Cancers, Vol. 12, Pages 1501: Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways Cancers doi: 10.3390/cancers12061501 Authors: Rahul R. Singh Jiyan Mohammad Megan Orr Katie M. Reindl Glutathione S-transferase pi-1 (GSTP1) plays an important role in regulating oxidative stress by conjugating glutathione to electrophiles. GSTP1 is overexpressed in breast, colon, lung, and prostate tumors, where...
Tue Jun 09, 2020 03:00
Cancers, Vol. 12, Pages 1500: Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma Cancers doi: 10.3390/cancers12061500 Authors: Laurie Signetti Nelli Elizarov Méliné Simsir Agnès Paquet Dominique Douguet Fabien Labbal Delphine Debayle Audrey Di Giorgio Valérie Biou Christophe Girard Maria Duca Lionel Bretillon Corine Bertolotto Bernard Verrier Stéphane Azoulay Isabelle Mus-Veteau Melanoma...
Tue Jun 09, 2020 03:00
Cancers, Vol. 12, Pages 1502: Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors
Cancers, Vol. 12, Pages 1502: Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors Cancers doi: 10.3390/cancers12061502 Authors: Florent Peyraud Antoine Italiano Genomic instability is a hallmark of cancer related to DNA damage response (DDR) deficiencies, offering vulnerabilities for targeted treatment. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) interfere with the efficient repair of DNA damage, particularly in tumors with existing defects in DNA repair,...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1432: Symmetry Breaking and Emergence of Directional Flows in Minimal Actomyosin Cortices Cells doi: 10.3390/cells9061432 Authors: Sven K. Vogel Christian Wölfer Diego A. Ramirez-Diaz Robert J. Flassig Kai Sundmacher Petra Schwille Cortical actomyosin flows, among other mechanisms, scale up spontaneous symmetry breaking and thus play pivotal roles in cell differentiation, division, and motility. According to many model systems, myosin motor-induced...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1435: Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats Cells doi: 10.3390/cells9061435 Authors: Yu-Chin Lien Paul Zhiping Wang Xueqing Maggie Lu Rebecca A. Simmons Intrauterine growth retardation (IUGR), which induces epigenetic modifications and permanent changes in gene expression, has been associated with the development of type 2 diabetes. Using a rat model of IUGR, we performed ChIP-Seq to identify...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1433: An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells Cells doi: 10.3390/cells9061433 Authors: Herrmann Fichtner Karunakaran About 1–5% of human blood T cells are Vγ9Vδ2 T cells. Their hallmark is the expression of T cell antigen receptors (TCR) whose γ-chains contain a rearrangement of Vγ9 with JP (TRGV9JP or Vγ2Jγ1.2) and are paired with Vδ2...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1434: Mechanical Adaptations of Epithelial Cells on Various Protruded Convex Geometries Cells doi: 10.3390/cells9061434 Authors: Sun-Min Yu Bo Li Steve Granick Yoon-Kyoung Cho The shape of epithelial tissue supports physiological functions of organs such as intestinal villi and corneal epithelium. Despite the mounting evidence showing the importance of geometry in tissue microenvironments, the current understanding on how it affects biophysical behaviors...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1436: Sex Chromosomes and Sex Phenotype Contribute to Biased DNA Methylation in Mouse Liver Cells doi: 10.3390/cells9061436 Authors: Qinwei Kim-Wee Zhuang Jose Hector Galvez Qian Xiao Najla AlOgayil Jeffrey Hyacinthe Teruko Taketo Guillaume Bourque Anna K. Naumova Sex biases in the genome-wide distribution of DNA methylation and gene expression levels are some of the manifestations of sexual dimorphism in mammals. To advance our understanding...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1427: The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment Cells doi: 10.3390/cells9061427 Authors: Giuseppa Augello Maria R. Emma Antonella Cusimano Antonina Azzolina Giuseppe Montalto James A. McCubrey Melchiorre Cervello The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1430: High Throughput strategies Aimed at Closing the GAP in Our Knowledge of Rho GTPase Signaling Cells doi: 10.3390/cells9061430 Authors: Manel Dahmene Laura Quirion Mélanie Laurin Since their discovery, Rho GTPases have emerged as key regulators of cytoskeletal dynamics. In humans, there are 20 Rho GTPases and more than 150 regulators that belong to the RhoGEF, RhoGAP, and RhoGDI families. Throughout development, Rho GTPases choregraph a plethora of cellular...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1429: With Age Comes Maturity: Biochemical and Structural Transformation of a Human Centriole in the Making Cells doi: 10.3390/cells9061429 Authors: Catherine Sullenberger Alejandra Vasquez-Limeta Dong Kong Jadranka Loncarek Centrioles are microtubule-based cellular structures present in most human cells that build centrosomes and cilia. Proliferating cells have only two centrosomes and this number is stringently maintained through the temporally and spatially...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1431: Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection Cells doi: 10.3390/cells9061431 Authors: Yvonne Drechsler Elton J. R. Vasconcelos Lisa M. Griggs Pedro P. P. V. Diniz Ellen Collisson Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1426: HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders Cells doi: 10.3390/cells9061426 Authors: Laura Cheney Hillary Guzik Frank P. Macaluso Fernando Macian Ana Maria Cuervo Joan W. Berman A significant number of people living with HIV (PLWH) develop HIV-associated neurocognitive disorders (HAND) despite highly effective antiretroviral therapy...
