Abstract Melanoma is a disease associated with a very high mutation burden and thus the possibility of a diverse range of oncogenic mechanisms that allow it to evade therapeutic interventions and the immune system. Here we describe the characterisation of a panel of 102 cell lines from metastatic melanomas (the NZM lines), including using whole‐exome and RNA sequencing to analyse genetic variants and gene expression changes in a subset of this panel. Lines possessing all major melanoma genotypes...
Mon Jun 22, 2020 15:00
Publication date: Available online 22 June 2020Source: Annals of Diagnostic PathologyAuthor(s):
Tue Jun 23, 2020 12:36
Background High‐dose, high‐volume steroid nasal irrigations (NSI) have been incorporated into the medical management of recalcitrant CRS, primarily following surgical intervention. The objective of this study was to evaluate the role of NSI as a preoperative management and to identify the percentage of patients who ultimately underwent ESS for recalcitrant CRS despite being on NSI. Methods Retrospective chart review of patients presenting with CRS who underwent a trial of NSI for at least...
Mon Jun 22, 2020 21:10
Background Post‐viral olfactory dysfunction (PVOD) is one of the most common causes of olfactory loss. Despite its prevalence, optimal treatment strategies remain unclear. This article provides a comprehensive review of PVOD treatment options and provides evidence‐based recommendations for their use. Methods A systematic review of the Medline, Embase, Cochrane, Web of Science, Scopus, and Google Scholar databases was completed according to the Preferred Reporting Items for Systematic Reviews...
Mon Jun 22, 2020 13:32
Background. Vascular calcification is common and associated with unfavorable outcomes among patients with end-stage renal disease (ESRD). Nevertheless, little is known whether the progression of vascular calcification outweighs the baseline calcification in association with overall and cardiovascular (CV) mortality in hemodialysis (HD) patients. Methods. This study included 140 maintenance HD patients. Vascular calcification was assessed using the aortic arch calcification (AoAC) score measured from...
Tue Jun 23, 2020 06:20
Abstract Numerical simulations of cardiovascular mass transport pose significant challenges due to the wide range of PĂ©clet numbers and backflow at Neumann boundaries. In this paper we present and discuss several numerical tools to address these challenges in the context of a stabilized finite element computational framework. To overcome numerical instabilities when backflow occurs at Neumann boundaries, we propose an approach based on the prescription of the total flux. In addition, we introduce...
Mon Jun 22, 2020 18:50
Abstract This report introduces an alternative clinical and laboratory technique for the direct fabrication of a custom post‐and‐core pattern using poly (vinyl siloxane) (PVS) occlusal registration material, followed by a digital workflow. This technique decreases chairside time, eliminates the risk of locking the pattern into the post space and improves accuracy of the custom post‐and‐core. This article is protected by copyright. All rights reserved
Mon Jun 22, 2020 14:05
Abstract Purpose To study the effect of implant analog system, print orientation, and analog holder radial offset on 3D linear and absolute angular distortions of implant analogs in 3D printed resin models. Materials and Methods A sectional master model simulating a 2‐implant, 3‐unit fixed prosthesis in a partially edentulous jaw was fabricated. Three implant analog systems for 3D printed resin models – Straumann (ST), Core3DCentres (CD) and Medentika (MD) – were tested. The corresponding...
Mon Jun 22, 2020 11:55
Objective: Determine the prevalence of clinical insomnia and its associations with anxiety, depression, and tinnitus in adult cochlear implant (CI) users. Design: Self-reported information on tinnitus, sleep, and demographic variables was collected from adult CI users (n = 127). Tinnitus presence, its persistence, related emotional distress, and difficulties with sleep were assessed using questions from the UK Biobank study (www.ukbiobank.ac.uk). Tinnitus-related handicap was assessed...
Tue Jun 16, 2020 03:00
Mon Jun 22, 2020 15:24
Objective There are no validated methods for predicting the timing of seizures. Using machine learning, we sought to forecast 24‐hour risk of self‐reported seizure from e‐diaries. Methods Data from 5,419 patients of SeizureTracker.com (including seizure count, type and duration) was split into training (3,806 patients/1,665,215 patient‐days) and testing (1,613 patients/549,588 patient‐days) sets with no overlapping patients. An artificial intelligence (AI) program, consisting recurrent networks...
Mon Jun 22, 2020 15:21
Mon Jun 22, 2020 16:04
The Journal of Antibiotics, Published online: 23 June 2020; doi:10.1038/s41429-020-0338-xBitter compounds in two Tricholoma species, T. aestuans and T. virgatum
Tue Jun 23, 2020 03:00
Background There is a lack of predictive markers informing on the risk of colitis in patients treated with immune checkpoint inhibitors (ICIs). The aim of this study was to identify potential factors associated with development of ICI colitis. Methods We performed a retrospective analysis of melanoma patients at Dana‐Farber Cancer Institute who received PD‐1, CTLA‐4, or combination ICIs between May 2011 to October 2017. Clinical and laboratory characteristics associated with pathologically...
