Medicine by Alexandros G. Sfakianakis

A 23-year-old man with left lung atelectasis treated with a targeted segmental recruitment maneuver: a case report

Lung atelectasis are nonventilated parts of lung tissue and occur as a result of the collapse of the pulmonary parenchyma (alveoli). Various therapeutic procedures for inflating the collapsed pulmonary parench...

A 95-year-old patient with unexpected coronavirus disease 2019 masked by aspiration pneumonia: a case report

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Severe acute respiratory syndrome coronavirus-2 infection has become a pandemic disease (coronavirus disease 2019). The infection has moved from China to the rest of the world and Italy represents one of the m...

Investigation of Burkholderia cepacia complex bacteremia outbreak in a neonatal intensive care unit: a case series

Tue Jun 23, 2020 03:00

Burkholderia cepacia complex is a ubiquitous organism with a high virulence potential. It is found most commonly in moist environments. Hospital outbreaks have been reported from diverse sources such as contamina...

Immunoglobulin M (IgM) multiple myeloma versus Waldenström macroglobulinemia: diagnostic challenges and therapeutic options: two case reports

Tue Jun 23, 2020 03:00

Immunoglobulin M multiple myeloma and Waldenström macroglobulinemia are two different hematological diseases with the common finding of an immunoglobulin M monoclonal gammopathy of unknown significance. Howeve...

Mon Jun 22, 2020 03:00

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The optimal management of Seymour fractures in children and adolescents: a systematic review protocol

Seymour fractures are open, displaced juxta-epiphyseal fractures of the distal phalanx, with an overlying nail bed laceration that occur in children and adolescents with an open physis. This fracture occurs ra...

Harms associated with gambling: abbreviated systematic review protocol

Tue Jun 23, 2020 03:00

According to the Gambling Commission, in 2018, almost half of the general population aged 16 and over had participated in gambling in the 4 weeks before being surveyed. Such surveys suggest that the proportion...

Velamentous cord insertion: results from a rapid review of incidence, risk factors, adverse outcomes and screening

Tue Jun 23, 2020 03:00

Velamentous cord insertion (VCI) is an umbilical cord attachment to the membranes surrounding the placenta instead of the central mass. VCI is strongly associated with vasa praevia (VP), where umbilical vessel...

International journal of basic and clinical endocrinology

Tue Jun 23, 2020 03:00

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Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing’s syndrome

International journal of basic and clinical endocrinology

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International Journal of Primatology

Geophagy in Wild Yellow-Tailed Woolly Monkeys ( Lagothrix flavicauda ) Is Brief and Rare

Abstract Many primates intentionally consume earth. This geophagy has probable health benefits, such as mineral supplementation or gastrointestinal tract protection, and is likely to be an important behavior for a species’ ecology, health, diet, and conservation. We investigated geophagy in the Critically Endangered yellow-tailed woolly monkey (Lagothrix flavicauda). We collected observational data and camera trap records over 2 years at La Esperanza study site, northern Peru....

International Journal of Primatology

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Composition of Caenorhabditis elegans extracellular vesicles suggests roles in metabolism, immunity, and aging

Abstract The nematode Caenorhabditis elegans has been instrumental in the identification of evolutionarily conserved mechanisms of aging. C. elegans also has recently been found to have evolutionarily conserved extracellular vesicle (EV) signaling pathways. We have been developing tools that allow for the detailed study of EV biology in C. elegans. Here we apply our recently published method for high specificity purification of EVs from C. elegans to carry out target-independent...

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity

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Abstract Species longevity varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of longevity could converge in the mammalian target of rapamycin (mTOR) signalling pathway. The present study focuses on the comparative approach in heart tissue from 8 mammalian species with a ML ranging from 3.5 to 46 years. Gene expression, protein content, and concentration...

Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition

Tue Jun 23, 2020 03:00

Abstract The unprecedented COVID-19 pandemic is rapidly and unpredictably evolving and the majority of deaths are occurring in older people. A partial description of the magnitude of the scenario is provided by numbers and statistics, which probably underestimate the ongoing tragedy. In the present opinion paper, we have focused our attention on the evidence of the relationship among malnutrition, immunosenescence, and the higher morbidity and mortality in elderly patients. In...

Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways

Tue Jun 23, 2020 03:00

Abstract Freshwater polyps of the genus Hydra do not age. However, temperature stress induces aging and a shift from reproduction by asexual budding to sexual gamete production in a cold-sensitive (CS) strain of H. oligactis. We sequenced the transcriptome of a male CS strain before and after this life history shift and compared changes in gene expression relative to those seen in a cold-resistant (CR) strain that does not undergo a life history shift in response to altered temperature....

