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Wednesday, June 24, 2020


The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme
Abstract The aggressive nature of glioblastoma multiforme (GBM) may be attributed to the dysregulation of pathways driving both proliferation and invasion. EphrinB2, a membrane‐bound ligand for some of the Eph receptors, has emerged as a critical target regulating these pathways. In this study, we investigated the role of ephrinB2 in regulating proliferation and invasion in GBM using intracranial and subcutaneous xenograft models. The Cancer Genome Atlas analysis suggested high transcript and low...
Molecular Carcinogenesis
Mon Jun 22, 2020 14:05
An exceptional neurovascular system in abelisaurid theropod skull: New evidence from Skorpiovenator bustingorryi
Skorpiovenator bustingorry is a abelisaurid theropod featured by a row of neurovascular foramina in the nasal bones. Further, it has distinctive foramina on the skull roof. The nasal foramina show an internal canal that links each one, which probably represent correlates of blood vessels and nerves. The possible implications of this neurovascular system include thermoregulation and nourishing of display structures, but other speculative hypotheses such as sensory functions are not discarded. ...
Journal of Anatomy
Mon Jun 22, 2020 22:15
P > .05: The incorrect interpretation of “not significant” results is a significant problem
Abstract Statistically nonsignificant (p  > .05) results from a null hypothesis significance test (NHST) are often mistakenly interpreted as evidence that the null hypothesis is true—that there is “no effect” or “no difference.” However, many of these results occur because the study had low statistical power to detect an effect. Power below 50% is common, in which case a result of no statistical significance is more likely to be incorrect than correct. The inference of “no effect” is not valid...
American Journal of Physical Anthropology
Mon Jun 22, 2020 12:39
Striatal cholinergic interneurons exert inhibition on competing default behaviors controlled by the nucleus accumbens and dorsolateral striatum
Abstract With repeated practice, learned actions become more skilled, and eventually highly stereotypical. This transition is accompanied by a shift in striatal control over behavior from ventral and dorsomedial striatum to dorsolateral striatum. The cholinergic interneurons (CINs) in the striatum are central to striatal computation. Yet, their role in the transition from motivated to stereotypic behavior is still unclear. In this study we examined whether CINs contribute to the competition between...
European Journal of Neuroscience
Mon Jun 22, 2020 11:15
Telemedicine allows quantitative measuring of olfactory dysfunction in COVID‐19
Allergy
Mon Jun 22, 2020 22:18
Cross‐reactive carbohydrate determinant‐specific IgE obscures true atopy and exhibits ⍺‐1,3‐fucose epitope‐specific inverse associations with asthma
Abstract Background In high‐income, temperate countries, IgE to allergen extracts is a risk factor for, and mediator of, allergy‐related diseases (ARDs). In the tropics, positive IgE tests are also prevalent, but rarely associated with ARD. Instead, IgE responses to ubiquitous cross‐reactive carbohydrate determinants (CCDs) on plant, insect and parasite glycoproteins, rather than to established major allergens, are dominant. Because anti‐CCD IgE has limited clinical relevance, it may impact ARD...
Allergy
Mon Jun 22, 2020 17:46
Hydroxytyrosol Plays Antiatherosclerotic Effects through Regulating Lipid Metabolism via Inhibiting the p38 Signal Pathway
Purpose. Hydroxytyrosol (HT) processes multiaspect pharmacological properties such as antithrombosis and antidiabetes. The aim of this study was to explore the antistherosclerotic roles and relevant mechanisms of HT. Methods. Male apoE-/- mice were randomly divided into 2 groups: the control group and the HT group (10 mg/kg/day orally). After 16 weeks, blood tissue, heart tissue, and liver tissue were obtained to detect the atherosclerotic lesions, histological analysis, lipid parameters, and inflammation....
BioMed Research International
Tue Jun 23, 2020 10:35
Bacteriological Study of Electronic Devices Used by Healthcare Workers at Ruhengeri Referral Hospital
Electronic devices have become one of the most essential accessories being used in hospitals. Those devices increase the communication and contact making healthcare delivery more efficient and quality service oriented. The study was designed to collect reliable information about the spreading of pathogens through electronic devices especially in sensitive departments. The objectives of this study were to evaluate the bacterial colonization of electronic devices and determine the effectiveness of...
BioMed Research International
Tue Jun 23, 2020 09:35
Deep Vein Thrombosis in the Uninjured Limb in Patients with Lower Extremity Fractures: A Retrospective Study
Objective. This study is aimed at investigating the incidence of deep vein thrombosis (DVT) in the uninjured limb during hospitalization and 1 month after surgery in patients with lower extremity fractures. Methods. We collected the clinical data of patients with lower extremity fractures in Xi’an Honghui Hospital. Doppler ultrasonography was used to diagnose DVT. According to the results of ultrasonography, the patients were divided into two groups: uninjured limb with DVT group and uninjured limb...
BioMed Research International
Tue Jun 23, 2020 09:20
Association between Sleep Deprivation in Caregivers and Risk of Injury among Toddlers: A Propensity Score Analysis
Introduction. Unintentional injury remains the leading cause of death in children worldwide. Adequate parental supervision is a crucial strategy for preventing injury. Many factors, such as a large family size, poor socioeconomic status, and the caregiver being a single mother, contribute to unintentional injury in children. In addition, sleep deprivation in caregivers might be associated with injury in children because sleep deprivation causes impaired daytime cognitive function, wake-state instability,...
