Neuroinflammation is a major pathophysiological feature of traumatic brain injury (TBI). Early and persistent activation of innate immune response signaling pathways by primary injuries is associated with secondary cellular injuries that cause TBI outcomes to change over time. We used a Drosophila melanogaster model to investigate the role of antimicrobial peptides (AMPs) in acute and chronic outcomes of closed-head TBI. AMPs are effectors of pathogen and stress defense mechanisms mediated by the...
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In recent years, improved sequencing technology and computational tools have made de novo genome assembly more accessible. Many approaches, however, generate either an unphased or only partially resolved representation of a diploid genome, in which polymorphisms are detected but not assigned to one or the other of the homologous chromosomes. Yet chromosomal phase information is invaluable for the understanding of phenotypic trait inheritance in the cases of compound heterozygosity, allele-specific...
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Candida albicans is an opportunistic yeast pathogen within the human microbiota with significant medical importance because of its pathogenic potential. The yeast produces highly resistant biofilms, which are crucial for maintaining infections. Though antifungals are available, their effectiveness is dwindling due to resistance. Alternate options that comprise the combination of existing azoles and polyunsaturated fatty acids, such as arachidonic acid (AA), have been shown to increase azoles susceptibility...
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British Journal of Cancer, Published online: 07 July 2020; doi:10.1038/s41416-020-0970-zIQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma
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British Journal of Cancer, Published online: 07 July 2020; doi:10.1038/s41416-020-0950-3Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication
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Multiple mouse models of early postnatal malnutrition exhibit slow small bowel progression of FITC‐dextran, delayed gastric emptying, and abnormal gross appearance of the stomach. Altered duodenal contractility and permeability are specific to malnourished males. Abstract Background Slow gastrointestinal (GI) transit occurs in moderate‐to‐severe malnutrition. Mechanisms underlying malnutrition‐associated dysmotility remain unknown, partially due to lack of animal models....
Mon Jul 06, 2020 15:05
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02117
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05718
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01668
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01817
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00693
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00668
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00478
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02216
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00938
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01757
Mon Jul 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02222
Sun Jul 05, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01062
Sat Jul 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05530
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03574
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05525
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03418
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05904
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01366
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03957
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04964
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05650
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02450
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05161
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03383
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06756
Mon Jul 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05507
Sun Jul 05, 2020 07:00
Facial Plast SurgDOI: 10.1055/s-0040-1713790Lower blepharoplasty is a commonly performed procedure to improve the aesthetic of the lower eyelid and upper midface. Combined fat pad transposition and fat grafting has not been previously studied using three-dimensional (3D) analysis. The aim of the study is to demonstrate the benefits of fat pad transposition with concomitant autologous fat grafting in lower blepharoplasty and to determine quantitative volumetric effects on the tear trough and lower...
Mon Jul 06, 2020 02:00
LaryngorhinootologieDOI: 10.1055/a-1130-6321 Hintergrund Vestibularisschwannome (VS) sind benigne Tumoren, die anhand der Hannover-Klassifikation bzw. der Koos-Klassifizierung eingeteilt werden. Trotz der umfangreichen Literatur sind die Klinik und die Behandlungskonzepte speziell bei großen VS selten beschrieben. Material und Methoden Zwischen 2003 und 2018 wurden 61 Patienten mit VS Typ IV durch die Arbeitsgruppe Schädelbasischirurgie am Klinikum Dortmund behandelt. Die radiologischen...
Mon Jul 06, 2020 02:00
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