Related ArticlesEvaluation of brain SERT with 4-[18F]-ADAM/micro-PET and hearing protective effects of dextromethorphan in hearing loss rat model. Toxicol Appl Pharmacol. 2019 09 01;378:114604 Authors: Liu CT, Huang YS, Chen HC, Ma KH, Wang CH, Chiu CH, Shih JH, Kang HH, Shiue CY, Li IH Abstract This study investigated the protective effects of dextromethorphan (DXM) on noise-induced hearing loss (NIHL) in rats. This study aimed to improve the auditory...
Thu May 21, 2020 13:08
Related ArticlesLaryngomalacia and Swallow Dysfunction. Ear Nose Throat J. 2019 Dec;98(10):613-616 Authors: Scott BL, Lam D, MacArthur C Abstract OBJECTIVES: Laryngomalacia is an established cause of stridor and sleep-disordered breathing in children. However, the relationship between laryngomalacia and dysphagia has not been well characterized. The objectives of this study were to (1) describe the patient characteristics, symptoms, and prevalence of...
Thu May 21, 2020 13:08
Related ArticlesTrigeminal Trophic Syndrome-A Unique Clinical Presentation of a Rare Condition. Ear Nose Throat J. 2019 Dec;98(10):606-608 Authors: Bradburn KH, Elston D, Murphey AW, Patel KG Abstract This study describes a unique clinical presentation of trigeminal trophic syndrome (TTS), which is not well described within the otolaryngology literature. Trigeminal trophic syndrome classically presents with a triad of symptoms: trigeminal anesthesia,...
Thu May 21, 2020 13:08
Related ArticlesEgg Consumption and Risk of Upper Aero-Digestive Tract Cancers: A Systematic Review and Meta-Analysis of Observational Studies. Adv Nutr. 2019 07 01;10(4):660-672 Authors: Aminianfar A, Fallah-Moshkani R, Salari-Moghaddam A, Saneei P, Larijani B, Esmaillzadeh A Abstract Limited data are available that summarize the relation between egg intake and the risk of upper aero-digestive tract (UADT) cancers. This systematic review and meta-analysis...
Thu May 21, 2020 13:08
Related ArticlesChromosome 3q arm gain linked to immunotherapy response in advanced cutaneous squamous cell carcinoma. Eur J Cancer. 2019 05;113:1-9 Authors: Kacew AJ, Harris EJ, Lorch JH, Haddad RI, Chau NG, Rabinowits G, LeBoeuf NR, Schmults CD, Thakuria M, MacConaill LE, Hanna GJ Abstract AIMS: The activity that the immune checkpoint inhibitor (ICI) cemiplimab has recently demonstrated has led to a paradigm shift in the management of patients with...
Thu May 21, 2020 13:08
β-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans. J Nutr. 2020 May 20;: Authors: Amengual J, Coronel J, Marques C, Aradillas-GarcÃa C, Morales JMV, Andrade FCD, Erdman JW, Teran-Garcia M Abstract BACKGROUND: Plasma cholesterol is one of the strongest risk factors associated with the development of atherosclerotic cardiovascular disease (ASCVD) and myocardial infarction. Human studies suggest that elevated...
Thu May 21, 2020 13:07
Maternal Long-Chain Polyunsaturated Fatty Acid Status, Methylmercury Exposure, and Birth Outcomes in a High-Fish-Eating Mother-Child Cohort. J Nutr. 2020 May 20;: Authors: Yeates AJ, Zavez A, Thurston SW, McSorley EM, Mulhern MS, Alhamdow A, Engström K, Wahlberg K, Strain JJ, Watson GE, Myers GJ, Davidson PW, Shamlaye CF, Broberg K, van Wijngaarden E Abstract BACKGROUND: Maternal status of long-chain PUFAs (LC-PUFAs) may be related to fetal growth. Maternal...
Thu May 21, 2020 13:07
The Homozygous Hemoglobin EE Variant Is Associated with Poorer Riboflavin Status in Cambodian Women of Reproductive Age. J Nutr. 2020 May 20;: Authors: Williams BA, Cochrane KM, Fischer JAJ, Aljaadi AM, McAnena L, Ward M, McNulty H, Kroeun H, Green TJ, Whitfield KC, Karakochuk CD Abstract BACKGROUND: Riboflavin is required for erythropoiesis, which is increased in people with hemoglobinopathies due to increased hemolysis and erythrocyte turnover. Dietary...
