Related Articles A Validated T Cell Radiomics Score is Associated with Clinical Outcomes Following Multi-site SBRT and Pembrolizumab. Int J Radiat Oncol Biol Phys. 2020 Jun 19;: Authors: Korpics MC, Polley MY, Bhave SR, Redler G, Pitroda SP, Luke JJ, Chmura SJ Abstract PURPOSE: Combining immune checkpoint blockade(ICB) with stereotactic body radiotherapy(SBRT) may improve the local response to radiation and the systemic response to immunotherapy....
Tue Jun 23, 2020 14:51
Related Articles The forefront of ovarian cancer therapy: update on PARP inhibitors. Ann Oncol. 2020 Jun 19;: Authors: Mirza MR, Coleman RL, González-Martín A, Moore KN, Colombo N, Ray-Coquard I, Pignata S Abstract BACKGROUND: In recurrent ovarian cancer, poly(ADP-ribose) polymerase (PARP)-inhibiting agents have transformed the treatment of platinum-sensitive disease. New data support use of PARP inhibitors earlier in the treatment algorithm....
Tue Jun 23, 2020 14:51
Related Articles The Past, Present and Future of Literature Pertaining to Betel (Areca) Nut: A Citation Analysis. Subst Use Misuse. 2020;55(9):1403-1412 Authors: Vashney M, Parmar A, Mishra AK Abstract Objective and method: Betel (areca) nut has recently received interest from researchers and policy makers for its role as a psychoactive substance. It was historically limited to Asia-pacific region, but with the advent of globalization, it has...
Tue Jun 23, 2020 14:51
Related Articles Psychological interventions to improve self-management of type 1 and type 2 diabetes: a systematic review. Health Technol Assess. 2020 Jun;24(28):1-232 Authors: Winkley K, Upsher R, Stahl D, Pollard D, Kasera A, Brennan A, Heller S, Ismail K Abstract BACKGROUND: For people with diabetes mellitus to achieve optimal glycaemic control, motivation to perform self-management is important. The research team wanted to determine whether...
Tue Jun 23, 2020 14:51
Related Articles Development of a Data Model and Data Commons for Germ Cell Tumors. JCO Clin Cancer Inform. 2020 Jun;4:555-566 Authors: Ci B, Yang DM, Krailo M, Xia C, Yao B, Luo D, Zhou Q, Xiao G, Xu L, Skapek SX, Murray MM, Amatruda JF, Klosterkemper L, Shaikh F, Faure-Conter C, Fresneau B, Volchenboum SL, Stoneham S, Lopes LF, Nicholson J, Frazier AL, Xie Y Abstract Germ cell tumors (GCTs) are considered a rare disease but are the most common...
Tue Jun 23, 2020 14:51
Related Articles Internet-delivered insomnia intervention improves sleep and quality of life for adolescent and young adult cancer survivors. Pediatr Blood Cancer. 2020 Jun 22;:e28506 Authors: Zhou ES, Recklitis CJ Abstract BACKGROUND: Insomnia is common among adolescent and young adult (AYA) cancer survivors. Cognitive-behavioral therapy for insomnia (CBT-I) is considered the gold standard treatment. Standard CBT-I was designed for adults and...
Tue Jun 23, 2020 14:51
Related Articles Sumoylation as an Emerging Target in Therapeutics against Cancer. Curr Pharm Des. 2020 Jun 22;: Authors: Liu S, Wang L, Jiang D, Wei W, Nasir MF, Khan MS, Yousafi Q, Liu X, Fu X, Li X, Li J Abstract Sumoylation is the Posttranslational modification gaining most of the research interest recently. Sumoylation is involved in various crucial functions of the cell such as regulation of cell cycle, DNA damage repair, apoptosis etc....
Tue Jun 23, 2020 14:51
Related Articles Analysis of risk factors for high postoperative D-dimer levels: A single-center nurse-observational study. Int J Biol Markers. 2020 Jun 20;:1724600820931861 Authors: Qin L, Fu Y, Li C, Chen S, Lv Y, Hao M, Zhang H, Wang Y Abstract BACKGROUND: As an elevated D-dimer level is directly proportional to the degrees of trauma and coagulation, it is often used to assess the severity of the trauma as well as the risk of thrombosis....
Tue Jun 23, 2020 14:51
Related Articles The clinical training centers fellowships: a European School of Oncology career development program (2013-2019). Future Oncol. 2020 Jun 21;: Authors: Pavlidis N, Peccatori FA, Aapro M, Eniu A, Cavalli F, Costa A Abstract Aim: This article refers to the European School of Oncology Clinical Training Centers (CTCs) program, which is a granted Fellowships program dedicated to young oncologists in training. Materials & methods:...
