Key Points TNF is required for mycobacteria-induced upregulation of MINCLE and DECTIN-2. Inhibition of TNF in vivo abrogates Th17 responses by a MINCLE-dependent adjuvant.
Mon Jul 06, 2020 23:00
Key Points Recombinant L. monocytogenes primes accumulation of ZIKV-specific CD8+ T cells. ZIKV levels are reduced in recombinant Listeria–primed mice. Expanded CD8+ T cells neither improve nor worsen clinical susceptibility.
Mon Jul 06, 2020 23:00
Key Points Mucus limits oral protein Ag OVA from disseminating into the general circulation. Mucus helps shield developing thymocytes from selection by the oral Ag OVA.
Mon Jul 06, 2020 23:00
Key Points Hypercapnia increases lung injury and mortality in mice infected with influenza A. Hypercapnia inhibits antiviral responses and increases influenza replication in MØs. Hypercapnic suppression of the MØ antiviral response is mediated by Akt1.
Mon Jul 06, 2020 23:00
Key Points Ag potency and ITK control graded IRF4 expression. Altered kinetics of NFAT activation provide a mechanism linking ITK and IRF4.
Mon Jul 06, 2020 23:00
Key Points FCRL4 recognizes systemic J chain–linked IgA. FCRL4 recognition of J chain–linked IgA can be inhibited by secretory component. Primary FCRL4+ memory B cells are decorated with systemic J chain–linked IgA.
Mon Jul 06, 2020 23:00
Key Points In murine autoimmunity, IL-23 promotes Tfh–IL-17 and suppresses Tfh–IFN-. Lack of IL-23 leads to lower IgG2b class switch in murine autoimmunity. Il17ra gene expression is synchronized with GC program genes used to initiate CSR.
Mon Jul 06, 2020 23:00
Key Points Stimulation-based profiling defined genotype- and cell-specific Atg16L1 programs. Cell type and stimulation strongly influence Atg16L1 T300A genotypic differences. Genotype- and stimulation-dependent lipid metabolism genes impair mucosal immunity.
Mon Jul 06, 2020 23:00
Key Points Myelin-specific CD8 T cells must sense their own IFN- to optimally inhibit EAE. IFN-R–/– CD8s exhibit less IFN-, granzyme B, and CD107a and exhibit potential killing defects. IFN-R–/– CD8s exhibit less CXCR3 and decreased migration to the CNS upon transfer.
Mon Jul 06, 2020 23:00
Key Points A large proportion of immunity-relevant anti-Salmonella Abs bind O Ags. Accessibility of shared O Ags is critical for cross-protection with Abs. O Ags of Salmonella may be involved in host–pathogen interaction.
Mon Jul 06, 2020 23:00
Key Points Serum BK-des-arg-9 is significantly elevated in mice and patients with lupus. A similar but less pronounced increase is also noted in RA serum. Increased conversion of BK to proinflammatory BK-des-arg-9 may mediate nephritis.
Mon Jul 06, 2020 23:00
Key Points HSV-specific CD8+ T cells from HSV-1–infected symptomatic patients are exhausted. Blocking of LAG-3 and PD-1 synergistically restored anti-HSV CD8+ T cell responses. LAG-3 and PD-1 blockade reduced recurrent ocular herpes in HSV-1–infected mice.
Mon Jul 06, 2020 23:00
Key Points Th17 cells are associated with renal dysfunction and IL-27 suppresses these cells. IL-27R limits renal fibrosis after UUO.
Mon Jul 06, 2020 23:00
Key Points Postinfluenza IPA can be effectively modeled in mice. Neutrophil recruitment to the lung is decreased in postinfluenza IPA. STAT1 signaling increases susceptibility to postinfluenza IPA.
Mon Jul 06, 2020 23:00
Key Points P2Y6 deficiency enhances DC-mediated Th1/Th17 differentiation. P2Y6 deficiency aggravates the pathogenesis of EAE.
Mon Jul 06, 2020 23:00
Key Points NK cells exhibit enhanced proinflammatory phenotype in 3xTg-AD mice. Depletion of NK cells enhances cognitive function of 3xTg-AD mice. Depletion of NK cells alleviates neuroinflammation in 3xTg-AD mice.
Mon Jul 06, 2020 23:00
Key Points Calcitriol downregulates MerTK expression in human macrophages and microglia. Calcitriol inhibits MerTK-mediated phagocytosis of myelin and apoptotic T cells. Inflammation increases CYP27B1-mediated metabolism of 25OHD and MerTK inhibition.
Mon Jul 06, 2020 23:00
Key Points Absence of tetraspanin CD53 restricts neutrophil transmigration. CD53-deficient neutrophils show alterations in α3 integrin expression and trafficking. Serum-transfer arthritis is delayed in CD53-deficient mice.
