G3: .Genes, Genomes, Genetics Mission - Online First Articles

Loss of the Antimicrobial Peptide Mechnikowin Protects Against Traumatic Brain Injury Outcomes in Drosophila melanogaster

Neuroinflammation is a major pathophysiological feature of traumatic brain injury (TBI). Early and persistent activation of innate immune response signaling pathways by primary injuries is associated with secondary cellular injuries that cause TBI outcomes to change over time. We used a Drosophila melanogaster model to investigate the role of antimicrobial peptides (AMPs) in acute and chronic outcomes of closed-head TBI. AMPs are effectors of pathogen and stress defense mechanisms mediated by the...

G3: .Genes, Genomes, Genetics Mission - Online First Articles

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Fully Phased Sequence of a Diploid Human Genome Determined de Novo from the DNA of a Single Individual

In recent years, improved sequencing technology and computational tools have made de novo genome assembly more accessible. Many approaches, however, generate either an unphased or only partially resolved representation of a diploid genome, in which polymorphisms are detected but not assigned to one or the other of the homologous chromosomes. Yet chromosomal phase information is invaluable for the understanding of phenotypic trait inheritance in the cases of compound heterozygosity, allele-specific...

G3: .Genes, Genomes, Genetics Mission - Online First Articles

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Transcriptome Analyses of Candida albicans Biofilms, Exposed to Arachidonic Acid and Fluconazole, Indicates Potential Drug Targets

Candida albicans is an opportunistic yeast pathogen within the human microbiota with significant medical importance because of its pathogenic potential. The yeast produces highly resistant biofilms, which are crucial for maintaining infections. Though antifungals are available, their effectiveness is dwindling due to resistance. Alternate options that comprise the combination of existing azoles and polyunsaturated fatty acids, such as arachidonic acid (AA), have been shown to increase azoles susceptibility...

G3: .Genes, Genomes, Genetics Mission - Online First Articles

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 Cancer

IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma

British Journal of Cancer, Published online: 07 July 2020; doi:10.1038/s41416-020-0970-zIQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma

Cancer

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Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication

British Journal of Cancer, Published online: 07 July 2020; doi:10.1038/s41416-020-0950-3Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication

Cancer

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Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication

Cancer

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IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma

Cancer

01:22

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 The European Gastrointestinal Motility Society

Early‐life malnutrition causes gastrointestinal dysmotility that is sexually dimorphic

Multiple mouse models of early postnatal malnutrition exhibit slow small bowel progression of FITC‐dextran, delayed gastric emptying, and abnormal gross appearance of the stomach. Altered duodenal contractility and permeability are specific to malnourished males. Abstract Background Slow gastrointestinal (GI) transit occurs in moderate‐to‐severe malnutrition. Mechanisms underlying malnutrition‐associated dysmotility remain unknown, partially due to lack of animal models....

The European Gastrointestinal Motility Society

Mon Jul 06, 2020 15:05

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 Analytical Chemistry

[ASAP] Highly Sensitive and Selective Photoelectrochemical Aptasensor for Cancer Biomarker CA125 Based on AuNPs/GaN Schottky Junction

Analytical ChemistryDOI: 10.1021/acs.analchem.0c02117

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Resolution of Isomeric Mixtures in Ion Mobility Using a Combined Demultiplexing and Peak Deconvolution Technique

Analytical ChemistryDOI: 10.1021/acs.analchem.9b05718

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] In Situ Catalysis and Extraction Approach for Fast Evaluation of Heterogeneous Catalytic Efficiency

Analytical ChemistryDOI: 10.1021/acs.analchem.0c01668

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Absolute Chiral Recognition with Hybrid Wireless Electrochemical Actuators

Analytical ChemistryDOI: 10.1021/acs.analchem.0c01817

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Ag-Embedded Silica Core–Shell Nanospheres for <italic toggle="yes">Operando</italic> Surface Enhanced Raman Spectroscopy of High-Temperature Processes

Analytical ChemistryDOI: 10.1021/acs.analchem.0c00693

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Isomeric Separation of N-Glycopeptides Derived from Glycoproteins by Porous Graphitic Carbon (PGC) LC-MS/MS

Analytical ChemistryDOI: 10.1021/acs.analchem.0c00668

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Proteomics Using Protease Alternatives to Trypsin Benefits from Sequential Digestion with Trypsin

Analytical ChemistryDOI: 10.1021/acs.analchem.0c00478

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Two-Dimensional Device with Light-Controlled Capability for Treatment of Cancer-Relevant Infection Diseases

Analytical ChemistryDOI: 10.1021/acs.analchem.0c02216

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Detection of High-Explosive Materials within Fingerprints by Means of Optical-Photothermal Infrared Spectromicroscopy

