Related Articles Skin sympathetic nerve activity in patients with obstructive sleep apnea. Heart Rhythm. 2020 Jun 19;: Authors: He W, Tang Y, Meng G, Wang D, Wong J, Mitscher GA, Adams D, Everett TH, Chen PS, Manchanda S Abstract BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased cardiac arrhythmia and sudden cardiac death. We recently developed a new method (neuECG) to non-invasively measure electrocardiogram and skin sympathetic...
Tue Jun 23, 2020 14:16
Related Articles Disordered Leptin signaling in the retrotrapezoid nucleus is associated with the impaired hypercapnic ventilatory response in obesity. Life Sci. 2020 Jun 19;:117994 Authors: Wei Z, Hao Y, Yu H, Shi L, Jing X, Zhang X, Liu N, Li T, Zhang X, Yuan F Abstract Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary...
Tue Jun 23, 2020 14:16
Related Articles Current Management of CPAP After Otologic and Neurotologic Surgery. Otol Neurotol. 2020 Jun 19;: Authors: Cass ND, Babu SC Abstract BACKGROUND: Obstructive sleep apnea is a highly prevalent disorder often treated with continuous positive airway pressure (CPAP). CPAP transmits high pressures through the Eustachian tube, and has significant implications for patients undergoing surgery of the middle ear, inner ear, and lateral...
Tue Jun 23, 2020 14:16
Related Articles Sleep Apnea Screening for Commercial Drivers: A retrospective comparison of the 2016 FMCSA MRB Recommendations and the 2006 Joint Task Force Consensus Guidelines. J Occup Environ Med. 2020 Jun 16;: Authors: Wilcox C, Yang J, Filler R, Chen PH, Hyun YJ, Rielly A, Kales SN Abstract OBJECTIVE: Compare the 2016 Federal Motor Carrier Safety Administration (FMCSA) and 2006 Joint Task Force (JTF) Guidelines for commercial drivers'...
Tue Jun 23, 2020 14:16
Related Articles Obstructive Sleep Apnea In a Lean Child with Type 1 Diabetes: Is It Linked to Diabetes? Endocr Pract. 2020 Jun;26(6):691 Authors: Gourgari E, Phull G, Konstantinopoulou S PMID: 32568570 [PubMed - as supplied by publisher]
Tue Jun 23, 2020 14:16
Related Articles Effect of Nocturnal Oxygen Therapy on Nocturnal Hypoxemia and Sleep Apnea Among Patients With Chronic Obstructive Pulmonary Disease Traveling to 2048 Meters: A Randomized Clinical Trial. JAMA Netw Open. 2020 Jun 01;3(6):e207940 Authors: Tan L, Latshang TD, Aeschbacher SS, Huber F, Flueck D, Lichtblau M, Ulrich S, Hasler ED, Scheiwiller PM, Ulrich S, Bloch KE, Furian M Abstract Importance: There are no established measures to...
Tue Jun 23, 2020 14:16
Related Articles Adult Palatopharyngoplasty: Trends in Morbidity and Mortality from the NSQIP Database. Ann Otol Rhinol Laryngol. 2020 Jun 21;:3489420936711 Authors: Gates C, Ramadan J, Coutras S, Carr M Abstract OBJECTIVES: Describe the postop morbidity of adults undergoing palatopharyngoplasty (PPP). METHOD: Adults who underwent PPP were studied using ACS-NSQIP (American College of Surgeons National Surgical Quality Improvement Program)...
Tue Jun 23, 2020 14:16
Related Articles Sleep apnea and atrial fibrillation - A different kind of rhythm. Int J Cardiol Heart Vasc. 2020 Aug;29:100548 Authors: Sousa S, Silva Cunha P, Oliveira MM, Drummond M, Bugalho A PMID: 32566720 [PubMed]
Tue Jun 23, 2020 14:16
Related Articles Nasopharyngeal Vascular Hamartoma in a Dog. Case Rep Vet Med. 2020;2020:9716179 Authors: Judy AN, Krebs AI, Haynes J, Kieves NR Abstract An 8-year-old spayed female 32 kg Labrador retriever was presented for further investigation into the underlying cause of dyspnea, stertor, and sleep apnea present for three months and worsening over 30 days. There were significant reduction in airflow through the nares and loud inspiratory...
