Summary Purpose MDM2 is a negative regulator of the tumor suppressor p53. RO6839921 is an inactive pegylated prodrug of idasanutlin, an MDM2 antagonist, developed for intravenous administration. On cleavage by plasma esterases, the active principle (AP = idasanutlin) is released. This phase 1 study investigated the safety, pharmacokinetics, and pharmacodynamics of RO6839921 in patients with advanced solid tumors (NCT02098967). Methods Patients were evaluated on a 5-day dosing...
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Summary Chemotherapy has always been the first therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) with untreatable oncogenic mutations. However, chemotherapy has demonstrated limited success and is associated with severe side effects. This research aimed to investigate the antitumor efficacy and cytotoxic safety of the conjugate ZHER2:V2-pemetrexed, a novel targeted chemotherapeutic drug. In this context, human epidermal growth factor receptor 2...
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Summary This study provides new information on the cellular effects of 1,3,5-triazine nitrogen mustards with different peptide groups in DLD and Ht-29 human colon cancer cell lines. A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives bearing 2-chloroethyl and oligopeptide moieties was designed and synthesized. The most cytotoxic derivative was triazine with an Ala-Ala-OMe substituent on the ring (compound 7b). This compound induced time- and dose-dependent cytotoxicity...
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Summary Gliomas account for nearly 70% of the central nervous system tumors and present a median survival of approximately 12–17 months. Studies have shown that administration of novel natural antineoplastic agents is been highly effective for treating gliomas. This study was conducted to investigate the antitumor potential (in vitro and in vivo) of Miconia chamissois Naudin for treating glioblastomas. We investigated the cytotoxicity of the chloroform partition and its sub-fraction...
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Summary Background Resistance to Epidermal Growth Factor inhibition (EGFRi) in patients with KRAS wild-type (wt) Colorectal Cancer (CRC) may occur as a result of PI3K/AKT/mTOR signaling. We conducted a study to establish the recommended phase II dose (RP2D) and response rate of panitumumab, an EGFRi, plus BKM120, a PI3K inhibitor, in advanced CRC. Methods Patients with chemotherapy refractory KRAS wt CRC, who were EGFRi naive were enrolled. A 3 + 3 dose escalation design was...
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HSP27 regulates viability and migration of cancer cell lines following irradiation. J Proteomics. 2020 Jul 01;:103886 Authors: Ernst BP, Wiesmann N, Gieringer R, Eckrich J, Briege J Abstract Despite improvements of radiotherapy and better outcomes of cancer patients resistances still limit the therapeutic success. The combined treatment of tumors by the use of irradiation as well as targeted therapies is a promising approach. By the use...
Mon Jul 06, 2020 13:28
METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m6A Methylation in Oral Squamous Cell Carcinoma. Mol Ther. 2020 Jun 24;: Authors: Liu L, Wu Y, Li Q, Liang J, He Q, Zhao L, Chen J, Cheng M, Huang Z, Ren H, Chen J, Peng L, Gao F, Chen D, Wang A Abstract RNA modification plays an essential function in regulating gene expression and diverse biological processes. RNA modification enzyme methyltransferase-like 3 (METTL3) affects tumor...
Mon Jul 06, 2020 13:28
A Mindfulness-Based Intervention as a Supportive Care Strategy for Patients with Metastatic Non-Small Cell Lung Cancer and their Spouses: Results of a 3-Arm Pilot Randomized Controlled Trial. Oncologist. 2020 Jul 04;: Authors: Milbury K, Li Y, Durrani S, Liao Z, Tsao AS, Carmack C, Cohen L, Bruera E Abstract BACKGROUND: Although mindfulness-based interventions have been widely examined in patients with non-metastatic cancer, the feasibility...
