Related ArticlesKockdown of ACP5 inhibits hepatocellular carcinoma progression. Am J Transl Res. 2020;12(5):1904-1912 Authors: Shi R, Liu T, Liu Z, Yang L, Shi Y, Zhang Y Abstract Tartrate-resistant acid phosphatase (ACP5) could regulate cancer cell proliferation; however, its role in hepatocellular carcinoma (HCC) remains largely unknown. Here, we investigated the function of ACP5 in HCC and examined the underlying molecular mechanisms. The expression...
Tue Jun 09, 2020 14:09
Related ArticlesKinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma. Am J Transl Res. 2020;12(5):1614-1639 Authors: Li X, Huang W, Huang W, Wei T, Zhu W, Chen G, Zhang J Abstract Kinesin superfamily proteins (KIFs) comprise a family of molecular motors that transport membranous organelles and protein complexes in a microtubule- and ATP-dependent manner, with multiple...
Tue Jun 09, 2020 14:09
Related ArticlesThe G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division. Cell Div. 2020;15:9 Authors: Lemonnier T, Dupré A, Jessus C Abstract Cell division is orchestrated by the phosphorylation and dephosphorylation of thousands of proteins. These post-translational modifications underlie the molecular cascades converging to the activation of the universal mitotic kinase, Cdk1, and entry into cell division. They...
Tue Jun 09, 2020 14:09
Related ArticlesCCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis. Front Pharmacol. 2020;11:737 Authors: Li X, Yu X, Zhou D, Chen B, Li W, Zheng X, Zeng H, Long L, Zhou W Abstract Triple-negative breast cancer (TNBC) has a poor prognosis due to the lack of specific therapeutic targets. CCT020312, a selective eukaryotic translation initiation factor 2 alpha (eIF2α)/protein kinase...
Tue Jun 09, 2020 14:09
Related ArticlesElucidating the role of excision repair cross-complement group 1 in oral epithelial dysplasia and early invasive squamous cell carcinoma: An immunohistochemical study. J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):20-25 Authors: Kulkarni S, Solomon M, Pankaj D, Carnelio S, Chandrashekar C, Shetty N Abstract Objectives: Oral epithelial dysplasia (OED) is characterized by cellular alterations which have the proclivity of progressing...
Tue Jun 09, 2020 14:09
Related ArticlesDNA damage checkpoint kinases in cancer. Expert Rev Mol Med. 2020 Jun 08;22:e2 Authors: Smith HL, Southgate H, Tweddle DA, Curtin NJ Abstract DNA damage response (DDR) pathway prevents high level endogenous and environmental DNA damage being replicated and passed on to the next generation of cells via an orchestrated and integrated network of cell cycle checkpoint signalling and DNA repair pathways. Depending on the type of damage,...
Tue Jun 09, 2020 14:09
Related ArticlesKnockdown of Ubiquitin-Specific Protease 53 Enhances the Radiosensitivity of Human Cervical Squamous Cell Carcinoma by Regulating DNA Damage-Binding Protein 2. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820929792 Authors: Zhou Q, Yao X, Wu C, Chen S, Fan D Abstract BACKGROUND: Cervical cancer ranks fourth in incidence and mortality among women. Ubiquitin-specific protein 53 binds to damage-specific DNA binding protein 2 and...
Tue Jun 09, 2020 14:09
Related ArticlesHOTAIR-EZH2 inhibitor AC1Q3QWB upregulates CWF19L1 and enhances cell cycle inhibition of CDK4/6 inhibitor palbociclib in glioma. Clin Transl Med. 2020 Jan;10(1):182-198 Authors: Shi J, Lv S, Wu M, Wang X, Deng Y, Li Y, Li K, Zhao H, Zhu X, Ye M Abstract BACKGROUND: Glioblastoma (GBM) is the most common primary tumor in the brain, and the median survival time for GBM patients is only about 14 months; therefore, there is an urgent need...
Tue Jun 09, 2020 13:09
Related ArticlesCombination of cyclin-dependent kinase and immune checkpoint inhibitors for the treatment of bladder cancer. Cancer Immunol Immunother. 2020 Jun 06;: Authors: Long Q, Ma AH, Zhang H, Cao Z, Xia R, Lin TY, Sonpavde GP, de Vere White R, Guo J, Pan CX Abstract BACKGROUND: Perturbation of the CDK4/6 pathway is frequently observed in advanced bladder cancer. We investigated the potential of targeting this pathway alone or in combination...