Tue Jun 23, 2020 14:16
Related Articles Sleep-disordered Breathing and Free Fatty Acid Metabolism. Chest. 2020 Jun 18;: Authors: Stefanovski D, Boston R, Punjabi NM Abstract BACKGROUND: Sleep-disordered breathing (SDB) is independently associated with insulin resistance, glucose intolerance, and type 2 diabetes mellitus. However, the data on whether SDB alters metabolism of free fatty acids (FFA) are lacking. RESEARCH QUESTION: The primary objective of the...
Tue Jun 23, 2020 14:16
Related Articles Assessment and Management of Postoperative Pain Associated with Sleep Apnea Surgery. Otolaryngol Clin North Am. 2020 Jun 18;: Authors: Waxman JA, Shenouda KG, Lin HS Abstract A literature review was conducted regarding the assessment and treatment of postoperative pain following surgery for obstructive sleep apnea (OSA). Given the risks of opioid use by patients with OSA, special attention to opioid risk reduction and avoidance...
Tue Jun 23, 2020 14:16
Related Articles Obstructive sleep apnea and nonalcoholic fatty liver disease: do we need to consider this association in current clinical practice? Sleep Med. 2020 May 20;: Authors: Labarca G, Horta G PMID: 32564917 [PubMed - as supplied by publisher]
Tue Jun 23, 2020 14:16
Related Articles A Review of Research Studies on Sleep-Disordered Breathing in Children Relevant to Dental Professionals. Compend Contin Educ Dent. 2020 Jun;41(6):e1-e13 Authors: Bergersen EO Abstract This article provides an overview of research available on sleep-disordered breathing (SDB) in the pediatric patient. People with SDB have symptoms of primary snoring, mouth breathing, and interrupted breathing (hypopnea). Most SBD research has...
Tue Jun 23, 2020 14:16
Related Articles Rapid Eye Movement-related Sleep-disordered Breathing and Cardiovascular Risk: Additional Clarity or More Questions? Ann Am Thorac Soc. 2020 05;17(5):559-560 Authors: Strollo PJ, Olafiranye O, Peker Y PMID: 32356692 [PubMed - indexed for MEDLINE]
Tue Jun 23, 2020 14:16
Related Articles Cardiovascular Benefits of Continuous Positive Airway Pressure: The Quest Continues…. Ann Am Thorac Soc. 2020 04;17(4):427-428 Authors: Mansukhani MP, Vungarala S, Somers VK PMID: 32233859 [PubMed - indexed for MEDLINE]
Tue Jun 23, 2020 14:16
Related Articles More Than Obstruction: Rethinking Obesity Hypoventilation? Ann Am Thorac Soc. 2020 03;17(3):282-283 Authors: Randerath W PMID: 32108498 [PubMed - indexed for MEDLINE]
Tue Jun 23, 2020 14:16
Related Articles Response to: Respiratory muscle dysfunction in facioscapulohumeral muscular dystrophy. Letter to the editor-reference article: sleep-related breathing disorders in facioscapulohumeral dystrophy (https://doi.org/10.1007/s11325-019-01843-1) by Santos DB et al. Sleep Breath. 2020 06;24(2):675-676 Authors: Runte M, Spiesshoefer J, Heidbreder A, Dreher M, Young P, Brix T, Boentert M PMID: 31853834 [PubMed - indexed for MEDLINE]
Tue Jun 23, 2020 14:16
Related Articles Respiratory muscle dysfunction in facioscapulohumeral muscular dystrophy : Reference article: Sleep-related breathing disorders in facioscapulohumeral dystrophy (https://doi.org/10.1007/s11325-019-01843-1). Sleep Breath. 2020 06;24(2):603-604 Authors: Santos DR, Boussaid G, Stojkovic T, Behin A, Orlikowski D, Lofaso F, Prigent H, Letilly N, Butel S PMID: 31853833 [PubMed - indexed for MEDLINE]
Tue Jun 23, 2020 14:16
Related Articles CPAP adherence and cardiovascular disease: beware of the healthy adherer effect. Sleep Breath. 2020 06;24(2):599-600 Authors: Kunisaki KM PMID: 31054092 [PubMed - indexed for MEDLINE]
Tue Jun 23, 2020 14:16
Related Articles Response to letter entitled "CPAP adherence and cardiovascular disease: beware of the healthy adherer effect". Sleep Breath. 2020 06;24(2):601-602 Authors: Myllylä M, Hammais A, Stepanov M, Anttalainen U, Saaresranta T, Laitinen T PMID: 31030391 [PubMed - indexed for MEDLINE]
Tue Jun 23, 2020 14:16
Background: A new liquid levothyroxine (LT4) dissolved in glycerol and water has recently been developed by a Greek pharmaceutical company (Uni-Pharma, Athens, Greece). Objectives: To evaluate the therapeutic equivalence of this new liquid LT4 preparation versus the already existing tablet formulation of the same manufacturer, in order to obtain approval by the Greek National Organization for Medicines. Methods: This was a prospective, randomized, cross-over phase III study. The study included 50...