Mon Jul 06, 2020 13:28
Efficacy and long-term follow-up of positional therapy by vibrotactile neck-based device in the management of positional OSA. J Clin Sleep Med. 2020 Jul 06;: Authors: De Corso E, Mastrapasqua RF, Fiorita A, Settimi S, Mele DA, Picciotti PM, Loperfido A, Marrone S, Rizzotto G, Paludetti G, Scarano E Abstract STUDY OBJECTIVES: Different therapeutic strategies have been investigated for the treatment of positional-OSA (POSA), but more evidence...
Mon Jul 06, 2020 13:28
Affective symptoms and swallow-specific quality of life in total laryngectomy patients. Head Neck. 2020 Jul 04;: Authors: Kemps GJF, Krebbers I, Pilz W, Vanbelle S, Baijens LWJ Abstract BACKGROUND: The aim of this study is to determine the prevalence of clinically relevant affective symptoms and level of swallow-specific quality of life (QoL) in patients with dysphagic total laryngectomy (TL) and to explore the relationship between affective...
Mon Jul 06, 2020 13:28
Peripheral Vestibular Disorders: Nationwide Evidence From Taiwan. Laryngoscope. 2020 Jul 04;: Authors: Yang TH, Xirasagar S, Cheng YF, Wu CS, Kuo NW, Lin HC Abstract OBJECTIVES/HYPOTHESIS: This study aimed to evaluate the prevalence of peripheral vestibular disorders in an Asian population of predominantly Han Chinese ethnicity. STUDY DESIGN: Cross-sectional study. METHODS: Patients with a peripheral vertigo disorder...
Mon Jul 06, 2020 13:28
Esophageal Dysmotility is Common in Patients With Multiple System Atrophy. Laryngoscope. 2020 Jul 04;: Authors: Ueha R, Sato T, Goto T, Yamauchi A, Nativ-Zeltzer N, Mitsui J, Belafsky PC, Yamasoba T Abstract OBJECTIVES: Esophageal dysmotility (ED) in patients with multiple system atrophy (MSA) are poorly understood. This study aimed to investigate the prevalence of ED in patients with MSA and to assess the relationship of esophageal abnormalities...
Mon Jul 06, 2020 13:28
Related Articles Respiratory droplet generation and dispersal during nasoendoscopy and upper respiratory swab testing. Head Neck. 2020 Jul 04;: Authors: Tan VYJ, Zhang EZY, Daniel D, Sadovoy A, Teo NWY, Kiong KL, Toh ST, Yuen HW Abstract Respiratory particle generation and dispersal during nasoendoscopy and swab testing is studied with high-speed video and laser light illumination. Video analysis reveals droplet formation in three manoeuvres...
Mon Jul 06, 2020 13:28
Related Articles Evaluation of natural growth rate and recommended age for shaving procedure by volumetric analysis of craniofacial fibrous dysplasia. Head Neck. 2020 Jul 04;: Authors: Park JW, Jung JH, Park SJ, Lim SY Abstract BACKGROUND: We evaluated the preoperative natural growth pattern of craniofacial fibrous dysplasia and postoperative volume changes in patients undergoing shaving procedures. METHODS: Thirty-three patients...
Mon Jul 06, 2020 13:28
Related Articles Sensory change in the chin and neck after transoral thyroidectomy: Prospective study of mental nerve injury. Head Neck. 2020 Jul 04;: Authors: Tae K, Lee DW, Bang HS, Ahn YH, Park JH, Kim DS Abstract BACKGROUND: The study aimed to evaluate the sensory changes on the chin and neck in transoral thyroidectomy. METHODS: We prospectively assessed the cutaneous sensation of 10 zones of the chin, face, and neck in 43...
Mon Jul 06, 2020 13:28
Related Articles Single-port transoral robotic combined approach with sialendoscopy for sialolithiasis: Case report and review of the literature. Head Neck. 2020 Jul 04;: Authors: Frost AS, Byrnes YM, Wen CZ, Rassekh CH Abstract BACKGROUND: The da Vinci single-port (SP) is utilized in transoral robotic surgery (TORS) procedures for malignant oropharyngeal tumors. We report a case utilizing the da Vinci SP in TORS for sialolith removal....
