Mucosal Immunology, Published online: 23 June 2020; doi:10.1038/s41385-020-0306-6Dysregulation of intestinal epithelial CFTR-dependent Cl− ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice
Tue Jun 23, 2020 03:00
Mucosal Immunology, Published online: 23 June 2020; doi:10.1038/s41385-020-0314-6R848 or influenza virus can induce potent innate immune responses in the lungs of neonatal mice
Tue Jun 23, 2020 03:00
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Tue Jun 23, 2020 03:00
Publication date: July 2020Source: Human Pathology, Volume 101Author(s):
Tue Jun 23, 2020 21:19
Publication date: July 2020Source: Human Pathology, Volume 101Author(s):
Tue Jun 23, 2020 21:19
Publication date: July 2020Source: Human Pathology, Volume 101Author(s):
Tue Jun 23, 2020 21:19
Here, we present a protocol to detect total cellular reactive oxygen species (ROS) using 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA). This method can visualize cellular ROS localization in adherent cells with a fluorescence microscope and quantify ROS intensity with a fluorescence plate reader. This protocol is simple, efficient and cost-effective.
Tue Jun 23, 2020 20:55
Thelohanellus kitauei, is a member of obligate parasitic myxozoans, which causes intestinal giant-cystic disease of common carp (Cyprinus carpio) and has resulted in significant economic losses in carp farms. Cys...
Tue Jun 23, 2020 03:00
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): Loic Ysebaert, Anne Quinquenel, Fontané Bijou, Emmanuelle Ferrant, Anne-Sophie Michallet, French Innovative Leukemia Organization (FiLO) CLL group
Tue Jun 23, 2020 20:30
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16138-3Preclinical evidence suggests that a fasting mimicking diet (FMD) can make cancer cells more vulnerable to chemotherapy, while protecting normal cells. In this randomized phase II clinical trial of 131 patients with HER2 negative early stage breast cancer, the authors demonstrate that FMD is safe and enhances the effects of neoadjuvant chemotherapy on radiological and pathological tumor response.
Tue Jun 23, 2020 03:00
Tue Jun 23, 2020 03:00
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16343-0Complex systems in the real world are often characterized by connected patterns interacting between each other in multiple ways. Here, Della Rossa et al. describe a general method to determine symmetries in multilayer networks and then relate them to different synchronization modes that the networks can exhibit.
Tue Jun 23, 2020 03:00
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16472-6Optically refrigerated resonators may be useful in optical devices and exploring quantum effects. Here, the authors show laser refrigeration of a semiconductor mechanical oscillator Yb:YLF host crystal and lowering the thermal load temperature.
Tue Jun 23, 2020 03:00
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16849-7The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that TLR2 expression on monocytes correlates with disease severity in patients.
Tue Jun 23, 2020 03:00
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16943-wMitogen-Activated Protein Kinases integrate extracellular information in all eukaryotic cells. Using a live mRNA reporter, here the authors monitor transcriptional bursting in Saccharomyces cerevisiae upon hyper-osmotic shock and characterize the influence of MAPK signalling, chromatin and transcription factors on the dynamics of transcription.
Tue Jun 23, 2020 03:00
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16950-xPeptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.
Tue Jun 23, 2020 03:00
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16977-0Research in hydrogen-bonded organic frameworks (HOFs) has gained interest in recent years due to their facile design and synthesis but no semiconducting HOF has been reported to date. Here the authors report a thermally stable and proton-conductive organic semiconductor based on a porphyrin HOF.
Tue Jun 23, 2020 03:00
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16974-3Sequencing tumour genomes can reveal information about the processes that drive the formation of cancer. Here, the authors describe a method that can detect these mutational signatures from small amounts of DNA and degraded samples.
Tue Jun 23, 2020 03:00
Nature Communications, Published online: 23 June 2020; doi:10.1038/s41467-020-16920-3Synthetic peptide libraries can access broad chemical space, but generally examine only ~ 106 compounds. Here, the authors show that in-solution affinity selection, interfaced with nLC-MS/MS sequencing, can identify binders from fully randomized synthetic libraries of 108 members.
Tue Jun 23, 2020 03:00
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AbstractDiverticulitis, though a common gastrointestinal disease, is rare following open-heart surgery. There is insufficient data regarding its incidence and management post-cardiac surgery. Especially in patients with atypical presentation, diagnosis and management can be challenging. This case outlines one such atypical diverticulitis case in which a 57-year-old female patient developed perforated diverticulitis with pelvic abscess accumulation following left ventricular aneurysm (LVA) repair....
Mon Jun 22, 2020 03:00
AbstractWe present a rare case of a duplicated cystic duct encountered during an elective laparoscopic cholecystectomy in a patient with biliary colic. Prompt recognition of an intraoperative bile leak followed by thorough examination and recognition of the source allowed for timely and appropriate management of the affected patient with a satisfactory post-operative outcome. Our case is unique by the lack of availability of intraoperative cholangiogram at the time of surgery, which posed a significant...
Fri Jun 19, 2020 03:00
AbstractFibrous solitary tumors (FST) are mesenchymal tumors that can appear in different body regions. It is estimated that around 30% are found in the thoracic region, while rarely in meninges, abdomen, pelvis, extremities and bones. A correct diagnosis is important because 15–20% of cases develop a malignant behavior. Treatment of choice is surgical and posterior follow-up is essential. We present two atypical extrapleural FST cases, diagnosed in our center. Both were treated with surgery and...
Thu Jun 18, 2020 03:00
AbstractA 4-year-old girl underwent an open-neck surgical procedure for a recurrent pyriform sinus fistula (PSF). A catheter could not be inserted through the endoscope into the opening of the fistula. An open-neck surgical procedure with coring out of the fistula stained with a dye revealed that the fistula was missed near the upper lobe of the left thyroid. A guide wire was successfully inserted via the endoscope into the fistula, and the wire was gripped with forceps under fluoroscopic guidance...
Thu Jun 18, 2020 03:00
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