Thu May 21, 2020 13:07
Inverse Association between Iron Deficiency and Glycated Hemoglobin Levels in Ghanaian Adults-the RODAM Study. J Nutr. 2020 May 20;: Authors: Lyons J, van der Linden EL, Meeks K, Beune E, Smeeth L, Bahendeka S, Spranger J, Klipstein-Grobusch K, Mockenhaupt FP, Danquah I, Agyemang C Abstract BACKGROUND: Glycated hemoglobin (HbA1c) is often used to diagnose type 2 diabetes (T2D), but studies show that iron deficiency (ID) is associated with elevated HbA1c...
Thu May 21, 2020 13:07
In-vitro and in-vivo evaluation of chitosan-based thermosensitive gel containing lorazepam NLCs for the treatment of status epilepticus. IET Nanobiotechnol. 2020 Apr;14(2):148-154 Authors: Taymouri S, Minaiyan M, Ebrahimi F, Tavakoli N Abstract The objective of this study was to develop an in-situ gel containing lorazepam (LZM) loaded nanostructured lipid carriers (NLCs) for direct nose-to-brain delivery in order to increase drug therapeutic efficacy...
Thu May 21, 2020 13:05
Time course of 75%-100% efficacy response of adjunctive brivaracetam. Acta Neurol Scand. 2020 May 20;: Authors: Klein P, Laloyaux C, Elmoufti S, Gasalla T, Martin MS Abstract BACKGROUND: Time to sustained seizure frequency reduction can provide clinically meaningful epilepsy outcomes. AIMS OF THE STUDY: Examine the time course of brivaracetam (BRV) efficacy in adults with focal seizures and focal to bilateral tonic-clonic seizures (FBTCS). ...
Thu May 21, 2020 13:05
Clinical and Electroencephalographic Features of the Seizures in Neuronal Surface Antibody-Associated Autoimmune Encephalitis. Front Neurol. 2020;11:280 Authors: Wang Y, Yu Y, Hu Y, Li Y, Song F, Wang Y Abstract Objectives: To investigate clinical and electroencephalographic features of the seizures in different types of neuronal surface antibody (NSAb)-associated autoimmune encephalitis (AE). Methods: The clinical data of the seizures were analyzed...
Thu May 21, 2020 13:05
Verapamil and Alzheimer's Disease: Past, Present, and Future. Front Pharmacol. 2020;11:562 Authors: Popović N, Morales-Delgado N, Vidal Mena D, Alonso A, Pascual MartÃnez M, Caballero Bleda M, Popović M Abstract Verapamil is a phenylalkylamine class calcium channel blocker that for half a century has been used for the treatment of cardiovascular diseases. Nowadays, verapamil is also considered as a drug option for the treatment of several neurological...
Thu May 21, 2020 13:05
Lacosamide for children with paroxysmal kinesigenic dyskinesia. Brain Dev. 2020 May 16;: Authors: Furukawa G, Negishi Y, Takeuchi T, Ishihara N, Okumura A Abstract OBJECTIVES: This study was performed to evaluate the efficacy and tolerability of lacosamide (LCM) for paroxysmal kinesigenic dyskinesia (PKD) in children. METHODS: We retrospectively reviewed the medical charts of pediatric PKD patients (aged <16 years) treated with LCM. Data...
Thu May 21, 2020 13:05
Persistence of pregabalin treatment in Taiwan: a nation-wide population-based study. J Headache Pain. 2020 May 19;21(1):54 Authors: Wang YF, Chen YT, Tsai CW, Yen YC, Chen YC, Shia BC, Wang SJ Abstract BACKGROUND: Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among different indications in Asia...
Thu May 21, 2020 13:05
Related ArticlesArtificial escape from XCI by DNA methylation editing of the CDKL5 gene. Nucleic Acids Res. 2020 03 18;48(5):2372-2387 Authors: Halmai JANM, Deng P, Gonzalez CE, Coggins NB, Cameron D, Carter JL, Buchanan FKB, Waldo JJ, Lock SR, Anderson JD, O'Geen H, Segal DJ, Nolta J, Fink KD Abstract A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic...
Thu May 21, 2020 13:05
Related ArticlesBone turnover analysis and vitamin D status in children with epilepsy. Seizure. 2019 Dec;73:83 Authors: Sharawat IK, Dawman L PMID: 31420231 [PubMed - indexed for MEDLINE]
Thu May 21, 2020 13:05
Related ArticlesLooking to the Future: Speech, Language, and Academic Outcomes in an Adolescent with Childhood Apraxia of Speech. Folia Phoniatr Logop. 2019;71(5-6):203-215 Authors: Turner SJ, Vogel AP, Parry-Fielder B, Campbell R, Scheffer IE, Morgan AT Abstract OBJECTIVE: The clinical course of childhood apraxia of speech (CAS) is poorly understood. Of the few longitudinal studies in the field, only one has examined adolescent outcomes in speech,...
