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Wednesday, June 24, 2020


Treatment and outcome in 12 cases of olfactory neuroblastoma at Mexico´s National Cancer Institute: A retrospective clinical analysis and literature review.
Related Articles Treatment and outcome in 12 cases of olfactory neuroblastoma at Mexico´s National Cancer Institute: A retrospective clinical analysis and literature review. Cir Cir. 2020;88(4):453-460 Authors: Navarro-Fernández JO, Serrato-Avila JL, Hernández-Varela M, Tejada-Pineda MF, Hernández-Reséndiz RE, Monroy-Sosa A, Cacho-Díaz B, Herrera-Gómez Á, Reyes-Soto G Abstract Introduction: Olfactory neuroblastoma (ONB) is a malignant neoplasm...
Skull Base
Tue Jun 23, 2020 18:07
Arachnoid prolapse in endoscopic transsphenoidal surgery of pituitary adenoma, technical note.
Related Articles Arachnoid prolapse in endoscopic transsphenoidal surgery of pituitary adenoma, technical note. Br J Neurosurg. 2020 Jun 22;:1-7 Authors: Sharifi G, Akbari Dilmaghani N, Sadrhosseini SM, Arastou S Abstract Purpose: An arachnoid prolapse after endoscopic transsphenoidal surgery for a pituitary adenoma is an uncommon, but important, phenomenon which should be managed. We have evaluated the efficacy of a new simple technique to...
Skull Base
Tue Jun 23, 2020 18:07
Surgical anatomy of the labyrinthine and subarcuate arteries and clinical implications.
Related Articles Surgical anatomy of the labyrinthine and subarcuate arteries and clinical implications. World Neurosurg. 2020 Jun 18;: Authors: Salgado-Lopez L, Pereira Leonel LC, Aydin SO, Peris-Celda M Abstract OBJECTIVE: To study the surgical anatomy of the labyrinthine artery (LA) and the subarcuate artery (SA) their anatomical relationships, and clinical implications as injury of the LA can result in hearing loss. METHODS: Ten...
Skull Base
Tue Jun 23, 2020 14:06
Predictors of Distant Metastasis and Survival in Adenoid Cystic Carcinoma of the External Auditory Canal.
Related Articles Predictors of Distant Metastasis and Survival in Adenoid Cystic Carcinoma of the External Auditory Canal. Otol Neurotol. 2019 12;40(10):e1006-e1011 Authors: Zhang Y, Liu H, Wu Q, Wang S, Dai C Abstract OBJECTIVE: To analyze the predictors of both distant metastasis and survival in patients with adenoid cystic carcinoma of the external auditory canal. STUDY DESIGN: Retrospective patient review. SETTING: A single...
Skull Base
Tue Jun 23, 2020 14:06
Direct targeting of the mouse optic nerve for therapeutic delivery.
Related Articles Direct targeting of the mouse optic nerve for therapeutic delivery. J Neurosci Methods. 2019 02 01;313:1-5 Authors: Mesentier-Louro LA, Dodd R, Domizi P, Nobuta H, Wernig M, Wernig G, Liao YJ Abstract BACKGROUND: Animal models of optic nerve injury are often used to study central nervous system (CNS) degeneration and regeneration, and targeting the optic nerve is a powerful approach for axon-protective or remyelination therapy....
Skull Base
Tue Jun 23, 2020 14:06
A lysosome-targeted ruthenium(II) polypyridyl complex as photodynamic anticancer agent.
Related Articles A lysosome-targeted ruthenium(II) polypyridyl complex as photodynamic anticancer agent. J Inorg Biochem. 2020 Jun 10;210:111132 Authors: Chen J, Tao Q, Wu J, Wang M, Su Z, Qian Y, Yu T, Wang Y, Xue X, Liu HK Abstract Polypyridyl ruthenium complexes as novel photosensitizers had drawn attention due to its high selectivity towards cancer cells and low toxicity to normal cells. Herein, we synthesized a lysosome-targeted polypyridyl...
pubmed: "j inorg biochem"[jo...
Tue Jun 23, 2020 18:09
Corrigendum to "Evaluation of the cell cytotoxicity and DNA/BSA binding and cleavage activity of some dioxidovanadium(V) complexes containing aroylhydrazones" [J. Inorg. Biochem. 144 (2015) 1-12].
