Anlotinib can overcome acquired resistance to EGFR-TKIs via FGFR1 signaling in non-small cell lung cancer without harboring EGFR T790M mutation. Thorac Cancer. 2020 May 20;: Authors: Lian Z, Du W, Zhang Y, Fu Y, Liu T, Wang A, Cai T, Zhu J, Zeng Y, Liu Z, Huang JA Abstract BACKGROUND: Although many studies have defined mechanisms of resistance to EGFR-TKIs, acquired resistance remains the major limitation of monotherapy with EGFR-TKIs. ...
Thu May 21, 2020 13:18
Highly cytotoxic gold(i)-phosphane dithiocarbamate complexes trigger an ER stress-dependent immune response in ovarian cancer cells. Dalton Trans. 2020 May 20;: Authors: Le HV, Babak MV, Ehsan MA, Altaf M, Reichert L, Gushchin AL, Ang WH, Isab AA Abstract Ovarian cancer is a highly aggressive disease which is treated by surgery and platinum chemotherapy. However, a significant proportion of treated patients develop resistance to platinum treatment...
Thu May 21, 2020 13:18
Tetrandrine Reverses Paclitaxel Resistance in Human Ovarian Cancer via Inducing Apoptosis, Cell Cycle Arrest Through β-Catenin Pathway. Onco Targets Ther. 2020;13:3631-3639 Authors: Jiang L, Hou R Abstract Background: Paclitaxel (PTX) resistance is a great obstacle for the treatment of ovarian cancer. A previous study indicated that tetrandrine (TET) could induce the apoptosis of ovarian cancer cells. This study aimed to explore the effect of TET...
Thu May 21, 2020 13:18
Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress. Phytother Res. 2020 May 19;: Authors: Yi C, Li X, Chen S, Liu M, Lu W, Ye X Abstract Natural product corynoline is a unique isoquinoline alkaloid extracted from traditional Chinese medicine Corydalis bungeana Turcz, whereas its anticancer properties have not been investigated. In this study, we found that corynoline potently impairs the growth of melanoma...
Thu May 21, 2020 13:18
Curcumin Loaded in Niosomal Nanoparticles Improved the Anti-tumor Effects of Free Curcumin on Glioblastoma Stem-like Cells: an In Vitro Study. Mol Neurobiol. 2020 May 19;: Authors: Sahab-Negah S, Ariakia F, Jalili-Nik M, Afshari AR, Salehi S, Samini F, Rajabzadeh G, Gorji A Abstract Using a novel curcumin-loaded niosome nanoparticle (CM-NP), the present study was designed to evaluate the effect of curcumin on human glioblastoma stem-like cells (GSCs)....
Thu May 21, 2020 13:18
A novel role of vitronectin in promoting survival of mesenchymal stem cells under serum deprivation stress. Stem Cell Res Ther. 2020 May 19;11(1):181 Authors: Goyal U, Ta M Abstract BACKGROUND: Due to their immunomodulatory and trophic support functions, mesenchymal stem cells (MSCs) are promising in the field of cell-based regenerative medicine. However, MSC survival post-transplantation is challenged by various microenvironment stress factors....
Thu May 21, 2020 13:18
Broussoflavonol B from Broussonetia kazinoki Siebold Exerts Anti-Pancreatic Cancer Activity through Downregulating FoxM1. Molecules. 2020 May 16;25(10): Authors: Jeong JH, Ryu JH Abstract Pancreatic cancer has a high mortality rate due to poor rates of early diagnosis. One tumor suppressor gene in particular, p53, is frequently mutated in pancreatic cancer, and mutations in p53 can inactivate normal wild type p53 activity and increase expression...
Thu May 21, 2020 13:18
Focus on the Role of Klotho Protein in Neuro-Immune Interactions in HT-22 Cells Upon LPS Stimulation. Cells. 2020 May 16;9(5): Authors: Rusinek K, Sołek P, Tabęcka-Łonczyńska A, Koziorowski M, Mytych J Abstract Neuroinflammation is defined as the activation of the brain's innate immune system in response to an inflammatory challenge and is considered to be a prominent feature of neurodegenerative diseases. The contribution of overactivated neuroglial...
Thu May 21, 2020 13:18
p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions.
Related Articlesp53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions. Mol Syst Biol. 2019 09;15(9):e8685 Authors: Harton MD, Koh WS, Bunker AD, Singh A, Batchelor E Abstract The p53 tumor suppressor regulates distinct responses to cellular stresses. Although different stresses generate different p53 dynamics, the mechanisms by which cells decode p53 dynamics to differentially regulate target genes are...
Thu May 21, 2020 13:18
Related ArticlesEnsemble docking-based virtual screening toward identifying inhibitors against Wee1 kinase. Future Med Chem. 2019 08;11(15):1889-1906 Authors: Li Y, Wu DM, Kong LM, Zhang S, Du H, Sun W, Zhang L, Li Y, Zuo Z Abstract Aim: Wee1 kinase plays a key role in the arrest of G2/M checkpoint that prevents mitotic entry in response to DNA damage. This work is to discover potent Wee1 inhibitors which can be considered valuable. Materials &...