Tue Jun 23, 2020 14:51
Related Articles Discordance between pediatric self-report and parent proxy-report symptom scores and creation of a dyad symptom screening tool (co-SSPedi). Cancer Med. 2020 Jun 21;: Authors: Tomlinson D, Plenert E, Dadzie G, Loves R, Cook S, Schechter T, Furtado J, Dupuis LL, Sung L Abstract Symptom Screening in Pediatrics Tool (SSPedi) (age 8-18 years) and mini-SSPedi (age 4-7 years) can be used to self-report and proxy-report bothersome symptoms...
Tue Jun 23, 2020 13:23
Related Articles Vitamin D intake is associated with decreased risk of immune checkpoint inhibitor-induced colitis. Cancer. 2020 Jun 22;: Authors: Grover S, Dougan M, Tyan K, Giobbie-Hurder A, Blum SM, Ishizuka J, Qazi T, Elias R, Vora KB, Ruan AB, Martin-Doyle W, Manos M, Eastman L, Davis M, Gargano M, Haq R, Buchbinder EI, Sullivan RJ, Ott PA, Hodi FS, Rahma OE Abstract BACKGROUND: There is a lack of predictive markers informing on the risk...
Tue Jun 23, 2020 13:23
Related Articles Interobserver Variability in Ductal Carcinoma In Situ of the Breast. Am J Clin Pathol. 2020 Jun 22;: Authors: Van Bockstal MR, Berlière M, Duhoux FP, Galant C Abstract OBJECTIVES: Since most patients with ductal carcinoma in situ (DCIS) of the breast are treated upon diagnosis, evidence on its natural progression to invasive carcinoma is limited. It is estimated that around half of the screen-detected DCIS lesions would have...
Tue Jun 23, 2020 13:23
Related Articles Prevalence of software alerts in radiotherapy. Tech Innov Patient Support Radiat Oncol. 2020 Jun;14:32-35 Authors: Reijnders-Thijssen P, Geerts D, van Elmpt W, Pawlicki T, Wallis A, Coffey M Abstract Radiotherapy software messages (sometimes called alerts, pop-up windows, alarms, or error messages) to the user appear continuously on computer screens. These software messages sometimes require decisions to be made as to the next...
Tue Jun 23, 2020 13:23
Related Articles A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community). F1000Res. 2020;9: Authors: Orengo C, Velankar S, Wodak S, Zoete V, Bonvin AMJJ, Elofsson A, Feenstra KA, Gerloff DL, Hamelryck T, Hancock JM, Helmer-Citterich M, Hospital A, Orozco M, Perrakis A, Rarey M, Soares C, Sussman JL, Thornton JM, Tuffery P, Tusnady G, Wierenga R, Salminen T, Schneider B Abstract Structural bioinformatics...
Tue Jun 23, 2020 13:23
Related Articles Novel Molecular Mechanisms of Pulmonary Hypertension: A Search for Biomarkers and Novel Drug Targets-From Bench to Bed Site. Oxid Med Cell Longev. 2020;2020:7265487 Authors: Gajecki D, Gawrys J, Szahidewicz-Krupska E, Doroszko A Abstract Pulmonary hypertension (PH) is defined as increased mean pulmonary artery pressure (mPAP) above 25 mmHg, measured at rest by right heart catheterization. The exact global prevalence of PH is...
Tue Jun 23, 2020 13:23
Related Articles The Effects of Auricular Therapy for Cancer Pain: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2020;2020:1618767 Authors: Yang Y, Wen J, Hong J Abstract Objective: This study aims to systematically assess the efficacy and safety of auricular therapy for cancer pain. Methods: A systematic search was conducted using PubMed, EMBASE, Cochrane library databases, CNKI, VIP, WanFang Data, and...
Tue Jun 23, 2020 13:23
Related Articles Pathways to a cancer-free future: a protocol for modelled evaluations to minimise the future burden of colorectal cancer in Australia. BMJ Open. 2020 Jun 21;10(6):e036475 Authors: Feletto E, Lew JB, Worthington J, He E, Caruana M, Butler K, Hui H, Taylor N, Banks E, Barclay K, Broun K, Butt A, Carter R, Cuff J, Dessaix A, Ee H, Emery J, Frayling IM, Grogan P, Holden C, Horn C, Jenkins MA, Kench JG, Laaksonen MA, Leggett B, Mitchell G, Morris...
