Related ArticlesCommentary: Preservation of a remote fear memory requires new myelin formation. Front Neural Circuits. 2020;14:28 Authors: Li Y, Shi H PMID: 32508599 [PubMed - in process]
Tue Jun 09, 2020 17:09
Related ArticlesA Randomized Controlled Study of Group-Administered Cognitive Behavioral Therapy for Hypersexual Disorder in Men. J Sex Med. 2019 05;16(5):733-745 Authors: Hallberg J, Kaldo V, Arver S, Dhejne C, Jokinen J, Öberg KG Abstract BACKGROUND: Hypersexual disorder (HD) is defined as a condition in which the individual loses control over engagement in sexual behaviors, leading to distress and negative effects on key life areas. Cognitive behavioral...
Tue Jun 09, 2020 16:58
Related ArticlesRound window accessibility during cochlear implantation. Eur Arch Otorhinolaryngol. 2020 Jun 06;: Authors: Stuermer K, Winter T, Nachtsheim L, Klussmann JP, Luers JC Abstract OBJECTIVE: To assess data regarding round window (RW) visibility and surgical approaches in cochlear implant cases, and to describe and analyze surgical steps relevant for the RW approach in cochlear implantation. STUDY DESIGN: Prospective clinical study....
Tue Jun 09, 2020 16:56
Related ArticlesLong-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society. Eur Arch Otorhinolaryngol. 2020 Jun 06;: Authors: Piazza C, Filauro M, Dikkers FG, Nouraei SAR, Sandu K, Sittel C, Amin MR, Campos G, Eckel HE, Peretti G Abstract INTRODUCTION: The novel Coronavirus disease 2019 (COVID-19), caused by the severe...
Tue Jun 09, 2020 16:56
Related ArticlesClinical characteristics of herpes zoster laryngitis. Eur Arch Otorhinolaryngol. 2020 Jun 06;: Authors: Park JM, Kim SE, Yang HC Abstract INTRODUCTION: Herpes zoster laryngitis (HZL) is a recently recognized rare disease, easily mistaken for common viral laryngopharyngitis. There are only a few case reports in the English literature. No study has evaluated the clinical characteristics of HZL. In this study, we analyzed the clinical characteristics...
Tue Jun 09, 2020 16:56
Breslow thickness and Clark level are still important factors for cutaneous melanoma, but do not provide a precise prognosis in all cases. It is necessary to find new factors capable of a more accurate prediction of the tumor course. Angiogenesis is essential for tumor development and progression and is regulated by vascular endothelial growth factor A (VEGF-A) and semaphorins (SEMA), in particular, SEMA3A inhibits angiogenesis by affecting VEGF signaling. However, the prognostic role of angiogenetic...
Mon Jun 08, 2020 03:00
Talimogene laherparepvec (T-VEC) is an oncolytic virus, approved for the treatment of stage IIIb-IVM1a melanoma with injectable disease (cutaneous, subcutaneous or lymphatic). It is a modified herpes simplex virus type 1 that induces tumor-specific T-cell responses via reduction of virally mediated suppression of antigen presentation, stimulation of viral pathogenicity and enhancement of tumor-selective replication. Response rates up to 82.6% have been reported for stage III disease. Acral lentiginous...
Mon Jun 08, 2020 03:00
Related ArticlesAuditory gating in adults with dyslexia: An ERP account of diminished rapid neural adaptation. Clin Neurophysiol. 2019 11;130(11):2182-2192 Authors: Peter B, McCollum H, Daliri A, Panagiotides H Abstract OBJECTIVE: A recent functional magnetic resonance imaging (fMRI) study of adults with dyslexia showed a general deficit in suppressing responses to various types of repetitive stimuli. This diminished neural adaptation may interfere...
