Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation. Cell Oncol (Dordr). 2020 Jul 04;: Authors: Yu Z, Feng H, Zhuo Y, Li M, Zhu X, Huang L, Zhang X, Zhou Z, Zheng C, Jiang Y, Le F, Yu DY, Cheng AS, Sun X, Gao Y Abstract PURPOSE: Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), which has a male predominance,...
Mon Jul 06, 2020 13:44
Secondary metabolites from acridocarpus orientalis inhibits 4T1 cells and promotes mesenchymal stem cells (MSCs) proliferation. Mol Biol Rep. 2020 Jul 04;: Authors: Jamshidi-Adegani F, Vakilian S, Rehman NU, Al-Broumi M, Al-Kindi J, Alam K, Mozafarinahavandi P, Hasan A, Al-Riyami H, Hussain J, White S, Al-Harrasi A, Al-Hashmi S Abstract Among medicinal plants, Acridocarpus orientalis (AO) possesses a remarkable anti-cancer potential, possibly...
Mon Jul 06, 2020 13:44
Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma. Transl Oncol. 2020 Jul 02;13(10):100809 Authors: Wang J, Sato K, O'Donnell E, Singla A, Yaguare S, Aldahamsheh O, Batko B, Borjihan H, Tingling J, Zhang J, Weiser DA, Loeb DM, Gorlick R, Schwartz EL, Yang R, Zi X, Zhao H, Geller DS, Hoang BH Abstract Synovial sarcoma (SS) is an aggressive soft-tissue cancer with a poor prognosis and a propensity...
Mon Jul 06, 2020 13:44
Lappaconitine sulfate induces apoptosis and G0/G1 phase cell cycle arrest by PI3K/AKT signaling pathway in human non-small cell lung cancer A549 cells. Acta Histochem. 2020 Jul;122(5):151557 Authors: Qu D, Ma J, Song N, Hui L, Yang L, Guo Y, Sang C Abstract Lappaconitine sulfate (LS) has good solubility and bioavailability. We have previously studied the anti-proliferative activity of LS on colon cancer HT-29 cell, but its anti-proliferative...
Mon Jul 06, 2020 13:44
Levamisole enhances DR4-independent apoptosis induced by TRAIL through inhibiting the activation of JNK in lung cancer. Life Sci. 2020 Jul 01;:118034 Authors: Qiao X, Wang C, Wang W, Shang Y, Li Y, Ni J, Chen SZ Abstract THE HEADINGS AIMS: Levamisole has anti-parasite and antitumor activities, but the anti-lung cancer mechanism has not been studied. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is regarded as a promising...
Mon Jul 06, 2020 13:44
CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Anti-proliferative Response in Human Melanoma Cells in vitro and in vivo. Photochem Photobiol. 2020 Jul 04;: Authors: Garcia-Peterson LM, Ndiaye MA, Chhabra G, Singh CK, Guzmán-Pérez G, Iczkowski KA, Ahmad N Abstract Melanoma is one of the most aggressive, potentially fatal forms of skin cancer, and has been shown to be associated with solar ultraviolet radiation-dependent initiation...
Mon Jul 06, 2020 13:44
Related Articles Oocytes and hypoxanthine orchestrate the G2-M switch mechanism in ovarian granulosa cells. Development. 2020 Jul 03;147(13): Authors: Li C, Meng X, Liu S, Li W, Zhang X, Zhou J, Yao W, Dong C, Liu Z, Zhou J, Li J, Tao J, Wu W, Shen M, Liu H Abstract In mammalian growing follicles, oocytes are arrested at the diplotene stage (which resembles the G2/M boundary in mitosis), while the granulosa cells (GCs) continue to proliferate...
Mon Jul 06, 2020 13:44
Related Articles ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer. J Transl Med. 2020 Jul 03;18(1):269 Authors: Kyte JA, Andresen NK, Russnes HG, Fretland SØ, Falk RS, Lingjærde OC, Naume B Abstract BACKGROUND: Immunotherapy with checkpoint inhibitors (CPI) targeting PD-1 or CTLA-4 has emerged as an important...
Mon Jul 06, 2020 13:44
Related Articles Central metabolism in mammals and plants as a hub for controlling cell fate. Antioxid Redox Signal. 2020 Jul 03;: Authors: Selinski J, Scheibe R Abstract Significance The importance of oxido-reductases in energy metabolism together with the occurrence of enzymes of central metabolism in the nucleus gave rise to the active research field aiming to understand moonlighting enzymes that undergo post-translational modifications...
