Abstract Heparan sulfate proteoglycans (HSPGs) act as signaling coreceptors by interactions of their sulfated glycosaminoglycan chains with numerous signaling molecules. In breast cancer, the function of heparan sulfate 2‐O‐sulfotransferase (HS2ST1 ), the enzyme mediating 2‐O‐sulfation of HS, is largely unknown. Hence, a comparative study on the functional consequences of HS2ST1 overexpression and siRNA knockdown was performed in the breast cancer cell lines MCF‐7 and MDA‐MB‐231. HS2ST1 overexpression...
Tue Jun 23, 2020 12:04
Abstract Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor cell centric‐view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed...
Tue Jun 23, 2020 12:04
Abstract Thalidomide and its analogues are known as immunomodulatory drugs (IMiDs) that possess direct anti‐myeloma effects, in addition to other secondary effects, including anti‐angiogenic, anti‐inflammatory and immuno‐modulatory effects. Although the involvement of NK cells in the anti‐tumor effects of IMiDs has been reported, it is unclear whether IMiDs inhibit cancer cell metastasis by regulating the anti‐tumor function of NK cells. In this study, we examined the protective effects of thalidomide...
Tue Jun 23, 2020 11:43
Related Articles OmpA of Klebsiella pneumoniae ATCC 13883 induces pyroptosis in HEp-2 cells, leading to cell-cycle arrest and apoptosis. Microbes Infect. 2020 Jun 19;: Authors: You HS, Lee SH, Kang SS, Hyun SH Abstract Klebsiella pneumoniae is an opportunistic pathogenic bacterium that commonly causes pneumonia in elderly people. OmpA, a toxin that is highly expressed in the outer membrane of the bacterium, is one of the primary factors...
Tue Jun 23, 2020 14:27
Related Articles Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS). J Toxicol Environ Health A. 2020 Jun 22;:1-21 Authors: Silva JDN, Monção NBN, de Farias RRS, Citó AMDGL, Chaves MH, Araújo MRS, Lima DJB, Pessoa C, Lima A, Araújo ECDC, Militão GCG, Costa MPD, Capasso R, Ferreira PMP Abstract Caatinga flora which are found in a poor...
Tue Jun 23, 2020 14:27
Related Articles Cumulative effects of ciprofloxacin and pilocarpine on cytotoxicity and G0 phase arrest in hepatoma-derived Hep G2 cell line. J Pharm Pharmacol. 2020 Jun 21;: Authors: Sadeghi L, Maleki S, Dehghan G Abstract OBJECTIVES: Uncontrolled cell proliferation was caused by multiple deficient pathways that inhibition of one pathway may result to activate an alternative pathway. Therefore, combination of drugs which targeted multiple...
Tue Jun 23, 2020 13:28
Related Articles TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy. Biomed Res Int. 2020;2020:1641340 Authors: Zhu H, Ding W, Wu J, Ma R, Pan Z, Mao X Abstract TRAF2 is a crucial adaptor protein involved in various signaling pathways. However, its biological functions in nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we found that TRAF2 was overexpressed...
Tue Jun 23, 2020 13:28
Related Articles A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment. Bone Joint Res. 2020 May;9(5):225-235 Authors: Peng X, Zhang C, Bao JP, Zhu L, Shi R, Xie ZY, Wang F, Wang K, Wu XT Abstract Aims: Inflammatory response plays a pivotal role in the pathophysiological process of intervertebral disc degeneration (IDD). A20 (also known as tumour necrosis factor...
Tue Jun 23, 2020 13:28
Related Articles Hydrogen Sulfide Promotes Cardiomyocyte Proliferation and Heart Regeneration via ROS Scavenging. Oxid Med Cell Longev. 2020;2020:1412696 Authors: Pei J, Wang F, Pei S, Bai R, Cong X, Nie Y, Chen X Abstract Neonatal mouse hearts can regenerate completely in 21 days after cardiac injury, providing an ideal model to exploring heart regenerative therapeutic targets. The oxidative damage by Reactive Oxygen Species (ROS) is one...
Tue Jun 23, 2020 13:28
Related Articles SATB2 knockdown decreases hypoxia-induced autophagy and stemness in oral squamous cell carcinoma. Oncol Lett. 2020 Jul;20(1):794-802 Authors: Dong W, Chen Y, Qian N, Sima G, Zhang J, Guo Z, Wang C Abstract Increasing evidence has suggested that special AT-rich sequence-binding protein 2 (SATB2) may be involved in the progression of numerous types of human cancer; however, the biological function of SATB2 in oral squamous...
