Abstract Standing genetic variation is considered a major contributor to the adaptive potential of species. The low heritable genetic variation observed in self‐fertilising populations has led to the hypothesis that species with this mating system would be less likely to adapt. However, a non‐negligible amount of cryptic genetic variation for polygenic traits, accumulated through negative linkage disequilibrium, could prove to be an important source of standing variation in self‐fertilising species....
Tue Jun 09, 2020 11:10
Abstract Meta‐analysis is increasingly used in biology to both quantitatively summarize available evidence for specific questions, and generate new hypotheses. While this powerful tool has mostly been deployed to study mean effects, there is untapped potential to study effects on (trait) variance. Here, we use a recently published dataset as a case study to demonstrate how meta‐analysis of variance can be used to provide insights into biological processes. This dataset included 704 effect sizes...
Mon Jun 08, 2020 22:00
Abstract Purpose Replacing the temporomandibular joint poses an important challenge to maxillofacial surgeons, and for certain disorders, it represents the treatment’s gold standard. Computer-assisted surgery (comprising preoperative virtual planning, virtual intraoperative navigation and 3D printing) is a useful tool for this type of surgery. However, we do not know if and how much the final position of the prosthesis differs, in absolute...
Tue Jun 09, 2020 03:00
Evidence from rocks billions of years old suggest that volcanoes played a key role in the rise of oxygen in the atmosphere of the early Earth.
Tue Jun 09, 2020 21:44
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00947D, PaperJuhong Chen, Fuguo Jiang, Chao-Wei Huang, Liwei LinThe current clinical protocol to conduct bacteria antibiotic susceptibility test (AST) requires at least 18 hours, which cannot be accomplished during a single visit for patients. Here, a new method...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 09, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00830C, PaperAnna Baranowska-Korczyc, Ewa Jaworska, Marcin Strawski, Bohdan Paterczyk, Krzysztof Maksymiuk, Agata MichalskaCore-shell modified nanofibers mats were used as ion-selective membranes for the first time. Keeping the overall macroscopic size of the sensing element as for classical plasticized poly(vinyl chloride) membranes, herein...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 09, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00588F, PaperYi Xiao, Suhua Chen, Guocan Zhang, Zhimao Li, Han Xiao, Chuanpin Chen, Chunlian He, Ran Zhang, Xiaoping YangNicotine analysis is essential to medicine, toxicology and tobacco industry. However, no simple, portable and disposable method was developed to fulfill the demands. Here, we report a simple, rapid and...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 09, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00653J, CommunicationLinbo Liu, Haoyan Xu, Haibo Xiu, Nan Xiang, Zhonghua NiThe lack of a simple operable method for on-demand engineering of longitudinal dynamic self-assembly of particles is one of the main problems in applying particle manipulation to biomedical researches. Herein,...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 09, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00762E, PaperKarolina Chrabaszcz, Tobias Meyer, Hyeonsoo Bae, Michael Schmitt, Agnieszka Jasztal, Marta Smeda, Marta Stojak, Jürgen Popp, Kamilla Malek, Katarzyna M. MarzecThe comparison of the potential of FT-IR in standard and high definition modes with multimodal CARS/TPEF/SHG/FLIMS imaging for detection of the early stage of pulmonary metastasis of murine breast cancer is presented.To cite this article before page numbers are assigned, use the DOI...
Tue Jun 09, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00491J, PaperEmily L. Jackson-Holmes, Amanda W. Schaefer, Todd C. McDevitt, Hang LuThis work explores how media exchange frequency and device geometry modulate the biochemical environment and impact three-dimensional stem cell differentiation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 09, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00868K, PaperMarcus Johns, Anna E. Lewandowska, Ellen Green, Stephen James EichhornPhotoluminescence of cellulose, and other polysaccharides, has long been presumed to be due to contamination of the material by other autofluorescent compounds – such as lignin, or proteins. This is...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Jun 09, 2020 02:00
Diabetes is a highly prevalent chronic disease that places a large burden on individuals and health care systems. Models predicting the risk (also called predictive models) of other conditions often compare pe...
Mon Jun 08, 2020 03:00
Alcohol use is a challenging problem which attributes to more than 5% of the overall global burden of disease. It is more common among persons with HIV infection than the general population. Although there are...