Tue Jun 09, 2020 03:00
Cells, Vol. 9, Pages 1428: A Novel Approach of Harvesting Viable Single Cells from Donor Corneal Endothelium for Cell-Injection Therapy Cells doi: 10.3390/cells9061428 Authors: Hon Shing Ong Gary Peh Dawn Jin Hui Neo Heng-Pei Ang Khadijah Adnan Chan Lwin Nyein Fernando Morales-Wong Maninder Bhogal Viridiana Kocaba Jodhbir S. Mehta Donor corneas with low endothelial cell densities (ECD) are deemed unsuitable for corneal endothelial transplantation. This study...
Tue Jun 09, 2020 03:00
Diagnostics, Vol. 10, Pages 389: Identification of Human Ovarian Adenocarcinoma Cells with Cisplatin-resistance by Feature Extraction of Gray Level Co-occurrence Matrix Using Optical Images Diagnostics doi: 10.3390/diagnostics10060389 Authors: Chih-Ling Huang Meng-Jia Lian Yi-Hsuan Wu Wei-Ming Chen Wen-Tai Chiu Ovarian cancer is the most malignant of all gynecological cancers. A challenge that deteriorates with ovarian adenocarcinoma in neoplastic disease patients has been...
Tue Jun 09, 2020 03:00
Diagnostics, Vol. 10, Pages 388: Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy Diagnostics doi: 10.3390/diagnostics10060388 Authors: Enes Akyuz Kristina Polat Sukru Ates Demet Unalmis Adem Tokpinar Seher Yilmaz Emin Kaymak Zuleyha Doganyigit Chiara Villa Epilepsy is a group of neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS) and recurrent seizures representing...
Tue Jun 09, 2020 03:00
Diagnostics, Vol. 10, Pages 387: Fold-Over Oversampling Effects in the Measurements of Cerebral Cerebrospinal Fluid and Blood Flows with 2D Cine Phase-Contrast MRI Diagnostics doi: 10.3390/diagnostics10060387 Authors: Fadoua Saadani-Makki Serge Metanbou Garance Arbeaumont-Trocme Julien Van Gysel Malek I. Makki This prospective study investigated the effects of fold-over oversampling on phase-offset background errors with 2D-Cine phase contrast (Cine-PC) magnetic resonance...
Tue Jun 09, 2020 03:00
Diagnostics, Vol. 10, Pages 386: Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study Diagnostics doi: 10.3390/diagnostics10060386 Authors: Federica Pezzuto Gabriella Serio Francesco Fortarezza Anna Scattone Concetta Caporusso Alessandra Punzi Domenica Cavone Antonio Pennella Andrea Marzullo Luigi Vimercati Diffuse malignant peritoneal mesothelioma (DMPM) is a...
Tue Jun 09, 2020 03:00
Diseases, Vol. 8, Pages 19: The m.9143T>C Variant: Recurrent Infections and Immunodeficiency as an Extension of the Phenotypic Spectrum in MT-ATP6 Mutations? Diseases doi: 10.3390/diseases8020019 Authors: Diana Lehmann Urban Leila Motlagh Scholle Matias Wagner Albert C. Ludolph Angela Rosenbohm Pathogenic variants in the MT-ATP6 are a well-known cause for maternally inherited mitochondrial disorders associated with a wide range of clinical phenotypes. Here, we present...
