Lung atelectasis are nonventilated parts of lung tissue and occur as a result of the collapse of the pulmonary parenchyma (alveoli). Various therapeutic procedures for inflating the collapsed pulmonary parench...
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Severe acute respiratory syndrome coronavirus-2 infection has become a pandemic disease (coronavirus disease 2019). The infection has moved from China to the rest of the world and Italy represents one of the m...
Tue Jun 23, 2020 03:00
Burkholderia cepacia complex is a ubiquitous organism with a high virulence potential. It is found most commonly in moist environments. Hospital outbreaks have been reported from diverse sources such as contamina...
Tue Jun 23, 2020 03:00
Immunoglobulin M multiple myeloma and Waldenström macroglobulinemia are two different hematological diseases with the common finding of an immunoglobulin M monoclonal gammopathy of unknown significance. Howeve...
Mon Jun 22, 2020 03:00
Seymour fractures are open, displaced juxta-epiphyseal fractures of the distal phalanx, with an overlying nail bed laceration that occur in children and adolescents with an open physis. This fracture occurs ra...
Tue Jun 23, 2020 03:00
According to the Gambling Commission, in 2018, almost half of the general population aged 16 and over had participated in gambling in the 4 weeks before being surveyed. Such surveys suggest that the proportion...
Tue Jun 23, 2020 03:00
Velamentous cord insertion (VCI) is an umbilical cord attachment to the membranes surrounding the placenta instead of the central mass. VCI is strongly associated with vasa praevia (VP), where umbilical vessel...
Tue Jun 23, 2020 03:00
Abstract Many primates intentionally consume earth. This geophagy has probable health benefits, such as mineral supplementation or gastrointestinal tract protection, and is likely to be an important behavior for a species’ ecology, health, diet, and conservation. We investigated geophagy in the Critically Endangered yellow-tailed woolly monkey (Lagothrix flavicauda). We collected observational data and camera trap records over 2 years at La Esperanza study site, northern Peru....
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Abstract The nematode Caenorhabditis elegans has been instrumental in the identification of evolutionarily conserved mechanisms of aging. C. elegans also has recently been found to have evolutionarily conserved extracellular vesicle (EV) signaling pathways. We have been developing tools that allow for the detailed study of EV biology in C. elegans. Here we apply our recently published method for high specificity purification of EVs from C. elegans to carry out target-independent...
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Abstract Species longevity varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of longevity could converge in the mammalian target of rapamycin (mTOR) signalling pathway. The present study focuses on the comparative approach in heart tissue from 8 mammalian species with a ML ranging from 3.5 to 46 years. Gene expression, protein content, and concentration...
Tue Jun 23, 2020 03:00
Abstract The unprecedented COVID-19 pandemic is rapidly and unpredictably evolving and the majority of deaths are occurring in older people. A partial description of the magnitude of the scenario is provided by numbers and statistics, which probably underestimate the ongoing tragedy. In the present opinion paper, we have focused our attention on the evidence of the relationship among malnutrition, immunosenescence, and the higher morbidity and mortality in elderly patients. In...
Tue Jun 23, 2020 03:00
Abstract Freshwater polyps of the genus Hydra do not age. However, temperature stress induces aging and a shift from reproduction by asexual budding to sexual gamete production in a cold-sensitive (CS) strain of H. oligactis. We sequenced the transcriptome of a male CS strain before and after this life history shift and compared changes in gene expression relative to those seen in a cold-resistant (CR) strain that does not undergo a life history shift in response to altered temperature....
Tue Jun 23, 2020 03:00
Tue Jun 23, 2020 19:19
Abstract To examine the effectiveness of a brief mindfulness-based interventions (MBIs) and educational interventions (EI) on self-efficacy and burden among family caregivers (FCs) of patients with cancer in Jordan. A quasi-experimental design was conducted. Two interventions were performed: the brief MBIs and the EIs were applied. A sampling of 138 FCs completed the study interventions. The FCs in the mindfulness group demonstrated a significant improvement in measures of self-efficacy...
Tue Jun 23, 2020 03:00
Abstract With increased age as a leading risk factor for cancer, many patients depend on Medicare benefits to manage their disease. As such, this study explores (1) Medicare decision-making, (2) Medicare satisfaction, and (3) understanding of Medicare coverage among cancer patients. This cross-sectional study used focus group and survey methodology to explore patient decision-making regarding Medicare benefit selection and patient understanding and satisfaction of Medicare. Focus...