Thu May 21, 2020 13:05
Related ArticlesAssociation of quality of paediatric epilepsy care with mortality and unplanned hospital admissions among children and young people with epilepsy in England: a national longitudinal data linkage study. Lancet Child Adolesc Health. 2019 09;3(9):627-635 Authors: Hargreaves DS, Arora S, Viveiro C, Hale DR, Ward JL, Sherlaw-Johnson C, Viner RM, Dunkley C, Cross JH Abstract BACKGROUND: Concerns have been raised about variation in care quality...
Thu May 21, 2020 13:05
Related ArticlesThe expression of the distal dystrophin isoforms Dp140 and Dp71 in the human epileptic hippocampus in relation to cognitive functioning. Hippocampus. 2019 02;29(2):102-110 Authors: Hoogland G, Hendriksen RGF, Slegers RJ, Hendriks MPH, Schijns OEMG, Aalbers MW, Vles JSH Abstract Dystrophin is an important protein within the central nervous system. The absence of dystrophin, characterizing Duchenne muscular dystrophy (DMD), is associated...
Thu May 21, 2020 13:05
Publication date: Available online 21 May 2020Source: Annals of Diagnostic PathologyAuthor(s): Badr AbdullGaffar, Farzad Awadhi
Thu May 21, 2020 13:01
Immune checkpoint inhibitors in patients with recurrent hepatocellular carcinoma after liver transplantation: one case report and literature review. Curr Cancer Drug Targets. 2020 May 19;: Authors: Qiu J, Tang W, Du C Abstract BACKGROUND: Immune checkpoint modulators, such as the programmed death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitor, cytotoxic T-Lymphocyte-associated antigen 4 (CTLA-4) inhibitor have been investigated with encouraging...
Thu May 21, 2020 13:01
Objectives We used laser ablation inductively coupled plasma mass spectrometry to quantify gadolinium in hair samples from autopsy cases with gadolinium-based contrast agent (GBCA) exposure. Hair gadolinium data were correlated with gadolinium concentrations in brain, skin, and bone tissues from the same case to investigate a potential noninvasive method for gadolinium quantification and monitoring. Materials and Methods Medical records from autopsy cases at our institution were screened...
Tue May 19, 2020 03:00
New England Journal of Medicine, Ahead of Print.
Wed May 20, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Wed May 20, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 21, Page 2033-2033, May 2020.
Wed May 20, 2020 11:56
New England Journal of Medicine, Volume 382, Issue 21, Page 2034-2043, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, Page 1975-1977, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, Page 2047-2048, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, Page 2059-2061, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, Page 2056-2058, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, Page 2066-2066, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, Page 2023-2032, May 2020.
Wed May 20, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 21, Page 2064-2066, May 2020.
Wed May 20, 2020 11:55
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:Intermittent hypoxia, a significant feature of obstructive sleep apnea, has pro-tumorigenic effects. Here, we investigated the effect of sodium tanshinone IIA sulfonate on oxidative stress and apoptosis in a mouse model of Lewis lung carcinoma with intermittent hypoxia.Methods:Mice were randomly assigned to normoxia (control), normoxia plus sodium tanshinone IIA sulfonate (control + sodium tanshinone...
Wed May 20, 2020 13:20
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Wed May 20, 2020 13:29
Journal of Cutaneous Medicine and Surgery, Ahead of Print. IntroductionIn this article, we present the Canadian Dermatology Association’s (CDA) Choosing Wisely Canada (CWC) list of top “Five Things Physicians and Patients Should Question in Dermatology” and the evidence in support of each recommendation.MethodsUsing a nominal technique, the CDA Working Group and Task Force generated an initial list based on literature review and expert consultation. After several rounds of list refinement via a modified...
Wed May 20, 2020 13:27
Abstract Background Recent data substantiate the importance of acute gastroenteritis in the development of irritable bowel syndrome (IBS). An animal model of postinfectious IBS determined the importance of cytolethal distending toxin B (CdtB) during live Campylobacter jejuni infection and its development of autoimmunity to vinculin. In this study, we examine whether subcutaneous exposure to CdtB alone is sufficient to produce the postinfectious IBS effect and autoimmunity. Methods Sixty...
Thu May 21, 2020 11:14
Abstract The clinical relevance of numerical predictions of failure mechanisms in femoral prosthesis could be impaired due to simplification of musculoskeletal loading. This study investigated the extent to which loading configurations affect the preclinical analysis of an uncemented femoral implant. Patient‐specific, CT‐scan based FE models of intact and implanted femurs were developed and analysed using three loading configurations, which comprised of load cases representing daily activities....
Thu May 21, 2020 11:57
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