Current procedures for inferring population history are generally performed under the assumption of complete neutrality - that is, by neglecting both direct selection and the effects of selection on linked sites. We here examine how the presence of direct purifying and background selection may bias demographic inference by evaluating two commonly-used methods (MSMC and fastsimcoal2), specifically studying how the underlying shape of the distribution of fitness effects (DFE) and the fraction of directly...
Mon Jul 06, 2020 03:00
Abstract Purpose To perform a systematic review and meta-analysis of the impact of brachytherapy (BT) technique (two-dimensional [2D] or three-dimensional image-guided [3D]) on outcomes of cervical cancer patients. Methods PubMed and EMBASE databases were searched up to April 16, 2019, for studies which evaluated the effect of 3D-BT compared to 2D-BT...
Mon Jul 06, 2020 03:00
Sweety Trivedi, Ashis Datta, Santosh Trivedi, A Shobhana, Dipendra K Pradhan, Kajari Bhattacharya, Moulima BanerjeeNeurology India 2020 68(3):677-680 Bruns syndrome is characterized by attacks of sudden severe headache, vomiting, and vertigo precipitated due to abrupt movements of the head due to presence of mobile deformable intraventricular lesion causing episodic obstructive hydrocephalus. Proposed underlying mechanism is intermittent or positional CSF obstruction resulting from ball-valve...
Mon Jul 06, 2020 00:00
P Sarat ChandraNeurology India 2020 68(3):532-533
Mon Jul 06, 2020 00:00
Mauro Monforte, Giacomo Della Marca, Emilio LozuponeNeurology India 2020 68(3):718-719
Mon Jul 06, 2020 00:00
Prakash N TandonNeurology India 2020 68(3):534-539
Mon Jul 06, 2020 00:00
Harrison M Thompson, Bradford A WoodworthNeurology India 2020 68(3):701-701
Mon Jul 06, 2020 00:00
RS JainNeurology India 2020 68(3):540-544
Mon Jul 06, 2020 00:00
Boby Varkey MaramattomNeurology India 2020 68(3):660-664There could be an association between cryptococcal meningitis and the later development of moyamoya syndrome. We performed serial clinical and radiological assessments in an immunosuppressed post-renal transplant patient who had previously suffered from cryptococcal meningitis and then went on to develop a moyamoya syndrome (MMS). We also performed a literature search and review of post-infectious MMS cases from 1976 to 2019. The clinical course...
Mon Jul 06, 2020 00:00
Prakash N TandonNeurology India 2020 68(3):545-546
Mon Jul 06, 2020 00:00
Jenny Mukeshchandra Gandhi, Shilpa Sankhe, Prasad UdmaleNeurology India 2020 68(3):691-693
Mon Jul 06, 2020 00:00
PN TandonNeurology India 2020 68(3):547-547
Mon Jul 06, 2020 00:00
Chirag Kamal Ahuja, Manisha Joshi, Sandeep Mohindra, Niranjan KhandelwalNeurology India 2020 68(3):708-709
Mon Jul 06, 2020 00:00
Tariq Dhiyab Al-Saadi, Marija Glisic, Ali Al Sharqi, Safiya Al Kharosi, Malik Al Shaqsi, Noor Al Jabri, Awahir Al SharqiNeurology India 2020 68(3):548-554 Objective: To assess the safety of pregnancy in ventriculoperitoneal (VP) shunt-dependent women. Methods: Three electronic databases MEDLINE (PubMed), EMBASE, and the Cochrane Library were systematically searched to identify studies published in English between 1950 and 2019. We additionally searched Web of Science, Google Scholar, and...
Mon Jul 06, 2020 00:00
Krishnan GanapathyNeurology India 2020 68(3):555-559 Background: The COVID-19 pandemic has within months turned the world upside down. With personal distancing and shortage of personal protective equipment, face-to-face health care encounters are increasingly becoming problematic. Neurological manifestations are also being observed in clinical presentations. Objective: Worldwide most countries, the World Health Organization (WHO) and Centre for Disease Control (USA) have recommended use of...
Mon Jul 06, 2020 00:00
Malay Jhancy, Ammar Al Homsi, Fatema Chowdhury, Samiha Hossain, Reshme AhamedNeurology India 2020 68(3):669-672 Van der Knaap disease, also known as megalencephalic leukoencephalopathy with subcortical cysts (MLC), is a rare autosomal disorder, with no exact prevalence but more than 150 cases were reported in the literature. It was more prevalent in some ethnicities where consanguinity is common.[1] It is usually characterized by infantile-onset macrocephaly, cerebral leukoencephalopathy and...
