Publication date: Available online 20 May 2020Source: Archives of Oral BiologyAuthor(s): Fan Yang, Xin Yu, Liwen Fan, Zian Xu, Shiyi Kan, Guirong Zhu, Min Gu, Shu Lou, Dandan Li, Lan Ma, Weibing Zhang, Lin Wang, Yongchu Pan
Publication date: Available online 20 May 2020Source: Archives of Oral BiologyAuthor(s): Dae-Gun Park, Da Jeong Kim, Bok Hee Woo, Hye Jung Kim, Young Whan Choi, Hae Ryoun Park
Publication date: Available online 20 May 2020Source: Archives of Oral BiologyAuthor(s): Omer Bender, Evgeny Weinberg, Ofer Moses, Carlos E. Nemcovsky, Miron Weinreb
Publication date: Available online 20 May 2020Source: Archives of Oral BiologyAuthor(s): Vanessa Camila da Silva, Rafael Scaf de Molon, Renato Parsekian Martins, Fernando Salimon Ribeiro, Ana Emília Farias Pontes, Daniela Leal Zandim-Barcelos, Fábio Renato Manzolli Leite, Carlos Benatti Neto, Rosemary Adriana Chiérici Marcantonio, Joni Augusto Cirelli
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Abstract Periodontitis is a dental plaque–induced chronic inflammatory disease. Long-term exposure of the host to periodontal pathogens leads to a hyporesponsive state to the following stimulations, which is described as endotoxin tolerance. Neutrophils are the most abundant innate immune cells in the body. To clarify the roles of endotoxin tolerance in periodontitis, inflammatory responses in Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS)–tolerized neutrophils...
Abstract Macrophage-dependent inflammation plays a critical role in atherogenesis. Inducible nitric oxide synthase (iNOS) is one of key pro-inflammatory mediators produced in macrophages and its levels can be upregulated by lipopolysaccharide (LPS). The epigenetic mechanism whereby LPS induces iNOS transcription is incompletely understood. We show here myocardin-related transcription factor A (MRTF-A) potentiated iNOS promoter activity...
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