Mon Jul 06, 2020 13:44
Potent anti-myeloma efficacy of dendritic cell therapy in combination with pomalidomide and programmed death-ligand 1 blockade in a preclinical model of multiple myeloma. Cancer Immunol Immunother. 2020 Jul 04;: Authors: Chu TH, Vo MC, Park HS, Lakshmi TJ, Jung SH, Kim HJ, Lee JJ Abstract Dendritic cell (DC)-based vaccines are recognized as a promising immunotherapeutic strategy against cancer; however, the efficacy of immunotherapy with DCs...
Mon Jul 06, 2020 13:44
Bisphosphonates in common pediatric and adult bone sarcomas. Bone. 2020 Jul 02;:115523 Authors: Heymann MF, Lezot F, Heymann D Abstract The therapeutic strategies proposed currently for bone sarcomas are based on neo-adjuvant chemotherapy, delayed en-bloc wide resection, and adjuvant chemotherapy. Unfortunately, bone sarcomas are characterized by high rates of poor drug response, with a high risk of drug resistance, local recurrence and/or...
Mon Jul 06, 2020 13:44
4D CT analysis of organs at risk (OARs) in stereotactic radiotherapy. Radiother Oncol. 2020 Jul 02;: Authors: Nardone V, Maria Giugliano F, Reginelli A, Sangiovanni A, Mormile M, Iadanza L, Cappabianca S, Guida C Abstract Internal organs at risk volumes (IRV) represent the propagation of organs at risk (OARs) in 4DCT. Sixty consecutive patients that underwent 4DCT for thoracic stereotactic radiotherapy were analyzed and IRVs for heart, trachea,...
Mon Jul 06, 2020 13:44
Recent scenario of long non-coding RNAs as a diagnostic and prognostic biomarkers of prostate cancer. Urol Oncol. 2020 Jul 01;: Authors: Shukla KK, Misra S, Sankanagoudar S, Sharma H, Choudhary GR, Pareek P, Vishnoi JR, Sharma P Abstract Prostate cancer (CaP) is a leading cause of cancer deaths in the worldwide with broad range of clinical manifestations ranging from relatively indolent to aggressive metastasis. Altered expression of many circulating...
Mon Jul 06, 2020 13:44
Dual Regulation of miR-34a and Notch Signaling in Triple-Negative Breast Cancer by Antibody/miRNA Nanocarriers. Mol Ther Nucleic Acids. 2020 Jun 09;21:290-298 Authors: Valcourt DM, Day ES Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks expression of the three most common receptors present on other subtypes, leaving it unsusceptible to current targeted or hormonal therapies. In this study, we...
Mon Jul 06, 2020 13:44
Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis. Lung Cancer. 2020 Jun 21;146:318-326 Authors: Cantini L, Pecci F, Murrone A, Tomasetti M, Copparoni C, Fiordoliva I, Morgese F, Rinaldi S, Mazzanti P, Rubini C, Cimadamore A, Barbisan F, Giampieri R, Scarpelli M, Santarelli L, Berardi R Abstract INTRODUCTION: The prognostic role...
Mon Jul 06, 2020 13:44
A comprehensive overview of promising biomarkers in stage II colorectal cancer. Cancer Treat Rev. 2020 Jun 23;88:102059 Authors: Parent P, Cohen R, Rassy E, Svrcek M, Taieb J, André T, Turpin A Abstract Colon cancer (CC) has the highest incidence rate among gastrointestinal cancers and ranks the third in mortality among all cancers, which contributes to the current CC burden and constitutes a major public health issue. While therapeutic strategies...
Mon Jul 06, 2020 13:44
Biomarkers for HER2-positive metastatic breast cancer: Beyond hormone receptors. Cancer Treat Rev. 2020 Jun 24;88:102064 Authors: Dieci MV, Miglietta F, Griguolo G, Guarneri V Abstract The overexpression of human epidermal growth factor receptor-2 (HER2) results in a biologically and clinically aggressive breast cancer (BC) subtype. Since the introduction of anti-HER2 targeted agents, survival rates of patients with HER2-positive metastatic...