Mon Jul 06, 2020 13:28
Related Articles An optimized and highly repeatable MRI acquisition and processing pipeline for quantitative susceptibility mapping in the head-and-neck region. Magn Reson Med. 2020 Jul 03;: Authors: Karsa A, Punwani S, Shmueli K Abstract PURPOSE: Quantitative Susceptibility Mapping (QSM) is an emerging technique sensitive to disease-related changes including oxygenation. It is extensively used in brain studies and has increasing clinical...
Mon Jul 06, 2020 13:28
Related Articles A randomized controlled trial on the efficacy of life review therapy targeting incurably ill cancer patients: do their informal caregivers benefit? Support Care Cancer. 2020 Jul 03;: Authors: Kleijn G, Lissenberg-Witte BI, Bohlmeijer ET, Willemsen V, Becker-Commissaris A, Eeltink CM, Bruynzeel AME, van der Vorst MJ, Cuijpers P, Verdonck-de Leeuw IM Abstract PURPOSE: Investigate whether Life Review Therapy and Memory Specificity...
Mon Jul 06, 2020 13:28
Related Articles Minimally invasive procedure for diagnosis and treatment of vallecular cysts in children: review of 156 cases. Eur Arch Otorhinolaryngol. 2020 Jul 03;: Authors: Wang GX, Zhang FZ, Zhao J, Wang H, Li HB, Wang XM, Zhang J, Ni X Abstract PURPOSE: Vallecular cyst is an uncommon but potentially life-threatening disease. The aim of this study was to review the presentation, evaluation, and treatment of vallecular cysts in children....
Mon Jul 06, 2020 13:28
Related Articles Helicobacter pylori gastric infection in patients with laryngeal cancer and chronic laryngitis. Eur Arch Otorhinolaryngol. 2020 Jul 03;: Authors: Pajić Matić I, Matić I, Maslovara S, Veselski K, Stojadinović T, Vučković I Abstract BACKGROUND: The purpose of this study was to investigate the pathohistological status of mucous lining infected with Helicobacte pylori as the possible cause of chronic laryngitis and laryngeal...
Mon Jul 06, 2020 13:28
Related Articles How applicable is the TNM 8 staging for human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma (OPSCC) to a UK population of 106 patients? : A cohort comparison of the TNM 7 and TNM8 staging systems for HPV positive oropharyngeal cancer in a UK population. Eur Arch Otorhinolaryngol. 2020 Jul 03;: Authors: Bradish T, Fisher H, Paleri V, Robinson M, Meikle D, Kelly C, O'Hara J Abstract PURPOSE: TNM8 introduced...
Mon Jul 06, 2020 13:28
Related Articles Serum levels of the IL-6 family of cytokines predict prognosis in renal cell carcinoma (RCC). Cancer Immunol Immunother. 2020 Jul 03;: Authors: Gudbrandsdottir G, Aarstad HH, Bostad L, Hjelle KM, Aarstad HJ, Bruserud Ø, Tvedt THA, Beisland C Abstract PURPOSE: An improved understanding of RCC immunology should shed further light on RCC tumor biology. Our objective was to study to what extent serum levels of the IL-6 family...
Mon Jul 06, 2020 13:28
Related Articles Ex vivo culture of head and neck cancer explants in cell sheet for testing chemotherapeutic sensitivity. J Cancer Res Clin Oncol. 2020 Jul 03;: Authors: Lee J, You JH, Shin D, Roh JL Abstract PURPOSE: Tumor explant culture systems can mimic the in vivo tumor microenvironment, proposing as a substitute for preclinical studies for prediction of individual treatment response. Therefore, our study evaluated the potential usefulness...
