We present a 78-year-old man with suspicion of prostate cancer due to a PSA of 200 ng/mL, who underwent 18F-PSMA-1007 (prostate specific membrane antigen) PET/CT for primary staging. Besides heterogeneous uptake to the prostate, an increased PSMA uptake in the cecum was observed, located in the thickened cecal wall with suspicion of a secondary malignancy. Colonoscopic biopsy followed by hemicolectomy confirmed the diagnosis of colon adenocarcinoma. This case demonstrates the importance of bioptic...
Tue May 19, 2020 03:00
We report a case of a 50-year-old man diagnosed with cholecystocolonic fistula (CCF), confirmed by scintigraphy. After negative initial radiologic workup, a colonoscopy revealed findings of right-sided ischemic colitis. Soon after, a febrile episode prompted a repeat abdominal CT scan demonstrating a possible CCF, later confirmed with a nuclear medicine hepatobiliary scintigraphy and treated surgically. Less than 10% of CCFs are diagnosed preoperatively. Received for publication January 17, 2020;...
Tue May 19, 2020 03:00
We present a highly suspicious case of COVID-19 infection, incidentally found on 18F-FDG PET/CT images. Patient was scanned on February, 25, 2020, when COVID-19 outbreak was unrecognized in our country. She admitted having recent occasional dry cough and fever. A retrospective review of her clinical and laboratory data was strongly suggestive for diagnosis of COVID-19 infection. PET/CT images demonstrated hypermetabolic diffuse ground glass opacities in both lungs with bilateral nodules. There was...
Tue May 19, 2020 03:00
18F-fluorocholine PET/CT is commonly used for staging and assessing treatment response in prostate cancer patients. Growing clinical experience has shown that 18F-fluorocholine can actually accumulate in sites of inflammation. We report a rare case of a prostate cancer patient with incidentally detected Peyronie disease. Received for publication February 27, 2020; revision accepted March 20, 2020. Conflicts of interest and sources of founding: none declared. Correspondence to: Paulina...
Tue May 19, 2020 03:00
Purpose To compare the block sequential regularized expectation maximization (BSREM) algorithm with the ordered subsets expectation maximization (OSEM) algorithm and to evaluate how different penalty factors (b values) influence image quality and SUV measurements. Methods We analyzed data from 78 prostate cancer patients who underwent 68Ga-RM2 (n = 42) or 68Ga-prostate-specific membrane antigen (PSMA)-11 (n = 36) PET/MRI. The raw PET data were retrospectively reconstructed using both...
Tue May 19, 2020 03:00
This 37-year-old woman was diagnosed with breast cancer during pregnancy. After multidisciplinary meeting, she was referred to our department for an FDG PET/CT for staging, and chemotherapy with weekly infusion of paclitaxel was initiated before childbirth. We estimated the fetal dose from the PET/CT procedure, and our results show that, if deemed necessary, this examination can reasonably be performed during pregnancy. The patient gave birth vaginally at term to an apparently healthy girl. Received...
Tue May 19, 2020 03:00
We report the case of a 64-year-old man who presented with back pain, anorexia, and weight loss 9 months following bacillus Calmette-Guérin immunotherapy for high-grade transitional cell carcinoma of the bladder. A FDG PET/CT was performed, which demonstrated osteolysis and intense FDG avidity of the T6/T7 and T8/T9 vertebral endplates. In addition, an aneurysm with FDG-avid soft tissue was present of the distal left common iliac artery. The provisional diagnosis was disseminated bacillus Calmette-Guérin...
Tue May 19, 2020 03:00
A 66-year-old man with severe diarrhea and severe hypoproteinemia was referred for 99mTc-DTPA-human serum albumin (HSA-D) scintigraphy. The scintigraphy at 24 hours postinjection showed strong accumulation of 99mTc-HSA-D in not only the colon but also all his diapers containing his egested feces. The ratio of the diapers counts to the total counts was 17.0%, and a considerable amount of protein loss was confirmed. 99mTc-HSA-D scintigraphy has an important role in diagnosing protein-losing enteropathy,...
Tue May 19, 2020 03:00
Residual end of treatment (EOT) FDG-avid lesions are often due to infectious or inflammatory process and not due to refractory lymphoma. Nonetheless, such lesions prompt diagnostic and therapeutic interventions. We evaluate clinical and radiological characteristics of patients with EOT FDG-avid splenic lesions. Comparing metabolic volume (MV) ratio between EOT to interim, showed a marked difference between false positive and true positive lesions (0.5 vs 3.6, P = 0.02). EOT SUVmax was also significantly...
Tue May 19, 2020 03:00
A 55-year-old woman with papillary thyroid carcinoma under total thyroidectomy and cervical lymph node dissection was referred for 131I radioiodine therapy. Posttherapeutic whole-body scintigraphy revealed increased focal uptake in the right upper abdomen, which localized to the region of the head of the pancreas on SPECT/CT fusion images. Further evaluation with MRI affirmed the radioiodine retention corresponded to bile duct dilation. Received for publication January 29, 2020; revision accepted...
Tue May 19, 2020 03:00
We present a case of a 38-year-old woman who complained with cough, fever, and back pain with a weight loss. 18F-FDG PET/CT to search fever origin revealed uptake in the tracheobronchial and the left auricular cartilage and wall of the thoracic aorta. She underwent biopsy of the left auricle and was diagnosed with relapsing polychondritis (RP) complicating vasculitis. After steroid therapy, FDG PET/CT demonstrated regression of inflammation, showing decreases in the uptakes. Vasculitis should be...