Mon Jun 22, 2020 22:04
Abstract Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten‐related disorders. Both conditions can present with gastrointestinal and extraintestinal manifestations, which can be a challenge for physicians to discern between. Whilst coeliac serology and histological assessment are required for the diagnosis of CD, there are no clear biomarkers for the diagnosis of NCGS. The management of both conditions is with a gluten‐free diet (GFD), although...
Mon Jun 22, 2020 18:29
Mon Jun 22, 2020 20:50
Mon Jun 22, 2020 20:24
Objectives/Hypothesis Review safety and effectiveness of magnetic resonance imaging (MRI) of patients implanted with a cochlear implant (CI) containing a diametric magnet housed within the undersurface of the device. Study Design Retrospective chart review with additional review of MRI at a tertiary‐care children's hospital. Methods Seven patients with mean age of 8.4 years (range = 1.3–19 years) with a diametric magnet in situ during MRI. The intervention comprised one or more sessions...
Mon Jun 22, 2020 20:15
Objectives To explore the isolated or combined effects of cigarette smoke extract (CSE) and vibration on human vocal fold fibroblasts (hVFF) in an in vitro setting in order to elucidate their influence in the pathophysiology of Reinke's edema (RE). Study design Immortalized hVFF were exposed to CSE or control medium under static or vibrational conditions. A phonomimetic bioreactor was used to deliver vibrational patterns to hVFF over a period of 5 days. Methods Cytotoxicity was quantified...
Mon Jun 22, 2020 20:14
Objectives/Hypothesis The expiratory disproportion index (EDI) is the ratio of forced expiratory volume in 1 second divided by peak expiratory flow rate multiplied by 100. An elevated EDI (>50) can help differentiate upper airway stenosis from other dyspnea etiologies, but this has not been verified when considering body habitus. We hypothesize that the predictive value of elevated EDI in diagnosing airway stenosis will be lower in obese patients as compared to nonobese patients. Study Design...
Mon Jun 22, 2020 20:03
Abstract Objective To summarise the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarise results from recent INHANCE‐based publications updating our 2015 overview. Results 17 papers were published between 2015 and May 2020....
Mon Jun 22, 2020 19:48
Abstract Oral squamous cell carcinoma (OSCC) is a major subcategory of head and neck squamous cell carcinomas (HNSCC) and is currently the 6th highest cause of cancer mortality world‐wide (Bray et al., 2018; Siegel, Miller, & Jemal, 2019). Despite current treatments such as surgery with adjunctive radiation and chemotherapy, the 5‐year survival has remained at 50% for decades (Kumar, Nanavati, Modi, & Dobariya, 2016; Rivera, 2015). Most human solid cancers are believed to be driven by chronic...
Mon Jun 22, 2020 18:05
Abstract Objectives Although causal associations between oral leukoplakia (OL), oral squamous cell carcinoma (OSCC), and high‐risk human papillomavirus (HR‐HPV) have been speculated upon in several reports, conclusive evidence has not been presented. This study investigates whether the number of cases of HR‐HPV in OL has increased over time and whether the prevalence of HR‐HPV‐positive OL differs in various parts of the world. Patients and Methods A total of 432 patients with OL from Sweden,...
Mon Jun 22, 2020 18:03
Abstract We read with great interest recently published descriptive case‐control study by Gomes da Silva et al. evaluating orofacial parameters in systemic sclerosis (SSc) patients (Gomes da Silva et al., 2019). Oral manifestations of SSc are usual, however they are not part of the diagnostic criteria for this disease, whereas, oral manifestations are essential for the diagnosis of Sjögren's syndrome (SSj). SSc is complicated by xerostomia in up to 30–40% of SSc patients (Bajraktari et al., 2015;...
Mon Jun 22, 2020 15:20
Abstract Background Recently, insulin‐like growth factor‐1 (IGF‐1), forkhead box transcription factor (Fox) O1, and mechanistic target of rapamycin complex 1 (mTORC1) signalling have been introduced as key elements in acne pathogenesis. Objective To investigate the relationship between serum levels of IGF‐1, insulin‐like growth factor binding protein‐3 (IGFBP‐3), FoxO1 and mTORC1 and the components of metabolic syndrome (MS) and AV. Methods This prospective case‐control study was...
Mon Jun 22, 2020 13:26
Aplasia cutis congenita (ACC) associated with fetus papyraceus is a rare subtype of aplasia cutis categorized as type V in Frieden's classification. It is characterized by stellate lesions in a symmetrical distribution over the trunk and proximal extremities. Conservative treatment is recommended, but there is not a well‐defined therapeutic protocol. We report the case of a type V ACC in a preterm male newborn with lesions on the trunk and scalp successfully treated with topical 1% silver sulfadiazine...