Mon Jul 06, 2020 13:28
Related Articles Laryngopharyngeal reflux image quantization and analysis of its severity. Sci Rep. 2020 Jul 03;10(1):10975 Authors: Kuo CJ, Kao CH, Dlamini S, Liu SC Abstract Laryngopharyngeal reflux (LPR) is a prevalent disease affecting a high proportion of patients seeking laryngology consultation. Diagnosis is made subjectively based on history, symptoms, and endoscopic assessment. The results depend on the examiner's interpretation...
Mon Jul 06, 2020 13:28
Related Articles Against the odds: unlikely COVID-19 recovery. BMJ Support Palliat Care. 2020 Jul 03;: Authors: Bisson E, Presswood E, Kenyon J, Shelton F, Hall T Abstract BACKGROUND: We present a 67-year-old male, with palliative hypopharyngeal squamous cell carcinoma, who contracted COVID-19 infection while in hospital. Cancer diagnosis, among other clinical features, increases the risk of poor outcome of COVID-19 infection. A recently...
Mon Jul 06, 2020 13:28
Related Articles Comprehensive Analysis and Clinical Implication of PD-L1 Expression Considering HPV Status in Oropharyngeal Squamous Cell Carcinoma. Anticancer Res. 2020 Jul;40(7):4001-4010 Authors: Jeong JY, Park TI, Ahn D Abstract BACKGROUND/AIM: This study was conducted to comprehensively evaluate programmed cell death ligand 1 (PD-L1) expression, and analyze the clinical and prognostic implications of PD-L1 expression in oropharyngeal...
Mon Jul 06, 2020 13:28
Related Articles Tyrosine Kinase Inhibitors and Everolimus Reduce IGF1R Expression in HPV16-positive and -negative Squamous Cell Carcinoma. Anticancer Res. 2020 Jul;40(7):3847-3855 Authors: Kramer B, Schell A, Aderhold C, Huber L, Mueller CE, Rotter N, Birk R Abstract BACKGROUND/AIM: The effects of tyrosine kinase inhibitors (TKI) in head and neck squamous cell cancer (HNSCC) are not fully understood. We investigated the effects of selective...
Mon Jul 06, 2020 13:28
Related Articles Photosensitizer With Illumination Enhances In Vivo Antitumor Effect of Anti-ROBO1 Immunotoxin on Maxillary Sinus Squamous Cell Carcinoma. Anticancer Res. 2020 Jul;40(7):3793-3799 Authors: Komatsu N, Komatsu M, Ohashi R, Horii A, Hoshi K, Takato T, Abe T, Hamakubo T Abstract BACKGROUND/AIM: Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of cancer worldwide. Our study focused on the axon guidance...
Mon Jul 06, 2020 13:28
Related Articles Computer-assisted versus traditional technique in fibular free-flap mandibular reconstruction: A CT symmetry study. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Jun 30;: Authors: Bartier S, Mazzaschi O, Benichou L, Sauvaget E Abstract OBJECTIVES: In the past few years, virtual planning has been increasingly used for mandibular reconstruction. The objective of our study was to evaluate and compare symmetry and the accuracy...
Mon Jul 06, 2020 13:28
Related Articles Comparison of CBCT conversion methods for dose calculation in the head and neck region. Z Med Phys. 2020 Jun 30;: Authors: Irmak S, Georg D, Lechner W Abstract The purpose of this study was to compare different methods of CBCT conversion respect to dose calculation accuracy. Twelve head and neck cancer patients treated with VMAT using simultaneous integrated boost technique were selected for the study. For each patient...
Mon Jul 06, 2020 13:28
Related Articles Electrode Translocations in Perimodiolar Cochlear Implant Electrodes: Audiological and Electrophysiological Outcome. Z Med Phys. 2020 Jun 30;: Authors: Liebscher T, Mewes A, Hoppe U, Hornung J, Brademann G, Hey M Abstract INTRODUCTION: Despite using the soft-surgery technique, cochlear implantation may increase the damage of the intracochlear structures due to a scalar translocation of the electrode. The aim of this work...
