Police face an increased risk of developing mental health problems, yet reliable estimates of their psychological difficulties remain unknown. This systematic review and meta-analysis estimate the pooled prevalence and risk factors for mental health problems among police personnel worldwide. Three independent reviewers searched 16 databases and screened 11 506 articles published between January 1980 and October 2019. Eligible studies involved at least 100 active police professionals and used validated...
01:30
ObjectivesTo investigate the relation between changes in working conditions and exit from paid employment among workers with a chronic disease.MethodsSix waves from the longitudinal Study on Transitions in Employment, Ability and Motivation (2010–2016), enriched with tax-based employment information from Statistics Netherlands (2011–2017), were available for 4820 chronically ill workers aged 45–63 years (mean 55.3 years, SD 5.1). A change in working conditions (physical workload, psychological job...
Thu May 21, 2020 19:00
ObjectivesThe individual peripheral vascular disease risk factors are well documented, but the role of work conditions remains equivocal. This systematic review aims to assess relationships between lower limb peripheral venous diseases (lower limb varicose veins (LLVV), venous thromboembolism (VTE) comprising deep vein thrombosis and pulmonary embolism), peripheral arterial disease (intermittent claudication, aortic dissection, aortic aneurysm) and occupational constraints among working adults.MethodsSeveral...
Thu May 21, 2020 19:00
Thu May 21, 2020 16:49
Thu May 21, 2020 16:44
Thu May 21, 2020 16:35
Thu May 21, 2020 16:00
This experimental study aims to investigate the effect of platelet‐rich plasma gel on colon anastomosis in rats treated with hyperthermic intra‐peritoneal chemotherapy (HIPEC) using 5‐fluorouracil. The HIPEC procedure significantly reduces anastomotic bursting pressure through its negative effects on anastomotic healing. This paper suggests that the negative effect of HIPEC on anastomotic healing can be reversed by the application of platelet‐rich plasma gel. Abstract Background Hyperthermic...
Thu May 21, 2020 14:23
Abstract Background Clinical audit is a critical quality improvement exercise, yet efficient audit tools are lacking. The main objective of this study was to evaluate a recently deployed database in facilitating the process of clinical audit, and the secondary objective was to evaluate the outcomes of free flap reconstruction of the head and neck at our centre. Methods A head and neck cancer‐specific database was customized to suit the needs of our head and neck multidisciplinary team....
Thu May 21, 2020 14:23
Geraniin, a polyphenolic component isolated from Phyllanthus amarus, has been reported to possess diverse biological activities, including antitumor, antiinflammatory, antihyperglycemic, antihypertensive, and antioxidant. However, the role and underlying mechanisms of geraniin in colorectal cancer still remain unclear. In the present study, we found that geraniin notably inhibited cell proliferation and clonogenic formation of colorectal cancer cell SW480 and HT-29 in a dose-dependent manner by Cell...
Mon May 18, 2020 03:00
02:23
02:17
Background Lower eyelid reconstruction is challenging because of the risk of severe postreconstruction deformities of the lower eyelid, such as drooping, entropion, and ectropion. However, the risk factors for these postreconstruction deformities are unclear. The present study aimed to quantify the drooping deformity of the lower eyelid after reconstruction using a cheek rotation flap and to identify risk factors associated with postreconstruction deformities. Methods Our study group included...
02:22
Background There is little written about the scope of rural plastic surgery within the United States. Approximately 25 million people do not have immediate access to a plastic surgeon. Most areas are designated as rural, and this lack of specialty care can result in suboptimal care. Physicians are more likely to move to a rural area if they have prior life experience with rural areas, but exposure to rural plastic surgery in residency training is scarce. We attempted to examine the practice characteristics...
02:22
Becoming a competent microsurgeon requires training in a variety of skills and competences. However, instructing the next generation of microsurgeons seems to be a challenging task, considering the current trend to reduce training hours along with increased patient expectations. To evaluate the microsurgical training opportunities at the Queen Victoria Hospital, we conducted a retrospective review of the last 3 and a half years, to identify the opportunities given to trainees during breast reconstruction...
02:22
Axillary osmidrosis is characterized by offensive odor resulting from bacterial decomposition of apocrine secretions in the axillae, and individuals with axillary osmidrosis suffer detrimental effects to their psychosocial functioning. We searched the literature in January 2019 for all English-language publications discussing axillary osmidrosis to identify previous reports, present trends, and emerging treatments. Studies were listed chronologically by the country of the first author's institution....