Related Articles Corrigendum to "Evaluation of the cell cytotoxicity and DNA/BSA binding and cleavage activity of some dioxidovanadium(V) complexes containing aroylhydrazones" [J. Inorg. Biochem. 144 (2015) 1-12]. J Inorg Biochem. 2020 Jun 19;210:111135 Authors: Dash SP, Panda AK, Pasayat S, Majumder S, Biswas A, Kaminsky W, Mukhopadhyay S, Bhutia SK, Dinda R PMID: 32569883 [PubMed - as supplied by publisher]
pubmed: "j inorg biochem"[jo...
Tue Jun 23, 2020 18:09
An exploration of vestibular function pre and post unilateral cochlear implantation.
Related Articles An exploration of vestibular function pre and post unilateral cochlear implantation. Cochlear Implants Int. 2020 Jun 22;:1-11 Authors: Obeidat FS, Bell SL, Julie E Abstract Objectives: To examine the effects of unilateral cochlear implantation on the balance system for adult patients with bilateral severe to profound sensory neural hearing loss. Methods: 7 CI candidates. The function of the sacculus, utricle, and three...
British Cochlear Implant Group
Tue Jun 23, 2020 16:58
Phase 1 dose-escalation study of a novel oral PI3K/mTOR dual inhibitor, LY3023414, in patients with cancer
Summary LY3023414 is an oral, selective adenosine triphosphate-competitive inhibitor of class I phosphatidylinositol 3-kinase isoforms, mammalian target of rapamycin, and DNA-protein kinase in clinical development. We report results of a 3 + 3 dose-escalation Phase 1 study for twice-daily (BID) dosing of LY3023414 monotherapy in Japanese patients with advanced malignancies. The primary objective was to evaluate tolerability and safety of LY3023414. Secondary objectives were to...
Latest Results for Investigational New Drugs
Tue Jun 23, 2020 03:00
Correction to: Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B cell non-Hodgkin lymphoma
The original version of this article unfortunately contained an error. In the Conflict of interest statement, Anne-Marie Quinson is described as declaring no conflict of interest.
Latest Results for Investigational New Drugs
Tue Jun 23, 2020 03:00
Editorial Board
Publication date: June 2020Source: Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 31, Issue 2Author(s):
Otolaryngology-Head and Neck Surgery
Tue Jun 23, 2020 13:52
Effect of short-course glucocorticoid application on patients with chronic rhinosinusitis with nasal polyps.
Related Articles Effect of short-course glucocorticoid application on patients with chronic rhinosinusitis with nasal polyps. World Allergy Organ J. 2020 Jun;13(6):100131 Authors: Xu Z, Luo X, Xu L, Deng J, Gao W, Jiang L, Huang Z, Shi J, Lai Y Abstract Background: Local and systemic glucocorticoids are mainstay therapies for chronic rhinosinusitis. With respect to local glucocorticoids, nasal spray is used extensively, but some patients...
world allergy organ
Tue Jun 23, 2020 13:46
MORPHEUS: An automated tool for unbiased and reproducible cell morphometry.
Related Articles MORPHEUS: An automated tool for unbiased and reproducible cell morphometry. J Cell Physiol. 2020 Jun 21;: Authors: Ruffinatti FA, Genova T, Mussano F, Munaron L Abstract Here we present a new Fiji/ImageJ2 plugin called Multiparametric Morphometric Analysis of EUcaryotic cellS (MORPHEUS), designed for the automated evaluation of cell morphometry from images acquired by fluorescence microscopy. MORPHEUS works with sampling distributions...
pubmed: "j cell physiol"[jou...