Mon Jul 06, 2020 13:28
Related Articles Review and update on the use of the microanastomotic coupler device for arterial anastomosis in free tissue transfer. Br J Oral Maxillofac Surg. 2020 Jul 01;: Authors: El Baba B, Watfa W, Youssef L, Di Summa PG, Bou Khalil P, Jurjus AR, Loyens DB, Sertel S, Jurjus RA Abstract While a simple interrupted sutured anastomosis remains the gold standard in microsurgery, the introduction of the microanastomotic coupler device...
Mon Jul 06, 2020 13:28
Related Articles Free flap donor site during early review consultations: is it really an issue? Br J Oral Maxillofac Surg. 2020 Jul 01;: Authors: Kanatas AN, Lowe D, Rogers SN Abstract Donor site complications, following microvascular free tissue transfer, can limit recovery in patients treated for head and neck cancer, with a curative intent. The Patient Concerns Inventory (PCI-HN) is a prompt list that provides patients with repeated...
Mon Jul 06, 2020 13:28
Related Articles Challenges in topical therapy of chronic rhinosinusitis: The case of nasal drops application - A systematic review. Auris Nasus Larynx. 2020 Jun 30;: Authors: Trabut S, Friedrich H, Caversaccio M, Negoias S Abstract OBJECTIVE: Chronic rhinosinusitis (CRS) is a common health issue associated with a significant life quality impairment. Intranasal glucocorticoid is the treatment of choice both as initial therapy as well as...
Mon Jul 06, 2020 13:28
Related Articles [The alteration of smell and taste in COVID-19 patients. A diagnostic resource in primary care]. Aten Primaria. 2020 May 27;: Authors: Chiesa-Estomba CM, Lechien JR, Saussez S PMID: 32620292 [PubMed - as supplied by publisher]
Mon Jul 06, 2020 13:28
Related Articles Partial epiglottectomy improves residual apnea-hypopnea index in patients with epiglottis collapse. J Clin Sleep Med. 2020 Jun 29;: Authors: Jeong SH, Man Sung C, Lim SC, Yang HC Abstract None: Continuous positive airway pressure (CPAP) treatment aggravates airway obstruction in patients with epiglottis collapse. In these patients, partial epiglottectomy can resolve epiglottis collapse by partial excision of the obstructed...
Mon Jul 06, 2020 13:28
Related Articles Pembrolizumab for the treatment of esophageal cancer. Expert Opin Biol Ther. 2020 Jul 03;: Authors: Yamamoto S, Kato K Abstract INTRODUCTION: Esophageal cancer (EC) is the seventh most common cancer and the sixth leading cause of cancer death. However, the prognosis of unresectable advanced or recurrent EC patients remains poor and there are few effective therapeutic agents for EC. Pembrolizumab is a monoclonal antibody...
Mon Jul 06, 2020 13:28
The association between hyponatraemia and long-term functional outcome in patients with aneurysmal subarachnoid haemorrhage: A single centre prospective cohort study. J Clin Neurosci. 2020 Jul 01;: Authors: Quinn L, Tian DH, Fitzgerald E, Flower O, Andersen C, Hammond N, Davidson K, Delaney A Abstract To assess the association between hyponatraemia and long-term functional outcome and other relevant outcomes in patients with aneurysmal subarachnoid...
Mon Jul 06, 2020 13:27
Thirty-day outcomes of carotid endarterectomy in the elderly: A 17-year single-center study. J Clin Neurosci. 2020 Jul 01;: Authors: Feng Y, Bai X, Wang T, Wang Y, Chen Y, Li M, Hua Y, Ling F, Ma Y, Jiao L Abstract INTRODUCTION: Carotid endarterectomy (CEA) has been supported as a durable procedure for treating patients with carotid artery stenosis by many randomized controlled trials (RCTs). The aim of this study was to evaluate the 30-day...
Mon Jul 06, 2020 13:27
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