Tue Jun 09, 2020 16:54
Related ArticlesThat does not sound right: Sounds affect visual ERPs during a piano sight-reading task. Behav Brain Res. 2019 07 23;367:1-9 Authors: Delogu F, Brunetti R, Inuggi A, Campus C, Del Gatto C, D'Ausilio A Abstract Prolonged musical training induces important audio-visuo-motor plastic processes. However, little is known about how the musicians' brain resolves multimodal conflicts while preparing for musical action. We run an electroencephalographic...
Tue Jun 09, 2020 16:54
Background: Absence of interlobar collateral ventilation is essential to achieve lobar volume reduction after endobronchial valve (EBV) treatment and can be assessed using the Chartis measurement. However, especially in lower lobe measurements, Chartis can be complicated by the “no-flow phenomenon”, during which a sudden cessation of flow is observed, leading to an unreliable measurement. If this phenomenon occurs in the right lower lobe, when measuring collateral flow over the right major fissure,...
Tue Jun 09, 2020 11:03
Related ArticlesOsmotic Response of Dorsal Root Ganglion Neurons Expressing Wild-Type and Mutant KCC3 Transporters. Cell Physiol Biochem. 2020 Jun 08;54(4):577-590 Authors: Flores B, Delpire E Abstract BACKGROUND/AIMS: Loss-of-Function (LOF) of the potassium chloride cotransporter 3 (KCC3) results in hereditary sensorimotor neuropathy with Agenesis of the Corpus Callosum (HSMN/ACC). Our KCC3 knockout mouse recapitulated axonal swelling and tissue vacuolization...
Tue Jun 09, 2020 16:53
Abstract Anomalous origins of the vertebral arteries are uncommon and generally associated with other abnormalities of the supra-aortic vessels. We present an extremely rare case where the right vertebral artery is arising from the right common carotid artery, with an absent brachiocephalic trunk, and the right common carotid artery as the first branch of the aortic arch followed by right subclavian artery, without any other abnormalities of the supra-aortic vessels. This vessel...
Tue Jun 09, 2020 03:00
Cysteine-RIch Secretory Proteins (CRISP) are expressed in the reproductive tract of mammalian males and are involved in fertilization and related processes. Due to their important role in sperm performance and...
Mon Jun 08, 2020 03:00
Related ArticlesMaresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells. J Cell Physiol. 2020 Jun 08;: Authors: Olsen MV, Lyngstadaas AV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DA Abstract Mucin secretion from conjunctival goblet cells forms the tear film mucin layer and requires regulation to function properly. Maresin 1 (MaR1) is a specialized proresolving mediator produced...
Tue Jun 09, 2020 16:47
Related ArticlesIn vivo enrichment of genetically manipulated platelets for murine hemophilia B gene therapy. J Cell Physiol. 2020 Jun 08;: Authors: Chen Y, Schroeder JA, Gao C, Li J, Hu J, Shi Q Abstract Our previous studies have demonstrated that platelet-targeted factor IX (FIX) gene therapy can introduce sustained platelet-FIX expression in hemophilia B (FIXnull ) mice. In this study, we aimed to enhance platelet-FIX expression in FIXnull mice with...
Tue Jun 09, 2020 16:47
Related ArticlesLow shear stress regulates vascular endothelial cell pyroptosis through miR-181b-5p/STAT-3 axis. J Cell Physiol. 2020 Jun 08;: Authors: Xu X, Yang Y, Wang G, Yin Y, Han S, Zheng D, Zhou S, Zhao Y, Chen Y, Jin Y Abstract Low shear stress and pyroptosis both play an important role in the onset and development of atherosclerosis (AS). MicroRNAs (miRNAs) are a kind of short (18-22) nucleotide sequences that can bind to the 3'-untranslated...
Tue Jun 09, 2020 16:47
Related ArticlesExploration of the molecular characteristics of the tumor-immune interaction and the development of an individualized immune prognostic signature for neuroblastoma. J Cell Physiol. 2020 Jun 08;: Authors: Jin W, Zhang Y, Liu Z, Che Z, Gao M, Peng H Abstract Neuroblastoma (NBL) exists in a complex tumor-immune microenvironment. Immune cell infiltration and tumor-immune molecules play a critical role in tumor development and significantly...
