Related Articles Association of acute myocardial infarction with seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study. J Clin Neurosci. 2020 Jun 30;: Authors: Lee JK, Kim H, Hong JB, Sheen SH, Han IB, Sohn S Abstract BACKGROUND: The aim of this nationwide age- and sex matched longitudinal follow up study is to determine the risk of acute myocardial infarction (AMI) associated with the seropositive rheumatoid arthritis...
Mon Jul 06, 2020 13:27
Related Articles How the elderly fare after brain tumor surgery compared to younger patients within a 30-day follow-up: A National surgical Quality Improvement Program analysis of 30,183 cases. J Clin Neurosci. 2020 Jun 30;: Authors: Nia AM, Branch DW, Maynard K, Frank T, Yowtak-Guillet J, Patterson JT, Lall RR Abstract The growing elderly population in Western societies has led to an increasing number of primary brain tumors occurring in patients...
Mon Jul 06, 2020 13:27
Related Articles Surgical management of aggressive hemangiomas of the spine. J Clin Neurosci. 2020 Jun 30;: Authors: Qiu B, Joo P, Ajabnoor R, Boyce B, Mesfin A Abstract Our objective is to describe the surgical management and outcomes following surgical intervention for aggressive spine hemangiomas. Patients from 2005 to 2018 with an aggressive hemangioma of the cervical, thoracic, lumbar spine and sacrum treated surgically at a tertiary referral...
Mon Jul 06, 2020 13:27
Diagnosis and treatment of isolated snoring-open questions and areas for future research. Sleep Breath. 2020 Jul 04;: Authors: Hofauer B, Braumann B, Heiser C, Herzog M, Maurer JT, Plößl S, Sommer JU, Steffen A, Verse T, Stuck BA Abstract STUDY OBJECTIVES: Snoring is a common phenomenon which is generated by vibration of soft tissue of the upper airway during sleep. Due to the high incidence of isolated snoring and the substantial burden for...
Mon Jul 06, 2020 13:17
Related Articles Histopathological and biomechanical changes in soft palate in response to non-ablative 9.3-μm CO2 laser irradiation: an in vivo study. Lasers Med Sci. 2020 Jul 03;: Authors: Badreddine AH, Couitt S, Kerbage C Abstract The purpose of this study was to investigate in vivo the biomechanical and morphological changes in soft palates of Wistar rats from non-ablative irradiation with a 9.3-μm CO2 laser. A blinded, randomized, controlled...
Mon Jul 06, 2020 13:17
Related Articles Imaging of sleep-disordered breathing in adults. Clin Radiol. 2020 Jun 30;: Authors: Whyte A, Gibson D Abstract Sleep-disordered breathing (SDB) is a term that includes several chronic conditions in which partial or complete cessation of breathing occurs multiple times throughout the night. Central sleep apnoea (CSA) is uncommon and defined by the episodic cessation of airflow without respiratory effort. Lesions involving the...
Mon Jul 06, 2020 13:17
Potent anti-myeloma efficacy of dendritic cell therapy in combination with pomalidomide and programmed death-ligand 1 blockade in a preclinical model of multiple myeloma. Cancer Immunol Immunother. 2020 Jul 04;: Authors: Chu TH, Vo MC, Park HS, Lakshmi TJ, Jung SH, Kim HJ, Lee JJ Abstract Dendritic cell (DC)-based vaccines are recognized as a promising immunotherapeutic strategy against cancer; however, the efficacy of immunotherapy with...
Mon Jul 06, 2020 13:02
Bisphosphonates in common pediatric and adult bone sarcomas. Bone. 2020 Jul 02;:115523 Authors: Heymann MF, Lezot F, Heymann D Abstract The therapeutic strategies proposed currently for bone sarcomas are based on neo-adjuvant chemotherapy, delayed en-bloc wide resection, and adjuvant chemotherapy. Unfortunately, bone sarcomas are characterized by high rates of poor drug response, with a high risk of drug resistance, local recurrence and/or...
Mon Jul 06, 2020 13:02
4D CT analysis of organs at risk (OARs) in stereotactic radiotherapy. Radiother Oncol. 2020 Jul 02;: Authors: Nardone V, Maria Giugliano F, Reginelli A, Sangiovanni A, Mormile M, Iadanza L, Cappabianca S, Guida C Abstract Internal organs at risk volumes (IRV) represent the propagation of organs at risk (OARs) in 4DCT. Sixty consecutive patients that underwent 4DCT for thoracic stereotactic radiotherapy were analyzed and IRVs for heart,...