Analytical ChemistryDOI: 10.1021/acs.analchem.0c00938

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Submicron Particle and Cell Concentration in a Closed Chamber Surface Acoustic Wave Microcentrifuge

Analytical ChemistryDOI: 10.1021/acs.analchem.0c01757

Analytical Chemistry

Mon Jul 06, 2020 07:00

[ASAP] Lipophilic G-Quadruplex Isomers as Biomimetic Ion Channels for Conformation-Dependent Selective Transmembrane Transport

Analytical ChemistryDOI: 10.1021/acs.analchem.0c02222

Analytical Chemistry

Sun Jul 05, 2020 07:00

[ASAP] Electrochemical Long Period Fiber Grating Sensing for Electroactive Species

Analytical ChemistryDOI: 10.1021/acs.analchem.0c01062

Analytical Chemistry

Sat Jul 04, 2020 07:00

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 Journal of the American Chemical Society: Latest Articles (ACS Publications)

[ASAP] Boosting Interfacial Charge-Transfer Kinetics for Efficient Overall CO₂ Photoreduction via Rational Design of Coordination Spheres on Metal–Organic Frameworks

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05530

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Understanding How the Rate of C–H Bond Cleavage Affects Formate Oxidation Catalysis by a Mo-Dependent Formate Dehydrogenase

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03574

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Dissecting the Essential Role of Anomeric ß-Triflates in Glycosylation Reactions

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05525

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Detecting Nanoscale Distribution of Protein Pairs by Proximity-Dependent Super-resolution Microscopy

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03418

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Bi₈Se₇: Delocalized Interlayer p-Bond Interactions Enhancing Carrier Mobility and Thermoelectric Performance near Room Temperature

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05904

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Probing Heterogeneous Charge Distributions at the a-Al₂O₃(0001)/H₂O Interface

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01366

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Covalent vs Charge-Shift Nature of the Metal–Metal Bond in Transition Metal Complexes: A Unified Understanding

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03957

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Investigation of the Unusual Ability of the [FeFe] Hydrogenase from <italic toggle="yes">Clostridium beijerinckii</italic> to Access an O₂-Protected State

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04964

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Contrasting SnTe–NaSbTe₂ and SnTe–NaBiTe₂ Thermoelectric Alloys: High Performance Facilitated by Increased Cation Vacancies and Lattice Softening

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05650

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Zero-Overlap Fluorophores for Fluorescent Studies at Any Concentration

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02450

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Frequency-Agile Low-Temperature Solution-Processed Alumina Dielectrics for Inorganic and Organic Electronics Enhanced by Fluoride Doping

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05161

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Activation and Functionalization of C–C s Bonds of Alkylidene Cyclopropanes at Main Group Centers

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03383

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Iridium-Catalyzed Enantioselective a-C(sp³)–H Borylation of Azacycles

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06756

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Mon Jul 06, 2020 07:00

[ASAP] Helical Carbenium Ion: A Versatile Organic Photoredox Catalyst for Red-Light-Mediated Reactions

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05507

Journal of the American Chemical Society: Latest Articles (ACS Publications)

Sun Jul 05, 2020 07:00

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 Facial Plastic Surgery

Lower Blepharoplasty Three-Dimensional Volume Assessment after Fat Pad Transposition and Concomitant Fat Grafting

Facial Plast SurgDOI: 10.1055/s-0040-1713790Lower blepharoplasty is a commonly performed procedure to improve the aesthetic of the lower eyelid and upper midface. Combined fat pad transposition and fat grafting has not been previously studied using three-dimensional (3D) analysis. The aim of the study is to demonstrate the benefits of fat pad transposition with concomitant autologous fat grafting in lower blepharoplasty and to determine quantitative volumetric effects on the tear trough and lower...

Facial Plastic Surgery

Mon Jul 06, 2020 02:00

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 Laryngo-Rhino-Otologie

Management von Patienten mit Vestibularisschwannomen Typ IV

LaryngorhinootologieDOI: 10.1055/a-1130-6321 Hintergrund Vestibularisschwannome (VS) sind benigne Tumoren, die anhand der Hannover-Klassifikation bzw. der Koos-Klassifizierung eingeteilt werden. Trotz der umfangreichen Literatur sind die Klinik und die Behandlungskonzepte speziell bei großen VS selten beschrieben. Material und Methoden Zwischen 2003 und 2018 wurden 61 Patienten mit VS Typ IV durch die Arbeitsgruppe Schädelbasischirurgie am Klinikum Dortmund behandelt. Die radiologischen...

Laryngo-Rhino-Otologie

Mon Jul 06, 2020 02:00

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