Tue Jun 09, 2020 16:47
Related ArticlesThe aryl hydrocarbon receptor ligand ITE inhibits cell proliferation and migration and enhances sensitivity to drug-resistance in hepatocellular carcinoma. J Cell Physiol. 2020 Jun 08;: Authors: Zhang X, He B, Chen E, Lu J, Wang J, Cao H, Li L Abstract Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, is considered as a crucial gene during tumor formation and progress. Among various ligands, 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic...
Tue Jun 09, 2020 16:47
Related ArticlesSingle-cell RNA analysis on ACE2 expression provides insights into SARS-CoV-2 potential entry into the bloodstream and heart injury. J Cell Physiol. 2020 Jun 08;: Authors: Guo J, Wei X, Li Q, Li L, Yang Z, Shi Y, Qin Y, Zhang X, Wang X, Zhi X, Meng D Abstract Coronavirus disease-2019 (COVID-19) is a global pandemic with high infectivity and pathogenicity, accounting for tens of thousands of deaths worldwide. Recent studies have found...
Tue Jun 09, 2020 16:47
Related ArticlesJunB can enhance the transcription of IL-8 in oral squamous cell carcinoma. J Cell Physiol. 2020 Jun 08;: Authors: Tsunoda M, Fukasawa M, Nishihara A, Takada L, Asano M Abstract Proteasome inhibitor MG132 was shown to enhance the secretion of interleukin 8 (IL-8) by various cells. The enhancement is regulated by the transcription factor activator protein-1 (AP-1) at the transcriptional level. AP-1 is a dimer formed by AP-1 family proteins....
Tue Jun 09, 2020 16:47
Related ArticlesCholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor. J Cell Physiol. 2020 Jun 07;: Authors: Abrigo J, Gonzalez F, Aguirre F, Tacchi F, Gonzalez A, Meza MP, Simon F, Cabrera D, Arrese M, Karpen S, Cabello-Verrugio C Abstract Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression...
Tue Jun 09, 2020 16:47
Related ArticlesLong noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms. J Cell Physiol. 2020 Jun 07;: Authors: Wang X, Zhang J, Liu X, Wei B, Zhan L Abstract Endometriosis refers to a benign chronic gynecological disorder, and is defined as the ectopic growth of endometrium in pelvic cavity. Endometriosis affects about 10% of reproductive-aged women. Unfortunately, the pathogenesis of endometriosis remains obscure, and...
Tue Jun 09, 2020 16:47
Related ArticlesIn Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time. J Vis Exp. 2020 May 24;(159): Authors: Manz XD, Albers HJ, Symersky P, Aman J, van der Meer AD, Bogaard HJ, Szulcek R Abstract The formation of blood clots involves complex interactions between endothelial cells, their underlying matrix, various blood cells, and proteins. The endothelium is the primary source of...
Tue Jun 09, 2020 16:46
Related ArticlesPathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells. J Vis Exp. 2020 May 20;(159): Authors: Thies KA, Knoblaugh SE, Sizemore ST Abstract Metastasis, the primary cause of morbidity and mortality for most cancer patients, can be challenging to model preclinically in mice. Few spontaneous metastasis models are available. Thus, the experimental metastasis model involving tail-vein injection of...
Tue Jun 09, 2020 16:46
Related ArticlesMeasuring Erythrocyte Complement Receptor 1 Using Flow Cytometry. J Vis Exp. 2020 May 19;(159): Authors: Kisserli A, Audonnet S, Duret V, Tabary T, Cohen JHM, Mahmoudi R Abstract CR1 (CD35, Complement Receptor type 1 for C3b/C4b) is a high molecular weight membrane glycoprotein of about 200 kDa that controls complement activation, transports immune complexes, and participates in humoral and cellular immune responses. CR1 is present...