Mon Jul 06, 2020 13:44
High Precision Invasive FFR, Low-Cost Invasive iFR, Or Non-Invasive CFR?: Optimum Assessment of Coronary Artery Stenosis Based on the Patient-Specific Computational Models. Int J Numer Method Biomed Eng. 2020 Jul 04;:e3382 Authors: Tajeddini F, Nikmaneshi MR, Firoozabadi B, Pakravan HA, Ahmadi Tafti SH, Afshin H Abstract The objective of this paper is to apply computational fluid dynamic (CFD) as a complementary tool for clinical tests to not...
Mon Jul 06, 2020 13:44
The role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a Position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC). Eur J Heart Fail. 2020 Jul 04;: Authors: Čelutkienė J, Pudil R, López-Fernández T, Grapsa J, Nihoyannopoulos P, Bergler-Klein J, Cohen-Solal A, Farmakis D, Tocchetti CG,...
Mon Jul 06, 2020 13:44
Related Articles Definition and prospective assessment of functional recovery after liver transplantation: a new objective, consensus-based metric for safe discharge. Liver Transpl. 2020 Jul 04;: Authors: Brustia R, Boleslawski E, Monsel A, Barbier L, Dharancy S, Adam R, Dumortier J, Lesurtel M, Conti F, Scatton O, GREF2 and ACHBT collaborative group Abstract BACKGROUND: Standardized discharge criteria are critical to reduce the risk of premature...
Mon Jul 06, 2020 13:44
Related Articles Clinical Learning, Didactic Education, and Research Experiences of Radiation Oncology Resident Physicians in Canada. J Cancer Educ. 2020 Jul 04;: Authors: Wang MH, Loewen SK, Giuliani M, Fairchild A, Yee D, Debenham BJ Abstract Changes in the field of radiation oncology (RO) impacts residency training. Assessing trainee experiences is essential to inform curriculum development. We aim to explore gaps and strengths in current...
Mon Jul 06, 2020 13:44
Related Articles Living with the cerebellar mutism syndrome: long-term challenges of the diagnosis. Acta Neurochir (Wien). 2020 Jul 03;: Authors: Wibroe M, Ingersgaard MV, Larsen HB, Juhler M, Piil K Abstract BACKGROUND: After posterior fossa tumour surgery, up to 39% of children experience postoperative cerebellar mutism syndrome (CMS) characterized by mutism and other motor and cognitive impairments. There is a lack of knowledge on the patient-reported...
Mon Jul 06, 2020 13:44
Related Articles Pharmacogenomics for Immunotherapy and Immune-related Cardiotoxicity. Hum Mol Genet. 2020 Jul 03;: Authors: Castrillon JA, Eng C, Cheng F Abstract Immune checkpoint blockade (ICB) has become a standard of care in a subset of solid tumors. Although cancer survivorship has extended, rates of durable response of ICB remain poor; furthermore, cardiac adverse effects are emerging which impacts several mechanical aspects of the heart....
Mon Jul 06, 2020 13:44
Related Articles Complete blood count might help to identify subjects with high probability of testing positive to SARS-CoV-2. Clin Med (Lond). 2020 Jul 02;: Authors: Formica V, Minieri M, Bernardini S, Ciotti M, D'Agostini C, Roselli M, Andreoni M, Morelli C, Parisi G, Federici M, Paganelli C, Legramante JM Abstract The SARS-CoV-2 pandemic has dramatically increased the workload for health systems and a consequent need to optimise resources...
Mon Jul 06, 2020 13:44
Related Articles Prostate imaging: Contribution of PET PSMA and MRI. Cancer Radiother. 2020 Jun 30;: Authors: Abecassis JP, Ghazzar N, Peyromaure M, Giraud P Abstract Prostate cancer is the most common malignant tumour and represents the third cause of cancer-mortality in men. The management of prostate cancer has dramatically changed over the last decades, mainly due to improvement of diagnostic modalities and development of new therapeutic...
Mon Jul 06, 2020 13:44
Related Articles Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis. Orphanet J Rare Dis. 2020 Jul 03;15(1):175 Authors: Yamakawa N, Yagishita N, Matsuo T, Yamauchi J, Ueno T, Inoue E, Takata A, Nagasaka M, Araya N, Hasegawa D, Coler-Reilly A, Tsutsumi S, Sato T, Araujo A, Casseb J, Gotuzzo E, Jacobson S, Martin F, Puccioni-Sohler M, Taylor GP, Yamano Y, Japan Clinical Research Group on...