Tue Jun 23, 2020 03:00
Abstract Several observational studies have demonstrated the increased awareness of human papillomavirus (HPV) as an etiological factor of oropharyngeal cancers (OPCs). The incidence of OPCs has increased in recent times, particularly among younger women, and the efficacy of the HPV vaccine in preventing these cancers has gained attention among the medical community. The aim of this study was to explore the health literacy of Spanish adult women regarding factors associated with...
Tue Jun 23, 2020 03:00
Sprache · Stimme · GehörDOI: 10.1055/a-1161-1277Alternative and Augmentative Communication (AAC) is demanding a stronger inclusion of multilingualism. The implementation therefor is aggravated by the lack of multilingual communication aids and difficult collaboration with parental home. The German-Arabic communication aids demonstrate ways in which aspects of language acquisition theory and features of communicative competence can be conveyed. These can be used to encourage multilingualism. Additionally,...
Tue Jun 23, 2020 02:00
Sprache · Stimme · GehörDOI: 10.1055/a-1161-1208© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Jun 23, 2020 02:00
Small molecule targeted therapies have demonstrated outstanding potential in the clinic. These drugs are designed to minimize adverse effects by selectively attacking cancer cells while exerting minimal damage to normal cells. Although initial response to targeted therapies may be high, yielding positive response rates and often improving survival for an important percentage of patients, resistance often limits long-term effectiveness. On the other hand, immunotherapy has demonstrated durable results,...
Tue Jun 23, 2020 16:24
Background: Advances in prostate cancer (PCa) lag behind other tumor types partly due to the paucity of models reflecting key milestones in PCa progression. Objective: To develop clinically relevant PCa models. Design: Since 1996 we have generated clinically annotated patient-derived xenografts (PDXs) (the MDA PCa PDX series) linked to specific phenotypes reflecting all aspects of clinical PCa. Results: We studied two cell line-derived xenografts and the first 80 PDXs derived from 47 human PCa donors....
Tue Jun 23, 2020 16:24
Three national audiology assiociations sent a joint letter to the Centers for Medicare and Medicaid (CMS) requesting the removal of the Medicare physician order requirement. The Academy of Doctors of Audiology (ADA), the American Academy of Audiology (AAA), and the American Speech-Language-Hearing Association (ASHA) sent the letter on June 2."Our organizations request that CMS remove the requirement under Medicare that beneficiaries obtain a physician order prior to an appointment with an audiologist...
Mon Jun 22, 2020 14:57
We read with interest the recent publication from Urban et al. demonstrating the positive predictive value (PPV) of surveillance 12-week FDG-PET/CT is significantly lower in p16 positive tumours (between 26-31%), compared to p16 negative tumours[1]. These findings correlate with our published data on 155 patients reporting that 12-week surveillance FDG-PET/CT had a PPV of 30% for residual lymph node disease in p16 positive disease compared to 81.8% in p16 negative disease[2]. The growing evidence...
Tue Jun 23, 2020 03:00
Horm Metab ResDOI: 10.1055/a-1191-7953The aim of the work was to investigate the correlation between serum TSH (thyrotropin) levels within normal range and serum lipids. A total of 1962 subjects with normal thyroid function were enrolled. The subjects were divided into four groups according to the quartiles of serum normal TSH levels, [Q1 (0.27–1.68) mIU/l, Q2 (1.69–2.35) mIU/l, Q3 (2.36–3.07)...
Tue Jun 23, 2020 02:00
LaryngorhinootologieDOI: 10.1055/a-1190-4992 Hintergrund Tinnitus ist ein häufiges Begleitsymptom einer hochgradigen Hörminderung oder Ertaubung auch bei älteren Menschen. Die Hörrehabilitation dieser Patienten ist in der Regel nur noch mit einem Cochlea-Implantat (CI) möglich. In den letzten Jahren werden immer mehr ältere und sehr alte Patienten mit einem CI versorgt. Ziel dieser Studie war die Untersuchung des Einflusses der Hörrehabilitation mit einem CI auf die Tinnitus-Belastung...
Tue Jun 23, 2020 02:00
LaryngorhinootologieDOI: 10.1055/a-1197-0136 Hintergrund Die chronische Rhinosinusitis (CRS) betrifft weltweit ca. 5–12 % der Allgemeinbevölkerung und wird traditionell eingeteilt in einen Phänotyp ohne (CRSsNP) und einen mit Ausbildung von Nasenpolypen (CRSwNP). Wurden Nasenpolypen bis vor kurzem eher als mechanisches Hindernis mit der Notwendigkeit einer operativen Beseitigung betrachtet, wird die CRSwNP heute als eine multifaktorielle entzündliche Erkrankung der nasalen und paranasalen...