Tue Jun 09, 2020 16:46
Related ArticlesAcclimation Prior to an Intraperitoneal Insulin Tolerance Test to Mitigate Stress-Induced Hyperglycemia in Conscious Mice. J Vis Exp. 2020 May 22;(159): Authors: Hull RL, Hackney DJ, Giering EL, Zraika S Abstract The insulin tolerance test is commonly used in metabolic studies to assess whole body insulin sensitivity in rodents. It is a relatively simple test that involves measurement of blood glucose levels over time following a...
Tue Jun 09, 2020 16:46
Related ArticlesDevelopment of a Novel Task-oriented Rehabilitation Program using a Bimanual Exoskeleton Robotic Hand. J Vis Exp. 2020 May 20;(159): Authors: Chen YM, Lai SS, Pei YC, Hsieh CJ, Chang WH Abstract A robot-assisted hand is used for the rehabilitation of patients with impaired upper limb function, particularly for stroke patients with a loss of motor control. However, it is unclear how conventional occupational training strategies can...
Tue Jun 09, 2020 16:46
Related ArticlesObtaining High-Quality Transcriptome Data from Cereal Seeds by a Modified Method for Gene Expression Profiling. J Vis Exp. 2020 May 21;(159): Authors: Butardo VM, Seiler C, Sreeenivasulu N, Kuhlmann M Abstract The characterization of gene expression is dependent on RNA quality. In germinating, developing and mature cereal seeds, the extraction of high-quality RNA is often hindered by high starch and sugar content. These compounds...
Tue Jun 09, 2020 16:46
Related ArticlesThree-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy. J Vis Exp. 2020 May 22;(159): Authors: Jacob L, Brito J, Thomas JL Abstract The lymphatic system associated with the central nervous system (CNS) includes the lymphatic vasculature that spins around the brain, the spinal cord, and its associated LNs. The CNS-associated lymphatic system is involved in...
Tue Jun 09, 2020 16:46
Related ArticlesIn Utero Electroporation of Multiaddressable Genome-Integrating Color (MAGIC) Markers to Individualize Cortical Mouse Astrocytes. J Vis Exp. 2020 May 21;(159): Authors: Dumas L, Clavreul S, Durand J, Hernandez-Garzon E, Abdeladim L, Barry-Martinet R, Caballero-Megido A, Beaurepaire E, Bonvento G, Livet J, Loulier K Abstract Protoplasmic astrocytes (PrA) located in the mouse cerebral cortex are tightly juxtaposed, forming an apparently...
Tue Jun 09, 2020 16:46
Related ArticlesIsolation and Culture of Primary Neurons and Glia from Adult Rat Urinary Bladder. J Vis Exp. 2020 May 23;(159): Authors: Wang R, Huang ZT, Ren WK, Zhang J, Zhang Y, Tan B, Huang P, Cao HY Abstract The lower urinary tract has two main functions, namely, periodic urine storage and micturition; these functions are mediated through central and peripheral neuroregulation. Although extensive research on the lower urinary tract nervous system...
Tue Jun 09, 2020 16:46
Related ArticlesA Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior. J Vis Exp. 2020 May 21;(159): Authors: Comer AL, Sriram B, Yen WW, Cruz-Martín A Abstract As genome-wide association studies shed light on the heterogeneous genetic underpinnings of many neurological diseases, the need to study the contribution of specific genes to brain development and function increases. Relying on mouse models...
Tue Jun 09, 2020 16:46
Related ArticlesEstablishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment. J Vis Exp. 2020 May 25;(159): Authors: Sun S, Jiang Y, Zhen Z, Lai WH, Liao S, Tse HF Abstract Although advances have been achieved in the treatment of heart failure (HF) following myocardial infarction (MI), HF following MI remains one of the major causes of mortality and morbidity around the world. Cell-based therapies for cardiac repair...