Tue Jun 09, 2020 13:09
Related ArticlesDensely functionalized cinnolines: Controlled microwave-assisted facile one-pot multi-component synthesis and in vitro anticancer activity via apoptosis induction. Bioorg Chem. 2020 May 23;101:103932 Authors: Nazmy MH, Mekheimer RA, Shoman ME, Abo-Elsebaa M, Abd-Elmonem M, Sadek KU Abstract There is an urging continuous need for novel anti-cancer agents due to persistent chemoresistance. Herein, newly synthesized cinnolines are evaluated...
Tue Jun 09, 2020 13:09
Related ArticlesThe Effect of different types of exercise training on diet-induced obesity in rats, Cross-talk between cell cycle proteins and apoptosis. Gene. 2020 Jun 04;:144850 Authors: Tolouei Azar J, Habibi Maleki A, Moshari S, Razi M Abstract Obesity is associated with germ cell apoptosis, spermatogenesis arrest, and testicular endocrine suppression. The aim of the present study was to investigate the crosstalk between germ cell apoptosis and...
Tue Jun 09, 2020 13:09
Related ArticlesThe novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer. Biomed Pharmacother. 2020 Jun 04;128:110309 Authors: Chiu CF, Lin YQ, Park JM, Chen YC, Hung SW, Chiu CC, Chang CF Abstract OBJECTIVE: Breast cancer is the second leading cause of cancer deaths in women worldwide and represents a highly aggressive nature with limited therapeutic options; thus, investigating novel therapeutic...
Tue Jun 09, 2020 13:09
Related ArticlesDUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells. Biochem Biophys Res Commun. 2020 Jun 03;: Authors: Ratsada P, Hijiya N, Hidano S, Tsukamoto Y, Nakada C, Uchida T, Kobayashi T, Moriyama M Abstract Dual-specificity phosphatase 4 (DUSP4), a MAP kinase phosphatase, has been regarded as a tumor suppressor gene in several cancers. However, high-level expression of DUSP4 is occasionally...
Tue Jun 09, 2020 13:09
Related ArticlesThe use of adenosine to inhibit oocyte meiotic resumption in Bos taurus during pre-IVM and its potential to improve oocyte competence. Theriogenology. 2020 Jan 15;142:207-215 Authors: Caballero J, Blondin P, Vigneault C, Sirard MA, Richard FJ Abstract One of the major challenges of artificial reproductive technologies is to develop new methods for producing greater numbers of embryos. An oocyte fosters the ability to develop into an...
Tue Jun 09, 2020 13:09
Related ArticlesOlder and younger patients treated with immune checkpoint inhibitors have similar outcomes in real-life setting. Eur J Cancer. 2019 11;121:192-201 Authors: Corbaux P, Maillet D, Boespflug A, Locatelli-Sanchez M, Perier-Muzet M, Duruisseaux M, Kiakouama-Maleka L, Dalle S, Falandry C, Péron J Abstract BACKGROUND: Age-related immune dysfunction might impair the efficacy of immune checkpoint inhibitors (ICIs) in older patients. We aimed...
Tue Jun 09, 2020 13:09
Related ArticlesResponse to salvage chemotherapy after progression on immune checkpoint inhibitors in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. Eur J Cancer. 2019 11;121:123-129 Authors: Saleh K, Daste A, Martin N, Pons-Tostivint E, Auperin A, Herrera-Gomez RG, Baste-Rotllan N, Bidault F, Guigay J, Le Tourneau C, Saada-Bouzid E, Even C Abstract BACKGROUND: Immune checkpoint inhibitors (ICI) are active in...
Tue Jun 09, 2020 13:09
Related ArticlesCerebrospinal fluid lymphocytosis: a hallmark of neurological complications during checkpoint inhibition. Eur J Cancer. 2019 11;121:1-3 Authors: Tonk EHJ, Snijders TJ, Koldenhof JJ, van Lindert ASR, Suijkerbuijk KPM PMID: 31522128 [PubMed - indexed for MEDLINE]
Tue Jun 09, 2020 13:09
Related ArticlesUpregulation of lncRNA GAS5 inhibits the growth and metastasis of cervical cancer cells. J Cell Physiol. 2019 12;234(12):23571-23580 Authors: Yang W, Xu X, Hong L, Wang Q, Huang J, Jiang L Abstract This study aims to figure out the methylation of long non-coding RNA GAS5 promoter in cervical cancer and the mechanism of GAS5 on the progression of cervical cancer cells. The expression of GAS5 and methylation state of GAS5 in cervical cancer...
