Thu May 21, 2020 03:00
Abstract This study aimed to evaluate an existing liquid-thickening guideline provided by a major manufacturer of thickener in Hong Kong and to provide directions for the implementation of the IDDSI framework. Fifteen participants who are naïve to liquid thickening were required to prepare thickened liquids samples from three drink bases (i.e., Milk-tea, Chinese tea, and Herbal tea) at two target consistency levels (i.e., mildly and medium/moderately thick) based on two guidelines...
Thu May 21, 2020 03:00
Major depressive disorder (MDD) is a highly prevalent debilitating psychiatric disease and a serious public health problem worldwide. Brain structural MRI and postmortem studies on patients with depression have revealed changes in the anatomy and functionality in various brain regions, including the amygdala, thalamus, hippocampus, and prefrontal cortex (PFC). The alterations in these brain regions could be a result, in part, of the dysregulation of the neurotrophic factors. Neuregulin1 (NRG1) is...
03:33
Objective Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms and motor function in stroke patients. While metabolic derangement of the kynurenine pathway has been reported in stroke patients, the effect of rTMS on this pathway remains unknown. This study was performed to investigate the effect of rTMS on serum levels of kynurenine and tryptophan in stroke patients. Methods Sixty-two stroke patients received rTMS in addition to intensive rehabilitation and 33...
03:33
Gustatory dysfunctions are more frequent than other chemosensory dysfunctions in aging people. Gustatory event-related potentials (ERPs) has been suggested as a reliable and effective approach for assessing gustatory functions in young and middle subjects, but has rarely been investigated in aging people, leaving influencing factors of ERPs in that population not completely understood. In this study, we analyzed gustatory ERPs results of aging participants and characterized potential impacting factors,...
03:33
The cytoarchitectonic properties of the primary motor cortex have shown two distinct sub-regions: Anterior Broadmann area 4 (BA4a) and Posterior Broadmann area 4 (BA4p). Some previous studies have suggested that these two sub-regions are functionally different and showed that in few fMRI experiments, these sub-regions may have different roles in brain functions. Resting-state fMRI (rsfMRI) is advanced technique that allows investigating in detail the functional connectivity and provides a greater...
03:33
To compare the diagnostic value of T1-inversion recovery sequence (T1 IR) to that of a T2-sequence with contrast inversion (T2 CI) in the investigation of heterotopias. In this study, we processed a contrast-inverted copy of our coronal T2-sequence of 21 patients with subependymal and subcortical heterotopias on an online picture archiving and communication system workstation. The diagnostic performance of these images was compared with the T1 IR of the same patients by quantitative and qualitative...
03:33
Despite the regenerative capacity of the peripheral nerve system (PNS), functional recovery after mechanical nerve trauma is often incomplete, resulting in motor, sensory, and autonomic deficits. The elucidation of key molecules involved in trauma-induced Wallerian degeneration and the ensuing regeneration processes is a prerequisite for the development of disease modifying drugs. The chemokine (C-X-C motif) receptor 3 (CXCR3) has been implicated in the recruitment of macrophages, the major immune...
03:33
Increasing evidence verified that oxidative stress and neuroinflammatory response exacerbates motor deficits and increases neuronal loss in several rodent models of Parkinson’s disease. In the present study, we explore the neuroprotective effects of monascin in a rotenone-induced Parkinson’s disease model as well as the underlying mechanisms. Our results showed that monascin remarkedly attenuated behavioral impairments and the depletion of dopaminergic neurons induced by rotenone in the rats. Besides,...
03:33
The purpose of this study was to explore the role and mechanism of the PI3K/AKT/mTOR signaling pathway in painful diabetic neuropathy (PDN). The diabetes mellitus (DM) model was established by intraperitoneal injection of streptozocin into SD rats. After 3 weeks of modeling, the DM + LY group was treated with PI3K inhibitor, the DM + vehicle group was treated with DMSO, and the DM group was untreated. The paw mechanical withdrawal thresholds (MWT) was measured by Von Frey filaments, and the expression...
03:33
LncRNA SNHG4 has been reported to be an oncogenic lncRNA in osteosarcoma. Our preliminary analysis of the cancer genome atlas dataset revealed the upregulation of SNHG4 in glioblastoma (GBM). In this study, we confirmed the upregulation of SNHG4 in GBM tissues collected from GBM patients. In addition, lower survival rate of GBM patients was observed in patients with high SNHG4 expression level. SNHG4 can directly interact with miR-138, while SNHG4 expression was no altered after miR-138 overexpression....
03:33
Effective therapeutic drugs for prevent or reverse the pathobiology of Alzheimer’s disease (AD) have not been developed. Icariin (ICA), a prenylated flavonol glycoside derived from the traditional Chinese herb Epimedium sagittatum, exerts a variety of pharmacological activities and shows promise in the treatment and prevention of AD. This study investigated the neuroprotective effects of ICA in SAMP8 mice model of aspects of early AD and explored potential underlying mechanisms. Our results showed...
03:33
The Prorace cervical cap took off in England in 1915. (Science Museum, London/)Donna J. Drucker is senior adviser in English as the Language of Instruction at Technische Universität Darmstadt, Germany. She’s most recently the author of Contraception: A Concise History. This story originally featured on MIT Press Reader.Women have used internal barriers in an attempt to prevent pregnancies as far back as ancient Egypt. However, they only became widely known and used after World War I, when they became...
03:00
America has 90,000 damns listed in its national inventory, including the Hoover Dam, seen here. However, many of them are in need of repair. (Pixabay/)Two broken dams in midland Michigan have prompted the evacuation of more than 10,000 residents. The Edenville and Sanford dams were expected to reach peak flooding around 8 pm Eastern Time last night, Michigan Governor Gretchen Whitmer told reporters at a midday press conference. Last night, Governor Whitmer sent an official request to President Trump...