Mon Jun 08, 2020 03:00
Work-related musculoskeletal disorders impose a significant and most often underappreciated burden to the individual, nation, healthcare system, and society as a whole. To the best of our knowledge, there is a...
Mon Jun 08, 2020 03:00
Abstract This study aimed to evaluate the effects of partial reducing rumen-protected Lys (RPLys) on rumen fermentation and microbial composition in heifers. Three ruminal fistulated Holstein Friesian bulls were used to determine the effective degradability of RPLys using an in situ method at incubation times of 0, 2, 6, 12, 16, 24, 36, and 48 h. Thereafter, 36 Holstein heifers at 90 days of age were assigned to one of two dietary treatments: a theoretically balanced amino acid...
Tue Jun 09, 2020 03:00
Abstract 2,3-Dihydroxyisovalerate is an intermediate of valine and leucine biosynthesis pathway; however, no natural microorganism has been found yet that can accumulate this compound. Klebsiella pneumoniae is a useful bacterium that can be used as a workhorse for the production of a range of industrially desirable chemicals. Dihydroxy acid dehydratase, encoded by the ilvD gene, catalyzes the reaction of 2-ketoisovalerate formation from 2,3-dihydroxyisovalerate. In this study,...
Tue Jun 09, 2020 03:00
Tue Jun 09, 2020 03:00
Abstract Background Thionamide-induced agranulocytosis (TIA), namely antithyroid drug (ATD)-induced agranulocytosis, is one of the most feared adverse effect of ATDs. It is defined as a granulocyte count of less than 0.5 × 109/L after ATD administration. Several studies reported that TIA is associated with human leukocyte antigen (HLA) and nearby genes. Our previous study found that the susceptibility genes of TIA are similar in north...
Tue Jun 09, 2020 03:00
Fermented wheat germ extract has been reported to exert various pharmacological activities, including anti-oxidant, anti-cell growth and cell apoptosis in various cancer cells. Although 2,6-dimethoxy-1,4-benzo...
Tue Jun 09, 2020 03:00
Acylphosphatase 2 (ACYP2) is involved in cell differentiation, energy metabolism and hydrolysis of intracellular ion pump. It has been reported as a negative regulator in leukemia and a positive regulator in c...
Tue Jun 09, 2020 03:00
DCZ3301, a novel aryl-guanidino compound previously reported by our group, exerts cytotoxic effects against multiple myeloma (MM), diffused large B cell lymphoma (DLBCL), and T-cell leukemia/lymphoma. However,...
Tue Jun 09, 2020 03:00
Abstract Introduction Maximal extent of resection (EOR) of glioblastoma (GBM) is associated with greater progression free survival (PFS) and improved patient outcomes. Recently, a novel surgical system has been developed that includes a 2D, robotically-controlled exoscope and brain tractography display. The purpose of this study was to assess outcomes in a series of patients with GBM undergoing resections using this surgical exoscope....
Tue Jun 09, 2020 03:00
Publication date: Available online 9 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): H. Dekker, E.A.J.M. Schulten, L. van Ruijven, H.W. van Essen, G.J. Blom, E. Bloemena, Chr.M. ten Bruggenkate, A.M. Kullaa, N. Bravenboer
Tue Jun 09, 2020 21:14
Abstract Purpose MRI-based risk stratification should be established to identify patients with internal carotid artery stenosis (ICS) who require further PET or SPECT evaluation. This study assessed whether multiparametric flow analysis using time-resolved 3D phase-contrast (4D flow) MRI can detect cerebral hemodynamic impairment in patients with ICS. Methods ...
Tue Jun 09, 2020 03:00
Clinical Thyroidology, Volume 32, Issue 6, Page 259-259, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 290-292, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 261-262, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 284-286, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 263-265, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 296-299, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 266-269, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 279-283, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 270-272, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 287-289, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 273-275, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 293-295, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 276-278, June 2020.
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Clinical Thyroidology, Volume 32, Issue 6, Page 300-304, June 2020.
Fri Jun 05, 2020 10:00
Mucosal Immunology, Published online: 09 June 2020; doi:10.1038/s41385-020-0311-9A ligand-independent fast function of RARα promotes exit from metabolic quiescence upon T cell activation and controls T cell differentiation
Tue Jun 09, 2020 03:00
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