Tue Jun 23, 2020 13:44
Observed versus modelled lifetime overall survival of targeted therapies and immunotherapies for advanced non-small cell lung cancer patients – a systematic review
Publication date: Available online 22 June 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Martijn Simons, Bram Ramaekers, Andrea Peeters, Joanne Mankor, Marthe Paats, Joachim Aerts, Wim van Harten, Valesca Retèl, Manuela Joore
Critical Reviews in Oncology/Hematology (open access)
Tue Jun 23, 2020 13:44
Clinical performance of titanium-zirconium implants with a hydrophilic surface in patients with controlled type 2 diabetes mellitus: 2-year results from a prospective case-control clinical study
Abstract Objective Analyze the 2-year clinical performance of single-unit titanium-zirconium (TiZr) alloy narrow-diameter (3.3 mm) dental implants with a hydrophilic surface (Straumann® Roxolid®, SLActive®) in patients with controlled type 2 diabetes mellitus (T2DM), measured using the glycated hemoglobin A (HbA1c) concentration test, compared with results in individuals without T2DM. ...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Differential skeletal and dental effects after orthodontic treatment with bite jumping appliance or activator: a retrospective cephalometric study
Abstract Objectives The aim of this retrospective cephalometric study was to compare treatment outcomes with “bite jumping appliance” (BJA) or Andresen-Häupl type activator. It especially focused on skeletal and dental structures in patients with class II malocclusion. The study hypothesis was that differences in treatment-related changes would occur between patients treated with BJA or activator. ...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Changes of the patient management in dentistry during the pandemic caused by the SARS-Coronavirus 2—initial perspectives of a clinic of operative dentistry in Europe
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Four-year clinical prospective follow-up of resin composite restoration after selective caries removal using Er:YAG laser
Abstract Objectives The aim of this study was to longitudinally evaluate, after a 4-year period, the clinical longevity of composite resin restoration compared to the baseline, after selective caries removal in permanent molars using Er:YAG laser or bur preparation with biomodification of dentin with the use of chlorhexidine. Methods Selective...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Influence of accelerated ageing on the physical properties of CAD/CAM restorative materials
Abstract Objectives This study aims to investigate the influence of thermocycling on the physical properties of different CAD/CAM restorative materials and assess their ability to maintain energy dissipation capacities and damping effects. Materials and methods The results of a 3-point bending test were used to calculate flexural strength (FS),...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Effectiveness of a reciprocating single file, single cone endodontic treatment approach: a randomized controlled pragmatic clinical trial
Abstract Objectives To compare the root filling quality, the sealer extrusion, and the healing rates of apical lesions addressed via two endodontic treatment approaches. The hypothesis tested was that both techniques present similar apical periodontitis healing results. Materials and methods This study was a parallel-design, pragmatic, and randomized...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Fracture force of CAD/CAM resin composite crowns after in vitro aging
Abstract Objectives The aim of this in vitro study was to investigate the influence of material, preparation, and pre-treatment on the aging and fracture force of CAD/CAM resin composite molar crowns. Materials and methods CAD/CAM molar crowns (n = 80) were milled from four resin composites (Block HC, Shofu; Lava Ultimate, 3 M; Grandio Blocs,...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Dose-dependent green tea effect on decrease of inflammation in human oral gingival epithelial keratinocytes: in vitro study
Abstract Objectives This in vitro study aimed to analyze the anti-inflammatory and wound healing potential of green tea extract (GTE) in human gingival epithelial keratinocytes (HGEK) treated with lipopolysaccharides (LPS). Materials and methods A cell viability assay was conducted using MTT to determine nontoxic levels of GTE on immortalized...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Xenogeneic bone filling materials modulate mesenchymal stem cell recruitment: role of the Complement C5a
Abstract Objectives When bone filling materials are applied onto the periodontal tissues in vivo, they interact with the injured periodontal ligament (PDL) tissue and modulate its activity. This may lead to mesenchymal stem cells (MSCs) recruitment from bone marrow and initiate bone regeneration. Our hypothesis is that the filling materials affect PDL cells and MSCs functional activities by modulating PDL C5a secretion and subsequent...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Root caries lesions inhibition and repair using commercial high-fluoride toothpastes with or without tri-calcium phosphate and conventional toothpastes containing or not 1.5% arginine CaCO 3 : an in situ investigation
Abstract Objectives This double-blind, crossover, and in situ study evaluated the effect of commercial high-F toothpastes with or without functionalized β-tri-calcium phosphate (fTCP) and conventional-F toothpaste containing or not 1.5% arginine-CaCO3 in preventing and repairing root caries-like lesions. Methods Twelve volunteers wore palatal...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Chairside measurement of the marginal and internal fit of crowns: a new intraoral scan–based approach
Abstract Objectives To investigate the marginal and internal fit of crowns, a new intraoral scanner–based digital approach for chairside measurement (D-IOS) was systematically analysed and compared with the conventional silicone replica technique (CV-SR) and digital 3D analysis software (D-GOM). Materials and methods Two models, representing...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Incidence of postoperative pain after canal shaping by using Reciproc and Twisted File Adaptive systems: a prospective, randomized clinical trial
Abstract Objectives The aim of this prospective clinical trial was to investigate the incidence of postoperative pain after initial root canal treatment using Twisted File Adaptive (TFA) and Reciproc systems. Materials and methods A total of sixty-four previously initiated or necrotic posterior teeth were randomly assigned to two groups based...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Patient-, tooth-, and dentist-related factors influencing long-term tooth retention after resective therapy in an academic setting—a retrospective study
Abstract Objectives The aim of this study was to evaluate long-term (≥5 years) tooth survival after resective therapy of multi-rooted, periodontally treated teeth and investigate the influence of patient-, tooth-, and dentist-related risk factors on tooth loss. Materials and methods A total of 128 patients with root-resected molars were reexamined....