Tue Jun 09, 2020 13:09
Related ArticlesResveratrol inhibits the proliferation of melanoma cells by modulating cell cycle. Int J Food Sci Nutr. 2020 Feb;71(1):84-93 Authors: Yang HZ, Zhang J, Zeng J, Liu S, Zhou F, Zhang F, Giampieri F, Cianciosi D, Forbes-Hernandez TY, Ansary J, Gil E, Chen R, Battino M Abstract The aim of this study was to evaluate the inhibitory effects of resveratrol (RSV) in A375 and A431 melanoma cells, by assessing cell viability (CCK-8 assay), apoptosis...
Tue Jun 09, 2020 13:09
Related ArticlesDeletion of caveolin scaffolding domain alters cancer cell migration. Cell Cycle. 2019 06;18(11):1268-1280 Authors: Okada S, Raja SA, Okerblom J, Boddu A, Horikawa Y, Ray S, Okada H, Kawamura I, Murofushi Y, Murray F, Patel HH Abstract Caveolin-1 (Cav-1) is an integral membrane protein that plays an important role in proliferative and terminally differentiated cells. As a structural component of Caveolae, Cav-1 interacts with signaling...
Tue Jun 09, 2020 13:09
Related ArticlesCHK1-CENP B/MAD2 is associated with mild oxidative damage-induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilization. Free Radic Biol Med. 2019 06;137:181-193 Authors: Huang Y, Ha S, Li Z, Li J, Xiao W Abstract A high incidence of aneuploidy is observed in vitro fertilization (IVF)-derived embryos, but the formation and repair mechanisms are unknown. Here, we investigated the effects of slightly increased reactive...
Tue Jun 09, 2020 13:09
Related ArticlesDownregulated microRNA-135a ameliorates rheumatoid arthritis by inactivation of the phosphatidylinositol 3-kinase/AKT signaling pathway via phosphatidylinositol 3-kinase regulatory subunit 2. J Cell Physiol. 2019 08;234(10):17663-17676 Authors: Qu Y, Zhang YP, Wu J, Jie LG, Deng JX, Zhao DB, Yu QH Abstract Synovial fibroblasts (SFs) of rheumatoid arthritis (RA) are phenotypically aggressive, typically progressing into arthritic cartilage...
Tue Jun 09, 2020 13:09
Related ArticlesReview and analysis of biologic therapies currently in phase II and phase III clinical trials for atopic dermatitis. J Dermatolog Treat. 2020 Jun 08;:1-11 Authors: Uppal SK, Kearns DG, Chat VS, Han G, Wu JJ Abstract Biologic medications are recent advances that have clinical significance in the treatment of moderate-to-severe AD. A systemic literature review was performed to examine the efficacy and safety of biologic therapies currently...
Tue Jun 09, 2020 13:03
Related ArticlesThe effect of oral isotretinoin therapy on meibomian gland morphology and dry eye tests. J Dermatolog Treat. 2020 Jun 08;:1-7 Authors: Düzgün E, Özkur E Abstract Purpose: The aim of study was to evaluate the effects of oral isotretinoin on meibomian gland (MG) morphology detected with non-contact meibography and to investigate its relation with clinical dry eye tests.Methods: Forty-five acne patients treated with isotretinoin underwent...
Tue Jun 09, 2020 13:03
As the indications and clinical use of immune checkpoint inhibitors increase, it is expected that we will face some of their less frequently reported complications. Primary adrenal insufficiency is one of them, and given its unspecific symptoms and potentially serious consequences, it is important to have a high degree of clinical suspicion. We present 3 cases and a review of the literature concerning its main clinical characteristics, diagnostics, and management. Case Rep Oncol 2020;13:621–626
Tue Jun 09, 2020 11:01
Publication date: May 2020Source: Clinical Therapeutics, Volume 42, Issue 5Author(s):
Tue Jun 09, 2020 12:50
Publication date: May 2020Source: Clinical Therapeutics, Volume 42, Issue 5Author(s):
Tue Jun 09, 2020 12:50
Abstract Background Ileocolic intussusception is a common cause of intestinal obstruction in young children. Radiographs may be of limited value in the diagnosis of intussusception and are sometimes utilized primarily to exclude pneumoperitoneum before therapeutic enema reduction. Objective The goal of this study was to determine if radiographic findings...