00:00
It's challenging. (Photo by dylan nolte on Unsplash/)Jump ropes are more complex than you may realize. They range from the classic, nostalgia-inducing beaded ropes of playgrounds, to speed ropes equipped with a light, thin metal wire that can cost north of $100. With the pandemic keeping so many people at home, a good rope will allow you to exercise within whatever space you have available. Plus, flinging one around in a park while you sweat buckets and gasp for breath is a great way to ensure that...
Thu May 21, 2020 21:30
Arsia Mons once spewed molten rock across the surface of Mars, but some smaller volcanic features may have come from another source. (NASA/JPL/USGS/)Mars’s northern lowlands are dotted with tens of thousands of what appear to be run-of-the-mill volcanoes, given the lava-like ripples and fingers that appear around them. But geologists debate whether these bumpy landforms are really frozen magma. In a select few places on Earth, mud erupts rather than molten rock. Could Martian orbiters be sending...
Thu May 21, 2020 22:18
Before putting your visor on, make some room. Bumping into your coffee table will surely break the illusion that you're in the Grand Canyon. ( Hammer & Tusk / Unsplash/)Virtual reality is not nearly as popular as video game consoles or smartphones, but the technology is improving rapidly. Software is getting better, hardware is getting cheaper, and fewer people are coming away from these experiences feeling utterly nauseous.And although VR and gaming sometimes overlap, you should know that the...
Thu May 21, 2020 16:00
This image shows the disc around the young AB Aurigae star, where ESO’s Very Large Telescope (VLT) has spotted signs of planet birth. (ESO/Boccaletti et al./)520 light-years away from Earth, a baby planet is born. While thousands of exoplanets have been identified so far, researchers at the European Southern Observatory’s Very Large Telescope, or VLT, in Chile, have captured the birth of a planet for the very first time. Nestled in a thick disc of dust and gas surrounding a young star named AB Aurigae,...
Thu May 21, 2020 13:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01574
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02131
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01723
Thu May 21, 2020 07:00
[ASAP] Nanocrystals of Lead Chalcohalides: A Series of Kinetically Trapped Metastable Nanostructures
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03577
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03129
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02673
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13117
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06454
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03496
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03301
Thu May 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03153
Thu May 21, 2020 07:00
Abstract Background Peanut allergy (PA) is associated with marked quality‐of‐life (QoL) impairment. However, data are lacking on the experience and impact of living with PA from the perspectives of persons with PA (PwPA) and their caregivers. A llergy to P eanuts imP acting E motions A nd L ife study 1 (APPEAL‐1) was a pan‐European survey investigating these perspectives. This first of two articles reports clinical characteristics of PwPA and PA management practices. Methods APPEAL‐1 was...
Thu May 21, 2020 13:11
Abstract Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross‐reactivity. Despite sequence similarities, their allergenicity varies greatly between ingested and inhaled invertebrate sources. In this study, we investigated the relationship between the structural stability of different tropomyosins, their endolysosomal degradation patterns and T‐cell reactivity. Methods We investigated the differences between four...
Thu May 21, 2020 12:45
Condition: Oral CancerIntervention: Sponsor: Region Örebro CountyNot yet recruiting
02:49
Condition: HealthyInterventions: Other: HVLA C3/C4 manipulation; Other: Sham techniqueSponsor: Escola Superior de Tecnologia da Saúde do PortoNot yet recruiting
02:49
Conditions: Nasopharyngeal Carcinoma; Recurrent Carcinoma; Metastatic Cancer; Non-keratinizing CarinomaIntervention: Drug: Bintrafusp AlfaSponsors: The University of Hong Kong; Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, GermanyRecruiting
02:49
Conditions: Iatrogenic Hypocalcemia; Iatrogenic Hypoparathyroidism; Vocal Cord Paralysis; Vocal Cord Paresis; Vocal Cord; Injury, Superficial; Thyroid Cancer, Papillary; Thyroid Cancer; Multinodular Goiter; Thyroid Neoplasms; Thyroid Nodule; Calcium Deficiency; PTHIntervention: Procedure: Total thyroidectomySponsor: Umraniye Education and Research HospitalRecruiting
02:49
Conditions: Cancer; COVID; Solid Tumor; Social Inequality; French National Cohort; Chemotherapy; Immunotherapy; Surgery; RadiotherapyIntervention: Sponsors: Federation Francophone de Cancerologie Digestive; ARCAGY/ GINECO GROUP; GERCOR - Multidisciplinary Oncology Cooperative Group; GORTEC; IFCT; Association de Neuro-Oncologues d’Expression FrancaiseRecruiting
02:49
Condition: Nasopharyngeal CarcinomaIntervention: Drug: Chemotherapy plus radiotherapy and ToripalimabSponsor: Sun Yat-sen UniversityRecruiting
02:49
Abstract Pediatric adamantinomatous craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Arising in the sellar/suprasellar region, they grow in close proximity to critical neurological and vascular structures and can result in significant neuroendocrine morbidity. First-line treatment often involves surgical resection with or without radiotherapy and has been associated with significant morbidity and poor quality of...
02:47
Abstract The torcular Herophili is formed by the joining of the major dural venous sinuses including the superior sagittal sinus, transverse sinuses, straight sinuses, and the occipital sinus. Surgically, knowledge of the position of the torcular Herophili is vitally important to avoid catastrophic hemorrhage. Here, we present a case report of an elevated torcularia found on radiological imaging. Such an anatomical variation should be kept in mind by clinicians and anatomists...
Thu May 21, 2020 03:00
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.