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Effect of static compressive force on in vitro cultured PDL fibroblasts: monitoring of viability and gene expression over 6 days
Abstract Objectives The aim was to investigate the impact of static compressive force (CF) application on human PDL-derived fibroblasts (HPDF) in vitro for up to 6 days on the expression of specific genes and to monitor cell growth and cell viability. Materials and methods CF of 2 g/cm2 was applied on HPDFs for 1–6 days. On each day, gene expression...
Clinical Oral Investigations
Tue Jun 23, 2020 13:40
Invited Commentary ' Comparison of three different bone graft methods for single segment lumbar tuberculosis: A retrospective single-center cohort study.
Related Articles Invited Commentary ' Comparison of three different bone graft methods for single segment lumbar tuberculosis: A retrospective single-center cohort study. Int J Surg. 2020 Jun 19;: Authors: Wedam Atogebania DJ, Xun DB Abstract The study is designed to contrast the clinical efficacy of one stage posterior debridement with iliac bone graft, titanium mesh bone graft or granular bone graft in the surgical treatment of single...
International Journal of Surgery
Tue Jun 23, 2020 14:32
Surgical Complications of Skin-Sparing Mastectomy and Immediate Implant-Based Breast Reconstruction in Women Concurrently Treated With Adjuvant Chemotherapy for Breast Cancer.
Related Articles Surgical Complications of Skin-Sparing Mastectomy and Immediate Implant-Based Breast Reconstruction in Women Concurrently Treated With Adjuvant Chemotherapy for Breast Cancer. Ann Plast Surg. 2020 Jun 17;: Authors: Kooijman MML, Hage JJ, Oldenburg HSA, Stouthard JM, Woerdeman LAE Abstract BACKGROUND AND AIM: To date, studies on adjuvant chemotherapy as a risk factor for the surgical outcome of combined mastectomy and breast...
Annals of plastic surgery,http://goo.gl/rV0Vv8
Tue Jun 23, 2020 17:33
Use of Medial Sural Vessels as Recipient Vessels in a Previous Gastrocnemius Flap.
Related Articles Use of Medial Sural Vessels as Recipient Vessels in a Previous Gastrocnemius Flap. Ann Plast Surg. 2020 Jun 17;: Authors: Trapero A, Pérez-García A, Thione A, Sánchez-García A, Ruiz-Valls A PMID: 32568757 [PubMed - as supplied by publisher]
Annals of plastic surgery,http://goo.gl/rV0Vv8
Tue Jun 23, 2020 17:33
A Free Tool for Breast Aesthetic Scale Computation.
Related Articles A Free Tool for Breast Aesthetic Scale Computation. Ann Plast Surg. 2020 Jun 17;: Authors: Monton J, Kenig N, Chang-Azancot L, Jordan J, Insausti R Abstract BACKGROUND: Our work describes the concept of Breast Aesthetic Scale (BAS) as a score for quick and simple objective assessment of results in cosmetic breast surgery. It is obtained by running a software program that we created, based on the previous concept of Objective...
Annals of plastic surgery,http://goo.gl/rV0Vv8
Tue Jun 23, 2020 17:33
Aesthetic and Anatomic Reconstruction of Polysyndactyly of the Fifth Toe Fused With the Fourth Toe.
Related Articles Aesthetic and Anatomic Reconstruction of Polysyndactyly of the Fifth Toe Fused With the Fourth Toe. Ann Plast Surg. 2020 Jun 17;: Authors: Chen W, Chen L, Huang W, Tian X Abstract BACKGROUND: The aim of the study was to present a new operative technique for aesthetic and anatomic reconstruction of polysyndactyly of the fifth toe fused with the fourth toe. METHODS: Surgery was performed in 86 feet in 73 patients with...