Tue May 19, 2020 03:00
We report the case of a 64-year-old man referred for optic ataxia, constructional apraxia, and spatial orientation disorders evolving for 2 months. Benson syndrome (posterior cortical atrophy) was initially suspected. Brain 18F-FDG PET/CT depicted an asymmetric decreased uptake pattern consistent with Creutzfeldt-Jakob disease. 14-3-3 proteins were detected in the cerebrospinal fluid. Clinical evolution was quickly unfavorable. The patient died 1 month after the PET/CT, and Creutzfeldt-Jakob disease...
Tue May 19, 2020 03:00
A 64-year-old man with lung cancer underwent 18F-FDG PET/CT for restaging, which demonstrated intense 18F-FDG uptake in the right lobe of prostate gland and seminal vesicles, indicating a potential prostate cancer. In 68Ga-PSMA PET/CT, intense uptake in the right lobe of prostate gland and seminal vesicles was also observed but decreased in postmictional delayed images. Magnetic resonance imaging showed high signal intensity of urine in the same areas of uptakes. 18F-FDG and 68Ga-PSMA PET/CT findings...
Tue May 19, 2020 03:00
A 24-year-old woman with left hip pain for 4 months was admitted. Radiographs of the left hip showed a radiolucent lesion in the proximal femur. The lesion demonstrated hypointensity on T1-weighted and high intensity on T2-weighted fat saturated images. 99mTc-MDP bone scan and 18F-FDG PET/CT illustrated intense radiotracer accumulation at the osteolytic lesion. Postoperative pathology confirmed a low-grade myofibroblastic sarcoma (LGMS). LGMS is a rare neoplasm, which often occurred in the head and...
Tue May 19, 2020 03:00
International colon cancer guidelines suggest 18F-FDG PET/CT in a few circumstances: (1) at disease presentation in case of suspected or proven metastatic synchronous adenocarcinoma; (2) in the workup of recurrent colon cancer with metachronous metastases documented by CT, MRI, or biopsy and in case of serial CEA elevation with negative colonoscopy and negative CT; and (3) in case of contraindication to iodine- and gadolinium-based contrast agents. However, review of the literature has shown that...
Tue May 19, 2020 03:00
British Journal of Cancer, Published online: 22 May 2020; doi:10.1038/s41416-020-0897-4Racial differences in prostate cancer: does timing of puberty play a role?
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British Journal of Cancer, Published online: 22 May 2020; doi:10.1038/s41416-020-0898-3Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2–VEGFA axis
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British Journal of Cancer, Published online: 22 May 2020; doi:10.1038/s41416-020-0890-yIdentification of low-dose multidrug combinations for sunitinib-naive and pre-treated renal cell carcinoma
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British Journal of Cancer, Published online: 22 May 2020; doi:10.1038/s41416-020-0889-4A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity
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British Journal of Cancer, Published online: 22 May 2020; doi:10.1038/s41416-020-0899-2Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer
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British Journal of Cancer, Published online: 22 May 2020; doi:10.1038/s41416-020-0903-xTranslating current basic research into future therapies for neurofibromatosis type 1
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Abstract Cholangiocarcinoma (CCA) still affects the health of rural people in northeast Thailand. Most people had a high level of overall risk according to CCA risk assessment in 2014. The question is how to make prevention of CCA as cost-effective as possible. The most appropriate answer is that someone should become a health leader to transfer knowledge to the public. This is the reason for developing the training program for village health volunteers (VHVs)—who play the role...
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Abstract Obesity is a critical modifiable risk factor in cancer prevention, control, and survivorship. Comprehensive weight loss interventions (e.g., Diabetes Prevention Program (DPP)) have been recommended by governmental agencies to treat obesity. However, their high implementation costs limit their reach, especially in underserved African American (AA) communities. Community health workers (CHWs) or trusted community members can help increase access to obesity interventions...
Thu May 21, 2020 03:00
The 21st century has seen a global resurgence of sexually transmitted infections (STIs). From a nadir in the 1990s, the rates of gonorrhea, syphilis, and chlamydia infections have increased substantially in high-income countries, with particular increases among men who have sex with men (MSM).…
Thu May 21, 2020 03:00
Presentation of Case. Dr. Justine V. Cohen: A 47-year-old woman with malignant melanoma was seen in the pulmonary clinic of this hospital because of new abnormal findings on chest imaging. The patient had observed routine quarterly surveillance imaging after resection of right axillary melanoma,…
Thu May 21, 2020 03:00
Thu May 21, 2020 13:04
Nonadherence to oral anticancer medications (OAMs) in the United States is as low as 33% for some cancers. The reasons for nonadherence to these lifesaving medications are multifactorial, yet the majority of studies focus on patient‐level factors influencing uptake and adherence. Individually based interventions to increase patient adherence have not been effective, and this warrants attention to factors at the payor, pharmaceutical, and clinical systems levels. Based on the authors' research and...
Thu May 21, 2020 13:04
Background Fatigue is a common and distressing symptom for patients with gynecologic cancers. Few studies have empirically examined whether it spontaneously resolves. This study was aimed at identifying longitudinal patterns of fatigue and predictors of clinically significant fatigue 1 year after treatment completion. Methods This was a prospective cohort study of women with newly diagnosed ovarian (n = 81) or endometrial cancer (n = 181) that did not progress or recur within 1 year of treatment...
Thu May 21, 2020 15:03
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00495
Thu May 21, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01090
Thu May 21, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00828
Thu May 21, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00165
Thu May 21, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01070
Thu May 21, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05765
Thu May 21, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00516
Thu May 21, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00518
Thu May 21, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01099
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Analytical ChemistryDOI: 10.1021/acs.analchem.0c00981
Thu May 21, 2020 07:00
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