Mon Jun 22, 2020 11:42
Mon Jun 22, 2020 11:38
Abstract Objectives The aim of this study was to identify prognostic factors affecting the survival of the low grade Mucoepidermoid carcinomas (MEC) without clinical‐radiological lymph node involvement (cN0) at the time of the initial work‐up and to determinate the therapeutic strategy for the neck dissection Materials and methods One hundred and fifty two patients with cN0 low‐grade MEC of salivary glands, were prospectively included in the RĂ©seau d’Expertise Français sur les Cancers ORL...
Mon Jun 22, 2020 11:09
Key points 495·Exercise is considered medicine, however the individual degree of responsiveness to a standardised dose of exercise is idiosyncratic. 495·Individual responsiveness between distinct exercise modalities and the genetic/environmental contributions to exercise response are not well understood. 495·In this novel randomised cross‐over design study, monozygotic and dizygotic twins, as pairs, underwent 3 months of resistance and endurance training, separated by a 3 month washout period,...
Mon Jun 22, 2020 15:10
A patient per patient comparison of MNBI (mean nocturnal baseline impedance) data in NERD patients with or without biliary reflux. Those with biliary reflux showed lower values. Abstract Background Mean nocturnal baseline impedance (MNBI) and postreflux swallow‐induced peristaltic wave (PSPW) index are novel impedance‐based markers of reflux, but the effect of bile reflux on these metrics is unknown. The aim of this study was to evaluate bile reflux, MNBI, and PSPW index in patients with...
Mon Jun 22, 2020 18:12
Mutation in MRVI1 associated with isolated familial achalasia caused by disturbed cGMP signaling pathway. Abstract Background Achalasia is a condition characterized by impaired function of esophageal motility and incomplete relaxation of the lower esophagus sphincter, causing dysphagia and regurgitation. Rare cases of early‐onset achalasia appear often in combination with further symptoms in a syndromic form as an inherited disease. Methods Whole genome sequencing was used to investigate...
Mon Jun 22, 2020 17:54
Gastrointestinal symptoms correlate with gut function, supporting the rationale for whole gut motility investigation. Autonomic neuronal impairment is involved in gastrointestinal dysfunction and symptoms. Insensitivity due to long‐term impairment of the neural function is involved in the symptom genesis and maintenance. Abstract Background Although gastrointestinal (GI) symptoms are common in diabetes, they frequently do not correlate with measurable sensorimotor abnormalities. The wireless...
Mon Jun 22, 2020 17:34
AbstractExposure of the oral cavity to acidic solutions evokes not only a sensation of sour, but also of sharp or tangy. Acidic substances potentially stimulate both taste buds and acid-sensitive mucosal free nerve endings. Mice lacking taste function (P2X2/P2X3 double-KO mice) refuse acidic solutions similarly to wildtype mice and intraoral infusion of acidic solutions in these KO animals evokes substantial c-Fos activity within orosensory trigeminal nuclei as well as of the nucleus of the solitary...
Tue Jun 23, 2020 03:00
The desired α‐FAPbI3 perovskite phase is stabilized by protecting it with a two‐dimensional (2D) IBA2FAPb2I7 (IBA=iso ‐butylammonium overlayer, formed via stepwise annealing. The α‐FAPbI3/IBA2FAPb2I7‐based perovskite solar cell (PSC) reached a high power conversion efficiency (PCE) of close to 23 %. It showed excellent operational stability, retaining around 85 % of its initial efficiency under severe combined heat and light stress. Abstract As a result of their attractive optoelectronic...
Mon Jun 22, 2020 22:53
A dual‐site catalyst coordinated with a stable bridge‐O modifier has been designed and synthesized, tailoring the d‐orbital electronic structure of Fe and weakening the binding energy of oxygen reduction reaction (ORR) intermediates. Thus, the catalytic activity climbs upward along the left side of the ORR volcano plot. Abstract The applications of the most promising Fe—N–C catalysts are prohibited by their limited intrinsic activities. Manipulating the Fe energy level through anchoring...
Mon Jun 22, 2020 22:53
Disorderly conduct : A crystal‐engineering strategy has been introduced to narrow the band gap of benchmark double perovskite Cs2AgBiBr6. The band gap of Cs2AgBiBr6 crystals can be reduced from 1.98 eV to 1.72 eV, reaching the smallest reported band gap for Cs2AgBiBr6 under ambient conditions. DFT calculations indicate that Ag–Bi disorder in the crystal structure could lead to band‐gap narrowing. Abstract Environmentally friendly halide double perovskites with improved stability are regarded...
Mon Jun 22, 2020 22:52
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