02:22
Aim To determine whether patients with congenital lower lid epiblepharon treated with a modified Hotz procedure combined with epicanthoplasty have a decreased recurrence rate. Patients and Methods Patients with epiblepharon of the lower eyelid corrected using a modified Hotz method between 2007 and 2017 were evaluated retrospectively by chart review to determine rates of complications and recurrence as well as whether the Hotz method was combined with epicanthoplasty. The recurrence rates...
02:22
Background The latissimus dorsi myocutaneous flap is widely used in reconstructive surgery; however, primary donor-site closure remains challenging when a wide flap is harvested. Methods A large latissimus dorsi myocutaneous flap was elevated and transferred to repair defects. Perforators adjacent to the donor site of the myocutaneous flap were explored using an ultrasound Doppler probe or a technique of extensive exploration along the margins of the donor site wound. A single or multiple...
02:22
Background Pain, ecchymosis, and edema are well-known temporary consequences of septorhinoplasty procedure. They give rise to patient's complaints, discomfort, and dissatisfaction, increasing the patient's anxiety and recovery time in the early postoperative course. Several approaches have been described to reduce the level of these complaints. The aim of this clinical study was to determine the effect of nasal lavage with lidocaine and adrenaline mixture on early postoperative levels of pain,...
02:22
Composite tissue (CT) preservation is important to outcomes after replant or transplant. Since the first limb replant, the mainstay of preservation has been static cold storage with the amputated part being placed in moistened gauze over ice. Historically, the gold-standard in solid organ preservation has been static cold storage with specialized solution, but this has recently evolved in the last few decades to develop technologies such as machine perfusion and even persufflation. This review explores...
02:22
Background Complications after 2-stage tissue expander/implant breast reconstruction have been studied as outcomes of a single procedure. We separately evaluated complications after the second stage and assessed factors associated with the outcomes of the second stage of breast reconstruction. Methods Patients who underwent immediate 2-stage breast reconstruction between February 2010 and April 2017 were retrospectively reviewed. Patient demographics, surgical factors of the first stage of...
02:22
No abstract available
02:22
Background Geography is an important yet underexplored factor that may influence the care and outcomes of burn survivors. This study aims to examine the impact of geography on physical and psychosocial function after burn injury. Methods Data from the Burn Model Systems National Database (1997–2015) were analyzed. Individuals 18 years and older who were alive at discharge were included. Physical and psychosocial functions were assessed at 6, 12, and 24 months postinjury using the following...
02:22
Nerve grafts represent an invaluable tool, when reconstructing nerve defects of more than 1 cm. Historically, the criterion standard use of autografts has relied on the premise of using nonessential sensory nerves to fulfill the principle of replacing “like with like,” while simultaneously minimizing the infliction of undue morbidity on the patient. The reconstructive surgeon thus faces a dilemma when extensive nerve damage requires reconstruction, or when donor nerves are not available or limited...
02:22
Objective This study aimed to present the results of a series of forequarter amputations (FQAs) and to evaluate the reconstructive methods used. Summary Background Data Although FQA has become a rare procedure in the era of limb-sparing treatment of extremity malignancies, it is a useful option when resection of a shoulder girdle or proximal upper extremity tumor cannot be performed so as to retain a functional limb. Methods Thirty-four patients were treated with FQA in 1989 to 2017....
02:22
Abdominal wall reconstruction is indicated when 1 or more of the abdominal wall components (skin, fascia, or muscle) are either injured or absent. When faced with defects requiring flap reconstruction, the decision regarding flap choice should take into consideration the volume of soft tissue required, the extent of the defect, donor site morbidity, and prior surgical scars that affect flap vascularity. We present a case of an abdominal wall defect with limited reconstructive options in which a spare...
02:22
Background The current study introduces and demonstrates our experience of using a sequential thoracoacromial artery perforator (TAAP) flap to repair the sternocleidomastoid (SCM) flap donor site in this context. The aims of this technique are to optimize both esthetic and functional outcomes and to reduce postoperative complications for patients. Methods Between September 2013 and March 2017, the SCM flap combined with sequential TAAP flap was used for reconstruction postradical parotidectomy...
02:22
Background Nitric oxide (NO) is a multifunctional signaling molecule involved in regulating vascular tone and tissue oxygenation. It is also an important cytoprotective agent against ischemia-reperfusion injury (IRI). Enhancing NO bioavailability via exogenous NO synthases (NOSs) and L-arginine promotes conversation to NO, circumventing the problem of nonfunctioning NOSs under hypoxic and acidic conditions. In this study, the authors evaluated the therapeutic efficacy of neuronal, inducible, and...