Tue Jun 23, 2020 02:00
LaryngorhinootologieDOI: 10.1055/a-1190-4712 Einleitung Zur Abgrenzung einer EBV-Primärinfektion von einer bakteriellen Tonsillitis wird eine EBV-Serologie empfohlen. Schneller verfügbar ist, neben nur wenig zuverlässigen EBV-Schnelltests, ein instrumentelles Differenzialblutbild. Es wurde ausgewertet, ob sich hierbei bei bis zu 70 % mononukleär veränderten Lymphozyten signifikante Unterschiede zeigen und welche weiteren schnell verfügbaren klinischen Parameter eine Unterscheidung erleichtern....
Mon Jun 22, 2020 02:00
LaryngorhinootologieDOI: 10.1055/a-1190-4611 Hintergrund Die Detektionsrate von olfaktorischen chemosensorischen ereignisbezogenen EEG-Potenzialen (oCSERP) und trigeminalen chemosensorischen ereignisbezogenen EEG-Potenzialen (tCSERP) ist auch abhängig vom Reizstoff und vom Beurteiler der gemittelten EEG-Kurven. Methodik Es wurden bei 45 Probanden mit altersentsprechendem Riechvermögen (NP) und 20 Anosmikern (AN) oCSERP (Reizung mit Schwefelwasserstoff, H2S 6 ppm, und Phenylethylalkohol,...
Mon Jun 22, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00049C, PaperYanran Zhang, Yaqian Zhao, Lihan Shi , Li Zhang, Huifeng Du, hongmei huang, Yi Xiao, Youyu Zhang, Xiaoxiao He, Kemin WangConjugated polymers (CPs) can be fabricated into conjugated polymer nanoparticles of various shapes, thus tuning the hydrophobicity and sensing performances of the parent polymers. Herein, two new hydrophobic oligomeric CPs...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01046D, CommunicationKai Betlem, Francesco Canfarotta, Romain Raimbault, Craig E. Banks, Kasper Eersels, Bart Van Grinsven, Thomas Cleij, Robert Crapnell, Alexander D Hudson, Marloes PeetersIn this communication, molecularly imprinted nanoparticles (nanoMIPs) that are produced by solid-phase synthesis are functionalised onto thermistors via dip-coating. These thermistors are soldered onto a printed-circuit board to facilitate electrical...The content...
Tue Jun 23, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01085E, PaperZhongle Zhang, Yuan Luo, Xiaofeng Nie, Duli Yu, XiaoXing XingDielectrophoresis (DEP) is a powerful technique for label-free cell separation in microfluidics. Easily-fabricated DEP separtors with low cost and short turnaround time are extremely demanded in practical applications, especially the...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 23, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00808G, PaperYoon Ho Roh, Jiae Seo, Ju Yeon Kim, Hyeon Ung Kim, Seok Joon Mun, Ji-Hun Seo, Ki Wan BongDue to the growing interest in multiplex protein detection, encoded hydrogel microparticles have received attention as a possible path to high performance multiplex immunoassays through a combination of high multiplexing...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 23, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01049A, PaperYiping Wu, Yi Liu, Xuefei Tang, Zhengzhong Cheng, Honglin LiuIt is an important issue to develop novel sensors for simple, rapid, and quantitative detection of the residual antibiotics in food considering the potential threats on human health. Herein we...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 23, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00895H, PaperZian Lin, Kailong Luo, Baichuan Yang, Wenjing Guo, Qianqian Sun, Ouyang Dan, Zongwei CaiPolydopamine nanospheres (PDA) was designed to serve as a new substrate for surface-enhanced desorption/ionization mass spectrometry (SELDI-MS). In comparasion with conventional organic matrices, the PDA substrate showed superior LDI performance...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 23, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00378F, PaperLi Fan, Qi Zan, Bo Lin, Xiaodong Wang, Xiaojuan Gong, Zhonghua Zhao, Shaomin Shuang, Chuan Dong, Man Shing WongHypoxia in solid tumors is directly linked to the elevated levels of endogenous nitroreductase (NTR). We presented a novel fluorescent probe, namely NTNO for nitroreductase-specific detection based on the NTR-catalyzed...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 23, 2020 02:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05162
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05042
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02151
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04760
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03472
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05347
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06646
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04096
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05362
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05343
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04978
Tue Jun 23, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04404
Mon Jun 22, 2020 07:00
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Analytical ChemistryDOI: 10.1021/acs.analchem.0c00458
Tue Jun 23, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01292
Tue Jun 23, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00242
Tue Jun 23, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01545
Tue Jun 23, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01846
Tue Jun 23, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01519
Tue Jun 23, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01554
Tue Jun 23, 2020 07:00
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