Annals of plastic surgery,http://goo.gl/rV0Vv8
Tue Jun 23, 2020 17:33
Assessment of Opioid-Prescribing Practices in Breast Augmentation: Future Directions for Prescribing Guidelines.
Related Articles Assessment of Opioid-Prescribing Practices in Breast Augmentation: Future Directions for Prescribing Guidelines. Ann Plast Surg. 2020 Jun 17;: Authors: Crystal DT, Cuccolo NG, Plewinski MJ, Ibrahim AMS, Sinkin JC, Lin SJ, Agag RL, Lee BT Abstract BACKGROUND: The United States (US) is in the mid of an opioid epidemic propagated, in part, by prescription opioids. With excess overprescribing documented in a variety of surgical...
Annals of plastic surgery,http://goo.gl/rV0Vv8
Tue Jun 23, 2020 17:33
Role of Arterial Perfusion in Early Survival of Arterialized Venous Flaps: A Mechanism Study and Clinical Application.
Related Articles Role of Arterial Perfusion in Early Survival of Arterialized Venous Flaps: A Mechanism Study and Clinical Application. Ann Plast Surg. 2020 Jun 17;: Authors: Wang H, Hong S, Lu S, Wu T, Chai Y, Wen G Abstract BACKGROUND: The arterialized venous flap (AVF) is appropriate as a flap for hand and foot resurfacing meet the aesthetic demands in the same time. However, the inconsistency of survival rate limited its popularization in...
Annals of plastic surgery,http://goo.gl/rV0Vv8
Tue Jun 23, 2020 17:33
Tissue Expander-Based Breast Reconstruction in the Prepectoral Versus Subpectoral Plane: An Analysis of Short-Term Outcomes.
Related Articles Tissue Expander-Based Breast Reconstruction in the Prepectoral Versus Subpectoral Plane: An Analysis of Short-Term Outcomes. Ann Plast Surg. 2020 Jun 17;: Authors: Kraenzlin F, Darrach H, Khavanin N, Kokosis G, Aliu O, Broderick K, Rosson GD, Manahan MA, Sacks JM Abstract BACKGROUND: Breast reconstruction is becoming an increasingly important and accessible component of breast cancer care. We hypothesize that prepectoral patients...
Annals of plastic surgery,http://goo.gl/rV0Vv8
Tue Jun 23, 2020 17:33
Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells).
Related Articles Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells). Bioorg Chem. 2020 Jun 03;101:103995 Authors: Abdelhameid MK, Zaki I, Mohammed MR, Mohamed KO Abstract Novel azole derivatives 3-30 were designed, synthesized, and screened for their antitumor activity on HepG2 cell line. The cytotoxicity screening demonstrated that imidazolone 8 and triazoles 25 and 29 exhibited...
pubmed: cell cycle arrest
Tue Jun 23, 2020 14:27
MicroRNAs in cancer therapy: Their involvement in oxaliplatin sensitivity/resistance of cancer cells with a focus on colorectal cancer.
Related Articles MicroRNAs in cancer therapy: Their involvement in oxaliplatin sensitivity/resistance of cancer cells with a focus on colorectal cancer. Life Sci. 2020 Jun 19;:117973 Authors: Ashrafizadeh M, Zarrabi A, Hushmandi K, Hashemi F, Hashemi F, Samarghandian S, Najafi M Abstract The resistance of cancer cells into chemotherapy has restricted the efficiency of anti-tumor drugs. Oxaliplatin (OX) being an anti-tumor agent/drug is...
pubmed: cell cycle arrest
Tue Jun 23, 2020 14:27
OmpA of Klebsiella pneumoniae ATCC 13883 induces pyroptosis in HEp-2 cells, leading to cell-cycle arrest and apoptosis.
Related Articles OmpA of Klebsiella pneumoniae ATCC 13883 induces pyroptosis in HEp-2 cells, leading to cell-cycle arrest and apoptosis. Microbes Infect. 2020 Jun 19;: Authors: You HS, Lee SH, Kang SS, Hyun SH Abstract Klebsiella pneumoniae is an opportunistic pathogenic bacterium that commonly causes pneumonia in elderly people. OmpA, a toxin that is highly expressed in the outer membrane of the bacterium, is one of the primary factors...
pubmed: cell cycle arrest
Tue Jun 23, 2020 14:27

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