Mon Jul 06, 2020 13:44
Related Articles Analysis of H3K4me3 and H3K27me3 bivalent promotors in HER2+ breast cancer cell lines reveals variations depending on estrogen receptor status and significantly correlates with gene expression. BMC Med Genomics. 2020 Jul 03;13(1):92 Authors: Kaukonen D, Kaukonen R, Polit L, Hennessy BT, Lund R, Madden SF Abstract BACKGROUND: The role of histone modifications is poorly characterized in breast cancer, especially within the major...
Mon Jul 06, 2020 13:44
Publication date: Available online 5 July 2020Source: Journal of VoiceAuthor(s): Maude Desjardins, Lucinda Halstead, Annie Simpson, Patrick Flume, Heather Shaw Bonilha
Mon Jul 06, 2020 13:39
Coccidioidomycosis and Pulmonary Emboli: A Report of 5 Cases. Am J Case Rep. 2020 Jul 05;21:e924179 Authors: Prichard JG, Azimov MB, Oregel KZ Abstract BACKGROUND Coccidioidomycosis is endemic to the Sonoran life zone, which extends from Latin America to the western United States. The principle manifestation is pneumonia but disseminated disease also occurs. Venous thromboembolism occurring in association with this disease has not been reported....
Mon Jul 06, 2020 13:38
Related Articles The Heart of the Issue: A Case Report of Recurrent Reversible Stress-Induced Cardiomyopathy. Am J Case Rep. 2020 Jul 04;21:e924876 Authors: Platzer P, Espinosa Ginic MA, Potenziani Pradella S Abstract BACKGROUND Stress-induced cardiomyopathy is an increasingly recognized reversible cardiovascular condition. This type of cardiomyopathy usually occurs as an isolated event, and recurrent episodes are rare. Oftentimes, the underlying...
Mon Jul 06, 2020 13:38
Nature Communications, Published online: 06 July 2020; doi:10.1038/s41467-020-17102-xIn vitro models of the human mammary gland have struggled to mimic the 3D morphogenic processes that occur in vivo. Here the authors develop a 3D microfluidic platform of a vascularized human mammary duct that simulates diverse morphogenic transitions and paracrine crosstalk.
Mon Jul 06, 2020 03:00
Nature Communications, Published online: 06 July 2020; doi:10.1038/s41467-020-17024-8Author Correction: Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
Mon Jul 06, 2020 03:00
Nature Communications, Published online: 06 July 2020; doi:10.1038/s41467-020-17111-wChinese chestnut is widely cultivated for nut production and harbors value as a genetic resource for restoration of American and European chestnut trees destroyed by chestnut blight. Here, the authors reveal the genomic basis of homoploid hybrid speciation within Castanea spp. and find the nonrandom distribution of reproductive barrier loci based on a high-quality reference genome.
Mon Jul 06, 2020 03:00
Nature Communications, Published online: 06 July 2020; doi:10.1038/s41467-020-17048-0Author Correction: Epstein–Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma
Mon Jul 06, 2020 03:00
Nature Communications, Published online: 06 July 2020; doi:10.1038/s41467-020-17055-1Publisher Correction: A quantitative sequencing framework for absolute abundance measurements of mucosal and lumenal microbial communities
Mon Jul 06, 2020 03:00
Nature Communications, Published online: 06 July 2020; doi:10.1038/s41467-020-17062-2Despite evidence that astrocytes mediate sleep-dependent function, the involved signaling mechanisms are unknown. The authors show that astrocytic Ca2+ signalling exhibits distinct features across the sleep-wake cycle and ablation of this Ca2+ signalling pathway impairs slow wave sleep.
Mon Jul 06, 2020 03:00
Nature Communications, Published online: 06 July 2020; doi:10.1038/s41467-020-16628-4The authors here report tensile properties of polycrystalline methane hydrate at the micron scale by applying a contactless, thermos-induced stress to a tenuous shell of hydrate grown in a thin glass capillary. The results suggest that the cohesive strength of methane hydrate in marine settings may be an order of magnitude less than currently thought.
Mon Jul 06, 2020 03:00
Nature Communications, Published online: 06 July 2020; doi:10.1038/s41467-020-17182-9The authors demonstrate a two-dimensional optomechanical crystal cavity which traps a phonon mode within a phononic bandgap while yielding large thermal conductivity to the environment. High quantum cooperativity at millikelvin temperatures is realized, suitable for quantum coherent control.
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