Mon Jul 06, 2020 00:00
Ravindra K GargNeurology India 2020 68(3):560-572 COVID-19, in most patients, presents with mild flu-like illness. Elderly patients with comorbidities, like hypertension, diabetes, or lung and cardiac disease, are more likely to have severe disease and deaths. Neurological complications are frequently reported in severely or critically ill patients with comorbidities. In COVID-19, both central and peripheral nervous systems can be affected. The SARS-CoV-2 virus causes the disease COVID-19 and...
Mon Jul 06, 2020 00:00
Ananth P Abraham, Mandeep Singh Bindra, Ari George ChackoNeurology India 2020 68(3):684-687 The most common presenting form of neurocysticercosis in the Indian subcontinent is a solitary cysticercus granuloma (SCG). Patients with typical SCGs almost never require any form of surgical intervention. Herein, we report an extremely rare case of bacterial superinfection of a left frontal SCG in a 23-year-old female, resulting in severe perilesional edema and mass effect. The patient had to undergo...
Mon Jul 06, 2020 00:00
Niranjana Rajagopal, Sumit Thakar, Vinay Hegde, Saritha Aryan, Alangar S HegdeNeurology India 2020 68(3):573-578 Background: The sphenoid ostium (SO) is an important landmark for the endoscopic surgeon. Changes in size and position of the SO and variations in other skull base landmarks in acromegalics have not been adequately evaluated. Aims: The authors evaluated the morphometry and location of the SO and other landmarks in acromegaly and compared these findings with those in nonfunctioning...
Mon Jul 06, 2020 00:00
Ninad Dhokte, Charulata S Sankhla, Chelani Ratan, Milind SankheNeurology India 2020 68(3):696-697
Mon Jul 06, 2020 00:00
N JayashankarNeurology India 2020 68(3):579-580
Mon Jul 06, 2020 00:00
Binoy D Thavara, Bijukrishnan Rajagopalawarrier, Jyothi C Ramaswamy, Geo Senil KidanganNeurology India 2020 68(3):703-705
Mon Jul 06, 2020 00:00
Hui-Chien Beh, Hui-Jan Tan, Rozita Hod, Ching-Soong Khoo, Khairiyah MohamadNeurology India 2020 68(3):581-585 Background: Epilepsy is associated with cognitive impairment due to the disease itself or side-effects of antiepileptic drugs. Objective: We aimed to study the prevalence of visual memory dysfunction among epilepsy patients and identify the predictors that could contribute to the impairment. Materials and Methods: This was a cross-sectional study. We analyzed 250 patients with...
Mon Jul 06, 2020 00:00
Rajesh K Meena, Ramesh S Doddamani, Kanwaljeet Garg, Dipanshu Narula, Deepak AgrawalNeurology India 2020 68(3):713-715
Mon Jul 06, 2020 00:00
Bhargavi Ramanujan, Manjari TripathiNeurology India 2020 68(3):586-587
Mon Jul 06, 2020 00:00
Neha Dhir, Savita Verma Attri, Smita Pattanaik, M Praveen Kumar, Navjit Kaur Gill, Ajay Patial, Nidhi Rathore, Lekha Saha, Sandeep MohindraNeurology India 2020 68(3):588-592 Background: Phenytoin (PHT) is a routinely prescribed prophylactic antiepileptic following aneurysmal subarachnoid hemorrhage (aSAH). However, its prophylactic use in aSAH is controversial as emerging evidence suggests worsening of the neurological and functional outcomes. In addition, there is profound damage to the blood–brain...
Mon Jul 06, 2020 00:00
A Case of Ollier's Disease with P53 Mutation Positive and IDH1 (R132H) Negative Multicentric Gliomas
Y Nishtha, B Maya, Safal S Shetty, VH Ganaraj, P Nupur, TC Yasha, M NetravathiNeurology India 2020 68(3):657-659Ollier disease is a rare nonhereditary disorder characterized by multiple enchondromas (enchondromatosis). To report a rare case of Ollier disease with gliomas and its mutation analysis. We hereby report a young lady who presented with seizures. She had a past history of multiple bony swellings in the right foot (operated) and swelling over the anterior chest wall for the past 15 years....