Thu May 21, 2020 13:18
Related ArticlesCombined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells. Br J Cancer. 2019 10;121(7):600-610 Authors: Jette NR, Radhamani S, Arthur G, Ye R, Goutam S, Bolyos A, Petersen LF, Bose P, Bebb DG, Lees-Miller SP Abstract BACKGROUND: Up to 40% of lung adenocarcinoma have been reported to lack ataxia-telangiectasia mutated (ATM) protein expression....
Thu May 21, 2020 13:18
Non-stationary Group-Level Connectivity Analysis for Enhanced Interpretability of Oddball Tasks. Front Neurosci. 2020;14:446 Authors: Padilla-Buritica JI, Ferrandez-Vicente JM, Castaño GA, Acosta-Medina CD Abstract Neural responses of oddball tasks can be used as a physiological biomarker to evaluate the brain potential of information processing under the assumption that the differential contribution of deviant stimuli can be assessed accurately. Nevertheless,...
Thu May 21, 2020 13:17
Efficient Processing of Spatio-Temporal Data Streams With Spiking Neural Networks. Front Neurosci. 2020;14:439 Authors: Kugele A, Pfeil T, Pfeiffer M, Chicca E Abstract Spiking neural networks (SNNs) are potentially highly efficient models for inference on fully parallel neuromorphic hardware, but existing training methods that convert conventional artificial neural networks (ANNs) into SNNs are unable to exploit these advantages. Although ANN-to-SNN...
Thu May 21, 2020 13:17
Most Small Cerebral Cortical Veins Demonstrate Significant Flow Pulsatility: A Human Phase Contrast MRI Study at 7T. Front Neurosci. 2020;14:415 Authors: Driver ID, Traat M, Fasano F, Wise RG Abstract Phase contrast MRI (pcMRI) has been used to investigate flow pulsatility in cerebral arteries, larger cerebral veins, and the cerebrospinal fluid (CSF). Such measurements of intracranial pulsatility and compliance are beginning to inform understanding of...
Thu May 21, 2020 13:17
Multi-Functionalized Self-Assembling Peptides as Reproducible 3D Cell Culture Systems Enabling Differentiation and Survival of Various Human Neural Stem Cell Lines. Front Neurosci. 2020;14:413 Authors: Marchini A, Favoino C, Gelain F Abstract Neural stem cells-based therapies have shown great potential for central nervous system regeneration, with three-dimensional (3D) culture systems representing a key technique for tissue engineering applications,...
Thu May 21, 2020 13:17
Myoelectrically Controlled FES to Enhance Tenodesis Grip in People With Cervical Spinal Cord Lesion: A Usability Study. Front Neurosci. 2020;14:412 Authors: Thorsen R, Dalla Costa D, Beghi E, Ferrarin M Abstract People with tetraplegia are often lacking grip strength, causing impairment in activities of daily living. For them, improving hand function is a priority because it is important for autonomy and participation in daily life. A tendon transfer...
Thu May 21, 2020 13:17
Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies. Front Neurosci. 2020;14:398 Authors: Yamasaki TR, Ono K, Ho L, Pasinetti GM Abstract Misfolding, aggregation and deposition of α-synuclein (α-syn) are major pathologic characteristics of Parkinson's disease (PD) and the related synucleinopathy, multiple system atrophy (MSA). The spread of α-syn pathology across brain regions is thought to...
Thu May 21, 2020 13:17
Mechanisms of Dexmedetomidine in Neuropathic Pain. Front Neurosci. 2020;14:330 Authors: Zhao Y, He J, Yu N, Jia C, Wang S Abstract Dexmedetomidin is a new-generation, highly selective α2 adrenergic receptor agonist with a large number of advantages, including its sedative and analgesic properties, its ability to inhibit sympathetic nerves, its reduced anesthetic dosage, its hemodynamic stability, its mild respiratory depression abilities, and its ability...
Thu May 21, 2020 13:17
Publication date: Available online 21 May 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Haylee Yepson, Brittney Mazzone, Susan Eskridge, Kaeley Shannon, Elizabeth Awodele, Shawn Farrokhi
Thu May 21, 2020 13:14
Publication date: Available online 21 May 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Nicole Agaronnik, Charlotta Lindvall, Areej El-Jawahri, Wei He, Lisa Iezzoni
Thu May 21, 2020 13:14
Publication date: Available online 21 May 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Nicholas A. Giordano, Alexandra Kane, Kalyn C. Jannace, Winifred Rojas, Mary Jo Lindl, Eugenio Lujan, Harold Gelfand, Michael L. Kent, Krista B. Highland
Thu May 21, 2020 13:14
Publication date: Available online 21 May 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Agustín Camus-Molina, Felipe González-Seguel, Ana Cristina Castro-Ávila, Jaime Leppe
Thu May 21, 2020 13:14
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