Tue Jun 09, 2020 03:00
Diversity, Vol. 12, Pages 231: Lepidoptera are Relevant Bioindicators of Passive Regeneration in Tropical Dry Forests Diversity doi: 10.3390/d12060231 Authors: Luc Legal Marine Valet Oscar Dorado Jose Maria de Jesus-Almonte Karime López Régis Céréghino Most evaluations of passive regeneration/natural succession or restoration have dealt with tropical rain forest or temperate ecosystems. Very few studies have examined the regeneration of tropical dry forests (TDF), one...
Tue Jun 09, 2020 03:00
Diversity, Vol. 12, Pages 232: Basidiomycetes Associated with Alnus glutinosa Habitats in Andros Island (Cyclades, Greece) Diversity doi: 10.3390/d12060232 Authors: Elias Polemis Vassiliki Fryssouli Vassileios Daskalopoulos Georgios I. Zervakis Alluvial forests dominated by black alder (Alnus glutinosa) are widespread in Europe along river banks and watercourses forming a habitat of renowned ecological/conservation importance. Despite the considerable interest this habitat has...
Tue Jun 09, 2020 03:00
Environments, Vol. 7, Pages 43: Potentially Toxic Elements in Urban Soils of Havana, Cuba Environments doi: 10.3390/environments7060043 Authors: Juan Miguel Moreno-Alvarez Rosa Orellana-Gallego Maria Luisa Fernandez-Marcos Urban soils are characterised by a strong anthropogenic influence. Potentially toxic elements were studied in various horizons of 35 urban soils in Havana, Cuba, classified as Urbic or Garbic Technosols. Pseudo-total, available, and acid-oxalate extractable concentrations...
Tue Jun 09, 2020 03:00
Fermentation, Vol. 6, Pages 59: Production, Characterization, and Industrial Application of Pectinase Enzyme Isolated from Fungal Strains Fermentation doi: 10.3390/fermentation6020059 Authors: KC Upadhyaya Joshi Lekhak Kumar Chaudhary Raj Pant Raj Bajgai Dhital Khanal Koirala Raghavan Pectinases are the group of enzymes that catalyze the degradation of pectic substances. It has wide applications in food industries for the production and clarification...
Tue Jun 09, 2020 03:00
Foods, Vol. 9, Pages 761: Validation of Rapid Enzymatic Quantification of Acetic Acid in Vinegar on Automated Spectrophotometric System Foods doi: 10.3390/foods9060761 Authors: Irene Dini Ritamaria Di Lorenzo Antonello Senatore Daniele Coppola Sonia Laneri Vinegar is produced from the fermentation of agricultural materials and diluted acetic acid (diluted with water to 4–30% by volume) via sequential ethanol and acetic acid fermentation. The concentration of acetic...
Tue Jun 09, 2020 03:00
Foods, Vol. 9, Pages 760: Reduction of Salt and Fat in Frankfurter Sausages by Addition of Agaricus bisporus and Pleurotus ostreatus Flour Foods doi: 10.3390/foods9060760 Authors: Magdalena I. Cerón-Guevara Esmeralda Rangel-Vargas José M. Lorenzo Roberto Bermúdez Mirian Pateiro Jose A. Rodríguez Irais Sánchez-Ortega Eva M. Santos The reduction of fat and salt and the incorporation of fiber-rich compounds in frankfurters is a trend to improve their nutritional profile....
Tue Jun 09, 2020 03:00
Healthcare, Vol. 8, Pages 163: Objective Work-Related Factors, Job Satisfaction and Depression: An Empirical Study among Internal Migrants in China Healthcare doi: 10.3390/healthcare8020163 Authors: Zhang Chai This study examines the associations between objective work-related factors, job satisfaction and depression among migrants in China. Data from a representative sample of Chinese migrants named Management and Services of Migrants Study (MSMS) were used after excluding 1068...
Tue Jun 09, 2020 03:00
Healthcare, Vol. 8, Pages 162: Immediate Effect of Balance Taping Using Kinesiology Tape on Dynamic and Static Balance after Ankle Muscle Fatigue Healthcare doi: 10.3390/healthcare8020162 Authors: Hyun-Su Choi Jung-Hoon Lee The objective of this study was to investigate whether ankle balance taping (ABT) applied after muscle fatigue-inducing exercise can cause immediate improvements in dynamic and static balance. A total of 31 adults (16 males and 15 females) met the inclusion criteria....