Mon Jul 06, 2020 13:02
Recent scenario of long non-coding RNAs as a diagnostic and prognostic biomarkers of prostate cancer. Urol Oncol. 2020 Jul 01;: Authors: Shukla KK, Misra S, Sankanagoudar S, Sharma H, Choudhary GR, Pareek P, Vishnoi JR, Sharma P Abstract Prostate cancer (CaP) is a leading cause of cancer deaths in the worldwide with broad range of clinical manifestations ranging from relatively indolent to aggressive metastasis. Altered expression of many...
Mon Jul 06, 2020 13:02
Dual Regulation of miR-34a and Notch Signaling in Triple-Negative Breast Cancer by Antibody/miRNA Nanocarriers. Mol Ther Nucleic Acids. 2020 Jun 09;21:290-298 Authors: Valcourt DM, Day ES Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks expression of the three most common receptors present on other subtypes, leaving it unsusceptible to current targeted or hormonal therapies. In this study,...
Mon Jul 06, 2020 13:02
Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis. Lung Cancer. 2020 Jun 21;146:318-326 Authors: Cantini L, Pecci F, Murrone A, Tomasetti M, Copparoni C, Fiordoliva I, Morgese F, Rinaldi S, Mazzanti P, Rubini C, Cimadamore A, Barbisan F, Giampieri R, Scarpelli M, Santarelli L, Berardi R Abstract INTRODUCTION: The prognostic...
Mon Jul 06, 2020 13:02
A comprehensive overview of promising biomarkers in stage II colorectal cancer. Cancer Treat Rev. 2020 Jun 23;88:102059 Authors: Parent P, Cohen R, Rassy E, Svrcek M, Taieb J, André T, Turpin A Abstract Colon cancer (CC) has the highest incidence rate among gastrointestinal cancers and ranks the third in mortality among all cancers, which contributes to the current CC burden and constitutes a major public health issue. While therapeutic...
Mon Jul 06, 2020 13:02
Biomarkers for HER2-positive metastatic breast cancer: Beyond hormone receptors. Cancer Treat Rev. 2020 Jun 24;88:102064 Authors: Dieci MV, Miglietta F, Griguolo G, Guarneri V Abstract The overexpression of human epidermal growth factor receptor-2 (HER2) results in a biologically and clinically aggressive breast cancer (BC) subtype. Since the introduction of anti-HER2 targeted agents, survival rates of patients with HER2-positive metastatic...
Mon Jul 06, 2020 13:02
High Precision Invasive FFR, Low-Cost Invasive iFR, Or Non-Invasive CFR?: Optimum Assessment of Coronary Artery Stenosis Based on the Patient-Specific Computational Models. Int J Numer Method Biomed Eng. 2020 Jul 04;:e3382 Authors: Tajeddini F, Nikmaneshi MR, Firoozabadi B, Pakravan HA, Ahmadi Tafti SH, Afshin H Abstract The objective of this paper is to apply computational fluid dynamic (CFD) as a complementary tool for clinical tests...
Mon Jul 06, 2020 13:02
The role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a Position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC). Eur J Heart Fail. 2020 Jul 04;: Authors: Čelutkienė J, Pudil R, López-Fernández T, Grapsa J, Nihoyannopoulos P, Bergler-Klein J, Cohen-Solal A, Farmakis D, Tocchetti...
Mon Jul 06, 2020 13:02
Related Articles Definition and prospective assessment of functional recovery after liver transplantation: a new objective, consensus-based metric for safe discharge. Liver Transpl. 2020 Jul 04;: Authors: Brustia R, Boleslawski E, Monsel A, Barbier L, Dharancy S, Adam R, Dumortier J, Lesurtel M, Conti F, Scatton O, GREF2 and ACHBT collaborative group Abstract BACKGROUND: Standardized discharge criteria are critical to reduce the risk of...
Mon Jul 06, 2020 13:02
Related Articles Clinical Learning, Didactic Education, and Research Experiences of Radiation Oncology Resident Physicians in Canada. J Cancer Educ. 2020 Jul 04;: Authors: Wang MH, Loewen SK, Giuliani M, Fairchild A, Yee D, Debenham BJ Abstract Changes in the field of radiation oncology (RO) impacts residency training. Assessing trainee experiences is essential to inform curriculum development. We aim to explore gaps and strengths in current...