Mon Jul 06, 2020 23:00
Key Points Anti-HMGB1 neutralizing IgM autoantibody exists normally in healthy humans and mice. In mice, B-1 cells produce the Ab in response to extracellular HMGB1.
Mon Jul 06, 2020 23:00
Key Points Oxidation of Cys-containing peptides can inhibit MHC binding and T cell responses. Effects of inhibiting oxidation of Cys-containing peptides on binding and recognition are detailed.
Mon Jul 06, 2020 23:00
Carbapenemase-producing K. pneumoniae (CP-Kp) has been established as important nosocomial pathogen in most tertiary care hospitals in Greece. The aim of the present study was to examine the impact of an enhanced...
Mon Jul 06, 2020 03:00
The worldwide emergence and clonal spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is of great concern. The aim of this nationwide study was to investigate the prevalence of CRAB isolates in Serbia ...
Mon Jul 06, 2020 03:00
To determine the risk of SARS-CoV-2 transmission by aerosols, to provide evidence on the rational use of masks, and to discuss additional measures important for the protection of healthcare workers from COVID-19.
Mon Jul 06, 2020 03:00
Abstract Chlorpyrifos (CPF) is one of the most abundant and widely used pesticides in the world. CPF has detrimental effects on brain tissue, so it is possible to generate some neurodegenerative diseases. The aim of this study was to evaluate the effect of CPF on inducing the Parkinson’s disease affecting on central nervous system. 6 to 8-week-old animals were categorized into three groups. The first group was normal control which the animals did not received any treatment, while...
Mon Jul 06, 2020 03:00
Abstract The rubber-hand illusion is an illusion where a person embodies a rubber hand as if it were their own. After embodiment, many studies have threatened the false hand and measured physiological responses to the threat for the purposes of verification. For the first time, we tested if embodiment of the false hand could be modulated with a fearful stimulus already present prior to the elicitation of the illusion. This was done by having a live huntsman spider placed on top...
Mon Jul 06, 2020 03:00
Effects of moderate aerobic exercise on thoracic aortic remodeling of female LDL-receptor knockout ovariectomized mice. Acta Histochem. 2020 Jul;122(5):151575 Authors: de Lima NEA, Brianezi L, Nucci RAB, Cardoso CG, Magalhães WV, Chucata KLB, Fonseca FLA, Maifrino LBM Abstract Menopause is a major factor involved in dyslipidemia increasing the risk of atherosclerosis which may be reversed by a routine of aerobic physical activity. Thus, this...
Mon Jul 06, 2020 22:55
Remodeling of the soleus muscle of ovariectomized old female rats submitted to resistance training and different diet intake. Acta Histochem. 2020 Jul;122(5):151570 Authors: Braggion GF, Ornelas EM, Cury JCS, de Sousa JP, Nucci RAB, Fonseca FLA, Maifrino LBM Abstract Sarcopenia is a common condition that is associated mainly with hormonal factors, nutritional status, physical activity, leading to a lower quality of life. Thus, this study aimed...
Mon Jul 06, 2020 22:55
Lappaconitine sulfate induces apoptosis and G0/G1 phase cell cycle arrest by PI3K/AKT signaling pathway in human non-small cell lung cancer A549 cells. Acta Histochem. 2020 Jul;122(5):151557 Authors: Qu D, Ma J, Song N, Hui L, Yang L, Guo Y, Sang C Abstract Lappaconitine sulfate (LS) has good solubility and bioavailability. We have previously studied the anti-proliferative activity of LS on colon cancer HT-29 cell, but its anti-proliferative...
Mon Jul 06, 2020 22:55
Identification of aspartame-induced haematopoietic and lymphoid tumours in rats after lifetime treatment. Acta Histochem. 2020 Jul;122(5):151548 Authors: Tibaldi E, Gnudi F, Panzacchi S, Mandrioli D, Vornoli A, Manservigi M, Sgargi D, Falcioni L, Bua L, Belpoggi F Abstract Lymphomas and leukaemias involving the lung have in some cases been hard to distinguish from respiratory tract infection in Sprague-Dawley (SD) rats from long-term bioassays....
Mon Jul 06, 2020 22:55
Thyroidectomy induces thyroglobulin formation by parotid salivary glands in rats. Acta Histochem. 2020 Jul;122(5):151568 Authors: Helal MB, Labah DA, El-Magd MA, Sarhan NH, Nagy NB Abstract Structural changes in parotid gland (PG) were previously reported following ablation of thyroid gland. However, the functional alterations (especially for proteins) have not been elucidated yet. Herein, we investigated the effect of rat thyroidectomy on...