Tue Jun 09, 2020 16:46
Related ArticlesEfficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions. J Vis Exp. 2020 May 24;(159): Authors: Wu HF, Zeltner N Abstract Human pluripotent stem cells (hPSCs) have become a powerful tool for disease modeling and the study of human embryonic development in vitro. We previously presented a differentiation protocol for the derivation...
Tue Jun 09, 2020 16:46
Related ArticlesMagnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy. J Vis Exp. 2020 May 22;(159): Authors: Yin Y, Wang S, Hu D, Cai J, Chen F, Wang B, Gao Y Abstract The precision delivery of anti-cancer agents which aim for targeted and deep-penetrated delivery as well as a controlled release at the tumor site has been challenged. Here, we fabricate iron oxide...
Tue Jun 09, 2020 16:46
Related ArticlesEmbryo Microinjection Techniques for Efficient Site-Specific Mutagenesis in Culex quinquefasciatus. J Vis Exp. 2020 May 24;(159): Authors: Bui M, Li M, Raban RR, Liu N, Akbari OS Abstract Culex quinquefasciatus is a vector of a diverse range of vector-borne diseases such as avian malaria, West Nile virus (WNV), Japanese encephalitis, Eastern equine encephalitis, lymphatic filariasis, and Saint Louis encephalitis. Notably, avian malaria...
Tue Jun 09, 2020 16:46
Related ArticlesOsteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats. J Vis Exp. 2020 May 20;(159): Authors: Xu J, Yan L, Yan B, Zhou L, Tong P, Shan L Abstract The current animal models of osteoarthritis (OA) can be divided into spontaneous models and induced models, both of which aim to simulate the pathophysiological changes of human OA. However, as the main symptom in the late stage of OA, pain affects the...
Tue Jun 09, 2020 16:46
Related ArticlesTime-lapse Imaging of Bacterial Swarms and the Collective Stress Response. J Vis Exp. 2020 May 23;(159): Authors: Bru JL, Siryaporn A, Høyland-Kroghsbo NM Abstract Swarming is a form of surface motility observed in many bacterial species including Pseudomonas aeruginosa and Escherichia coli. Here, dense populations of bacteria move over large distances in characteristic tendril-shaped communities over the course of hours. Swarming...
Tue Jun 09, 2020 16:46
Related ArticlesA Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling. J Vis Exp. 2020 May 21;(159): Authors: Truesdell SL, George EL, Van Vranken CC, Saunders MM Abstract Bone remodeling is a tightly regulated process that is required for skeletal growth and repair as well as adapting to changes in the mechanical environment. During this process, mechanosensitive osteocytes regulate...
Tue Jun 09, 2020 16:46
Objective The aim of this study was to investigate acoustic noise reduction and image quality of cranial magnetic resonance imaging (MRI) at 7T MRI with and without sequence-based acoustic noise reduction. Materials and Methods Fifteen patients and 5 healthy volunteers underwent 7T MRI scanning. A fluid-attenuated inversion recovery (FLAIR) sequence was acquired with and without sequence-based acoustic noise reduction. The acoustic noise generated by each sequence was measured. Quantitative...
Mon Jun 08, 2020 03:00
Publication date: Available online 9 June 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Juan Enrique Berner, Patrick Will, Luke Geoghegan, Luigi Troisi, Jagdeep Nanchahal, Abhilash Jain
Tue Jun 09, 2020 17:25
Abstract The role of the small GTPase RAB27A as an essential melanosome trafficking regulator in melanocytes is well‐accepted. A decade ago, RAB27A was identified as a tumor dependency gene that promotes melanoma cell proliferation. RAB27A has since been linked to another propeller of cancer progression: exosome secretion. We have recently demonstrated that RAB27A is overexpressed in a subset of melanomas. High RAB27A gene and protein expression correlates with poor prognosis in melanoma patients....
Mon Jun 08, 2020 20:13
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