Tue Jun 23, 2020 13:23
Related Articles INSPIRE: A European training network to Foster research and training in cardiovascular safety pharmacology. J Pharmacol Toxicol Methods. 2020 Jun 18;:106889 Authors: Guns PD, Guth BD, Braam S, Kosmidis G, Matsa E, Delaunois A, Gryshkova V, Bernasconi S, Knot H, Shemesh Y, Chen A, Markert M, Fernandez M, Lombardi D, Grandmont C, Cillero-Pastor B, Heeren RMA, Martinet W, Woolard J, Skinner M, Segers VFM, Franssen C, Van Craenenbroeck EM, Volders...
Tue Jun 23, 2020 13:23
Related Articles What is the alternative? Responding strategically to cancer misinformation. Future Oncol. 2020 Jun 21;: Authors: Peterson JS, Swire-Thompson B, Johnson SB PMID: 32564627 [PubMed - as supplied by publisher]
Tue Jun 23, 2020 13:23
Related Articles B-cell epitope peptide cancer vaccines: a new paradigm for combination immunotherapies with novel checkpoint peptide vaccine. Future Oncol. 2020 Jun 21;: Authors: Kaumaya PT Abstract In light of the numerous US FDA-approved humanized monoclonal antibodies (mAbs) for cancer immunotherapy, it is surprising that the advancement of B-cell epitope vaccines designed to elicit a natural humoral polyclonal antibody response has not...
Tue Jun 23, 2020 13:23
ABSTRACT Background Budesonide, a poorly water‐soluble corticosteroid, is currently marketed as a suspension. Budesolv is a novel aqueous formulation containing dissolved Budesonide showing increased local availability in preclinical models. Budesolv contains ~85% less corticosteroid than the marketed comparator. Objective The study (EudraCT:2018‐001324‐19) was designed to assess non‐inferiority of Budesolv compared to to Rhinocort® aqua 64 (RA) and early onset of action. Methods In...
Mon Jun 22, 2020 20:28
ABSTRACT Ultrarush protocols induce tolerance over two to three day hospital admission. They are useful when protection is required as a matter of urgency, or there are circumstances that would preclude conventional weekly visits for up dosing.
Mon Jun 22, 2020 19:57
Abstract While there has been much interest in using biomarkers to select patients for particular targeted therapies, there has been much less attention paid to how these biomarkers change in patients once treatment begins. This is an area of great interest to practising clinicians, especially respiratory physicians and allergists who manage severe asthma.
Mon Jun 22, 2020 11:09
Related Articles A clinical dilemma amid COVID-19 pandemic: missed or encountered diagnosis of cancer? Future Oncol. 2020 Jun 21;: Authors: Yekedüz E, Karcıoğlu AM, Utkan G, Ürün Y PMID: 32564611 [PubMed - as supplied by publisher]
Tue Jun 23, 2020 13:23
Related Articles Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells. Mol Cancer Res. 2019 12;17(12):2522-2536 Authors: Nakano K, Iwanaga M, Utsunomiya A, Uchimaru K, Watanabe T Abstract The genetic and molecular alterations responsible for leukemogenesis and progression of HTLV-infected adult T-cell leukemia (ATL) have not been fully clarified. Previously, we reported that various genes are not only overexpressed...
Tue Jun 23, 2020 13:23
Related Articles Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 08 22;62(16):7575-7582 Authors: Su S, Yang Z, Gao H, Yang H, Zhu S, An Z, Wang J, Li Q, Chandarlapaty S, Deng H, Wu W, Rao Y Abstract A focused PROTAC library hijacking cancer therapeutic target CDK6 was developed. A design principle as "match/mismatch" was proposed for understanding the degradation profile differences...
Tue Jun 23, 2020 13:23
Related Articles Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer. Oncoimmunology. 2020 May 13;9(1):1758869 Authors: Alvero AB, Hanlon D, Pitruzzello M, Filler R, Robinson E, Sobolev O, Tedja R, Ventura A, Bosenberg M, Han P, Edelson RL, Mor G Abstract Ovarian cancer accounts for most deaths from gynecologic malignancies. Although more than 80% of patients respond to first-line...
Tue Jun 23, 2020 13:20
Related Articles Thyroid metastases from colorectal cancer 14 years later: A case report and literature review. Cir Cir. 2020;88(4):508-510 Authors: Rojo-Abecia M, Rivera-Alonso D, Herrero-Álvarez S, Ochagavía-Cámara S, Torres-García AJ Abstract Metastases to the thyroid gland are unusual, especially from a colorectal cancer. We present the case of an 85-year-old female with a history of colon cancer in 2004 treated with surgery, who 14 years...
Tue Jun 23, 2020 17:10
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