Mon Jul 06, 2020 22:55
Quercetin mitigates monosodium glutamate-induced excitotoxicity of the spinal cord motoneurons in aged rats via p38 MAPK inhibition. Acta Histochem. 2020 Jul;122(5):151554 Authors: Firgany AEL, Sarhan NR Abstract Various studies reported the possibility of deterioration of blood-brain barrier (BBB) integrity owing to the aging process. The current work was performed to investigate the ability of Monosodium glutamate (MSG) to cross BBB in aged...
Mon Jul 06, 2020 22:55
Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels. Acta Histochem. 2020 Jul;122(5):151559 Authors: Alves ÉR, Ferreira CGM, Silva MVD, Vieira Filho LD, Silva Junior VAD, Melo IMF, Neto CJCL, Santos LCDS, Teixeira ÁAC, Wanderley Teixeira V Abstract The aim of the present study was to analyze the effects of melatonin treatment on diabetic rat testes. Fifty albino rats were divided into...
Mon Jul 06, 2020 22:55
Differentiation of NSC-34 cells is characterized by expression of NGF receptor p75, glutaminase and NCAM L1, activation of mitochondria, and sensitivity to fatty acid intervention. Acta Histochem. 2020 Jul;122(5):151574 Authors: Keilhoff G, Mbou RP, Lucas B Abstract Motor neuronal damage due to diseases, traumatic insults or de-afferentation of the spinal cord is often incurable because of poor intrinsic regenerative capacity. Hence, medical...
Mon Jul 06, 2020 22:55
Autologously transplanted dermal fibroblasts improved diabetic wound in rat model. Acta Histochem. 2020 Jul;122(5):151552 Authors: Mutlu HS, Erdoğan A, Tapul L Abstract Healing of diabetic wounds are delayed due to late initiation and prolongation of the inflammatory phase, and inadequate growth factor synthesis, which may lead to chronic ulcers that may cause limb amputation, besides making the patients vulnerable to infections. In recent...
Mon Jul 06, 2020 22:55
MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9. Acta Histochem. 2020 Jul;122(5):151571 Authors: Zhang H, Lu X, Hao Y, Tang L, He Z Abstract Emerging evidence has unraveled the important implications of microRNAs (miRNAs/miRs) in intracerebral hemorrhage (ICH). The aim of the present study was to assess the possible regulatory role of miR-26a-5p in ICH both in vivo...
Mon Jul 06, 2020 22:55
Effects of adipose- derived stromal vascular fraction on asherman syndrome model. Acta Histochem. 2020 Jul;122(5):151556 Authors: Monsef F, Artimani T, Ramazani M, Alizadeh Z, Solgi G, Yavangi M, Soleimani Asl S Abstract Asherman's syndrome (AS) is an endometrial damage that results in infertility in women. Although stem cell therapy has been introduced as a potential treatment for this syndrome, its use in clinical settings remains challenging...
Mon Jul 06, 2020 22:55
Three-dimensional co-culture of human spermatogonial stem cells with Sertoli cells in soft agar culture system supplemented by growth factors and Laminin. Acta Histochem. 2020 Jul;122(5):151572 Authors: Jabari A, Sadighi Gilani MA, Koruji M, Gholami K, Mohsenzadeh M, Rastegar T, Khadivi F, Ghanami Gashti N, Nikmahzar A, Mojaverrostami S, Talebi A, Ashouri Movassagh S, Rezaie MJ, Abbasi M Abstract Application of a three-dimensional (3D) culture...
Mon Jul 06, 2020 22:55
Effects of short-term exposure to high-fat diet on histology of male and female gonads in rats. Acta Histochem. 2020 Jul;122(5):151558 Authors: Matuszewska J, Ziarniak K, Dudek M, Kołodziejski P, Pruszyńska-Oszmałek E, Śliwowska JH Abstract Obesity, which reaches an epidemic, is characterized by alterations in metabolic and hormonal profiles. Moreover, uncontrolled obesity may lead to development of diabetes type 2, which accounts for about...
Mon Jul 06, 2020 22:55
Ectopic subcutaneous transplantation of fetal rat urogenital sinus and seminal vesicle promotes the organ growth and formation. Acta Histochem. 2020 Jul;122(5):151569 Authors: Uemura KI, Hayashi T, Hiroshige T, Ueda K, Ohta K, Kanazawa T, Hirashima S, Nakiri M, Igawa T, Nakamura KI Abstract PURPOSE: The fate of subcutaneously transplanted urogenital sinus (UGS) and seminal vesicle (SV) was investigated in the present study. MATERIALS...
Mon Jul 06, 2020 22:5
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