Tue Jun 09, 2020 03:00
Objective Pathogenic variants in SCN3A , encoding the voltage‐gated sodium channel subunit Nav1.3, cause severe childhood‐onset epilepsy and malformation of cortical development. Here, we define the spectrum of clinical, genetic, and neuroimaging features of SCN3A ‐related neurodevelopmental disorder. Methods Patients were ascertained via an international collaborative network. We compared sodium channels containing wild‐type vs. variant Nav1.3 subunits co‐expressed with β1 and β2 subunits...
Mon Jun 08, 2020 21:44
Abstract Under resting conditions, cardioceptive accuracy—the acuity of the perception of heartbeats—is associated with the self‐reported intensity of affective states but not with reported valence. Physical exertion elicits positive affect below the anaerobic threshold and negative affect above the threshold while arousal gradually increases. The current research aimed to study the associations between cardioceptive accuracy and characteristics of the affective response (arousal and valence) during...
Mon Jun 08, 2020 21:03
Abstract Tobacco smoking is highly addictive and causes respiratory disease, cardiovascular disease and multiple types of cancer. Electronic‐cigarettes (e‐cigarettes) are non‐combustible tobacco alternatives that aerosolize nicotine and flavoring agents in a propylene glycol/vegetable glycerin (PG/VG) vehicle. They were originally envisaged as a tobacco cessation aid, but whether or not they help people to quit tobacco use is controversial. In this review, we have compared and contrasted what is...
Tue Jun 09, 2020 11:44
Key points Desmin, like dystrophin, is associated with costameric structures bridging sarcomeres to the extracellular matrix. Deletion of the desmin gene in mdx mice (DKO mice) induces marked muscle weakness and fatigue resistance, compared to mdx mice. Muscle fragility (higher susceptibility to contraction‐induced injury) was also aggravated in DKO mice as compared to mdx mice. In contrast to mdx mice, the DKO mice did not undergo muscle hypertrophy. Desmin cDNA transfer with adeno‐associated...
Mon Jun 08, 2020 21:00
Key points Diaphragm fatigue may increase the intensity (sensory dimension) and unpleasantness (affective dimension) of dyspnoea, which may partially explain why diaphragm fatigue negatively affects exercise performance. We hypothesized that diaphragm fatigue would negatively affect exercise performance via increases in both the intensity and unpleasantness of dyspnoea, and that the increase in dyspnoea would be mechanistically linked to an increase in diaphragmatic EMG (EMGdi), a surrogate measure...
Mon Jun 08, 2020 18:49
New Findings What is the central question of this study? Spinal cord injury leads to cardiac atrophy and the role of the renin‐angiotensin system with angiotensin II acting via its receptor AT1a in this effect has not been previously explored. What is the main finding and its importance? In mice undergone thoracic level 4 transection, we confirm cardiac atrophy. Knockout of AT1a does not protect mice from cardiac atrophy. We observed no histopathological signs but reduced load‐dependent...
Mon Jun 08, 2020 20:54
Abstract Purpose The current study aimed to systematically review the literature addressing the use of Deep Learning (DL) methods in Intra‐Operative surgery applications, focusing on the data collection, the objectives of these tools and, more technically, the DL‐based paradigms utilized. Methods A literature search with classic databases was performed: we identified, with the use of specific keywords, a total of 996 papers. Among them we selected 52 for effective analysis, focusing on...
Mon Jun 08, 2020 17:53
Background and Objectives Electronic pneumatic injection (EPI) is a technique for dermal drug delivery, which is increasingly being used in clinical practice. However, only few studies have been reported on cutaneous drug distribution and related clinical endpoints. We aimed to visualize the immediate cutaneous drug distribution, changes in skin architecture, and related clinical endpoint of EPI. Study Design/Materials and Methods Acridine orange (AO) solution was administered to ex vivo ...
Mon Jun 08, 2020 19:00
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