Tue Jun 23, 2020 13:28
Related Articles Long non-coding RNA AC023794.4-201 exerts a tumor-suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker. Oncol Lett. 2020 Jul;20(1):774-784 Authors: Shen Z, Yuan J, Tong Q, Hao W, Deng H, Li Q, Zhou C, Hu Y, Xu J Abstract After the expression level of lncRNA AC023794.4-201 was upregulated in 2 laryngeal squamous cell carcinoma (LSCC) cell lines (AMC-HN-8 and TU-212) and...
Tue Jun 23, 2020 13:28
Related Articles MiR-181a functions as an oncogene by regulating CCND1 in multiple myeloma. Oncol Lett. 2020 Jul;20(1):758-764 Authors: Yan X, Gao M, Zhang P, Ouyang G, Mu Q, Xu K Abstract MicroRNA-181a (miR-181a) has been demonstrated to be upregulated in patients with multiple myeloma (MM). In several studies, miR-181a has been demonstrated to be significantly overexpressed in MM; however, its potential role in development and progression...
Tue Jun 23, 2020 13:28
Related Articles lncRNA KCNQ1OT1 knockdown inhibits colorectal cancer cell proliferation, migration and invasiveness via the PI3K/AKT pathway. Oncol Lett. 2020 Jul;20(1):601-610 Authors: Duan Q, Cai L, Zheng K, Cui C, Huang R, Zheng Z, Xie L, Wu C, Yu X, Yu J Abstract Colorectal cancer (CRC) is one of the most common primary malignancies worldwide. Numerous studies have demonstrated that long non-coding RNAs (lncRNAs) are considered as...
Tue Jun 23, 2020 13:28
Inhibitory effect of dihydromyricetin on the proliferation of JAR cells and its mechanism of action.
Related Articles Inhibitory effect of dihydromyricetin on the proliferation of JAR cells and its mechanism of action. Oncol Lett. 2020 Jul;20(1):357-363 Authors: Zuo Y, Lu Y, Xu Q, Sun D, Liang X, Li X, Li Y Abstract Dihydromyricetin (DMY) is a novel natural drug with antitumor activity against some cancer cells without obvious toxicity. Previously, its apoptotic effect on human choriocarcinoma was detected. The present study further investigated...
Tue Jun 23, 2020 13:28
Related Articles A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway. Cancer Cell Int. 2020;20:256 Authors: Tang L, Long J, Li K, Zhang X, Chen X, Peng C Abstract Background: Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma. Methods:...
Tue Jun 23, 2020 13:28
Related Articles Arctigenin inhibits proliferation of ER-positive breast cancer cells through cell cycle arrest mediated by GSK3-dependent cyclin D1 degradation. Life Sci. 2020 Jun 18;:117983 Authors: Zhu L, Shen XB, Yuan PC, Shao TL, Wang GD, Liu XP Abstract Estrogen receptor (ER) positive accounts for a large proportion of breast cancer. Although there are many targeted therapeutic drugs, the emergence of drug resistance urgently requires...
Tue Jun 23, 2020 13:28
Related Articles [Next generation of anti-immune checkpoints antibodies]. Med Sci (Paris). 2019 Dec;35(12):966-974 Authors: Bonnefoy N, Olive D, Vanhove B Abstract Immune checkpoints balance initial antigen-driven T cell stimulation by enhancing or dampening activation, allowing co-existence of efficient immune responses and maintenance of self-tolerance. In oncology, checkpoints currently targeted by inhibitors to amplify activity of T cell,...
Tue Jun 23, 2020 13:28
Related Articles [Toxicities of immune checkpoint inhibitors and their management]. Med Sci (Paris). 2019 Dec;35(12):949-956 Authors: Kostine M, Marabelle A, Schaeverbeke T, Kfoury M Abstract Immunotherapeutic strategies, notably immune checkpoint inhibitors, have become a standard of care for the treatment of advanced cancers, with a growing spectrum of activity. These monoclonal antibodies target the co-inhibitory signals between tumor cells...
Tue Jun 23, 2020 13:28
Related Articles [The revolution of immuno-oncology therapy: review of immune checkpoint inhibitors efficacy]. Med Sci (Paris). 2019 Dec;35(12):937-945 Authors: Dubois M, Ardin C, André F, Scherpereel A, Mortier L Abstract Immunotherapy represents a major paradigm shift, as the treatment no longer directly targets tumor cells, but the patient him/herself, in order to restore an effective anti-tumor immunity. This article illustrates the growing...
Tue Jun 23, 2020 13:28
Related Articles Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains. J Biol Chem. 2019 12 27;294(52):19907-19922 Authors: McNamar R, Abu-Adas Z, Rothblum K, Knutson BA, Rothblum LI Abstract Our knowledge of the mechanism of rDNA transcription has benefited from the combined application of genetic and biochemical techniques in yeast. Nomura's laboratory...