Tue Jun 23, 2020 10:08
Abstract Generating high levels of muscular strength and power are important for success in sport and may have long-term implications for sporting careers in youth athletes. Importantly, maturation may confound the neuromuscular adaptations to resistance training when attempting to differentiate between training- vs. growth-induced strength and power gains; thus, potentially leading to erroneous conclusions regarding the efficacy of resistance training in youth athletes. The aim...
Tue Jun 23, 2020 03:00
Related Articles Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions. J Vis Exp. 2020 Jun 07;(160): Authors: Dror S, Meidan TD, Karady I, Ben-Zvi A Abstract Correct folding and assembly of proteins and protein complexes are essential for cellular function. Cells employ quality control pathways that correct, sequester or eliminate damaged proteins to maintain a healthy proteome, thus ensuring cellular proteostasis...
Tue Jun 23, 2020 18:08
Related Articles Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions. J Vis Exp. 2020 Jun 04;(160): Authors: Sinyuk M, Williams JL Abstract The methods presented here demonstrate laboratory procedures for the dissection of four different regions of the central nervous system (CNS) from murine neonates for the isolation of glial subpopulations. The purpose of the procedure is to dissociate microglia, oligodendrocyte...
Tue Jun 23, 2020 18:08
Related Articles Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. J Vis Exp. 2020 Jun 05;(160): Authors: Llewellyn SV, Conway GE, Shah UK, Evans SJ, Jenkins GJS, Clift MJD, Doak SH Abstract Due to the rapid development and implementation of a diverse array of engineered nanomaterials (ENM), exposure to ENM is inevitable and the development of robust, predictive in vitro test systems is...
Tue Jun 23, 2020 18:08
Related Articles Assessment of Memory Function in Pilocarpine-induced Epileptic Mice. J Vis Exp. 2020 Jun 04;(160): Authors: Park KM, Kim JE, Choi IY, Cho KO Abstract Cognitive impairment is one of the most common comorbidities in temporal lobe epilepsy. To recapitulate epilepsy-associated cognitive decline in an animal model of epilepsy, we generated pilocarpine-treated chronic epileptic mice. We present a protocol for three different...
Tue Jun 23, 2020 18:08
Related Articles Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids. J Vis Exp. 2020 Jun 05;(160): Authors: van Ineveld RL, Ariese HCR, Wehrens EJ, Dekkers JF, Rios AC Abstract Organoid technology, in vitro 3D culturing of miniature tissue, has opened a new experimental window for cellular processes that govern organ development and function as well as disease. Fluorescence microscopy has played a major role in characterizing...
Tue Jun 23, 2020 18:08
Related Articles Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells. J Vis Exp. 2020 Jun 05;(160): Authors: Sun X, Yang X, Zeng C, Attia Koutb Megahed F, Zhou Q, Liu T, Iqbal W, Sun P, Zhou X Abstract HBV mainly infects human hepatocytes, but it has also been found to infect extrahepatic tissues such as kidney and testis. Nonetheless, cell-based HBV models are limited to hepatoma cell lines (such as HepG2 and Huh7) overexpressing...
Tue Jun 23, 2020 18:08
Related Articles Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging. J Vis Exp. 2020 Jun 07;(160): Authors: Geisler JA, Spehar JM, Steck SA, Bratasz A, Shakya R, Powell K, Sizemore GM Abstract Metastatic spread of cancer is an unfortunate consequence of disease progression, aggressive cancer subtypes, and/or late diagnosis. Brain metastases are particularly devastating, difficult to treat, and confer...
Tue Jun 23, 2020 18:08
Related Articles Increasing Durability of Dissociated Neural Cell Cultures Using Biologically Active Coralline Matrix. J Vis Exp. 2020 Jun 03;(160): Authors: Weiss OE, Hendler RM, Baranes D Abstract Cultures of dissociated hippocampal neuronal and glial cells are a valuable experimental model for studying neural growth and function by providing high cell isolation and a controlled environment. However, the survival of hippocampal cells...
