methods Multicenter cohort study that involved four Italian hospitals. Three hundred and forty‐five COVID‐19 patients underwent objective chemosensitive evaluation. Results Chemosensitive disorders self‐reported by 256 patients (74.2%) but the 30.1% of the 89 patients who did not report dysfunctions proved objectively hyposmic. Twenty‐five percentage of patients were seen...
Thu May 21, 2020 16:49
Abstract Opioid receptors are widely distributed in the central and peripheral nervous systems and non‐neuronal tissues. Numerous researchers have noted the pivotal role of peripheral opioid receptors (PORs) in analgesia. Accumulating evidence has shown the existence of PORs in the trigeminal nerve system, indicating that PORs may be involved in the modulation of orofacial pain. In this review, we summarise the recent evidence for the role of PORs in orofacial pain and discuss the possible cellular...
Thu May 21, 2020 20:45
Abstract Objectives Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe complication of systemic nitrogen‐containing bisphosphonates (N‐BPs) administration, which lead to osteonecrosis, pain and infection. Despite much effort, effective remedies are yet to be established. This study aimed to investigate potential recovery effect of borate bioactive glass (BBG) in vitro and in vivo . Methods The effect of BBG on zoledronate treated bone marrow mesenchymal cells (BMSCs) and...
Thu May 21, 2020 13:06
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