Mon Jul 06, 2020 00:00
R Girish MenonNeurology India 2020 68(3):593-594
Mon Jul 06, 2020 00:00
Neena Baby, Sabu George Kunnathuparambil, Prasanth Varghese, Aneesh Mangalasseril KuriakoseNeurology India 2020 68(3):665-668 Ischemic stroke involving multiple artery territory with normal vessels gives a clue for an embolic stroke. Paradoxical embolization is a recognized cause of ischemic stroke. We describe a 48-year-old male who presented with acute onset giddiness, mild dysarthria, right hemiparesis, and ataxia. Clinical examinations indicated left cerebellar signs with right hemiparesis....
Mon Jul 06, 2020 00:00
Tejas Venkataram, Nishant Goyal, Chinmaya Dash, Prarthana P Chandra, Jitender Chaturvedi, Amol Raheja, Raghav Singla, Jayesh Sardhara, Bhoopendra Singh, Ravi GuptaNeurology India 2020 68(3):595-602 Background: The COVID-19 pandemic has created an unprecedented challenge for medical professionals throughout the world to tackle the rapidly changing scenario. The objective of this survey was to analyze the change in neurosurgical practice in India following the COVID-19 outbreak and assess its impact...
Mon Jul 06, 2020 00:00
Kanika Goyal, Chandana Bhagwat, Renu Suthar, Arushi Gahlot Saini, Namita Ravikumar, Paramjeet Singh, Reeta S Mani, Meenu SinghNeurology India 2020 68(3):673-676Rabies encephalitis is a universally fatal disease. Prolonged survival in children with rabies encephalitis has only been anecdotally reported. Case report: An 11-year-old boy presented with right-handed paraesthesia followed by flaccid weakness, progressive quadriparesis and encephalopathy following an unprovoked, class III dog bite over...
Mon Jul 06, 2020 00:00
Raju Birudu, TR Kanmani, B Indira DeviNeurology India 2020 68(3):603-608 Traumatic brain injuries [TBI] caused by road traffic accidents [RTA] are a serious health problem for people of all countries across the globe. RTA will be a leading cause of mortality, morbidity, disabilities and creating many rehabilitation needs. Hence, this, article highlights the clinical concerns, burden, challenges, role of medical and psychiatric social worker, rehabilitation strategies and practical guidelines...
Mon Jul 06, 2020 00:00
Erum Mubbashir ShariffNeurology India 2020 68(3):681-683 Hashimoto's encephalopathy (HE) is an uncommon neurological disorder of unknown etiology, found in association with thyroid autoimmunity, mostly uncommon in males. The disease occurs primarily in the fifth decade of life and may occur in two forms; a sudden vasculitic type or a progressive subacute type associated with cognitive dysfunction, confusion, and memory loss. We report a case of a 51-year-old Sri Lankan gentleman with no comorbidities...
Mon Jul 06, 2020 00:00
Jitesh Goel, Ravi Anadure, Salil Gupta, Vinny Wilson, Rajeev Saxena, Samaresh Sahu, Deepti MutrejaNeurology India 2020 68(3):609-616 Background: Sarcoidosis is an inflammatory granulomatous disease affecting multiple organ systems. Neurological manifestations are rare and seen in approximately 5% cases of sarcoidosis. They may commonly precede the diagnosis of sarcoidosis. Since there is paucity of Indian literature on this subject, we decided to review the clinical and radiological profile,...
Mon Jul 06, 2020 00:00
Liza Das, Nimisha Jain, Anshita Aggarwal, Pinaki Dutta, Anil BhansaliNeurology India 2020 68(3):688-690
Mon Jul 06, 2020 00:00
Vanitha Rajagopalan, Rajendra Singh Chouhan, Mihir Prakash Pandia, Ritesh Lamsal, Parmod Kumar Bithal, Girija Prasad RathNeurology India 2020 68(3):617-623 Introduction: Stellate ganglion block (SGB) is commonly performed to treat chronic painful conditions, such as complex regional pain syndrome (CRPS) and postherpetic neuralgia. However, whether it is effective in reducing anesthesia and analgesia requirement during surgery (acute pain) is not known. Materials and Methods: Sixty American Society...
Mon Jul 06, 2020 00:00
Menachem Weiss, Jorge RiscoNeurology India 2020 68(3):694-695
Mon Jul 06, 2020 00:00
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