BioMed Research International
Tue Jun 23, 2020 08:20
Relationship between Uric Acid Level and Severity of Acute Primary Cerebral Infarction: A Cross-Sectional Study
Numerous studies have shown that uric acid (UA) is associated with cerebrovascular disease, but whether UA is a protective factor or worsens the risk of developing cerebrovascular disease remains controversial. This study investigated the relationship between UA levels detected at admission and the severity of acute primary cerebral infarction. This cross-sectional study enrolled patients with acute primary cerebral infarction (, 157 men). We designated the levels of serum UA measured at the time...
BioMed Research International
Tue Jun 23, 2020 08:20
Overexpression of 14-3-3σ Modulates Cholangiocarcinoma Cell Survival by PI3K/Akt Signaling
The protein 14-3-3σ is involved in numerous cellular processes through its ability to bind phosphorylated serine/threonine residues. It is a key regulator of the cell cycle involving in G2 arrest by p53. Deregulation of 14-3-3σ expression has been associated with a large variety of human cancers. However, its physiological function and therapeutic significance have rarely been investigated in cholangiocarcinoma. Using immunohistochemistry (IHC), we evaluated 14-3-3σ expression in 65 human extrahepatic...
BioMed Research International
Tue Jun 23, 2020 08:05
tRNA-Derived Fragments in Podocytes with Adriamycin-Induced Injury Reveal the Potential Mechanism of Idiopathic Nephrotic Syndrome
Idiopathic nephrotic syndrome (INS) is a disease involving injury to podocytes in the glomerular filtration barrier, and its specific causes have not been elucidated. Transfer RNA-derived fragments (tRFs), products of precise tRNA cleavage, have been indicated to play critical roles in various diseases. Currently, there is no relevant research on the role of tRFs in INS. This study intends to explore the changes in and importance of tRFs during podocyte injury in vitro and to further analyze the...
BioMed Research International
Tue Jun 23, 2020 06:50
FOXA1 Expression in Nasopharyngeal Carcinoma: Association with Clinicopathological Characteristics and EMT Markers
The forkhead box (FOXA) family of transcription factors regulates gene expression and chromatin structure during tumorigenesis and embryonic development. Until now, the relationship between FOXA1 and the nasopharyngeal carcinoma (NPC) has not yet been reported. Therefore, our purpose is to analyze the expression of FOXA1 in 56 NPC patients compared to 10 normal nasopharyngeal mucosae and to correlate the expression with the clinicopathological features. Besides, we investigated the association between...
BioMed Research International
Tue Jun 23, 2020 06:50
Integrated Role of Nonpharmacological Interventions for Rehabilitation of Individuals with Musculoskeletal Disorders
BioMed Research International
Tue Jun 23, 2020 06:20
A Case of Advanced Gastroesophageal Junction Cancer with Bulky Lymph Node Metastases Treated with Nivolumab
A 71-year-old woman was diagnosed with advanced gastroesophageal junction cancer with bulky lymph nodes along the cardiac region and the lower mediastinum (GE-Circ type 3 T3 N3 M0 H0 stage III) and received treatment with S-1 and oxaliplatin (SOX) as first-line chemotherapy. After 3 cycles of SOX, severe anorexia and diarrhea were observed. We converted from this regimen of systemic chemotherapy to ramucirumab (RAM) monotherapy as second-line chemotherapy. This treatment resulted in a reduction in...
Case Reports in Oncology
Tue Jun 23, 2020 09:13
Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta‐analysis
Abstract The purpose of this systematic review and meta‐analysis was to estimate the overall and type‐specific prevalence of human papillomavirus (HPV) DNA in oral epithelial dysplasia and assess p16INK4a overexpression in relation to HPV‐status. A systematic literature search identified 31 eligible studies (832 cases) evaluating the presence of HPV DNA in oral epithelial dysplasia cases by PCR. Of these, six studies evaluated p16INK4a overexpression in relation to HPV‐status. The overall pooled...
Head & Neck
Tue Jun 23, 2020 10:11
Prevalence of PD‐L1 expression in head and neck squamous precancerous lesions: a systematic review and meta‐analysis
Abstract Background Studies concerning programmed death‐ligand 1 (PD‐L1) expression in precancerous lesions of head and neck (HN) region have shown variable results. Methods We systematically reviewed the published evidence on PD‐L1 expression in HN precancerous lesions. Results Of 1058 original articles, 14 were included in systematic review and 9 in meta‐analysis. The pooled estimate of PD‐L1 expression was 48.25% (confidence interval [CI] 21.07‐75.98, I 2 98%, tau2 0.18). PD‐L1...
Head & Neck
Mon Jun 22, 2020 13:54
Safety parameters of ferromagnetic device during thyroid surgery: Porcine model using continuous neuromonitoring
Abstract Background The ferromagnetic (FM) device is a new surgical energy modality. This study investigated dynamic recurrent laryngeal nerve (RLN) electromyographic (EMG) data to define safety parameters for using FM devices in thyroidectomy. Methods Real‐time EMG tracings obtained under continuous neuromonitoring were recorded from 24 RLNs (12 piglets). In the activation study, FM devices were activated at varying distances from the RLN. In the cooling study, FM devices were cooled for...
Head & Neck
Mon Jun 22, 2020 13:47
Letter to the editor regarding “How to avoid nosocomial spread during tracheostomy for Covid‐19 patients”
Head & Neck
Mon Jun 22, 2020 12:31
Reply to letter to the editor (HED‐20‐0582) regarding “how to avoid nosocomial spread during tracheostomy for COVID‐19 patients”
Head & Neck
Mon Jun 22, 2020 12:23
Letter to the editor regarding “US-guided microwave ablation of hyperplastic parathyroid glands: safety and efficacy in patients with end-stage renal disease—a pilot study”
Medical Oncology
Tue Jun 23, 2020 03:00

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