02:22
Purpose The purpose of this study was to characterize airway problems, speech outcomes, and facial growth in patients with Stickler syndrome undergoing cleft palate repair. Methods A retrospective, longitudinal study was performed at the Children's Hospital of Philadelphia on 25 patients with Stickler syndrome and 53 nonsyndromic patients with clefts of the secondary palate repaired between 1977 and 2000. Airway problems were characterized by the incidence of Pierre Robin Sequence (PRS) and...
02:22
Introduction The combined approach using both an implant and autologous tissue for breast reconstruction has become more common over the last 10 years. We sought to provide a systematic review and outcomes analysis of this technique. Methods We searched PubMed and the Cochrane Library database to identify studies that described implant augmentation of autologous flaps for breast reconstruction. The references of selected articles were also reviewed to identify any additional pertinent articles. ...
02:22
Background Free fascial flaps are widely used for the reconstruction of defects located on the distal extremities as they provide thin yet durable soft tissue coverage. The serratus anterior fascia flap stands out from other fascial flap alternatives as it has optimal anatomical properties that can provide ideal coverage in a wide range of reconstructive challenges. The purpose of this study was to present our experience with the serratus anterior fascia flap in a variety of complex soft tissue...
02:22
No abstract available
02:22
Introduction The profunda artery perforator (PAP) flap can be an alternative to the deep inferior epigastric artery flap. However, in some cases, the PAP may not be adequate to perfuse the whole flap. In this study, we describe 3 cases in which an alternative perforator was used for PAP flap perfusion. In addition, we describe an anatomical study to explore the perforasome of the PAP and alternative perforators. Materials and Methods Three cases are described in which an alternative perforator...
02:22
Developing safe and efficient delivery systems for therapeutic biomacromolecules is a long‐standing challenge. Herein, we report a newly developed combinatorial library of cholesteryl‐based disulfide bond‐containing biodegradable cationic lipidoid nanoparticles. We have identified a subset of this library which is effective for protein and mRNA delivery in vitro and in vivo. These lipidoids showed comparable transfection efficacies but much lower cytotoxicities compared to the Lpf2k in vitro. In...
Thu May 21, 2020 12:47
Arenes with β‐stereogenic centers are important substructures in pharmaceuticals and natural products. Their synthesis traditionally involves two separate and individually challenging steps: enantioselective synthesis of a chiral main‐group organometallic complex and subsequent cross‐coupling with an aryl electrophile. We describe the development of asymmetric anti‐Markovnikov hydroarylation of 1,1‐disubstituted olefins by dual palladium and copper hydride catalysis as a convenient and significantly...
Thu May 21, 2020 12:46
Halide perovskites show incredible photovoltaic power conversion efficiency coupled with several hundreds of hours of device stability for finely tuned material compositions. It is expected to employ such a successful photovoltaic material in (photo)electrochemical(PEC) systems, including solar water splitting. However their stability is very poor in aqueous electrolyte medium and they decompose instantly, which limits their use in PEC systems. Here we report a vacancy ordered halide perovskite,...
Thu May 21, 2020 12:46
Transition‐metal‐catalyzed hydroarylation of unactivated alkenes with strategic use of remote coordinating functional groups has received significant attentions recently in order to address the issues of both low reactivity and poor selectivity. A bidentate 8‐aminoquinoline amide group is the most successfully adopted in unactivated alkenes for Pd‐ and Ni‐catalysis. Herein, we describe the first manganese‐catalyzed hydroarylation of unactivated alkenes bearing diverse simple functionalities with...
Thu May 21, 2020 12:45
We report herein a novel conjugation chemistry of N‐terminal cysteines (NCys) that proceeds with fast kinetics and exquisite selectivity, allowing facile modification of NCys‐bearing proteins in complex biological milieu. This new NCys conjugation proceeds with a thiazolidine boronate (TzB) intermediate that results from fast ( k 2 : ~5000 M‐1s‐1) and reversible conjugation of NCys with 2‐formylphenylboronic acid (FPBA). We have designed a FPBA derivative that upon TzB formation elicits an intramolecular...
Thu May 21, 2020 17:43
Protein‐polymer conjugates are increasingly applied to biomedicine due to a unique combination of the biological activity from the proteins and the multifunctionality and flexibility from the polymers. However, traditional protein‐polymer conjugation techniques suffer from some unavoidable drawbacks, including non‐specificity and low efficiency. In this minireview, we discuss a new approach based on “ Precision Conjugation ” to the construction of the next‐generation protein‐polymer conjugates...
Thu May 21, 2020 16:45
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.