Tue Jun 23, 2020 13:28
Related Articles Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway. J Cell Physiol. 2019 12;234(12):22400-22410 Authors: Ma S, Liu T, Xu L, Wang Y, Zhou J, Huang T, Li P, Liu H, Zhang Y, Zhou X, Cui Y, Zang X, Wang Y, Guan F Abstract Esophageal squamous cell carcinoma (ESCC) is a malignant tumor with low survival rate, so new therapies are urgently...
Tue Jun 23, 2020 13:28
Related Articles CtIP is essential for early B cell proliferation and development in mice. J Exp Med. 2019 07 01;216(7):1648-1663 Authors: Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S Abstract B cell development requires efficient proliferation and successful assembly and modifications of the immunoglobulin gene products. CtIP is an essential gene implicated in end resection and DNA repair. Here, we...
Tue Jun 23, 2020 13:28
Related Articles Fuplatin: An Efficient and Low-Toxic Dual-Prodrug. J Med Chem. 2019 05 09;62(9):4543-4554 Authors: Zhang R, Song XQ, Liu RP, Ma ZY, Xu JY Abstract As FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To ameliorate their respective defects, a series of "dual-prodrug" by linking oxoplatin and 5-FU were designed and synthesized. The assembled...
Tue Jun 23, 2020 13:28
Related Articles An essential role for dNTP homeostasis following CDK-induced replication stress. J Cell Sci. 2019 03 25;132(6): Authors: Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R, Wilkins SE, Pfister SX, De León N, Schofield CJ, Bähler J, Carr AM, Humphrey TC Abstract Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent...
Tue Jun 23, 2020 13:28
Related Articles c-Rel is a cell cycle modulator in human melanoma cells. Exp Dermatol. 2019 02;28(2):121-128 Authors: Priebe MK, Dewert N, Amschler K, Erpenbeck L, Heinzerling L, Schön MP, Seitz CS, Lorenz VN Abstract Melanoma progression and resistance to therapy are associated with faulty regulation of signalling molecules including the central transcription factor NF-κB. Increased expression of the c-Rel subunit of NF-κB has been described...
Tue Jun 23, 2020 13:28
Related Articles CDC25A pathway toward tumorigenesis: Molecular targets of CDC25A in cell-cycle regulation. J Cell Biochem. 2019 03;120(3):2919-2928 Authors: Sadeghi H, Golalipour M, Yamchi A, Farazmandfar T, Shahbazi M Abstract The cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell-cycle phases during normal cell division, and in the case of DNA damage, they are key targets of the checkpoint machinery that ensure...
Tue Jun 23, 2020 13:28
Related Articles Barriers in accessing medical cannabis for children with drug-resistant epilepsy in Canada: A qualitative study. Epilepsy Behav. 2020 Jun 19;111:107120 Authors: Elliott J, DeJean D, Potter BK, Coyle D, Clifford T, McCoy B, Wells GA Abstract INTRODUCTION: The use of medical cannabis to treat drug-resistant epilepsy in children is increasing; however, there has been limited study of the experiences of parents with the current...
Tue Jun 23, 2020 16:53
Related Articles Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats. Neurosci Lett. 2020 Jun 19;:135162 Authors: Regner GG, Torres ILS, de Oliveira C, Pflüger P, da Silva LS, Scarabelot VL, Ströher R, de Souza A, Fregni F, Pereira P Abstract Despite the introduction of new antiepileptic drugs, about 30% of patients with epilepsy are...
Tue Jun 23, 2020 16:53
Related Articles Impairments in communication and social interaction in children with neurofibromatosis type 1: Characteristics and role of ADHD and language delay. Appl Neuropsychol Child. 2020 Jun 22;:1-6 Authors: Cohen R, Halevi A, Aharoni S, Aronson B, Diamond G Abstract Background: Neurofibromatosis type 1 (NF1) is a multisystem neurocutaneous disorder with increased risk of tumor formation and higher incidence of autism spectrum disorder...
Tue Jun 23, 2020 16:53
Related Articles The effect of normalization of sodium on bone turnover markers in patients with epilepsy. A randomized single-blinded placebo-controlled trial. Contemp Clin Trials Commun. 2020 Sep;19:100587 Authors: Diemar SS, Jørgensen NR, Eiken P, Suetta C, Andersen NB, Sejling AS Abstract Hyponatremia [p[Na]<136 mmol/L] is an independent risk factor for decreased bone mineral density (BMD). However, whether hyponatremia represents a surrogate...