Tue Jun 23, 2020 18:08
Related Articles Modified Methods for Loading of High-Throughput DNA Extraction Plates Reduce Potential for Contamination. J Vis Exp. 2020 Jun 03;(160): Authors: Custer GF, Dibner RR Abstract High-throughput DNA sequencing techniques have contributed substantially to advances in our understanding of relationships among microbial communities, host characteristics, and broader ecosystem functions. With this rapid increase in breadth and depth...
Tue Jun 23, 2020 18:08
Related Articles Circadian Entrainment of Drosophila Melanogaster. J Vis Exp. 2020 Jun 03;(160): Authors: Dada AO, Nguyen MQ, Peterson SM, Ngo VT, Cornelio-Parra DV, Omer BS, Thapa A, Rapp SR, Cloud VJ, Mohan RD Abstract Nearly universal among organisms, circadian rhythms coordinate biological activity to earth's orbit around the sun. To identify factors creating this rhythm and to understand the resulting outputs, entrainment of model...
Tue Jun 23, 2020 18:08
Related Articles A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig. J Vis Exp. 2020 Jun 04;(160): Authors: Valenzuela CV, Lee C, Buchman CA, Lichtenhan JT Abstract Endolymphatic hydrops is an enlargement of scala media that is most often associated with Meniere's disease, though the pathophysiologic mechanism(s) remain unclear. In order to adequately study the attributes of endolymphatic hydrops, such as the...
Tue Jun 23, 2020 18:08
Related Articles TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis. J Vis Exp. 2020 Jun 08;(160): Authors: Suzuki-Hatano S, Tsai AC, Daugherty A, Pacak CA Abstract Proteomic technologies are powerful methodologies that can aid our understanding of mechanisms of action in biological systems by providing a global view of the impact of a disease, treatment, or other condition on the proteome as a whole....
Tue Jun 23, 2020 18:08
Related Articles Enforced Activation of Enhancer RNAs In Situ through the dCas9 Synergistic Activation Mediator System. J Vis Exp. 2020 Jun 05;(160): Authors: Liao Z, Lee JH, Krakowiak J, Wang R, Li W Abstract Enhancers are pivotal genomic elements scattered through the mammalian genome and dictate tissue-specific gene expression programs. Increasing evidence has shown that enhancers not only provide DNA binding motifs for transcription...
Tue Jun 23, 2020 18:08
Related Articles Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens. J Vis Exp. 2020 Jun 06;(160): Authors: Sharma S, Wright GJ Abstract Intercellular communication mediated by direct interactions between membrane-embedded cell surface receptors is crucial for the normal development and functioning of multicellular organisms. Detecting these interactions remains technically challenging, however. This manuscript...
Tue Jun 23, 2020 18:08
Related Articles Measurement of Chladni Mode Shapes with an Optical Lever Method. J Vis Exp. 2020 Jun 05;(160): Authors: Feng R, Luo Y, Dong Y, Ma M, Wang Y, Zhang J, Ma W, Liu D Abstract Quantitatively determining the Chladni pattern of an elastic plate is of great interest in both physical science and engineering applications. In this paper, a method of measuring mode shapes of a vibrating plate based on an optical lever method is proposed....
Tue Jun 23, 2020 18:08
Related Articles Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization. J Vis Exp. 2020 Jun 04;(160): Authors: Zeng Z, Nallan Chakravarthula T, Alves NJ Abstract Thrombosis is a leading cause of death worldwide. Fibrin(ogen) is the protein primarily responsible for clot formation or thrombosis. Therefore, characterizing fibrin clot formation is beneficial to the study of thrombosis. Turbidity and thromboelastography...
Tue Jun 23, 2020 18:08
Related Articles A Gnotobiotic System for Studying Microbiome Assembly in the Phyllosphere and in Vegetable Fermentation. J Vis Exp. 2020 Jun 03;(160): Authors: Miller ER, O'Mara Schwartz J, Cox G, Wolfe BE Abstract The phyllosphere, the above ground portion of the plant that can be colonized by microbes, is a useful model system to identify processes of microbial community assembly. This protocol outlines a system for studying microbial...
Tue Jun 23, 2020 18:08
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