Tue Jun 23, 2020 03:00

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Reply to: Diversity, not Divisiveness, is the Future of Nuclear Medicine

Diversity, not Divisiveness, is the Future of Nuclear Medicine

Tue Jun 23, 2020 19:19

Peptide Receptor Radionuclide Therapy (PRRT) during the COVID-19 pandemic: are there any concerns?

Tue Jun 23, 2020 19:19

Reply to LTE: COVID-19 and pulmonary embolism: diagnostic imaging trends

Tue Jun 23, 2020 19:19

Tue Jun 23, 2020 19:19

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Clinical Trial on Mindfulness with Family Caregivers for Patients with Cancer

Abstract To examine the effectiveness of a brief mindfulness-based interventions (MBIs) and educational interventions (EI) on self-efficacy and burden among family caregivers (FCs) of patients with cancer in Jordan. A quasi-experimental design was conducted. Two interventions were performed: the brief MBIs and the EIs were applied. A sampling of 138 FCs completed the study interventions. The FCs in the mindfulness group demonstrated a significant improvement in measures of self-efficacy...

Medicare Decision-making, Understanding, and Satisfaction Among Cancer Survivors

Tue Jun 23, 2020 03:00

Abstract With increased age as a leading risk factor for cancer, many patients depend on Medicare benefits to manage their disease. As such, this study explores (1) Medicare decision-making, (2) Medicare satisfaction, and (3) understanding of Medicare coverage among cancer patients. This cross-sectional study used focus group and survey methodology to explore patient decision-making regarding Medicare benefit selection and patient understanding and satisfaction of Medicare. Focus...

Awareness Levels of the Link Between Oropharyngeal Cancer and HPV Infection Among Spanish Women: a Hospital-Based Cross-sectional Study

Tue Jun 23, 2020 03:00

Abstract Several observational studies have demonstrated the increased awareness of human papillomavirus (HPV) as an etiological factor of oropharyngeal cancers (OPCs). The incidence of OPCs has increased in recent times, particularly among younger women, and the efficacy of the HPV vaccine in preventing these cancers has gained attention among the medical community. The aim of this study was to explore the health literacy of Spanish adult women regarding factors associated with...

Kommunikative Kompetenz bei Mehrsprachigkeit und komplexer Kommunikationsbeeinträchtigung ermöglichen

Tue Jun 23, 2020 03:00

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Sprache · Stimme · Gehör

Sprache · Stimme · GehörDOI: 10.1055/a-1161-1277Alternative and Augmentative Communication (AAC) is demanding a stronger inclusion of multilingualism. The implementation therefor is aggravated by the lack of multilingual communication aids and difficult collaboration with parental home. The German-Arabic communication aids demonstrate ways in which aspects of language acquisition theory and features of communicative competence can be conveyed. These can be used to encourage multilingualism. Additionally,...

Sprache · Stimme · Gehör

Tue Jun 23, 2020 02:00

Kooperative, kompetenzorientierte und spezifische Diagnostik in Unterstützter Kommunikation: soziale Partizipation von Anfang an im Blick

Sprache · Stimme · GehörDOI: 10.1055/a-1161-1208© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text

Sprache · Stimme · Gehör

Tue Jun 23, 2020 02:00

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Clinical Cancer Research Online First Articles

Integrating immunotherapy and targeted therapy in cancer treatment: Mechanistic insights and clinical implications

Small molecule targeted therapies have demonstrated outstanding potential in the clinic. These drugs are designed to minimize adverse effects by selectively attacking cancer cells while exerting minimal damage to normal cells. Although initial response to targeted therapies may be high, yielding positive response rates and often improving survival for an important percentage of patients, resistance often limits long-term effectiveness. On the other hand, immunotherapy has demonstrated durable results,...

Clinical Cancer Research Online First Articles

Tue Jun 23, 2020 16:24

The MD Anderson prostate cancer patient-derived xenograft series (MDA PCa PDX) captures the molecular landscape of prostate cancer and facilitates marker-driven therapy development

Background: Advances in prostate cancer (PCa) lag behind other tumor types partly due to the paucity of models reflecting key milestones in PCa progression. Objective: To develop clinically relevant PCa models. Design: Since 1996 we have generated clinically annotated patient-derived xenografts (PDXs) (the MDA PCa PDX series) linked to specific phenotypes reflecting all aspects of clinical PCa. Results: We studied two cell line-derived xenografts and the first 80 PDXs derived from 47 human PCa donors....

Clinical Cancer Research Online First Articles

Tue Jun 23, 2020 16:24

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Audiology

Audiology Groups Request Removal of Medicare Physician Order Requirement

Three national audiology assiociations sent a joint letter to the Centers for Medicare and Medicaid (CMS) requesting the removal of the Medicare physician order requirement. The Academy of Doctors of Audiology (ADA), the American Academy of Audiology (AAA), and the American Speech-Language-Hearing Association (ASHA) sent the letter on June 2."Our organizations request that CMS remove the requirement under Medicare that beneficiaries obtain a physician order prior to an appointment with an audiologist...