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4126: Clinical Reasoning Behind Non-Pharmacological Interventions for the Management of Headaches: A Narrative Literature Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114126 Authors: Fernández-de-las-Peñas Florencio Plaza-Manzano Arias-Buría Headache is the clinical syndrome most commonly observed by neurologists in daily practice. Pharmacological and non-pharmacological treatments are commonly used...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4125: Malaria Vectors and Vector Surveillance in Limpopo Province (South Africa): 1927 to 2018 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114125 Authors: Braack Bornman Kruger Dahan-Moss Gilbert Kaiser Oliver Cornel Lee Norris Coetzee Brooke Jager Despite the annual implementation of a robust and extensive indoor residual spraying programme against malaria vectors in Limpopo...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4124: Preparedness and Preventive Behaviors for a Pandemic Disaster Caused by COVID-19 in Serbia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114124 Authors: Vladimir M. Cvetković Neda Nikolić Una Radovanović Nenadić Adem Öcal Eric K. Noji Miodrag Zečević Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. The disease was first detected in...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4123: Assessment of Functional Activities in Individuals with Parkinson’s Disease Using a Simple and Reliable Smartphone-Based Procedure International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114123 Authors: Serra-Añó Pedrero-Sánchez Inglés Aguilar-Rodríguez Vargas-Villanueva López-Pascual Parkinson’s disease (PD) is a progressive neurodegenerative disorder leading to functional impairment. In order...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4121: “Old Wine in a New Bottle”. Depression and Romantic Relationships in Italian Emerging Adulthood: The Moderating Effect of Gender International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114121 Authors: Fermani Bongelli Canestrari Muzi Riccioni Burro Intimate partner violence is an important social issue all over the world, and human sciences, in particular, are working to reduce it. Despite this, the topic...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4120: Exposure to Toenail Heavy Metals and Child Behavior Problems in Nine-Year-Old Children: A Cross-Sectional Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114120 Authors: Karatela Coomarasamy Paterson I. Ward Behavioral problems are multifactorial and includes perinatal, maternal, family, parenting, socio-economic and personal risk factors, but less is known about the association of postnatal heavy...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4122: Predictors of High Resource Consumption in Alcohol Intoxicated Patients in the Emergency Department International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114122 Authors: Rönz Hirschi Becker Krummrey Exadaktylos Sauter Hautz Müller Background: previous studies have reported that the incidence of alcohol-related visits to emergency departments (ED) has increased, but little is known about how the...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4118: Psychological Distress among College Students: Role of Food Insecurity and Other Social Determinants of Mental Health International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114118 Authors: Becerra Becerra Food insecurity is a major social determinant of health and an assessment of how it may impact college students’ mental health is imperative, as well as differential associations by self-identified gender. A...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4117: “Too Grey to Be True?” Sexual Violence in Older Adults: A Critical Interpretive Synthesis of Evidence International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114117 Authors: Nobels Vandeviver Beaulieu Inescu Nisen Van Den Noortgate Beken Lemmens Keygnaert Sexual violence (SV) is an important public health issue with a major impact on victims and their peers, offspring and community. However,...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4116: A Cross-International Study to Evaluate Knowledge and Attitudes Related to Basic Life Support among Undergraduate Nursing Students—A Questionnaire Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114116 Authors: Kwiecień-Jaguś Mędrzycka-Dąbrowska Galdikienė Via Clavero Kopeć Practicing the algorithms of basic life support (BLS) is essential in order to take adequate measures to save lives, and future...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4115: Determinants of Suicidality in the European General Population: A Systematic Review and Meta-Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114115 Authors: María Teresa Carrasco-Barrios Paloma Huertas Paloma Martín Carlos Martín Mª Carmen Castillejos Eleni Petkari Berta Moreno-Küstner Close to one million people commit suicide each year, with suicidal attempts being the main risk factor for...
Tue Jun 09, 2020 03:00
IJERPH, Vol. 17, Pages 4119: Air Quality Variation in Wuhan, Daegu, and Tokyo during the Explosive Outbreak of COVID-19 and Its Health Effects International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114119 Authors: Ma Kang This study was designed to assess the variation of the air quality actually measured from the air pollution monitoring stations (AQMS) in three cities (Wuhan, Daegu, and Tokyo), in Asian countries experiencing the explosive outbreak...
Tue Jun 09, 2020 03:00
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