Mon Jul 06, 2020 13:02
Related Articles Living with the cerebellar mutism syndrome: long-term challenges of the diagnosis. Acta Neurochir (Wien). 2020 Jul 03;: Authors: Wibroe M, Ingersgaard MV, Larsen HB, Juhler M, Piil K Abstract BACKGROUND: After posterior fossa tumour surgery, up to 39% of children experience postoperative cerebellar mutism syndrome (CMS) characterized by mutism and other motor and cognitive impairments. There is a lack of knowledge on the...
Mon Jul 06, 2020 13:02
Related Articles Pharmacogenomics for Immunotherapy and Immune-related Cardiotoxicity. Hum Mol Genet. 2020 Jul 03;: Authors: Castrillon JA, Eng C, Cheng F Abstract Immune checkpoint blockade (ICB) has become a standard of care in a subset of solid tumors. Although cancer survivorship has extended, rates of durable response of ICB remain poor; furthermore, cardiac adverse effects are emerging which impacts several mechanical aspects of the...
Mon Jul 06, 2020 13:02
Related Articles Complete blood count might help to identify subjects with high probability of testing positive to SARS-CoV-2. Clin Med (Lond). 2020 Jul 02;: Authors: Formica V, Minieri M, Bernardini S, Ciotti M, D'Agostini C, Roselli M, Andreoni M, Morelli C, Parisi G, Federici M, Paganelli C, Legramante JM Abstract The SARS-CoV-2 pandemic has dramatically increased the workload for health systems and a consequent need to optimise resources...
Mon Jul 06, 2020 13:02
Related Articles Prostate imaging: Contribution of PET PSMA and MRI. Cancer Radiother. 2020 Jun 30;: Authors: Abecassis JP, Ghazzar N, Peyromaure M, Giraud P Abstract Prostate cancer is the most common malignant tumour and represents the third cause of cancer-mortality in men. The management of prostate cancer has dramatically changed over the last decades, mainly due to improvement of diagnostic modalities and development of new therapeutic...
Mon Jul 06, 2020 13:02
Related Articles Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis. Orphanet J Rare Dis. 2020 Jul 03;15(1):175 Authors: Yamakawa N, Yagishita N, Matsuo T, Yamauchi J, Ueno T, Inoue E, Takata A, Nagasaka M, Araya N, Hasegawa D, Coler-Reilly A, Tsutsumi S, Sato T, Araujo A, Casseb J, Gotuzzo E, Jacobson S, Martin F, Puccioni-Sohler M, Taylor GP, Yamano Y, Japan Clinical Research Group...
Mon Jul 06, 2020 13:02
Related Articles Analysis of H3K4me3 and H3K27me3 bivalent promotors in HER2+ breast cancer cell lines reveals variations depending on estrogen receptor status and significantly correlates with gene expression. BMC Med Genomics. 2020 Jul 03;13(1):92 Authors: Kaukonen D, Kaukonen R, Polit L, Hennessy BT, Lund R, Madden SF Abstract BACKGROUND: The role of histone modifications is poorly characterized in breast cancer, especially within the...
Mon Jul 06, 2020 13:02
Abstract YY1 mutations cause Gabriele‐de Vries syndrome, a recently described condition involving cognitive impairment, facial dysmorphism and intrauterine growth restriction. Movement disorders were reported in 5/10 cases of the original series, but no detailed description was provided. Here we present a 21‐year‐old woman with a mild intellectual deficit, facial dysmorphism and a complex movement disorder including an action tremor, cerebellar ataxia, dystonia, and partial ocular apraxia as the...
Mon Jul 06, 2020 12:57
Abstract Genetic variations in the ASAH1 gene are associated with a spectrum of disorders ranging from Farber disease (FD) to spinal muscular atrophy with or without progressive myoclonic epilepsy (SMA‐PME). FD presents most commonly in infants with subcutaneous joint nodules, progressive arthritis and granulomas of the larynx and epiglottis leading to a hoarse cry. SMA‐PME is characterized by childhood onset progressive weakness due to motor neuron disease followed by progressive epilepsy, tremor,...
Sun Jul 05, 2020 21:49
Sun Jul 05, 2020 21:46
Abstract The aim of this article is to increase awareness of language practices in the deaf community that affect communication needs and health outcomes, focusing particularly on the prevalence of bilingualism among deaf adults. Language deprivation and poor health outcomes in the deaf population are risks that cannot be addressed solely by hearing intervention. We propose that bilingualism acts as a protective measure to minimize the health risks faced by deaf individuals. Provision...
Mon Jul 06, 2020 03:00
Abstract Objectives Young children living in low-income households experience disparities in language development compared to their advantaged peers, with large differences in language skill by kindergarten entry. In this study, we sought to determine whether there were disparities in early language trajectories within a low-income sample of children from 9 to 36 months as a function of maternal education. We hypothesized that children...