Audiology

Mon Jun 22, 2020 14:57

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Radiotherapy and Oncology

Letter to editor regarding Urban et al., FDG-PET/CT scan assessment of response 12 weeks post radical radiotherapy in oropharynx head and neck cancer: The impact of p16 status

We read with interest the recent publication from Urban et al. demonstrating the positive predictive value (PPV) of surveillance 12-week FDG-PET/CT is significantly lower in p16 positive tumours (between 26-31%), compared to p16 negative tumours[1]. These findings correlate with our published data on 155 patients reporting that 12-week surveillance FDG-PET/CT had a PPV of 30% for residual lymph node disease in p16 positive disease compared to 81.8% in p16 negative disease[2]. The growing evidence...

Radiotherapy and Oncology

Tue Jun 23, 2020 03:00

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Hormon- und Stoffwechselforschung

Correlation Between Serum TSH Levels Within Normal Range and Serum Lipid Profile

Horm Metab ResDOI: 10.1055/a-1191-7953The aim of the work was to investigate the correlation between serum TSH (thyrotropin) levels within normal range and serum lipids. A total of 1962 subjects with normal thyroid function were enrolled. The subjects were divided into four groups according to the quartiles of serum normal TSH levels, [Q1 (0.27–1.68) mIU/l, Q2 (1.69–2.35) mIU/l, Q3 (2.36–3.07)...

Hormon- und Stoffwechselforschung

Tue Jun 23, 2020 02:00

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Die Hörrehabilitation mittels Cochlea-Implantat – Eine Möglichkeit der Tinnitus-Reduktion im Alter

LaryngorhinootologieDOI: 10.1055/a-1190-4992 Hintergrund Tinnitus ist ein häufiges Begleitsymptom einer hochgradigen Hörminderung oder Ertaubung auch bei älteren Menschen. Die Hörrehabilitation dieser Patienten ist in der Regel nur noch mit einem Cochlea-Implantat (CI) möglich. In den letzten Jahren werden immer mehr ältere und sehr alte Patienten mit einem CI versorgt. Ziel dieser Studie war die Untersuchung des Einflusses der Hörrehabilitation mit einem CI auf die Tinnitus-Belastung...

Positionspapier: Anwendung von Biologika bei chronischer Rhinosinusitis mit Polyposis nasi (CRSwNP) im deutschen Gesundheitssystem – Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der AGs Klinische Immunologie, Allergologie und Umweltmedizin und Rhinologie und Rhinochirurgie der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC)

Tue Jun 23, 2020 02:00

LaryngorhinootologieDOI: 10.1055/a-1197-0136 Hintergrund Die chronische Rhinosinusitis (CRS) betrifft weltweit ca. 5–12 % der Allgemeinbevölkerung und wird traditionell eingeteilt in einen Phänotyp ohne (CRSsNP) und einen mit Ausbildung von Nasenpolypen (CRSwNP). Wurden Nasenpolypen bis vor kurzem eher als mechanisches Hindernis mit der Notwendigkeit einer operativen Beseitigung betrachtet, wird die CRSwNP heute als eine multifaktorielle entzündliche Erkrankung der nasalen und paranasalen...

Stellenwert des maschinellen Blutbildes bei der Diagnose der infektiösen Mononukleose durch EBV

Tue Jun 23, 2020 02:00

LaryngorhinootologieDOI: 10.1055/a-1190-4712 Einleitung Zur Abgrenzung einer EBV-Primärinfektion von einer bakteriellen Tonsillitis wird eine EBV-Serologie empfohlen. Schneller verfügbar ist, neben nur wenig zuverlässigen EBV-Schnelltests, ein instrumentelles Differenzialblutbild. Es wurde ausgewertet, ob sich hierbei bei bis zu 70 % mononukleär veränderten Lymphozyten signifikante Unterschiede zeigen und welche weiteren schnell verfügbaren klinischen Parameter eine Unterscheidung erleichtern....

Erkennungsraten von chemosensorisch evozierten Potenzialen bei gesunden und anosmischen Erwachsenen

Mon Jun 22, 2020 02:00

LaryngorhinootologieDOI: 10.1055/a-1190-4611 Hintergrund Die Detektionsrate von olfaktorischen chemosensorischen ereignisbezogenen EEG-Potenzialen (oCSERP) und trigeminalen chemosensorischen ereignisbezogenen EEG-Potenzialen (tCSERP) ist auch abhängig vom Reizstoff und vom Beurteiler der gemittelten EEG-Kurven. Methodik Es wurden bei 45 Probanden mit altersentsprechendem Riechvermögen (NP) und 20 Anosmikern (AN) oCSERP (Reizung mit Schwefelwasserstoff, H2S 6 ppm, und Phenylethylalkohol,...