Tue Jun 23, 2020 13:25
Related Articles Seizures in the Emergency Department: Clinical and diagnostic data from a series of 153 patients. Neurologia. 2020 Jun 18;: Authors: Gajate-García V, Gutiérrez-Viedma Á, Romeral-Jiménez M, Serrano-García I, Parejo-Carbonell B, Montalvo-Moraleda T, Valls-Carbó A, García-Morales I Abstract INTRODUCTION: Seizures are a frequent reason for admission to emergency departments and require early, precise diagnosis and treatment. The...
Tue Jun 23, 2020 13:25
Related Articles Two Different Manifestations of Neonatal Vascular Injury: Dyke-Davidoff-Masson Syndrome and Crossed Cerebellar Atrophy. J Stroke Cerebrovasc Dis. 2020 Mar;29(3):104600 Authors: Dilber B, Sahin S, Eyüboğlu I, Kamaşak T, Acar Arslan E, Durgut BD, Cansu A Abstract Dyke-Davidoff-Masson syndrome (DDMS) was first described in 1933 as a clinical condition characterized by hemiatrophy, hyperpneumatization of paranasal sinuses, contralateral...
Tue Jun 23, 2020 13:25
Related Articles The impact of neuropsychiatric disease on fetal growth: a case-control study. Arch Gynecol Obstet. 2019 12;300(6):1591-1600 Authors: Südekum L, Redlich A, Radusch A, Seeger S, Kropf S, Zhou L, Costa SD, Jorch G, Rissmann A Abstract PURPOSE: To determine the impact of depression, epilepsy and drug abuse during pregnancy on delivery and fetal outcome. Due to the worldwide increasing prevalence of neurological and psychiatric...
Tue Jun 23, 2020 13:25
Related Articles Nonacceptance of negative emotions in women with borderline personality disorder: association with neuroactivity of the dorsal striatum J Psychiatry Neurosci. 2019 09 01;44(5):303-312 Authors: Lamers A, Toepper M, Fernando SC, Schlosser N, Bauer E, Woermann F, Driessen M, Beblo T Abstract Background: Emotion dysfunction is a key symptom in patients with borderline personality disorder (BPD) and is considered a consequence of...
Tue Jun 23, 2020 13:25
Related Articles Perampanel Pharmacokinetics in Children: Correlation of Dose With Serum Concentrations. J Child Neurol. 2019 07;34(8):427-431 Authors: Gaudio E, Gienapp AJ, Wheless J Abstract Enzyme-inducing antiseizure drugs taken concomitantly with perampanel are known to influence perampanel serum concentrations. In this study, we examined perampanel dosage, serum concentrations, and the effect of concomitant enzyme-inducing antiseizure...
Tue Jun 23, 2020 13:25
Related Articles Reference dosimetry in MRI-linacs: evaluation of available protocols and data to establish a code of practice. Phys Med Biol. 2020 Jun 22;: Authors: de Pooter JA, Billas I, de Prez LA, Duane S, Kapsch RP, Karger C, van Asselen B, Wolthaus JWH Abstract With the rapid increase in clinical treatments with MRI-linacs, a consistent, harmonized and sustainable ground for reference dosimetry in MRI-linacs is needed. Specific for reference...
Tue Jun 23, 2020 14:51
Related Articles Global Surgery Electives: A Strategy to Improve Care to Domestic Underserved Populations? J Surg Res. 2020 Jun 19;255:247-254 Authors: Kauffmann RM, Neuzil K, Koch R, Terhune KP Abstract BACKGROUND: In the United States, a shortage of general surgeons exists, primarily in rural, poor, and minority communities. Identification of strategies that increase resident interest in underserved regions provides valuable information in...
Tue Jun 23, 2020 14:51
Related Articles The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer. Biomed Pharmacother. 2020 Jun 19;129:110401 Authors: Lukanović D, Herzog M, Kobal B, Černe K Abstract Ovarian cancer has the highest mortality rate among all gynecologic cancers, with most patients presenting with advanced stage tumors. About a third of patients do not respond to primary platinum-based...
Tue Jun 23, 2020 14:51
Related Articles Primary cell cultures for the personalized therapy in aggressive thyroid cancer of follicular origin. Semin Cancer Biol. 2020 Jun 19;: Authors: Fallahi P, Ferrari SM, Elia G, Ragusa F, Patrizio A, Paparo SR, Marone G, Galdiero MR, Guglielmi G, Foddis R, Cristaudo A, Antonelli A Abstract Thyroid cancer (TC) is the most prevalent endocrine malignancy. More than 90% of TC is represented by differentiated TC (DTC) arising from the...
Tue Jun 23, 2020 14:51
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