Mon Jul 06, 2020 03:00
Comparison of Early Life Obesity-Related Risk and Protective Factors in Non-Hispanic Black Subgroups
Abstract Objectives Previous obesity prevention studies in preschool-age children have included non-Hispanic Black (NHB) children, but few have investigated between-subgroup differences even though there may be cultural risk and protective practice differences, challenging the generalizability of findings. The purpose of this study was to examine differences in early childhood obesity-related factors in NHB subgroups (Haitian, other Caribbean...
Mon Jul 06, 2020 03:00
Abstract After the recent success and approvals of chimeric antigen receptor (CAR) T cells in haematological malignancies, its efficacy is currently evaluated in a broad spectrum of tumor entities including melanoma. However, severe and potentially life‐threatening side effects like cytokine release syndrome, neurologic toxicities, and the competing risk of morbidity and mortality from the treatment itself are still a major limiting factor in the current CAR T‐cell landscape. In addition, especially...
Sun Jul 05, 2020 20:16
Mon Jul 06, 2020 03:00
Abstract Carcinoma of Unknown Primary presenting primarily as hepatic metastases encompasses a dismal subgroup of tumors with a median survival of 5.9 months. Adenocarcinoma is the most common histological subtype identified upon biopsy and the primary tumor remains undetectable in the majority of cases despite extensive workup. It is important to have a validated and standardized algorithm to follow these tumors to avoid unnecessary tests, as the wishes and health status of the...
Mon Jul 06, 2020 03:00
With some large events being canceled this year and many Americans still sheltering at home, the American Speech-Language-Hearing Association (ASHA) is encouraging the public to take steps to protect their hearing if they are planning their own fireworks celebrations this Independence Day. Sales of consumer fireworks are up over previous years, according to several large fireworks companies. Fireworks and firecrackers can be as loud as 150 decibels—significantly louder than what is considered a safe...
Sat Jul 04, 2020 19:38
Key points In vascular smooth muscle cells (VSMCs), activation of Ca2+‐permeable store‐operated channels (SOCs) composed of canonical transient receptor potential channel 1 (TRPC1) subunits mediate Ca2+ entry pathways which regulate contraction, proliferation and migration that are processes associated with vascular disease. Activation of TRPC1‐based SOCs requires protein kinase C (PKC) activity, which is proposed to phosphorylate TRPC1 proteins to promote channel opening by phosphatidylinositol...
Mon Jul 06, 2020 12:32
Key points Cl− and HCO3 − had similar paracellular permeabilities in human airway epithelia. PCl/PNa of airway epithelia was unaltered by pH 7.4 vs. pH 6.0 solutions. Under basal conditions, calculated paracellular HCO3 − flux was secretory. Cytokines that increased airway surface liquid pH decreased or reversed paracellular HCO3 − flux. HCO3 − flux through the paracellular pathway may counterbalance effects of cellular H+ and HCO3 − secretion. Abstract Airway epithelia control...
Sun Jul 05, 2020 21:46
Abstract Background Dental Stem cell transplantation has become a new method for tooth tissue regeneration. However, its molecular mechanism of the dentinogenic differentiation is still unclear, limited its application. Our previous studies found that Insulin‐like growth factor binding protein 5 (IGFBP5) can promote the osteogenic differentiation of periodontal ligament stem cells and the regeneration of periodontal tissues. This study aims to clarify the effect and mechanism of IGFBP5 on the...
Sun Jul 05, 2020 19:04
Abstract 4D‐Flow MRI has enabled in‐vivo time‐resolved measurement of three‐dimensional blood flow velocities in the human vascular system. However, its clinical use has been hampered by two main issues, namely, low spatio‐temporal resolution and acquisition noise. While patient‐specific computational fluid dynamics (CFD) simulations can address the resolution and noise issues, its fidelity is impacted by accuracy of estimation of boundary conditions, model parameters, vascular geometry, and flow...
Mon Jul 06, 2020 12:03
Mutations that cause an error in the splicing of a messenger RNA (mRNA) can lead to diseases in humans. Various computational models have been developed to recognize the sequence pattern of the splice sites. In recent studies, Convolutional Neural Network (CNN) architectures were shown to outperform other existing models in predicting the splice sites. However, an insufficient effort has been put into extending the CNN model to predict the effect of the genomic variants on the splicing of mRNAs....
Mon Jul 06, 2020 03:00
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